ID   Q6ZN14_HUMAN            Unreviewed;       493 AA.
AC   Q6ZN14;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   22-FEB-2023, entry version 97.
DE   SubName: Full=cDNA FLJ16524 fis, clone OCBBF2003327, moderately similar to ADAM-TS 6 {ECO:0000313|EMBL:BAD18561.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD18561.1};
RN   [1] {ECO:0000313|EMBL:BAD18561.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD18561.1};
RA   Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., Arita M.,
RA   Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., Otsuki T., Sato H.,
RA   Ota T., Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y.,
RA   Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y.,
RA   Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K.,
RA   Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y.,
RA   Nagai K., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK131414; BAD18561.1; -; mRNA.
DR   RefSeq; NP_001269281.1; NM_001282352.1.
DR   RefSeq; NP_112219.3; NM_030957.3.
DR   AlphaFoldDB; Q6ZN14; -.
DR   DNASU; 81794; -.
DR   GeneID; 81794; -.
DR   KEGG; hsa:81794; -.
DR   CTD; 81794; -.
DR   PharmGKB; PA24537; -.
DR   OrthoDB; 2910701at2759; -.
DR   BioGRID-ORCS; 81794; 19 hits in 1146 CRISPR screens.
DR   GenomeRNAi; 81794; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723:SF26; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 10; 1.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 3.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR   PROSITE; PS50092; TSP1; 3.
DR   Genevisible; Q6ZN14; HS.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          123..192
FT                   /note="ADAMTS/ADAMTS-like cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF19236"
FT   DOMAIN          194..305
FT                   /note="ADAMTS/ADAMTS-like Spacer 1"
FT                   /evidence="ECO:0000259|Pfam:PF05986"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   493 AA;  51830 MW;  537BBDABE7D13009 CRC64;
     MGPTSVLRAG LTPSCLPPPS GATNGSVSPL GRAQRVWTEP GGRGLHGATA AGPVAAACPL
     LAVTATAPGQ PSGASTVWVR EGGTAPATRM TVPLAPRTSE KCSVLNLTAS LSVGNSTSGK
     RTGEACSLTC LAEGFNFYTE RAAAVVDGTP CRPDTVDICV SGECKHVGCD RVLGSDLRED
     KCRVCGGDGS ACETIEGVFS PASPGAGYED VVWIPKGSVH IFIQDLNLSL NHLALKGDQE
     SLLLEGLPGT PQPHRLPLAG TTFQLRQGPD QVQSLEALGP INASLIVMVL ARTELPALRY
     RFNAPIARDS LPPYSWHYAP WTRCSAQCAG GSQVQAVECR NQLDGSAVAP HYCSAHSKLP
     KRQRACNTEP CPPDWVVGNW SLCSRSCDAG VRSRSVVCQR RVSAAEEKAL DDSACPQPRP
     PVLEACHGPT CPPEWAALDW SECTPSCGPG LRHRVVLCKS ADHRATLPPA HCSPAAKPPA
     TMRCNLRRCP PAR
//