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Protein

Putative zinc finger protein 66

Gene

ZNF66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 66
Alternative name(s):
Zinc finger protein 66 pseudogene
Gene namesi
Name:ZNF66
Synonyms:ZNF66P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160229.11.
HGNCiHGNC:13135. ZNF66.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7617.
OpenTargetsiENSG00000160229.

Polymorphism and mutation databases

DMDMi519668683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049921 – 573Putative zinc finger protein 66Add BLAST573

Proteomic databases

EPDiQ6ZN08.
PaxDbiQ6ZN08.
PeptideAtlasiQ6ZN08.
PRIDEiQ6ZN08.

Expressioni

Gene expression databases

BgeeiENSG00000160229.
CleanExiHS_ZNF66.
ExpressionAtlasiQ6ZN08. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000461425.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN08.
SMRiQ6ZN08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN08.
OMAiFLECGPS.
OrthoDBiEOG091G02KC.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZN08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDMAQRNLYR DVMLENYRNL VFLGIVVSKP
60 70 80 90 100
DLITHLEQGK KPSTMQRHEM VANPSVLCSH FNQDLWPEQS IKDSFQKLIL
110 120 130 140 150
RRHKKCGHDN LQLKKGCESV DKCKVHKRGY NGLNQCLTTT QSKMFQCDKH
160 170 180 190 200
GKVFHQFSNT NRHKIRHTGK NPCKFTECGK AFNRSSTFTT HKKIHTGEKP
210 220 230 240 250
YKCIECGKAF NRSSHLTTHK IIHTGEKRYK CEDCGKAFNR SSNLTTHKKI
260 270 280 290 300
HTGEKPYKCE ECGKAFKRSS ILTTHKRIHT GEKPYKCEEC GKVFKYLSSL
310 320 330 340 350
STHKIIHTGE KPYKCEECGK AFNWSSHLTT HKRIHTGEKP YKCEECGKGF
360 370 380 390 400
KYSSTLTKHK IIHTGEKPYK CEECGEAFKY SCSLTAHKII HTGKKPYKCE
410 420 430 440 450
ECGKVFKHSS PLSKHKRIHT GEKPYKCEEC GKAFSRSSIL TTHKIIHTGE
460 470 480 490 500
KPYECEDCGK AFNRSSNLTK HKKIHTGEKP YKCEECGKAF KCSSILTTHK
510 520 530 540 550
RIHTADKPYK CEECGKDFKY SSTLTRHKKI HTGGKPHKCN KCGKAFISSS
560 570
NLSRHEIIHM GGNPYKCENV AKP
Length:573
Mass (Da):65,874
Last modified:June 26, 2013 - v3
Checksum:iFE7D5305F21F9D62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349G → S in AAA61333 (PubMed:1946370).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010329 Genomic DNA. No translation available.
M88375 Genomic DNA. Translation: AAA61333.1.
PIRiI45193.

Genome annotation databases

EnsembliENST00000344519; ENSP00000461425; ENSG00000160229.
UCSCiuc060wfa.1. human.

Similar proteinsi

Entry informationi

Entry nameiZNF66_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN08
Secondary accession number(s): I3L4P5, Q15939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 26, 2013
Last modified: September 27, 2017
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families