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Protein

RNA-binding protein MEX3B

Gene

MEX3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 558RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30810-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein MEX3B
Alternative name(s):
RING finger and KH domain-containing protein 3
RING finger protein 195
Gene namesi
Name:MEX3B
Synonyms:KIAA2009, RKHD3, RNF195
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25297. MEX3B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi177G → D: Prevents RNA binding. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000183496.
PharmGKBiPA162395820.

Polymorphism and mutation databases

DMDMi74762391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002787841 – 569RNA-binding protein MEX3BAdd BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei462Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZN04.
MaxQBiQ6ZN04.
PaxDbiQ6ZN04.
PeptideAtlasiQ6ZN04.
PRIDEiQ6ZN04.

PTM databases

iPTMnetiQ6ZN04.
PhosphoSitePlusiQ6ZN04.

Expressioni

Tissue specificityi

Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.1 Publication

Gene expression databases

BgeeiENSG00000183496.
CleanExiHS_MEX3B.
GenevisibleiQ6ZN04. HS.

Organism-specific databases

HPAiHPA041093.

Interactioni

Protein-protein interaction databases

BioGridi123945. 15 interactors.
IntActiQ6ZN04. 5 interactors.
MINTiMINT-1420202.
STRINGi9606.ENSP00000329918.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN04.
SMRiQ6ZN04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 127KH 1PROSITE-ProRule annotationAdd BLAST62
Domaini160 – 221KH 2PROSITE-ProRule annotationAdd BLAST62

Domaini

Binds RNA through its KH domains.

Sequence similaritiesi

Contains 2 KH domains.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 558RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2113. Eukaryota.
ENOG410YCYR. LUCA.
GeneTreeiENSGT00390000018714.
HOGENOMiHOG000236282.
HOVERGENiHBG071698.
InParanoidiQ6ZN04.
KOiK15686.
OMAiYTYTAGE.
OrthoDBiEOG091G06LE.
PhylomeDBiQ6ZN04.
TreeFamiTF315107.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSLFADLE RNGSGGGGGG SSGGGETLDD QRALQLALDQ LSLLGLDSDE
60 70 80 90 100
GASLYDSEPR KKSVNMTECV PVPSSEHVAE IVGRQGCKIK ALRAKTNTYI
110 120 130 140 150
KTPVRGEEPV FVVTGRKEDV AMARREIISA AEHFSMIRAS RNKNTALNGA
160 170 180 190 200
VPGPPNLPGQ TTIQVRVPYR VVGLVVGPKG ATIKRIQQQT HTYIVTPSRD
210 220 230 240 250
KEPVFEVTGM PENVDRAREE IEAHIALRTG GIIELTDEND FHANGTDVGF
260 270 280 290 300
DLHHGSGGSG PGSLWSKPTP SITPTPGRKP FSSYRNDSSS SLGSASTDSY
310 320 330 340 350
FGGGTSSSAA ATQRLADYSP PSPALSFAHN GNNNNNGNGY TYTAGGEASV
360 370 380 390 400
PSPDGCPELQ PTFDPAPAPP PGAPLIWAQF ERSPGGGPAA PVSSSCSSSA
410 420 430 440 450
SSSASSSSVV FPGGGASAPS NANLGLLVHR RLHPGTSCPR LSPPLHMAPG
460 470 480 490 500
AGEHHLARRV RSDPGGGGLA YAAYANGLGA QLPGLQPSDT SGSSSSSSSS
510 520 530 540 550
SSSSSSSSGL RRKGSRDCSV CFESEVIAAL VPCGHNLFCM ECANRICEKS
560
EPECPVCHTA VTQAIRIFS
Length:569
Mass (Da):58,832
Last modified:July 5, 2004 - v1
Checksum:iDA5D014C4D8E1BB8
GO
Isoform 2 (identifier: Q6ZN04-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-158: CKIKALRAKT...GAVPGPPNLP → RSRRDGEVGG...AALAGCTFFC
     159-569: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):16,780
Checksum:i53C7C1A592FF24F2
GO

