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Protein

Zinc finger protein 517

Gene

ZNF517

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri178 – 19922C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 517
Gene namesi
Name:ZNF517
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:27984. ZNF517.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889443.

Polymorphism and mutation databases

BioMutaiZNF517.
DMDMi296453044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Zinc finger protein 517PRO_0000047636Add
BLAST

Proteomic databases

PaxDbiQ6ZMY9.
PRIDEiQ6ZMY9.

PTM databases

PhosphoSiteiQ6ZMY9.

Expressioni

Gene expression databases

BgeeiQ6ZMY9.
CleanExiHS_ZNF517.
ExpressionAtlasiQ6ZMY9. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi131045. 25 interactions.
STRINGi9606.ENSP00000353058.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMY9.
SMRiQ6ZMY9. Positions 156-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri178 – 19922C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127258.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMY9.
KOiK09228.
OMAiDSRMEAG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZMY9.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMALPMPGP QEAVVFEDVA VYFTRIEWSC LAPDQQALYR DVMLENYGNL
60 70 80 90 100
ASLGFLVAKP ALISLLEQGE EPGALILQVA EQSVAKASLC TDSRMEAGIM
110 120 130 140 150
ESPLQRKLSR QAGLPGTVWG CLPWGHPVGG HPAPPHPHGG PEDGSDKPTH
160 170 180 190 200
PRAREHSASP RVLQEDLGRP VGSSAPRYRC VCGKAFRYNS LLLRHQIIHT
210 220 230 240 250
GAKPFQCTEC GKAFKQSSIL LRHQLIHTEE KPFQCGECGK AFRQSTQLAA
260 270 280 290 300
HHRVHTRERP YACGECGKAF SRSSRLLQHQ KFHTGEKPFA CTECGKAFCR
310 320 330 340 350
RFTLNEHGRI HSGERPYRCL RCGQRFIRGS SLLKHHRLHA QEGAQDGGVG
360 370 380 390 400
QGALLGAAQR PQAGDPPHEC PVCGRPFRHN SLLLLHLRLH TGEKPFECAE
410 420 430 440 450
CGKAFGRKSN LTLHQKIHTK EKPFACTECG KAFRRSYTLN EHYRLHSGER
460 470 480 490
PYRCRACGRA CSRLSTLIQH QKVHGREPGE DTEGRRAPCW AS
Length:492
Mass (Da):54,711
Last modified:May 18, 2010 - v2
Checksum:iB1DE889754324F2E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981I → V in BAD18586 (PubMed:14702039).Curated
Sequence conflicti349 – 3491V → A in BAD18586 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61P → L.
Corresponds to variant rs2976649 [ dbSNP | Ensembl ].
VAR_057425

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131440 mRNA. Translation: BAD18586.1.
AF235103 Genomic DNA. No translation available.
CCDSiCCDS6434.1.
RefSeqiNP_998770.2. NM_213605.2.
XP_011515316.1. XM_011517014.1.
XP_011515317.1. XM_011517015.1.
UniGeneiHs.521942.
Hs.639618.

Genome annotation databases

EnsembliENST00000359971; ENSP00000353058; ENSG00000197363.
ENST00000531720; ENSP00000436103; ENSG00000197363.
ENST00000533965; ENSP00000435166; ENSG00000197363.
GeneIDi340385.
KEGGihsa:340385.
UCSCiuc003zed.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131440 mRNA. Translation: BAD18586.1.
AF235103 Genomic DNA. No translation available.
CCDSiCCDS6434.1.
RefSeqiNP_998770.2. NM_213605.2.
XP_011515316.1. XM_011517014.1.
XP_011515317.1. XM_011517015.1.
UniGeneiHs.521942.
Hs.639618.

3D structure databases

ProteinModelPortaliQ6ZMY9.
SMRiQ6ZMY9. Positions 156-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131045. 25 interactions.
STRINGi9606.ENSP00000353058.

PTM databases

PhosphoSiteiQ6ZMY9.

Polymorphism and mutation databases

BioMutaiZNF517.
DMDMi296453044.

Proteomic databases

PaxDbiQ6ZMY9.
PRIDEiQ6ZMY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359971; ENSP00000353058; ENSG00000197363.
ENST00000531720; ENSP00000436103; ENSG00000197363.
ENST00000533965; ENSP00000435166; ENSG00000197363.
GeneIDi340385.
KEGGihsa:340385.
UCSCiuc003zed.1. human.

Organism-specific databases

CTDi340385.
GeneCardsiZNF517.
HGNCiHGNC:27984. ZNF517.
neXtProtiNX_Q6ZMY9.
PharmGKBiPA134889443.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127258.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMY9.
KOiK09228.
OMAiDSRMEAG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZMY9.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii340385.
NextBioi97844.
PROiQ6ZMY9.

Gene expression databases

BgeeiQ6ZMY9.
CleanExiHS_ZNF517.
ExpressionAtlasiQ6ZMY9. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Esophageal carcinoma.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN517_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.