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Q6ZN17

- LN28B_HUMAN

UniProt

Q6ZN17 - LN28B_HUMAN

Protein

Protein lin-28 homolog B

Gene

LIN28B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi129 – 1291Zinc 1By similarity
    Metal bindingi132 – 1321Zinc 1By similarity
    Metal bindingi137 – 1371Zinc 1By similarity
    Metal bindingi142 – 1421Zinc 1By similarity
    Metal bindingi151 – 1511Zinc 2By similarity
    Metal bindingi154 – 1541Zinc 2By similarity
    Metal bindingi159 – 1591Zinc 2By similarity
    Metal bindingi164 – 1641Zinc 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri127 – 14418CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri149 – 16618CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. RNA binding Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. miRNA catabolic process Source: UniProtKB
    2. pre-miRNA processing Source: UniProtKB
    3. regulation of transcription, DNA-templated Source: InterPro
    4. RNA 3'-end processing Source: UniProtKB

    Keywords - Biological processi

    RNA-mediated gene silencing

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ6ZN17.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lin-28 homolog B
    Short name:
    Lin-28B
    Gene namesi
    Name:LIN28B
    Synonyms:CSDD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:32207. LIN28B.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti635. Neuroblastoma.
    PharmGKBiPA142671543.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Protein lin-28 homolog BPRO_0000253793Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZN17.
    PaxDbiQ6ZN17.
    PeptideAtlasiQ6ZN17.
    PRIDEiQ6ZN17.

    PTM databases

    PhosphoSiteiQ6ZN17.

    Expressioni

    Tissue specificityi

    High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level).1 Publication

    Inductioni

    Might be negatively regulated by the microRNA let-7b.1 Publication

    Gene expression databases

    BgeeiQ6ZN17.
    CleanExiHS_LIN28B.
    GenevestigatoriQ6ZN17.

    Organism-specific databases

    HPAiHPA036630.
    HPA061745.

    Interactioni

    Subunit structurei

    Interacts with ZCCHC11/TUT4.1 Publication

    Protein-protein interaction databases

    BioGridi133142. 27 interactions.
    IntActiQ6ZN17. 3 interactions.
    STRINGi9606.ENSP00000344401.

    Structurei

    Secondary structure

    1
    250
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 3811
    Turni39 – 424
    Beta strandi43 – 519
    Beta strandi54 – 6512
    Helixi66 – 683
    Beta strandi71 – 744
    Beta strandi82 – 887
    Beta strandi95 – 1017
    Helixi102 – 1043

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4A4IX-ray1.95A/B24-111[»]
    ProteinModelPortaliQ6ZN17.
    SMRiQ6ZN17. Positions 26-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 10274CSDAdd
    BLAST

    Domaini

    The tandem zinc fingers, also referred as zinc knuckle domain (ZKD), mediate specific binding to the GGAG/GGUG motif while the CSD shows only limited pyrimidine-rich sequence specificity. Both domains bind single-stranded nucleic acids.

    Sequence similaritiesi

    Belongs to the lin-28 family.Curated
    Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 CSD (cold-shock) domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri127 – 14418CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri149 – 16618CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1278.
    HOGENOMiHOG000047091.
    HOVERGENiHBG081922.
    InParanoidiQ6ZN17.
    OMAiGGGHGCT.
    OrthoDBiEOG72JWJ8.
    PhylomeDBiQ6ZN17.
    TreeFamiTF316240.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    4.10.60.10. 1 hit.
    InterProiIPR011129. Cold_shock_prot.
    IPR002059. CSP_DNA-bd.
    IPR012340. NA-bd_OB-fold.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00313. CSD. 1 hit.
    PF00098. zf-CCHC. 1 hit.
    [Graphical view]
    PRINTSiPR00050. COLDSHOCK.
    SMARTiSM00357. CSP. 1 hit.
    SM00343. ZnF_C2HC. 2 hits.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEiPS50158. ZF_CCHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZN17-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGGASKGG GEEPGKLPEP AEEESQVLRG TGHCKWFNVR MGFGFISMIN    50
    REGSPLDIPV DVFVHQSKLF MEGFRSLKEG EPVEFTFKKS SKGLESIRVT 100
    GPGGSPCLGS ERRPKGKTLQ KRKPKGDRCY NCGGLDHHAK ECSLPPQPKK 150
    CHYCQSIMHM VANCPHKNVA QPPASSQGRQ EAESQPCTST LPREVGGGHG 200
    CTSPPFPQEA RAEISERSGR SPQEASSTKS SIAPEEQSKK GPSVQKRKKT 250
    Length:250
    Mass (Da):27,084
    Last modified:July 5, 2004 - v1
    Checksum:iDEF2920C5F1D0BBD
    GO
    Isoform 2 (identifier: Q6ZN17-2) [UniParc]FASTAAdd to Basket

    Also known as: LIN28BS

    The sequence of this isoform differs from the canonical sequence as follows:
         1-70: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:180
    Mass (Da):19,511
    Checksum:i26526F59F88068F7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7070Missing in isoform 2. CuratedVSP_027207Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ127228 mRNA. Translation: AAZ38897.1.
    AK131411 mRNA. Translation: BAD18558.1.
    Z95329, AL135911 Genomic DNA. Translation: CAI21661.2.
    AL135911, Z95329 Genomic DNA. Translation: CAI20969.2.
    CH471051 Genomic DNA. Translation: EAW48434.1.
    BC127712 mRNA. Translation: AAI27713.1.
    BC127713 mRNA. Translation: AAI27714.1.
    BC137526 mRNA. Translation: AAI37527.1.
    BC137527 mRNA. Translation: AAI37528.1.
    BC141960 mRNA. Translation: AAI41961.1.
    CCDSiCCDS34504.1. [Q6ZN17-1]
    RefSeqiNP_001004317.1. NM_001004317.3. [Q6ZN17-1]
    UniGeneiHs.23616.

