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Protein

Zinc finger protein 813

Gene

ZNF813

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 813
Gene namesi
Name:ZNF813
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198346.10
HGNCiHGNC:33257 ZNF813
neXtProtiNX_Q6ZN06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi126017
OpenTargetsiENSG00000198346
PharmGKBiPA162410661

Polymorphism and mutation databases

BioMutaiZNF813
DMDMi152112420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943631 – 617Zinc finger protein 813Add BLAST617

Proteomic databases

EPDiQ6ZN06
MaxQBiQ6ZN06
PaxDbiQ6ZN06
PeptideAtlasiQ6ZN06
PRIDEiQ6ZN06

PTM databases

iPTMnetiQ6ZN06
PhosphoSitePlusiQ6ZN06

Expressioni

Gene expression databases

BgeeiENSG00000198346
CleanExiHS_ZNF813
ExpressionAtlasiQ6ZN06 baseline and differential
GenevisibleiQ6ZN06 HS

Interactioni

Protein-protein interaction databases

BioGridi125948, 3 interactors
STRINGi9606.ENSP00000379684

Structurei

3D structure databases

ProteinModelPortaliQ6ZN06
SMRiQ6ZN06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 81KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00690000102079
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZN06
KOiK09228
OMAiHKAIHIG
OrthoDBiEOG091G02KC
PhylomeDBiQ6ZN06
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequencei

Sequence statusi: Complete.

Q6ZN06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMKEFSS TAQGNREVIH TGTLQRHESH HTGDFRFQEI DKDIHNLEFQ
110 120 130 140 150
WQEDERNSHE APMTEIKKLT GSADRYDQRH AGNKPIKDQL GSSFHSHLPE
160 170 180 190 200
LHMFQTQGKI GNQVEKSIND ASSISTSQRI SCRPKTHISN NYGNNFRNSS
210 220 230 240 250
LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLGE KQYKCDVCGK
260 270 280 290 300
VFNRKRNLVC HRRCHTGEKP YRCNECGKTF SQTYSLTCHR RLHTGEKPYK
310 320 330 340 350
CEECDKAFSF KSNLKRHRRI HAGEKPYKCN ECGKTFSQTS SLTCHRRLHT
360 370 380 390 400
GEKPFKCNEC GKTFSRKSSL TCHHRLHTGE KPYKCNECGK TFSQELTLKC
410 420 430 440 450
HRRLHTGEKP YKCNECGKVF NKKANLARHH RLHSGEKPYK CTECVKTFSR
460 470 480 490 500
NSALVIHKAI HIGEKRYKCN ECGKTFSRIS ALVIHTAIHT GEKPYKCNEC
510 520 530 540 550
GKGFNRKTHL ACHHRLHTGE KPYKCNECGK VFNRKTHLAH HHRLHTGDKP
560 570 580 590 600
YKCNECGKVF NQKAHLARHH RLHTGEKPYK CNECGKVFNQ KANLARHHRL
610
HTGEKPYKFN ECGKAFN
Length:617
Mass (Da):71,721
Last modified:July 10, 2007 - v2
Checksum:iB194D8BE2FA449FE
GO

Sequence cautioni

The sequence BAD18569 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05290562A → T. Corresponds to variant dbSNP:rs2617667Ensembl.1
Natural variantiVAR_05290693D → V. Corresponds to variant dbSNP:rs12609217Ensembl.1
Natural variantiVAR_052907168I → F. Corresponds to variant dbSNP:rs12460628Ensembl.1
Natural variantiVAR_052908192Y → C. Corresponds to variant dbSNP:rs3859494Ensembl.1
Natural variantiVAR_033167231R → K. Corresponds to variant dbSNP:rs10421308Ensembl.1
Natural variantiVAR_033168439Y → F. Corresponds to variant dbSNP:rs10422163Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022137 Genomic DNA No translation available.
AK131422 mRNA Translation: BAD18569.1 Different initiation.
CCDSiCCDS46172.1
RefSeqiNP_001004301.2, NM_001004301.3
UniGeneiHs.710780

Genome annotation databases

EnsembliENST00000396403; ENSP00000379684; ENSG00000198346
GeneIDi126017
KEGGihsa:126017
UCSCiuc002qbu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN813_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health