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Q6ZN17

- LN28B_HUMAN

UniProt

Q6ZN17 - LN28B_HUMAN

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Protein

Protein lin-28 homolog B

Gene

LIN28B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi129 – 1291Zinc 1By similarity
Metal bindingi132 – 1321Zinc 1By similarity
Metal bindingi137 – 1371Zinc 1By similarity
Metal bindingi142 – 1421Zinc 1By similarity
Metal bindingi151 – 1511Zinc 2By similarity
Metal bindingi154 – 1541Zinc 2By similarity
Metal bindingi159 – 1591Zinc 2By similarity
Metal bindingi164 – 1641Zinc 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri127 – 14418CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri149 – 16618CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
  3. RNA binding Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. miRNA catabolic process Source: UniProtKB
  2. pre-miRNA processing Source: UniProtKB
  3. regulation of transcription, DNA-templated Source: InterPro
  4. RNA 3'-end processing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ6ZN17.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-28 homolog B
Short name:
Lin-28B
Gene namesi
Name:LIN28B
Synonyms:CSDD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:32207. LIN28B.

Subcellular locationi

Cytoplasm. Nucleus
Note: Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti635. Neuroblastoma.
PharmGKBiPA142671543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Protein lin-28 homolog BPRO_0000253793Add
BLAST

Proteomic databases

MaxQBiQ6ZN17.
PaxDbiQ6ZN17.
PeptideAtlasiQ6ZN17.
PRIDEiQ6ZN17.

PTM databases

PhosphoSiteiQ6ZN17.

Expressioni

Tissue specificityi

High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level).1 Publication

Inductioni

Might be negatively regulated by the microRNA let-7b.1 Publication

Gene expression databases

BgeeiQ6ZN17.
CleanExiHS_LIN28B.
ExpressionAtlasiQ6ZN17. baseline.
GenevestigatoriQ6ZN17.

Organism-specific databases

HPAiHPA036630.
HPA061745.

Interactioni

Subunit structurei

Interacts with ZCCHC11/TUT4.1 Publication

Protein-protein interaction databases

BioGridi133142. 34 interactions.
IntActiQ6ZN17. 3 interactions.
STRINGi9606.ENSP00000344401.

Structurei

Secondary structure

1
250
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 3811Combined sources
Turni39 – 424Combined sources
Beta strandi43 – 519Combined sources
Beta strandi54 – 6512Combined sources
Helixi66 – 683Combined sources
Beta strandi71 – 744Combined sources
Beta strandi82 – 887Combined sources
Beta strandi95 – 1017Combined sources
Helixi102 – 1043Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A4IX-ray1.95A/B24-111[»]
ProteinModelPortaliQ6ZN17.
SMRiQ6ZN17. Positions 26-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10274CSDAdd
BLAST

Domaini

The tandem zinc fingers, also referred as zinc knuckle domain (ZKD), mediate specific binding to the GGAG/GGUG motif while the CSD shows only limited pyrimidine-rich sequence specificity. Both domains bind single-stranded nucleic acids.

Sequence similaritiesi

Belongs to the lin-28 family.Curated
Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation
Contains 1 CSD (cold-shock) domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri127 – 14418CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri149 – 16618CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1278.
GeneTreeiENSGT00390000001177.
HOGENOMiHOG000047091.
HOVERGENiHBG081922.
InParanoidiQ6ZN17.
OMAiGGGHGCT.
OrthoDBiEOG72JWJ8.
PhylomeDBiQ6ZN17.
TreeFamiTF316240.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZN17-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGGASKGG GEEPGKLPEP AEEESQVLRG TGHCKWFNVR MGFGFISMIN
60 70 80 90 100
REGSPLDIPV DVFVHQSKLF MEGFRSLKEG EPVEFTFKKS SKGLESIRVT
110 120 130 140 150
GPGGSPCLGS ERRPKGKTLQ KRKPKGDRCY NCGGLDHHAK ECSLPPQPKK
160 170 180 190 200
CHYCQSIMHM VANCPHKNVA QPPASSQGRQ EAESQPCTST LPREVGGGHG
210 220 230 240 250
CTSPPFPQEA RAEISERSGR SPQEASSTKS SIAPEEQSKK GPSVQKRKKT
Length:250
Mass (Da):27,084
Last modified:July 5, 2004 - v1
Checksum:iDEF2920C5F1D0BBD
GO
Isoform 2 (identifier: Q6ZN17-2) [UniParc]FASTAAdd to Basket

Also known as: LIN28BS

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.

