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Q6ZN01

- MASTR_HUMAN

UniProt

Q6ZN01 - MASTR_HUMAN

Protein

MEF2-activating motif and SAP domain-containing transcriptional regulator

Gene

MAMSTR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation By similarity.By similarity

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. RNA polymerase II transcription factor binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of myotube differentiation Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MEF2-activating motif and SAP domain-containing transcriptional regulator
    Alternative name(s):
    MEF2-activating SAP transcriptional regulatory protein
    Gene namesi
    Name:MAMSTR
    Synonyms:MASTR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26689. MAMSTR.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165393645.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415MEF2-activating motif and SAP domain-containing transcriptional regulatorPRO_0000319981Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZN01.
    PRIDEiQ6ZN01.

    PTM databases

    PhosphoSiteiQ6ZN01.

    Expressioni

    Tissue specificityi

    Expressed in skeletal muscle, brain, placenta and spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ6ZN01.
    BgeeiQ6ZN01.
    GenevestigatoriQ6ZN01.

    Organism-specific databases

    HPAiHPA057672.

    Interactioni

    Subunit structurei

    Interacts with MEF2C.By similarity

    Protein-protein interaction databases

    IntActiQ6ZN01. 1 interaction.
    STRINGi9606.ENSP00000324175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZN01.
    SMRiQ6ZN01. Positions 158-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini172 – 20635SAPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni215 – 415201Transcription activationBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 2817MEF2-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 392357Pro-richAdd
    BLAST
    Compositional biasi339 – 40567Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG43689.
    HOGENOMiHOG000082480.
    HOVERGENiHBG108119.
    InParanoidiQ6ZN01.
    OMAiPPPRMKP.
    OrthoDBiEOG7GJ6DT.
    PhylomeDBiQ6ZN01.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    InterProiIPR003034. SAP_dom.
    [Graphical view]
    PfamiPF02037. SAP. 1 hit.
    [Graphical view]
    SMARTiSM00513. SAP. 1 hit.
    [Graphical view]
    PROSITEiPS50800. SAP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZN01-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLAASSQRS QIIRSKFRSV LQLRIHRRNQ EQISDPDPWI SASDPPLAPA    50
    LPSGTAPFLF SPGVLLPEPE YCPPWRSPKK ESPKISQRWR ESKPRGNLTY 100
    HQYMPPEPRQ GSRADPQAEG SALGPPGPSL WEGTDSQQPH PRMKPSPLTP 150
    CPPGVPSPSP PPHKLELQTL KLEELTVSEL RQQLRLRGLP VSGTKSMLLE 200
    RMRGGAPPRE RPKPRREDSP AGAPWPRLKP KALAAARRQG SVKPSAASHR 250
    PPLPRAADTP GTAPAPTPTP APAAAPALTP SSGPGSAALT LEEELQEAIR 300
    RAQLLPNRGI DDILEDQVEP DDPLPPIPLD FPGSFDVLSP SPDSEGLSSV 350
    FSSSLPSPTN SSSPSPRDPT DSLDWLEALS GGPPLGSGPP PPSIFSADLS 400
    DSSSSRLWDL LEDPW 415
    Length:415
    Mass (Da):44,632
    Last modified:July 5, 2004 - v1
    Checksum:i61D6E8C60DCC2DE7
    GO
    Isoform 2 (identifier: Q6ZN01-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-103: Missing.

    Show »
    Length:312
    Mass (Da):32,843
    Checksum:iBAA9E8AB135C34E5
    GO
    Isoform 3 (identifier: Q6ZN01-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-103: Missing.
         178-242: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:247
    Mass (Da):25,637
    Checksum:i016AD05EEBA136C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti271 – 2711A → T in AAI06048. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 103103Missing in isoform 2 and isoform 3. 2 PublicationsVSP_031554Add
    BLAST
    Alternative sequencei178 – 24265Missing in isoform 3. 1 PublicationVSP_031555Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093389 mRNA. Translation: BAC04152.1.
    AK131427 mRNA. Translation: BAD18574.1.
    CH471177 Genomic DNA. Translation: EAW52390.1.
    CH471177 Genomic DNA. Translation: EAW52392.1.
    BC105056 mRNA. Translation: AAI05057.1.
    BC105058 mRNA. Translation: AAI05059.1.
    BC106047 mRNA. Translation: AAI06048.1.
    BC143443 mRNA. Translation: AAI43444.1.
    CCDSiCCDS12730.1. [Q6ZN01-2]
    CCDS46137.1. [Q6ZN01-1]
    RefSeqiNP_001124387.1. NM_001130915.1. [Q6ZN01-1]
    NP_872380.1. NM_182574.2. [Q6ZN01-2]
    XP_005258847.1. XM_005258790.1. [Q6ZN01-3]
    UniGeneiHs.191815.

