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Protein

Echinoderm microtubule-associated protein-like 6

Gene

EML6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

Enzyme and pathway databases

SignaLinkiQ6ZMW3.

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 6
Short name:
EMAP-6
Alternative name(s):
Echinoderm microtubule-associated protein-like 5-like
Gene namesi
Name:EML6
Synonyms:EML5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:35412. EML6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719036.

Polymorphism and mutation databases

BioMutaiEML6.
DMDMi190358904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19581958Echinoderm microtubule-associated protein-like 6PRO_0000325976Add
BLAST

Proteomic databases

EPDiQ6ZMW3.
MaxQBiQ6ZMW3.
PaxDbiQ6ZMW3.
PeptideAtlasiQ6ZMW3.
PRIDEiQ6ZMW3.

PTM databases

iPTMnetiQ6ZMW3.
PhosphoSiteiQ6ZMW3.

Expressioni

Gene expression databases

BgeeiENSG00000214595.
GenevisibleiQ6ZMW3. HS.

Organism-specific databases

HPAiHPA062808.
HPA068759.

Interactioni

Protein-protein interaction databases

BioGridi134838. 2 interactions.
STRINGi9606.ENSP00000348842.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMW3.
SMRiQ6ZMW3. Positions 7-594, 673-1266, 1592-1955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 10042WD 1Add
BLAST
Repeati104 – 14542WD 2Add
BLAST
Repeati148 – 18740WD 3Add
BLAST
Repeati195 – 23339WD 4Add
BLAST
Repeati235 – 27339WD 5Add
BLAST
Repeati280 – 32142WD 6Add
BLAST
Repeati323 – 36240WD 7Add
BLAST
Repeati364 – 40340WD 8Add
BLAST
Repeati406 – 44540WD 9Add
BLAST
Repeati561 – 60141WD 10Add
BLAST
Repeati725 – 76642WD 11Add
BLAST
Repeati770 – 81142WD 12Add
BLAST
Repeati814 – 85340WD 13Add
BLAST
Repeati861 – 90040WD 14Add
BLAST
Repeati901 – 94040WD 15Add
BLAST
Repeati996 – 103540WD 16Add
BLAST
Repeati1038 – 107740WD 17Add
BLAST
Repeati1080 – 112041WD 18Add
BLAST
Repeati1191 – 123040WD 19Add
BLAST
Repeati1236 – 127641WD 20Add
BLAST
Repeati1412 – 145645WD 21Add
BLAST
Repeati1460 – 150142WD 22Add
BLAST
Repeati1504 – 154340WD 23Add
BLAST
Repeati1553 – 159139WD 24Add
BLAST
Repeati1593 – 163846WD 25Add
BLAST
Repeati1685 – 172440WD 26Add
BLAST
Repeati1726 – 176742WD 27Add
BLAST
Repeati1768 – 180740WD 28Add
BLAST
Repeati1880 – 191940WD 29Add
BLAST
Repeati1925 – 195834WD 30Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1355 – 13584Poly-Lys

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated
Contains 30 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
InParanoidiQ6ZMW3.
KOiK18598.
OMAiAYKRQVH.
OrthoDBiEOG091G00FB.
PhylomeDBiQ6ZMW3.
TreeFamiTF317832.

