Reviewed, UniProtKB/Swiss-Prot Q6ZN16 (M3K15_HUMAN)

Names and origin

Protein names

Recommended name:
    Mitogen-activated protein kinase kinase kinase 15
    EC=2.7.11.25
Alternative name(s):
    MAPK/ERK kinase kinase 15
      Short name=MEK kinase 15
      Short name=MEKK 15

Gene names

Name:

MAP3K15

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1313 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of a protein kinase signal transduction cascade By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Enzyme regulation	Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-812, inhibited by phosphorylation at Ser-924 and Ser-994 By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase kinase kinase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZN16-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZN16-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-565: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6ZN16-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-525: Missing.
     526-582: GLRFPVLVIE...NFTASSIKGI → MACLTHRNET...CLSLQSSWDY

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1313	1313	Mitogen-activated protein kinase kinase kinase 15		PRO_0000253481
Regions
	Domain	652 – 908	257	Protein kinase
	Nucleotide binding	658 – 666	9	ATP By similarity
	Coiled coil	1179 – 1225	47	Potential
Sites
	Active site	773	1	Proton acceptor By similarity
	Binding site	681	1	ATP By similarity
Amino acid modifications
	Modified residue	68	1	Phosphoserine
	Modified residue	812	1	Phosphothreonine By similarity
	Modified residue	924	1	Phosphoserine By similarity
	Modified residue	936	1	Phosphothreonine
	Modified residue	943	1	Phosphothreonine
	Modified residue	994	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 565	565	Missing in isoform 2.		VSP_021038
	Alternative sequence	1 – 525	525	Missing in isoform 3.		VSP_021039
	Alternative sequence	526 – 582	57	GLRFP…SIKGI → MACLTHRNETDARMEFYSLF HKGNKAGVQWHDLGSLQPLP PRFKRFSCLSLQSSWDY in isoform 3.		VSP_021040
	Natural variant	192	1	A → T		VAR_040716
	Natural variant	199	1	S → N		VAR_040717
	Natural variant	226	1	D → H		VAR_040718
	Natural variant	255	1	R → S in a lung squamous cell carcinoma sample; somatic mutation. Ref.4		VAR_040719
	Natural variant	456	1	S → G		VAR_040720
	Natural variant	494	1	R → C		VAR_040721
	Natural variant	562	1	S → L in a lung adenocarcinoma sample; somatic mutation. Ref.4		VAR_040722
	Natural variant	677	1	R → Q in a metastatic melanoma sample; somatic mutation. Ref.4		VAR_040723
	Natural variant	838	1	G → S		VAR_040724
	Natural variant	993	1	S → L		VAR_040725
	Natural variant	1029	1	N → H		VAR_040726
	Natural variant	1247	1	W → R in a colorectal adenocarcinoma sample; somatic mutation. Ref.4		VAR_040727
	Natural variant	1251	1	Q → E		VAR_040728
Experimental info
	Sequence conflict	793	1	F → L in BAD18622. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 60751706D6AEE3E9	FASTA	1,313	147,437
	10 20 30 40 50 60 MESGGGNAPA GALGAASESP QCPPPPGVEG AAGPAEPDGA AEGAAGGSGE GESGGGPRRA 70 80 90 100 110 120 LRAVYVRSES SQGGAAGGPE AGARQCLLRA CEAEGAHLTS VPFGELDFGE TAVLDAFYDA 130 140 150 160 170 180 DVAVVDMSDV SRQPSLFYHL GVRESFDMAN NVILYHDTDA DTALSLKDMV TQKNTASSGN 190 200 210 220 230 240 YYFIPYIVTP CADYFCCESD AQRRASEYMQ PNWDNILGPL CMPLVDRFIS LLKDIHVTSC 250 260 270 280 290 300 VYYKETLLND IRKAREKYQG EELAKELARI KLRMDNTEVL TSDIIINLLL SYRDIQDYDA 310 320 330 340 350 360 MVKLVETLEM LPTCDLADQH NIKFHYAFAL NRRNSTGDRE KALQIMLQVL QSCDHPGPDM 370 380 390 400 410 420 FCLCGRIYKD IFLDSDCKDD TSRDSAIEWY RKGFELQSSL YSGINLAVLL IVAGQQFETS 430 440 450 460 470 480 LELRKIGVRL NSLLGRKGSL EKMNNYWDVG QFFSVSMLAH DVGKAVQAAE RLFKLKPPVW 490 500 510 520 530 540 YLRSLVQNLL LIRRFKKTII EHSPRQERLN FWLDIIFEAT NEVTNGLRFP VLVIEPTKVY 550 560 570 580 590 600 QPSYVSINNE AEERTVSLWH VSPTEMKQMH EWNFTASSIK GISLSKFDER CCFLYVHDNS 610 620 630 640 650 660 DDFQIYFSTE EQCSRFFSLV KEMITNTAGS TVELEGETDG DTLEYEYDHD ANGERVVLGK 670 680 690 700 710 720 GTYGIVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL HKYLKHRNIV QYLGSVSENG 730 740 750 760 770 780 YIKIFMEQVP GGSLSALLRS KWGPMKEPTI KFYTKQILEG LKYLHENQIV HRDIKGDNVL 790 800 810 820 830 840 VNTYSGVVKI SDFGTSKRLA GVNPCTETFT GTLQYMAPEI IDQGPRGYGA PADIWSLGCT 850 860 870 880 890 900 IIEMATSKPP FHELGEPQAA MFKVGMFKIH PEIPEALSAE ARAFILSCFE PDPHKRATTA 910 920 930 940 950 960 ELLREGFLRQ VNKGKKNRIA FKPSEGPRGV VLALPTQGEP MATSSSEHGS VSPDSDAQPD 970 980 990 1000 1010 1020 ALFERTRAPR HHLGHLLSVP DESSALEDRG LASSPEDRDQ GLFLLRKDSE RRAILYKILW 1030 1040 1050 1060 1070 1080 EEQNQVASNL QECVAQSSEE LHLSVGHIKQ IIGILRDFIR SPEHRVMATT ISKLKVDLDF 1090 1100 1110 1120 1130 1140 DSSSISQIHL VLFGFQDAVN KILRNHLIRP HWMFAMDNII RRAVQAAVTI LIPELRAHFE 1150 1160 1170 1180 1190 1200 PTCETEGVDK DMDEAEEGYP PATGPGQEAQ PHQQHLSLQL GELRQETNRL LEHLVEKERE 1210 1220 1230 1240 1250 1260 YQNLLRQTLE QKTQELYHLQ LKLKSNCITE NPAGPYGQRT DKELIDWLRL QGADAKTIEK 1270 1280 1290 1300 1310 IVEEGYTLSD ILNEITKEDL RYLRLRGGLL CRLWSAVSQY RRAQEASETK DKA
	Isoform 2. Checksum: B062EF833B28DB1C	FASTA	748	84,729
	10 20 30 40 50 60 MKQMHEWNFT ASSIKGISLS KFDERCCFLY VHDNSDDFQI YFSTEEQCSR FFSLVKEMIT 70 80 90 100 110 120 NTAGSTVELE GETDGDTLEY EYDHDANGER VVLGKGTYGI VYAGRDLSNQ VRIAIKEIPE 130 140 150 160 170 180 RDSRYSQPLH EEIALHKYLK HRNIVQYLGS VSENGYIKIF MEQVPGGSLS ALLRSKWGPM 190 200 210 220 230 240 KEPTIKFYTK QILEGLKYLH ENQIVHRDIK GDNVLVNTYS GVVKISDFGT SKRLAGVNPC 250 260 270 280 290 300 TETFTGTLQY MAPEIIDQGP RGYGAPADIW SLGCTIIEMA TSKPPFHELG EPQAAMFKVG 310 320 330 340 350 360 MFKIHPEIPE ALSAEARAFI LSCFEPDPHK RATTAELLRE GFLRQVNKGK KNRIAFKPSE 370 380 390 400 410 420 GPRGVVLALP TQGEPMATSS SEHGSVSPDS DAQPDALFER TRAPRHHLGH LLSVPDESSA 430 440 450 460 470 480 LEDRGLASSP EDRDQGLFLL RKDSERRAIL YKILWEEQNQ VASNLQECVA QSSEELHLSV 490 500 510 520 530 540 GHIKQIIGIL RDFIRSPEHR VMATTISKLK VDLDFDSSSI SQIHLVLFGF QDAVNKILRN 550 560 570 580 590 600 HLIRPHWMFA MDNIIRRAVQ AAVTILIPEL RAHFEPTCET EGVDKDMDEA EEGYPPATGP 610 620 630 640 650 660 GQEAQPHQQH LSLQLGELRQ ETNRLLEHLV EKEREYQNLL RQTLEQKTQE LYHLQLKLKS 670 680 690 700 710 720 NCITENPAGP YGQRTDKELI DWLRLQGADA KTIEKIVEEG YTLSDILNEI TKEDLRYLRL 730 740 RGGLLCRLWS AVSQYRRAQE ASETKDKA
	Isoform 3. Checksum: 5C9C9774E3F069F3	FASTA	788	89,423