    Genome annotation databases

    EnsembliENST00000318083; ENSP00000324175; ENSG00000176909. [Q6ZN01-1]
    ENST00000356751; ENSP00000349192; ENSG00000176909. [Q6ZN01-2]
    ENST00000594582; ENSP00000471590; ENSG00000176909. [Q6ZN01-3]
    GeneIDi284358.
    KEGGihsa:284358.
    UCSCiuc002pkf.2. human. [Q6ZN01-1]

    Polymorphism databases

    DMDMi74722919.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093389 mRNA. Translation: BAC04152.1 .
    AK131427 mRNA. Translation: BAD18574.1 .
    CH471177 Genomic DNA. Translation: EAW52390.1 .
    CH471177 Genomic DNA. Translation: EAW52392.1 .
    BC105056 mRNA. Translation: AAI05057.1 .
    BC105058 mRNA. Translation: AAI05059.1 .
    BC106047 mRNA. Translation: AAI06048.1 .
    BC143443 mRNA. Translation: AAI43444.1 .
    CCDSi CCDS12730.1. [Q6ZN01-2 ]
    CCDS46137.1. [Q6ZN01-1 ]
    RefSeqi NP_001124387.1. NM_001130915.1. [Q6ZN01-1 ]
    NP_872380.1. NM_182574.2. [Q6ZN01-2 ]
    XP_005258847.1. XM_005258790.1. [Q6ZN01-3 ]
    UniGenei Hs.191815.

    3D structure databases

    ProteinModelPortali Q6ZN01.
    SMRi Q6ZN01. Positions 158-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6ZN01. 1 interaction.
    STRINGi 9606.ENSP00000324175.

    PTM databases

    PhosphoSitei Q6ZN01.

    Polymorphism databases

    DMDMi 74722919.

    Proteomic databases

    PaxDbi Q6ZN01.
    PRIDEi Q6ZN01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318083 ; ENSP00000324175 ; ENSG00000176909 . [Q6ZN01-1 ]
    ENST00000356751 ; ENSP00000349192 ; ENSG00000176909 . [Q6ZN01-2 ]
    ENST00000594582 ; ENSP00000471590 ; ENSG00000176909 . [Q6ZN01-3 ]
    GeneIDi 284358.
    KEGGi hsa:284358.
    UCSCi uc002pkf.2. human. [Q6ZN01-1 ]

    Organism-specific databases

    CTDi 284358.
    GeneCardsi GC19M049216.
    HGNCi HGNC:26689. MAMSTR.
    HPAi HPA057672.
    MIMi 610349. gene.
    neXtProti NX_Q6ZN01.
    PharmGKBi PA165393645.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43689.
    HOGENOMi HOG000082480.
    HOVERGENi HBG108119.
    InParanoidi Q6ZN01.
    OMAi PPPRMKP.
    OrthoDBi EOG7GJ6DT.
    PhylomeDBi Q6ZN01.

    Miscellaneous databases

    GenomeRNAii 284358.
    NextBioi 94774.
    PROi Q6ZN01.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZN01.
    Bgeei Q6ZN01.
    Genevestigatori Q6ZN01.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    InterProi IPR003034. SAP_dom.
    [Graphical view ]
    Pfami PF02037. SAP. 1 hit.
    [Graphical view ]
    SMARTi SM00513. SAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skeletal muscle and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain and Uterus.
    4. "Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR."
      Creemers E.E., Sutherland L.B., Oh J., Barbosa A.C., Olson E.N.
      Mol. Cell 23:83-96(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiMASTR_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZN01
    Secondary accession number(s): B7ZKX4, Q3KQU9, Q8N9Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3