Sequence cautioni

The sequence BAC23105 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti414G → S in AAH36211 (PubMed:15489334).Curated1
Sequence conflicti536N → S in AAH36211 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04189187 – 158CKIKA…PPNLP → RSRRDGEVGGGGVGSQATAS RGRRVQYRDPRRGVPWGERK SRAMGRRPRQRKCRQAVSRS RAAALAGCTFFC in isoform 2. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_041892159 – 569Missing in isoform 2. 1 PublicationAdd BLAST411

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY950678 mRNA. Translation: AAY34146.1.
AK131424 mRNA. Translation: BAD18571.1.
AB095929 mRNA. Translation: BAC23105.1. Sequence problems.
BC036211 mRNA. Translation: AAH36211.1.
BC111545 mRNA. Translation: AAI11546.1.
AL136778 mRNA. Translation: CAB66712.2.
CCDSiCCDS10319.1. [Q6ZN04-1]
RefSeqiNP_115622.2. NM_032246.4. [Q6ZN04-1]
UniGeneiHs.104744.
Hs.745180.

Genome annotation databases

EnsembliENST00000329713; ENSP00000329918; ENSG00000183496. [Q6ZN04-1]
ENST00000558133; ENSP00000456938; ENSG00000183496. [Q6ZN04-3]
GeneIDi84206.
KEGGihsa:84206.
UCSCiuc002bgq.3. human. [Q6ZN04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY950678 mRNA. Translation: AAY34146.1.
AK131424 mRNA. Translation: BAD18571.1.
AB095929 mRNA. Translation: BAC23105.1. Sequence problems.
BC036211 mRNA. Translation: AAH36211.1.
BC111545 mRNA. Translation: AAI11546.1.
AL136778 mRNA. Translation: CAB66712.2.
CCDSiCCDS10319.1. [Q6ZN04-1]
RefSeqiNP_115622.2. NM_032246.4. [Q6ZN04-1]
UniGeneiHs.104744.
Hs.745180.

3D structure databases

ProteinModelPortaliQ6ZN04.
SMRiQ6ZN04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123945. 15 interactors.
IntActiQ6ZN04. 5 interactors.
MINTiMINT-1420202.
STRINGi9606.ENSP00000329918.

PTM databases

iPTMnetiQ6ZN04.
PhosphoSitePlusiQ6ZN04.

Polymorphism and mutation databases

DMDMi74762391.

Proteomic databases

EPDiQ6ZN04.
MaxQBiQ6ZN04.
PaxDbiQ6ZN04.
PeptideAtlasiQ6ZN04.
PRIDEiQ6ZN04.

Protocols and materials databases

DNASUi84206.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329713; ENSP00000329918; ENSG00000183496. [Q6ZN04-1]
ENST00000558133; ENSP00000456938; ENSG00000183496. [Q6ZN04-3]
GeneIDi84206.
KEGGihsa:84206.
UCSCiuc002bgq.3. human. [Q6ZN04-1]

Organism-specific databases

CTDi84206.
GeneCardsiMEX3B.
HGNCiHGNC:25297. MEX3B.
HPAiHPA041093.
MIMi611008. gene.
neXtProtiNX_Q6ZN04.
OpenTargetsiENSG00000183496.
PharmGKBiPA162395820.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2113. Eukaryota.
ENOG410YCYR. LUCA.
GeneTreeiENSGT00390000018714.
HOGENOMiHOG000236282.
HOVERGENiHBG071698.
InParanoidiQ6ZN04.
KOiK15686.
OMAiYTYTAGE.
OrthoDBiEOG091G06LE.
PhylomeDBiQ6ZN04.
TreeFamiTF315107.

Enzyme and pathway databases

BioCyciZFISH:G66-30810-MONOMER.

Miscellaneous databases

GeneWikiiMEX3B.
GenomeRNAii84206.
PROiQ6ZN04.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183496.
CleanExiHS_MEX3B.
GenevisibleiQ6ZN04. HS.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEX3B_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN04
Secondary accession number(s): Q4G0W1, Q8IVG2, Q9H0J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.