Family and domain databases

Gene3Di2.130.10.10. 11 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR011048. Haem_d1.
IPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF03451. HELP. 3 hits.
PF00400. WD40. 9 hits.
[Graphical view]
SMARTiSM00320. WD40. 30 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
SSF50998. SSF50998. 5 hits.
SSF51004. SSF51004. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR
60 70 80 90 100
EHSQKFFLGH NDDIISLALH PDKTLVATGQ VGKEPYICIW DSYNVQTVSL
110 120 130 140 150
LKDVHTHGVA CLAFDSDGQR LASVGLDAKN TVCIWDWRKG KLLASATGHS
160 170 180 190 200
DRIFDISWDP YQPNRVVSCG VKHIKFWTLC GNALTAKRGI FGKTGDLQTI
210 220 230 240 250
LCLACAKEDI TYSGALNGDI YVWKGLNLVR TIQGAHSAGI FSMYACEEGF
260 270 280 290 300
ATGGRDGCIR LWDTDFKPIT KIDLRETEQG YKGLSIRSVC WKADRLLAGT
310 320 330 340 350
QDSEIFEVIV RERDKPMLIL QGHCEGELWA LALHPKKPLA VTGSDDRSVR
360 370 380 390 400
LWSLADHALI ARCNMEEAVR SVAFSPDGSQ LALGMKDGSF IVLRVRDMTE
410 420 430 440 450
VVHIKDRKEV IHEMKFSPDG SYLAVGSNDG PVDVYAVAQR YKKIGECSKS
460 470 480 490 500
LSFITHIDWS LDSKYLQTND GAGERLFYRM PSGKPLTSKE EIKGIPWASW
510 520 530 540 550
TCVKGPEVSG IWPKYTEVTD INSVDANYNS SVLVSGDDFG LVKLFKFPCL
560 570 580 590 600
KRGAKFRKYV GHSAHVTNVR WSHDFQWVLS TGGADHSVFQ WRFIPEGVSN
610 620 630 640 650
GMLETAPQEG GADSYSEESD SDLSDVPELD SDIEQEAQIN YDRQVYKEDL
660 670 680 690 700
PQLKQQSKEK NHAVPFLKRE KAPEDSLKLQ FIHGYRGYDC RNNLFYTQAG
710 720 730 740 750
EVVYHIAAVA VVYNRQQHSQ RLYLGHDDDI LSLTIHPVKD YVATGQVGRD
760 770 780 790 800
AAIHVWDTQT LKCLSLLKGQ HQRGVCALDF SADGKCLVSV GLDDFHSIVF
810 820 830 840 850
WDWKKGEKIA TTRGHKDKIF VVKCNPHHVD KLVTVGIKHI KFWQQAGGGF
860 870 880 890 900
TSKRGTFGSV GKLETMMCVS YGRMEDLVFS GAATGDIFIW KDILLLKTVK
910 920 930 940 950
AHDGPVFAMY ALDKGFVTGG KDGIVELWDD MFERCLKTYA IKRSALSTSS
960 970 980 990 1000
KGLLLEDNPS IRAITLGHGH ILVGTKNGEI LEIDKSGPMT LLVQGHMEGE
1010 1020 1030 1040 1050
VWGLAAHPLL PICATVSDDK TLRIWELSAQ HRMLAVRKLK KGGRCCAFSP
1060 1070 1080 1090 1100
DGKALAVGLN DGSFLVVNAD TVEDMVSFHH RKEMISDIKF SKDTGKYLAV
1110 1120 1130 1140 1150
ASHDNFVDIY NVLTSKRVGI CKGASSYITH IDWDSRGKLL QVNSGAREQL
1160 1170 1180 1190 1200
FFEAPRGKRH IIRPSEIEKI EWDTWTCVLG PTCEGIWPAH SDITDVNAAS
1210 1220 1230 1240 1250
LTKDCSLLAT GDDFGFVKLF SYPVKGQHAR FKKYVGHSAH VTNVRWLHND
1260 1270 1280 1290 1300
SVLLTVGGAD TALMIWTREF VGTQESKLVD SEESDTDVEE DGGYDSDVAR
1310 1320 1330 1340 1350
EKAIDYTTKI YAVSIREMEG TKPHQQLKEV SVEERPPVSR AAPQPEKLQK
1360 1370 1380 1390 1400
NNITKKKKLV EELALDHVFG YRGFDCRNNL HYLNDGADII FHTAAAGIVQ
1410 1420 1430 1440 1450
NLSTGSQSFY LEHTDDILCL TVNQHPKYRN VVATSQIGTT PSIHIWDAMT
1460 1470 1480 1490 1500
KHTLSMLRCF HSKGVNYINF SATGKLLVSV GVDPEHTITV WRWQEGAKVA
1510 1520 1530 1540 1550
SRGGHLERIF VVEFRPDSDT QFVSVGVKHM KFWTLAGSAL LYKKGVIGSL
1560 1570 1580 1590 1600
GAAKMQTMLS VAFGANNLTF TGAINGDVYV WKDHFLIRLV AKAHTGPVFT
1610 1620 1630 1640 1650
MYTTLRDGLI VTGGKERPTK EGGAVKLWDQ EMKRCRAFQL ETGQLVECVR
1660 1670 1680 1690 1700
SVCRGKGKIL VGTKDGEIIE VGEKNAASNI LIDGHMEGEI WGLATHPSKD
1710 1720 1730 1740 1750
LFISASNDGT ARIWDLADKK LLNKVSLGHA ARCAAYSPDG EMVAIGMKNG
1760 1770 1780 1790 1800
EFVILLVNSL KVWGKKRDRK SAIQDIRISP DNRFLAVGSS EHTVDFYDLT
1810 1820 1830 1840 1850
QGTNLNRIGY CKDIPSFVIQ MDFSADGKYI QVSTGAYKRQ VHEVPLGKQV
1860 1870 1880 1890 1900
TEAVVIEKIT WASWTSVLGD EVIGIWPRNA DKADVNCACV THAGLNIVTG
1910 1920 1930 1940 1950
DDFGLVKLFD FPCTEKFAKH KRYFGHSAHV TNIRFSYDDK YVVSTGGDDC