Show »
Length:180
Mass (Da):19,511
Checksum:i26526F59F88068F7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform 2. CuratedVSP_027207Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ127228 mRNA. Translation: AAZ38897.1.
AK131411 mRNA. Translation: BAD18558.1.
Z95329, AL135911 Genomic DNA. Translation: CAI21661.2.
AL135911, Z95329 Genomic DNA. Translation: CAI20969.2.
CH471051 Genomic DNA. Translation: EAW48434.1.
BC127712 mRNA. Translation: AAI27713.1.
BC127713 mRNA. Translation: AAI27714.1.
BC137526 mRNA. Translation: AAI37527.1.
BC137527 mRNA. Translation: AAI37528.1.
BC141960 mRNA. Translation: AAI41961.1.
CCDSiCCDS34504.1. [Q6ZN17-1]
RefSeqiNP_001004317.1. NM_001004317.3. [Q6ZN17-1]
UniGeneiHs.23616.

Genome annotation databases

EnsembliENST00000345080; ENSP00000344401; ENSG00000187772. [Q6ZN17-1]
GeneIDi389421.
KEGGihsa:389421.
UCSCiuc003pqv.2. human. [Q6ZN17-1]

Polymorphism databases

DMDMi74758701.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ127228 mRNA. Translation: AAZ38897.1 .
AK131411 mRNA. Translation: BAD18558.1 .
Z95329 , AL135911 Genomic DNA. Translation: CAI21661.2 .
AL135911 , Z95329 Genomic DNA. Translation: CAI20969.2 .
CH471051 Genomic DNA. Translation: EAW48434.1 .
BC127712 mRNA. Translation: AAI27713.1 .
BC127713 mRNA. Translation: AAI27714.1 .
BC137526 mRNA. Translation: AAI37527.1 .
BC137527 mRNA. Translation: AAI37528.1 .
BC141960 mRNA. Translation: AAI41961.1 .
CCDSi CCDS34504.1. [Q6ZN17-1 ]
RefSeqi NP_001004317.1. NM_001004317.3. [Q6ZN17-1 ]
UniGenei Hs.23616.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4A4I X-ray 1.95 A/B 24-111 [» ]
ProteinModelPortali Q6ZN17.
SMRi Q6ZN17. Positions 26-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 133142. 34 interactions.
IntActi Q6ZN17. 3 interactions.
STRINGi 9606.ENSP00000344401.

PTM databases

PhosphoSitei Q6ZN17.

Polymorphism databases

DMDMi 74758701.

Proteomic databases

MaxQBi Q6ZN17.
PaxDbi Q6ZN17.
PeptideAtlasi Q6ZN17.
PRIDEi Q6ZN17.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345080 ; ENSP00000344401 ; ENSG00000187772 . [Q6ZN17-1 ]
GeneIDi 389421.
KEGGi hsa:389421.
UCSCi uc003pqv.2. human. [Q6ZN17-1 ]

Organism-specific databases

CTDi 389421.
GeneCardsi GC06P105404.
HGNCi HGNC:32207. LIN28B.
HPAi HPA036630.
HPA061745.
MIMi 611044. gene.
neXtProti NX_Q6ZN17.
Orphaneti 635. Neuroblastoma.
PharmGKBi PA142671543.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1278.
GeneTreei ENSGT00390000001177.
HOGENOMi HOG000047091.
HOVERGENi HBG081922.
InParanoidi Q6ZN17.
OMAi GGGHGCT.
OrthoDBi EOG72JWJ8.
PhylomeDBi Q6ZN17.
TreeFami TF316240.

Enzyme and pathway databases

SignaLinki Q6ZN17.

Miscellaneous databases

GenomeRNAii 389421.
NextBioi 102860.
PROi Q6ZN17.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZN17.
CleanExi HS_LIN28B.
ExpressionAtlasi Q6ZN17. baseline.
Genevestigatori Q6ZN17.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
4.10.60.10. 1 hit.
InterProi IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view ]
PRINTSi PR00050. COLDSHOCK.
SMARTi SM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEi PS50158. ZF_CCHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of Lin28A and Lin28B in post-implantation mouse embryos."
    Moss E.G., Kemper K.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma."
    Guo Y., Chen Y., Ito H., Watanabe A., Ge X., Kodama T., Aburatani H.
    Gene 384:51-61(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  7. "Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA."
    Heo I., Joo C., Cho J., Ha M., Han J., Kim V.N.
    Mol. Cell 32:276-284(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, RNA-BINDING.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation."
    Heo I., Joo C., Kim Y.-K., Ha M., Yoon M.-J., Cho J., Yeom K.-H., Han J., Kim V.N.
    Cell 138:696-708(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING, INTERACTION WITH ZCCHC11.
  10. Cited for: POSSIBLE INVOLVEMENT IN CANCERS.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The Lin28 cold-shock domain remodels pre-let-7 microRNA."
    Mayr F., Schutz A., Doge N., Heinemann U.
    Nucleic Acids Res. 40:7492-7506(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 24-111, ZINC KNUCKLE DOMAIN.

Entry informationi

Entry nameiLN28B_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN17
Secondary accession number(s): A1L165, B2RPN6, Q5TCM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpressed in primary tumors (overall frequency approximately 15%), overexpression being linked to repression of let-7 family miRNAs and derepression of let-7 targets. Facilitates cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3