    Genome annotation databases

    EnsembliENST00000345080; ENSP00000344401; ENSG00000187772. [Q6ZN17-1]
    GeneIDi389421.
    KEGGihsa:389421.
    UCSCiuc003pqv.2. human. [Q6ZN17-1]

    Polymorphism databases

    DMDMi74758701.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ127228 mRNA. Translation: AAZ38897.1 .
    AK131411 mRNA. Translation: BAD18558.1 .
    Z95329 , AL135911 Genomic DNA. Translation: CAI21661.2 .
    AL135911 , Z95329 Genomic DNA. Translation: CAI20969.2 .
    CH471051 Genomic DNA. Translation: EAW48434.1 .
    BC127712 mRNA. Translation: AAI27713.1 .
    BC127713 mRNA. Translation: AAI27714.1 .
    BC137526 mRNA. Translation: AAI37527.1 .
    BC137527 mRNA. Translation: AAI37528.1 .
    BC141960 mRNA. Translation: AAI41961.1 .
    CCDSi CCDS34504.1. [Q6ZN17-1 ]
    RefSeqi NP_001004317.1. NM_001004317.3. [Q6ZN17-1 ]
    UniGenei Hs.23616.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4A4I X-ray 1.95 A/B 24-111 [» ]
    ProteinModelPortali Q6ZN17.
    SMRi Q6ZN17. Positions 26-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 133142. 27 interactions.
    IntActi Q6ZN17. 3 interactions.
    STRINGi 9606.ENSP00000344401.

    PTM databases

    PhosphoSitei Q6ZN17.

    Polymorphism databases

    DMDMi 74758701.

    Proteomic databases

    MaxQBi Q6ZN17.
    PaxDbi Q6ZN17.
    PeptideAtlasi Q6ZN17.
    PRIDEi Q6ZN17.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345080 ; ENSP00000344401 ; ENSG00000187772 . [Q6ZN17-1 ]
    GeneIDi 389421.
    KEGGi hsa:389421.
    UCSCi uc003pqv.2. human. [Q6ZN17-1 ]

    Organism-specific databases

    CTDi 389421.
    GeneCardsi GC06P105404.
    HGNCi HGNC:32207. LIN28B.
    HPAi HPA036630.
    HPA061745.
    MIMi 611044. gene.
    neXtProti NX_Q6ZN17.
    Orphaneti 635. Neuroblastoma.
    PharmGKBi PA142671543.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1278.
    HOGENOMi HOG000047091.
    HOVERGENi HBG081922.
    InParanoidi Q6ZN17.
    OMAi GGGHGCT.
    OrthoDBi EOG72JWJ8.
    PhylomeDBi Q6ZN17.
    TreeFami TF316240.

    Enzyme and pathway databases

    SignaLinki Q6ZN17.

    Miscellaneous databases

    GenomeRNAii 389421.
    NextBioi 102860.
    PROi Q6ZN17.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZN17.
    CleanExi HS_LIN28B.
    Genevestigatori Q6ZN17.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    4.10.60.10. 1 hit.
    InterProi IPR011129. Cold_shock_prot.
    IPR002059. CSP_DNA-bd.
    IPR012340. NA-bd_OB-fold.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00313. CSD. 1 hit.
    PF00098. zf-CCHC. 1 hit.
    [Graphical view ]
    PRINTSi PR00050. COLDSHOCK.
    SMARTi SM00357. CSP. 1 hit.
    SM00343. ZnF_C2HC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEi PS50158. ZF_CCHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of Lin28A and Lin28B in post-implantation mouse embryos."
      Moss E.G., Kemper K.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma."
      Guo Y., Chen Y., Ito H., Watanabe A., Ge X., Kodama T., Aburatani H.
      Gene 384:51-61(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    7. "Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA."
      Heo I., Joo C., Cho J., Ha M., Han J., Kim V.N.
      Mol. Cell 32:276-284(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, RNA-BINDING.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation."
      Heo I., Joo C., Kim Y.-K., Ha M., Yoon M.-J., Cho J., Yeom K.-H., Han J., Kim V.N.
      Cell 138:696-708(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, RNA-BINDING, INTERACTION WITH ZCCHC11.
    10. Cited for: POSSIBLE INVOLVEMENT IN CANCERS.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The Lin28 cold-shock domain remodels pre-let-7 microRNA."
      Mayr F., Schutz A., Doge N., Heinemann U.
      Nucleic Acids Res. 40:7492-7506(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 24-111, ZINC KNUCKLE DOMAIN.

    Entry informationi

    Entry nameiLN28B_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZN17
    Secondary accession number(s): A1L165, B2RPN6, Q5TCM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Overexpressed in primary tumors (overall frequency approximately 15%), overexpression being linked to repression of let-7 family miRNAs and derepression of let-7 targets. Facilitates cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3