Q6ZN01 (MASTR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MEF2-activating motif and SAP domain-containing transcriptional regulator

Alternative name(s):
MEF2-activating SAP transcriptional regulatory protein

Gene names

Name:	MAMSTR
Synonyms:	MASTR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation By similarity.
Subunit structure	Interacts with MEF2C By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in skeletal muscle, brain, placenta and spleen. Ref.4
Sequence similarities	Contains 1 SAP domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of myotube differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II transcription factor binding transcription factor activity Inferred from electronic annotation. Source: Compara nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZN01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZN01-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Isoform 3 (identifier: Q6ZN01-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     178-242: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	MEF2-activating motif and SAP domain-containing transcriptional regulator		PRO_0000319981
Regions
	Domain	172 – 206	35	SAP
	Region	215 – 415	201	Transcription activation By similarity
	Motif	12 – 28	17	MEF2-binding By similarity
	Compositional bias	36 – 392	357	Pro-rich
	Compositional bias	339 – 405	67	Ser-rich
Natural variations
	Alternative sequence	1 – 103	103	Missing in isoform 2 and isoform 3.		VSP_031554
	Alternative sequence	178 – 242	65	Missing in isoform 3.		VSP_031555
Experimental info
	Sequence conflict	271	1	A → T in AAI06048. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 61D6E8C60DCC2DE7	FASTA	415	44,632
	10 20 30 40 50 60 MTLAASSQRS QIIRSKFRSV LQLRIHRRNQ EQISDPDPWI SASDPPLAPA LPSGTAPFLF 70 80 90 100 110 120 SPGVLLPEPE YCPPWRSPKK ESPKISQRWR ESKPRGNLTY HQYMPPEPRQ GSRADPQAEG 130 140 150 160 170 180 SALGPPGPSL WEGTDSQQPH PRMKPSPLTP CPPGVPSPSP PPHKLELQTL KLEELTVSEL 190 200 210 220 230 240 RQQLRLRGLP VSGTKSMLLE RMRGGAPPRE RPKPRREDSP AGAPWPRLKP KALAAARRQG 250 260 270 280 290 300 SVKPSAASHR PPLPRAADTP GTAPAPTPTP APAAAPALTP SSGPGSAALT LEEELQEAIR 310 320 330 340 350 360 RAQLLPNRGI DDILEDQVEP DDPLPPIPLD FPGSFDVLSP SPDSEGLSSV FSSSLPSPTN 370 380 390 400 410 SSSPSPRDPT DSLDWLEALS GGPPLGSGPP PPSIFSADLS DSSSSRLWDL LEDPW
	Isoform 2 [UniParc]. Checksum: BAA9E8AB135C34E5	FASTA	312	32,843
	10 20 30 40 50 60 MPPEPRQGSR ADPQAEGSAL GPPGPSLWEG TDSQQPHPRM KPSPLTPCPP GVPSPSPPPH 70 80 90 100 110 120 KLELQTLKLE ELTVSELRQQ LRLRGLPVSG TKSMLLERMR GGAPPRERPK PRREDSPAGA 130 140 150 160 170 180 PWPRLKPKAL AAARRQGSVK PSAASHRPPL PRAADTPGTA PAPTPTPAPA AAPALTPSSG 190 200 210 220 230 240 PGSAALTLEE ELQEAIRRAQ LLPNRGIDDI LEDQVEPDDP LPPIPLDFPG SFDVLSPSPD 250 260 270 280 290 300 SEGLSSVFSS SLPSPTNSSS PSPRDPTDSL DWLEALSGGP PLGSGPPPPS IFSADLSDSS 310 SSRLWDLLED PW
	Isoform 3 [UniParc]. Checksum: 016AD05EEBA136C3	FASTA	247	25,637
	10 20 30 40 50 60 MPPEPRQGSR ADPQAEGSAL GPPGPSLWEG TDSQQPHPRM KPSPLTPCPP GVPSPSPPPH 70 80 90 100 110 120 KLELQTLKLE ELTVKPSAAS HRPPLPRAAD TPGTAPAPTP TPAPAAAPAL TPSSGPGSAA 130 140 150 160 170 180 LTLEEELQEA IRRAQLLPNR GIDDILEDQV EPDDPLPPIP LDFPGSFDVL SPSPDSEGLS 190 200 210 220 230 240 SVFSSSLPSP TNSSSPSPRD PTDSLDWLEA LSGGPPLGSG PPPPSIFSAD LSDSSSSRLW DLLEDPW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Skeletal muscle and Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Uterus.
[4]	"Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR." Creemers E.E., Sutherland L.B., Oh J., Barbosa A.C., Olson E.N. Mol. Cell 23:83-96(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093389 mRNA. Translation: BAC04152.1. AK131427 mRNA. Translation: BAD18574.1. CH471177 Genomic DNA. Translation: EAW52390.1. CH471177 Genomic DNA. Translation: EAW52392.1. BC105056 mRNA. Translation: AAI05057.1. BC105058 mRNA. Translation: AAI05059.1. BC106047 mRNA. Translation: AAI06048.1. BC143443 mRNA. Translation: AAI43444.1.
IPI	IPI00167845. IPI00640666. IPI00654637.
RefSeq	NP_001124387.1. NM_001130915.1. NP_872380.1. NM_182574.2.
UniGene	Hs.191815.
3D structure databases
ProteinModelPortal	Q6ZN01.
SMR	Q6ZN01. Positions 163-206.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZN01. 1 interaction.
STRING	9606.ENSP00000324175.
PTM databases
PhosphoSite	Q6ZN01.
Polymorphism databases
DMDM	74722919.
Proteomic databases
PaxDb	Q6ZN01.
PRIDE	Q6ZN01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318083; ENSP00000324175; ENSG00000176909. ENST00000356751; ENSP00000349192; ENSG00000176909. ENST00000377367; ENSP00000366584; ENSG00000176909. ENST00000419611; ENSP00000393801; ENSG00000176909. ENST00000594582; ENSP00000471590; ENSG00000176909.
GeneID	284358.
KEGG	hsa:284358.
UCSC	uc002pkf.2. human.
Organism-specific databases
CTD	284358.
GeneCards	GC19M049216.
HGNC	HGNC:26689. MAMSTR.
MIM	610349. gene.
neXtProt	NX_Q6ZN01.
PharmGKB	PA165393645.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43689.
HOGENOM	HOG000082480.
HOVERGEN	HBG108119.
InParanoid	Q6ZN01.
OMA	PHPRMKP.
OrthoDB	EOG42Z4RZ.
Gene expression databases
Bgee	Q6ZN01.
Genevestigator	Q6ZN01.
Family and domain databases
Gene3D	1.10.720.30. 1 hit.
InterPro	IPR003034. SAP_dom. [Graphical view]
Pfam	PF02037. SAP. 1 hit. [Graphical view]
SMART	SM00513. SAP. 1 hit. [Graphical view]
PROSITE	PS50800. SAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284358.
NextBio	94774.
SOURCE	Search...

Entry information

Entry name

MASTR_HUMAN

Accession

Primary (citable) accession number: Q6ZN01
Secondary accession number(s): B7ZKX4, Q3KQU9, Q8N9Y3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.