	10 20 30 40 50 60 MACLTHRNET DARMEFYSLF HKGNKAGVQW HDLGSLQPLP PRFKRFSCLS LQSSWDYSLS 70 80 90 100 110 120 KFDERCCFLY VHDNSDDFQI YFSTEEQCSR FFSLVKEMIT NTAGSTVELE GETDGDTLEY 130 140 150 160 170 180 EYDHDANGER VVLGKGTYGI VYAGRDLSNQ VRIAIKEIPE RDSRYSQPLH EEIALHKYLK 190 200 210 220 230 240 HRNIVQYLGS VSENGYIKIF MEQVPGGSLS ALLRSKWGPM KEPTIKFYTK QILEGLKYLH 250 260 270 280 290 300 ENQIVHRDIK GDNVLVNTYS GVVKISDFGT SKRLAGVNPC TETFTGTLQY MAPEIIDQGP 310 320 330 340 350 360 RGYGAPADIW SLGCTIIEMA TSKPPFHELG EPQAAMFKVG MFKIHPEIPE ALSAEARAFI 370 380 390 400 410 420 LSCFEPDPHK RATTAELLRE GFLRQVNKGK KNRIAFKPSE GPRGVVLALP TQGEPMATSS 430 440 450 460 470 480 SEHGSVSPDS DAQPDALFER TRAPRHHLGH LLSVPDESSA LEDRGLASSP EDRDQGLFLL 490 500 510 520 530 540 RKDSERRAIL YKILWEEQNQ VASNLQECVA QSSEELHLSV GHIKQIIGIL RDFIRSPEHR 550 560 570 580 590 600 VMATTISKLK VDLDFDSSSI SQIHLVLFGF QDAVNKILRN HLIRPHWMFA MDNIIRRAVQ 610 620 630 640 650 660 AAVTILIPEL RAHFEPTCET EGVDKDMDEA EEGYPPATGP GQEAQPHQQH LSLQLGELRQ 670 680 690 700 710 720 ETNRLLEHLV EKEREYQNLL RQTLEQKTQE LYHLQLKLKS NCITENPAGP YGQRTDKELI 730 740 750 760 770 780 DWLRLQGADA KTIEKIVEEG YTLSDILNEI TKEDLRYLRL RGGLLCRLWS AVSQYRRAQE ASETKDKA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Teratocarcinoma and Testis.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; THR-936 AND THR-943, MASS SPECTROMETRY.
[4]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-192; ASN-199; HIS-226; SER-255; GLY-456; CYS-494; LEU-562; GLN-677; SER-838; LEU-993; HIS-1029; ARG-1247 AND GLU-1251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK131412 mRNA. Translation: BAD18559.1. AK131477 mRNA. Translation: BAD18622.1. AL732423, AL732326 Genomic DNA. Translation: CAM17478.1. Different initiation. AL732423, AL732326 Genomic DNA. Translation: CAM17479.1. Different initiation. AL732326, AL732423 Genomic DNA. Translation: CAM23142.1. AL732326, AL732423 Genomic DNA. Translation: CAM23143.1.
IPI	IPI00412740. IPI00418575. IPI00797566.
RefSeq	NP_001001671.2.
UniGene	Hs.713701
3D structure databases
HSSP	HSSP built from PDB template 2CLQ based on UniProtKB Q99683.
SMR	Q6ZN16. Positions 643-909.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZN16.
Proteomic databases
PRIDE	Q6ZN16.
Genome annotation databases
Ensembl	ENST00000338883; ENSP00000345629; ENSG00000180815; Homo sapiens. [Genome view]
GeneID	389840.
KEGG	hsa:389840.
UCSC	uc004czj.1. human. uc004czk.1. human.
Organism-specific databases
CTD	389840.
GeneCards	GC0XM019288.
HGNC	HGNC:31689. MAP3K15.
HPA	HPA004006.
PharmGKB	PA134935369.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14105.
HOGENOM	HBG380040.
HOVERGEN	Q6ZN16.
InParanoid	Q6ZN16.
OMA	DSDCKDD.
OrthoDB	EOG9909VQ.
Enzyme and pathway databases
BRENDA	2.7.11.25. 247.
Gene expression databases
Bgee	Q6ZN16.
CleanEx	HS_MAP3K15.
Genevestigator	Q6ZN16.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR010993. SAM_homology. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	103137.

Entry information

Entry name

M3K15_HUMAN

Accession

Primary (citable) accession number: Q6ZN16
Secondary accession number(s): A2AI49 , A2AI50, A6NJ61, Q5JPR4, Q6ZMV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	February 9, 2010
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.