ID   MASTR_HUMAN             Reviewed;         415 AA.
AC   Q6ZN01; B7ZKX4; Q3KQU9; Q8N9Y3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 138.
DE   RecName: Full=MEF2-activating motif and SAP domain-containing transcriptional regulator;
DE   AltName: Full=MEF2-activating SAP transcriptional regulatory protein;
GN   Name=MAMSTR; Synonyms=MASTR;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Skeletal muscle, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Brain, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=16818234; DOI=10.1016/j.molcel.2006.05.026;
RA   Creemers E.E., Sutherland L.B., Oh J., Barbosa A.C., Olson E.N.;
RT   "Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR.";
RL   Mol. Cell 23:83-96(2006).
CC   -!- FUNCTION: Transcriptional coactivator. Stimulates the transcriptional
CC       activity of MEF2C. Stimulates MYOD1 activity in part via MEF2,
CC       resulting in an enhancement of skeletal muscle differentiation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MEF2C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6ZN01-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZN01-2; Sequence=VSP_031554;
CC       Name=3;
CC         IsoId=Q6ZN01-3; Sequence=VSP_031554, VSP_031555;
CC   -!- TISSUE SPECIFICITY: Expressed in skeletal muscle, brain, placenta and
CC       spleen. {ECO:0000269|PubMed:16818234}.
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DR   EMBL; AK093389; BAC04152.1; -; mRNA.
DR   EMBL; AK131427; BAD18574.1; -; mRNA.
DR   EMBL; CH471177; EAW52390.1; -; Genomic_DNA.
DR   EMBL; CH471177; EAW52392.1; -; Genomic_DNA.
DR   EMBL; BC105056; AAI05057.1; -; mRNA.
DR   EMBL; BC105058; AAI05059.1; -; mRNA.
DR   EMBL; BC106047; AAI06048.1; -; mRNA.
DR   EMBL; BC143443; AAI43444.1; -; mRNA.
DR   CCDS; CCDS12730.1; -. [Q6ZN01-2]
DR   CCDS; CCDS46137.1; -. [Q6ZN01-1]
DR   CCDS; CCDS74415.1; -. [Q6ZN01-3]
DR   RefSeq; NP_001124387.1; NM_001130915.1. [Q6ZN01-1]
DR   RefSeq; NP_001284682.1; NM_001297753.1. [Q6ZN01-3]
DR   RefSeq; NP_872380.1; NM_182574.2. [Q6ZN01-2]
DR   RefSeq; XP_011525109.1; XM_011526807.2. [Q6ZN01-2]
DR   RefSeq; XP_011525111.1; XM_011526809.2. [Q6ZN01-3]
DR   RefSeq; XP_016882134.1; XM_017026645.1.
DR   AlphaFoldDB; Q6ZN01; -.
DR   SMR; Q6ZN01; -.
DR   IntAct; Q6ZN01; 1.
DR   STRING; 9606.ENSP00000324175; -.
DR   GlyGen; Q6ZN01; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6ZN01; -.
DR   PhosphoSitePlus; Q6ZN01; -.
DR   BioMuta; MAMSTR; -.
DR   DMDM; 74722919; -.
DR   MassIVE; Q6ZN01; -.
DR   PaxDb; 9606-ENSP00000324175; -.
DR   PeptideAtlas; Q6ZN01; -.
DR   ProteomicsDB; 67946; -. [Q6ZN01-1]
DR   ProteomicsDB; 67947; -. [Q6ZN01-2]
DR   Antibodypedia; 45786; 100 antibodies from 14 providers.
DR   DNASU; 284358; -.
DR   Ensembl; ENST00000318083.11; ENSP00000324175.5; ENSG00000176909.12. [Q6ZN01-1]
DR   Ensembl; ENST00000356751.8; ENSP00000349192.3; ENSG00000176909.12. [Q6ZN01-2]
DR   Ensembl; ENST00000594582.1; ENSP00000471590.1; ENSG00000176909.12. [Q6ZN01-3]
DR   GeneID; 284358; -.
DR   KEGG; hsa:284358; -.
DR   MANE-Select; ENST00000318083.11; ENSP00000324175.5; NM_001130915.2; NP_001124387.1.
