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Q6ZN01 (MASTR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MEF2-activating motif and SAP domain-containing transcriptional regulator
Alternative name(s):
MEF2-activating SAP transcriptional regulatory protein
Gene names
Name:MAMSTR
Synonyms:MASTR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation By similarity.

Subunit structure

Interacts with MEF2C By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in skeletal muscle, brain, placenta and spleen. Ref.4

Sequence similarities

Contains 1 SAP domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZN01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZN01-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
Isoform 3 (identifier: Q6ZN01-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     178-242: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415MEF2-activating motif and SAP domain-containing transcriptional regulator
PRO_0000319981

Regions

Domain172 – 20635SAP
Region215 – 415201Transcription activation By similarity
Motif12 – 2817MEF2-binding By similarity
Compositional bias36 – 392357Pro-rich
Compositional bias339 – 40567Ser-rich

Natural variations

Alternative sequence1 – 103103Missing in isoform 2 and isoform 3.
VSP_031554
Alternative sequence178 – 24265Missing in isoform 3.
VSP_031555

Experimental info

Sequence conflict2711A → T in AAI06048. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 61D6E8C60DCC2DE7

FASTA41544,632
        10         20         30         40         50         60 
MTLAASSQRS QIIRSKFRSV LQLRIHRRNQ EQISDPDPWI SASDPPLAPA LPSGTAPFLF 

        70         80         90        100        110        120 
SPGVLLPEPE YCPPWRSPKK ESPKISQRWR ESKPRGNLTY HQYMPPEPRQ GSRADPQAEG 

       130        140        150        160        170        180 
SALGPPGPSL WEGTDSQQPH PRMKPSPLTP CPPGVPSPSP PPHKLELQTL KLEELTVSEL 

       190        200        210        220        230        240 
RQQLRLRGLP VSGTKSMLLE RMRGGAPPRE RPKPRREDSP AGAPWPRLKP KALAAARRQG 

       250        260        270        280        290        300 
SVKPSAASHR PPLPRAADTP GTAPAPTPTP APAAAPALTP SSGPGSAALT LEEELQEAIR 

       310        320        330        340        350        360 
RAQLLPNRGI DDILEDQVEP DDPLPPIPLD FPGSFDVLSP SPDSEGLSSV FSSSLPSPTN 

       370        380        390        400        410 
SSSPSPRDPT DSLDWLEALS GGPPLGSGPP PPSIFSADLS DSSSSRLWDL LEDPW 

« Hide

Isoform 2 [UniParc].

Checksum: BAA9E8AB135C34E5
Show »

FASTA31232,843
Isoform 3 [UniParc].

Checksum: 016AD05EEBA136C3
Show »

FASTA24725,637

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Skeletal muscle and Testis.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Brain and Uterus.
[4]"Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR."
Creemers E.E., Sutherland L.B., Oh J., Barbosa A.C., Olson E.N.
Mol. Cell 23:83-96(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK093389 mRNA. Translation: BAC04152.1.
AK131427 mRNA. Translation: BAD18574.1.
CH471177 Genomic DNA. Translation: EAW52390.1.
CH471177 Genomic DNA. Translation: EAW52392.1.
BC105056 mRNA. Translation: AAI05057.1.
BC105058 mRNA. Translation: AAI05059.1.
BC106047 mRNA. Translation: AAI06048.1.
BC143443 mRNA. Translation: AAI43444.1.
RefSeqNP_001124387.1. NM_001130915.1.
NP_872380.1. NM_182574.2.
XP_005258847.1. XM_005258790.1.
UniGeneHs.191815.

3D structure databases

ProteinModelPortalQ6ZN01.
SMRQ6ZN01. Positions 158-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6ZN01. 1 interaction.
STRING9606.ENSP00000324175.

PTM databases

PhosphoSiteQ6ZN01.

Polymorphism databases

DMDM74722919.

Proteomic databases

PaxDbQ6ZN01.
PRIDEQ6ZN01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318083; ENSP00000324175; ENSG00000176909. [Q6ZN01-1]
ENST00000356751; ENSP00000349192; ENSG00000176909. [Q6ZN01-2]
ENST00000377367; ENSP00000366584; ENSG00000176909. [Q6ZN01-3]
ENST00000419611; ENSP00000393801; ENSG00000176909. [Q6ZN01-2]
ENST00000594582; ENSP00000471590; ENSG00000176909. [Q6ZN01-3]
GeneID284358.
KEGGhsa:284358.
UCSCuc002pkf.2. human. [Q6ZN01-1]

Organism-specific databases

CTD284358.
GeneCardsGC19M049216.
HGNCHGNC:26689. MAMSTR.
HPAHPA057672.
MIM610349. gene.
neXtProtNX_Q6ZN01.
PharmGKBPA165393645.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43689.
HOGENOMHOG000082480.
HOVERGENHBG108119.
InParanoidQ6ZN01.
OMAPPPRMKP.
OrthoDBEOG7GJ6DT.
PhylomeDBQ6ZN01.

Gene expression databases

ArrayExpressQ6ZN01.
BgeeQ6ZN01.
GenevestigatorQ6ZN01.

Family and domain databases

Gene3D1.10.720.30. 1 hit.
InterProIPR003034. SAP_dom.
[Graphical view]
PfamPF02037. SAP. 1 hit.
[Graphical view]
SMARTSM00513. SAP. 1 hit.
[Graphical view]
PROSITEPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi284358.
NextBio94774.
PROQ6ZN01.
SOURCESearch...

Entry information

Entry nameMASTR_HUMAN
AccessionPrimary (citable) accession number: Q6ZN01
Secondary accession number(s): B7ZKX4, Q3KQU9, Q8N9Y3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM