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Protein

MEF2-activating motif and SAP domain-containing transcriptional regulator

Gene

MAMSTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MEF2-activating motif and SAP domain-containing transcriptional regulator
Alternative name(s):
MEF2-activating SAP transcriptional regulatory protein
Gene namesi
Name:MAMSTR
Synonyms:MASTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26689. MAMSTR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176909.
PharmGKBiPA165393645.

Polymorphism and mutation databases

BioMutaiMAMSTR.
DMDMi74722919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199811 – 415MEF2-activating motif and SAP domain-containing transcriptional regulatorAdd BLAST415

Proteomic databases

PaxDbiQ6ZN01.
PRIDEiQ6ZN01.

PTM databases

iPTMnetiQ6ZN01.
PhosphoSitePlusiQ6ZN01.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, brain, placenta and spleen.1 Publication

Gene expression databases

BgeeiENSG00000176909.
ExpressionAtlasiQ6ZN01. baseline and differential.
GenevisibleiQ6ZN01. HS.

Organism-specific databases

HPAiHPA057672.

Interactioni

Subunit structurei

Interacts with MEF2C.By similarity

Protein-protein interaction databases

IntActiQ6ZN01. 1 interactor.
STRINGi9606.ENSP00000324175.

Structurei

3D structure databases

ProteinModelPortaliQ6ZN01.
SMRiQ6ZN01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 206SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni215 – 415Transcription activationBy similarityAdd BLAST201

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 28MEF2-bindingBy similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 392Pro-richAdd BLAST357
Compositional biasi339 – 405Ser-richAdd BLAST67

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410II34. Eukaryota.
ENOG4111CQH. LUCA.
GeneTreeiENSGT00390000003056.
HOGENOMiHOG000082480.
HOVERGENiHBG108119.
InParanoidiQ6ZN01.
OMAiPPPRMKP.
OrthoDBiEOG091G0IHX.
PhylomeDBiQ6ZN01.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZN01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLAASSQRS QIIRSKFRSV LQLRIHRRNQ EQISDPDPWI SASDPPLAPA
60 70 80 90 100
LPSGTAPFLF SPGVLLPEPE YCPPWRSPKK ESPKISQRWR ESKPRGNLTY
110 120 130 140 150
HQYMPPEPRQ GSRADPQAEG SALGPPGPSL WEGTDSQQPH PRMKPSPLTP
160 170 180 190 200
CPPGVPSPSP PPHKLELQTL KLEELTVSEL RQQLRLRGLP VSGTKSMLLE
210 220 230 240 250
RMRGGAPPRE RPKPRREDSP AGAPWPRLKP KALAAARRQG SVKPSAASHR
260 270 280 290 300
PPLPRAADTP GTAPAPTPTP APAAAPALTP SSGPGSAALT LEEELQEAIR
310 320 330 340 350
RAQLLPNRGI DDILEDQVEP DDPLPPIPLD FPGSFDVLSP SPDSEGLSSV
360 370 380 390 400
FSSSLPSPTN SSSPSPRDPT DSLDWLEALS GGPPLGSGPP PPSIFSADLS
410
DSSSSRLWDL LEDPW
Length:415
Mass (Da):44,632
Last modified:July 5, 2004 - v1
Checksum:i61D6E8C60DCC2DE7
GO
Isoform 2 (identifier: Q6ZN01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:312
Mass (Da):32,843
Checksum:iBAA9E8AB135C34E5
GO
Isoform 3 (identifier: Q6ZN01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     178-242: Missing.