DR   UCSC; uc002pkf.3; human. [Q6ZN01-1]
DR   AGR; HGNC:26689; -.
DR   CTD; 284358; -.
DR   DisGeNET; 284358; -.
DR   GeneCards; MAMSTR; -.
DR   HGNC; HGNC:26689; MAMSTR.
DR   HPA; ENSG00000176909; Group enriched (adrenal gland, skeletal muscle, tongue).
DR   MIM; 610349; gene.
DR   neXtProt; NX_Q6ZN01; -.
DR   OpenTargets; ENSG00000176909; -.
DR   PharmGKB; PA165393645; -.
DR   VEuPathDB; HostDB:ENSG00000176909; -.
DR   eggNOG; ENOG502RJE6; Eukaryota.
DR   GeneTree; ENSGT00940000154181; -.
DR   HOGENOM; CLU_055830_0_0_1; -.
DR   InParanoid; Q6ZN01; -.
DR   OMA; PKISQHW; -.
DR   OrthoDB; 4273628at2759; -.
DR   PhylomeDB; Q6ZN01; -.
DR   PathwayCommons; Q6ZN01; -.
DR   SignaLink; Q6ZN01; -.
DR   BioGRID-ORCS; 284358; 15 hits in 1153 CRISPR screens.
DR   ChiTaRS; MAMSTR; human.
DR   GenomeRNAi; 284358; -.
DR   Pharos; Q6ZN01; Tbio.
DR   PRO; PR:Q6ZN01; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6ZN01; Protein.
DR   Bgee; ENSG00000176909; Expressed in hindlimb stylopod muscle and 122 other cell types or tissues.
DR   ExpressionAtlas; Q6ZN01; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0010831; P:positive regulation of myotube differentiation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.720.30; SAP domain; 1.
DR   InterPro; IPR003034; SAP_dom.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   PANTHER; PTHR23251; LYSINE-RICH CEACAM1 CO-ISOLATED PROTEIN LYRIC PROTEIN; 1.
DR   PANTHER; PTHR23251:SF1; MEF2-ACTIVATING MOTIF AND SAP DOMAIN-CONTAINING TRANSCRIPTIONAL REGULATOR; 1.
DR   Pfam; PF02037; SAP; 1.
DR   SMART; SM00513; SAP; 1.
DR   SUPFAM; SSF68906; SAP domain; 1.
DR   PROSITE; PS50800; SAP; 1.
DR   Genevisible; Q6ZN01; HS.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..415
FT                   /note="MEF2-activating motif and SAP domain-containing
FT                   transcriptional regulator"
FT                   /id="PRO_0000319981"
FT   DOMAIN          172..206
FT                   /note="SAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
FT   REGION          28..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..415
FT                   /note="Transcription activation"
FT                   /evidence="ECO:0000250"
FT   MOTIF           12..28
FT                   /note="MEF2-binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        74..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..163
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..222
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..277
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..103
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031554"
FT   VAR_SEQ         178..242
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031555"
FT   CONFLICT        271
FT                   /note="A -> T (in Ref. 3; AAI06048)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   415 AA;  44632 MW;  61D6E8C60DCC2DE7 CRC64;
     MTLAASSQRS QIIRSKFRSV LQLRIHRRNQ EQISDPDPWI SASDPPLAPA LPSGTAPFLF
     SPGVLLPEPE YCPPWRSPKK ESPKISQRWR ESKPRGNLTY HQYMPPEPRQ GSRADPQAEG
     SALGPPGPSL WEGTDSQQPH PRMKPSPLTP CPPGVPSPSP PPHKLELQTL KLEELTVSEL
     RQQLRLRGLP VSGTKSMLLE RMRGGAPPRE RPKPRREDSP AGAPWPRLKP KALAAARRQG
     SVKPSAASHR PPLPRAADTP GTAPAPTPTP APAAAPALTP SSGPGSAALT LEEELQEAIR
     RAQLLPNRGI DDILEDQVEP DDPLPPIPLD FPGSFDVLSP SPDSEGLSSV FSSSLPSPTN
     SSSPSPRDPT DSLDWLEALS GGPPLGSGPP PPSIFSADLS DSSSSRLWDL LEDPW
//