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Protein

Zinc finger protein 813

Gene

ZNF813

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 813
Gene namesi
Name:ZNF813
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33257. ZNF813.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410661.

Polymorphism and mutation databases

BioMutaiZNF813.
DMDMi152112420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Zinc finger protein 813PRO_0000294363Add
BLAST

Proteomic databases

EPDiQ6ZN06.
MaxQBiQ6ZN06.
PaxDbiQ6ZN06.
PeptideAtlasiQ6ZN06.
PRIDEiQ6ZN06.

PTM databases

iPTMnetiQ6ZN06.
PhosphoSiteiQ6ZN06.

Expressioni

Gene expression databases

BgeeiQ6ZN06.
CleanExiHS_ZNF813.
ExpressionAtlasiQ6ZN06. baseline and differential.
GenevisibleiQ6ZN06. HS.

Interactioni

Protein-protein interaction databases

BioGridi125948. 3 interactions.
STRINGi9606.ENSP00000379684.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN06.
SMRiQ6ZN06. Positions 166-617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8174KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN06.
KOiK09228.
OMAiHKAIHIG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZN06.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZN06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMKEFSS TAQGNREVIH TGTLQRHESH HTGDFRFQEI DKDIHNLEFQ
110 120 130 140 150
WQEDERNSHE APMTEIKKLT GSADRYDQRH AGNKPIKDQL GSSFHSHLPE
160 170 180 190 200
LHMFQTQGKI GNQVEKSIND ASSISTSQRI SCRPKTHISN NYGNNFRNSS
210 220 230 240 250
LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLGE KQYKCDVCGK
260 270 280 290 300
VFNRKRNLVC HRRCHTGEKP YRCNECGKTF SQTYSLTCHR RLHTGEKPYK
310 320 330 340 350
CEECDKAFSF KSNLKRHRRI HAGEKPYKCN ECGKTFSQTS SLTCHRRLHT
360 370 380 390 400
GEKPFKCNEC GKTFSRKSSL TCHHRLHTGE KPYKCNECGK TFSQELTLKC
410 420 430 440 450
HRRLHTGEKP YKCNECGKVF NKKANLARHH RLHSGEKPYK CTECVKTFSR
460 470 480 490 500
NSALVIHKAI HIGEKRYKCN ECGKTFSRIS ALVIHTAIHT GEKPYKCNEC
510 520 530 540 550
GKGFNRKTHL ACHHRLHTGE KPYKCNECGK VFNRKTHLAH HHRLHTGDKP
560 570 580 590 600
YKCNECGKVF NQKAHLARHH RLHTGEKPYK CNECGKVFNQ KANLARHHRL
610
HTGEKPYKFN ECGKAFN
Length:617
Mass (Da):71,721
Last modified:July 10, 2007 - v2
Checksum:iB194D8BE2FA449FE
GO

Sequence cautioni

The sequence BAD18569.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621A → T.
Corresponds to variant rs2617667 [ dbSNP | Ensembl ].
VAR_052905
Natural varianti93 – 931D → V.
Corresponds to variant rs12609217 [ dbSNP | Ensembl ].
VAR_052906
Natural varianti168 – 1681I → F.
Corresponds to variant rs12460628 [ dbSNP | Ensembl ].
VAR_052907
Natural varianti192 – 1921Y → C.
Corresponds to variant rs3859494 [ dbSNP | Ensembl ].
VAR_052908
Natural varianti231 – 2311R → K.
Corresponds to variant rs10421308 [ dbSNP | Ensembl ].
VAR_033167
Natural varianti439 – 4391Y → F.
Corresponds to variant rs10422163 [ dbSNP | Ensembl ].
VAR_033168

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022137 Genomic DNA. No translation available.
AK131422 mRNA. Translation: BAD18569.1. Different initiation.
CCDSiCCDS46172.1.
RefSeqiNP_001004301.2. NM_001004301.3.
UniGeneiHs.710780.

Genome annotation databases

EnsembliENST00000396403; ENSP00000379684; ENSG00000198346.
GeneIDi126017.
KEGGihsa:126017.
UCSCiuc002qbu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022137 Genomic DNA. No translation available.
AK131422 mRNA. Translation: BAD18569.1. Different initiation.
CCDSiCCDS46172.1.
RefSeqiNP_001004301.2. NM_001004301.3.
UniGeneiHs.710780.

3D structure databases

ProteinModelPortaliQ6ZN06.
SMRiQ6ZN06. Positions 166-617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125948. 3 interactions.
STRINGi9606.ENSP00000379684.

PTM databases

iPTMnetiQ6ZN06.
PhosphoSiteiQ6ZN06.

Polymorphism and mutation databases

BioMutaiZNF813.
DMDMi152112420.

Proteomic databases

EPDiQ6ZN06.
MaxQBiQ6ZN06.
PaxDbiQ6ZN06.
PeptideAtlasiQ6ZN06.
PRIDEiQ6ZN06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396403; ENSP00000379684; ENSG00000198346.
GeneIDi126017.
KEGGihsa:126017.
UCSCiuc002qbu.3. human.

Organism-specific databases

CTDi126017.
GeneCardsiZNF813.
HGNCiHGNC:33257. ZNF813.
neXtProtiNX_Q6ZN06.
PharmGKBiPA162410661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZN06.
KOiK09228.
OMAiHKAIHIG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZN06.
TreeFamiTF341892.

Miscellaneous databases

GenomeRNAii126017.
PROiQ6ZN06.

Gene expression databases

BgeeiQ6ZN06.
CleanExiHS_ZNF813.
ExpressionAtlasiQ6ZN06. baseline and differential.
GenevisibleiQ6ZN06. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-617.
    Tissue: Brain.

Entry informationi

Entry nameiZN813_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.