Note: No experimental confirmation available.
Show »
Length:247
Mass (Da):25,637
Checksum:i016AD05EEBA136C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271A → T in AAI06048 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0315541 – 103Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST103
Alternative sequenceiVSP_031555178 – 242Missing in isoform 3. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093389 mRNA. Translation: BAC04152.1.
AK131427 mRNA. Translation: BAD18574.1.
CH471177 Genomic DNA. Translation: EAW52390.1.
CH471177 Genomic DNA. Translation: EAW52392.1.
BC105056 mRNA. Translation: AAI05057.1.
BC105058 mRNA. Translation: AAI05059.1.
BC106047 mRNA. Translation: AAI06048.1.
BC143443 mRNA. Translation: AAI43444.1.
CCDSiCCDS12730.1. [Q6ZN01-2]
CCDS46137.1. [Q6ZN01-1]
CCDS74415.1. [Q6ZN01-3]
RefSeqiNP_001124387.1. NM_001130915.1. [Q6ZN01-1]
NP_001284682.1. NM_001297753.1. [Q6ZN01-3]
NP_872380.1. NM_182574.2. [Q6ZN01-2]
XP_011525109.1. XM_011526807.2. [Q6ZN01-2]
XP_011525111.1. XM_011526809.2. [Q6ZN01-3]
XP_016882134.1. XM_017026645.1. [Q6ZN01-3]
UniGeneiHs.191815.

Genome annotation databases

EnsembliENST00000318083; ENSP00000324175; ENSG00000176909. [Q6ZN01-1]
ENST00000356751; ENSP00000349192; ENSG00000176909. [Q6ZN01-2]
ENST00000594582; ENSP00000471590; ENSG00000176909. [Q6ZN01-3]
GeneIDi284358.
KEGGihsa:284358.
UCSCiuc002pkf.3. human. [Q6ZN01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093389 mRNA. Translation: BAC04152.1.
AK131427 mRNA. Translation: BAD18574.1.
CH471177 Genomic DNA. Translation: EAW52390.1.
CH471177 Genomic DNA. Translation: EAW52392.1.
BC105056 mRNA. Translation: AAI05057.1.
BC105058 mRNA. Translation: AAI05059.1.
BC106047 mRNA. Translation: AAI06048.1.
BC143443 mRNA. Translation: AAI43444.1.
CCDSiCCDS12730.1. [Q6ZN01-2]
CCDS46137.1. [Q6ZN01-1]
CCDS74415.1. [Q6ZN01-3]
RefSeqiNP_001124387.1. NM_001130915.1. [Q6ZN01-1]
NP_001284682.1. NM_001297753.1. [Q6ZN01-3]
NP_872380.1. NM_182574.2. [Q6ZN01-2]
XP_011525109.1. XM_011526807.2. [Q6ZN01-2]
XP_011525111.1. XM_011526809.2. [Q6ZN01-3]
XP_016882134.1. XM_017026645.1. [Q6ZN01-3]
UniGeneiHs.191815.

3D structure databases

ProteinModelPortaliQ6ZN01.
SMRiQ6ZN01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZN01. 1 interactor.
STRINGi9606.ENSP00000324175.

PTM databases

iPTMnetiQ6ZN01.
PhosphoSitePlusiQ6ZN01.

Polymorphism and mutation databases

BioMutaiMAMSTR.
DMDMi74722919.

Proteomic databases

PaxDbiQ6ZN01.
PRIDEiQ6ZN01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318083; ENSP00000324175; ENSG00000176909. [Q6ZN01-1]
ENST00000356751; ENSP00000349192; ENSG00000176909. [Q6ZN01-2]
ENST00000594582; ENSP00000471590; ENSG00000176909. [Q6ZN01-3]
GeneIDi284358.
KEGGihsa:284358.
UCSCiuc002pkf.3. human. [Q6ZN01-1]

Organism-specific databases

CTDi284358.
GeneCardsiMAMSTR.
HGNCiHGNC:26689. MAMSTR.
HPAiHPA057672.
MIMi610349. gene.
neXtProtiNX_Q6ZN01.
OpenTargetsiENSG00000176909.
PharmGKBiPA165393645.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II34. Eukaryota.
ENOG4111CQH. LUCA.
GeneTreeiENSGT00390000003056.
HOGENOMiHOG000082480.
HOVERGENiHBG108119.
InParanoidiQ6ZN01.
OMAiPPPRMKP.
OrthoDBiEOG091G0IHX.
PhylomeDBiQ6ZN01.

Miscellaneous databases

GenomeRNAii284358.
PROiQ6ZN01.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176909.
ExpressionAtlasiQ6ZN01. baseline and differential.
GenevisibleiQ6ZN01. HS.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMASTR_HUMAN
AccessioniPrimary (citable) accession number: Q6ZN01
Secondary accession number(s): B7ZKX4, Q3KQU9, Q8N9Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.