SVFVWRCL
Length:1,958
Mass (Da):217,899
Last modified:June 10, 2008 - v2
Checksum:i0A634ACFE1CDF891
GO
Isoform 2 (identifier: Q6ZMW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1832-1958: VSTGAYKRQV...DCSVFVWRCL → MQLTLLVGNH...WPAVVVMGWP

Show »
Length:1,874
Mass (Da):208,805
Checksum:iCDE15BA84F799B10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1828 – 18281K → Y in BAD18612 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1832 – 1958127VSTGA…VWRCL → MQLTLLVGNHTQRTAILGLW KIARKWMRRKMGKWPAVVVM GWP in isoform 2. 1 PublicationVSP_034221Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013414 Genomic DNA. No translation available.
AC093110 Genomic DNA. No translation available.
AC104781 Genomic DNA. No translation available.
AK131467 mRNA. Translation: BAD18612.1.
CCDSiCCDS46286.1. [Q6ZMW3-1]
RefSeqiNP_001034842.2. NM_001039753.2. [Q6ZMW3-1]
UniGeneiHs.656692.

Genome annotation databases

EnsembliENST00000356458; ENSP00000348842; ENSG00000214595. [Q6ZMW3-1]
GeneIDi400954.
KEGGihsa:400954.
UCSCiuc002ryb.5. human. [Q6ZMW3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013414 Genomic DNA. No translation available.
AC093110 Genomic DNA. No translation available.
AC104781 Genomic DNA. No translation available.
AK131467 mRNA. Translation: BAD18612.1.
CCDSiCCDS46286.1. [Q6ZMW3-1]
RefSeqiNP_001034842.2. NM_001039753.2. [Q6ZMW3-1]
UniGeneiHs.656692.

3D structure databases

ProteinModelPortaliQ6ZMW3.
SMRiQ6ZMW3. Positions 7-594, 673-1266, 1592-1955.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134838. 2 interactions.
STRINGi9606.ENSP00000348842.

PTM databases

iPTMnetiQ6ZMW3.
PhosphoSiteiQ6ZMW3.

Polymorphism and mutation databases

BioMutaiEML6.
DMDMi190358904.

Proteomic databases

EPDiQ6ZMW3.
MaxQBiQ6ZMW3.
PaxDbiQ6ZMW3.
PeptideAtlasiQ6ZMW3.
PRIDEiQ6ZMW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356458; ENSP00000348842; ENSG00000214595. [Q6ZMW3-1]
GeneIDi400954.
KEGGihsa:400954.
UCSCiuc002ryb.5. human. [Q6ZMW3-1]

Organism-specific databases

CTDi400954.
GeneCardsiEML6.
HGNCiHGNC:35412. EML6.
HPAiHPA062808.
HPA068759.
neXtProtiNX_Q6ZMW3.
PharmGKBiPA164719036.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
InParanoidiQ6ZMW3.
KOiK18598.
OMAiAYKRQVH.
OrthoDBiEOG091G00FB.
PhylomeDBiQ6ZMW3.
TreeFamiTF317832.

Enzyme and pathway databases

SignaLinkiQ6ZMW3.

Miscellaneous databases

GenomeRNAii400954.
PROiQ6ZMW3.

Gene expression databases

BgeeiENSG00000214595.
GenevisibleiQ6ZMW3. HS.

Family and domain databases

Gene3Di2.130.10.10. 11 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR011048. Haem_d1.
IPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF03451. HELP. 3 hits.
PF00400. WD40. 9 hits.
[Graphical view]
SMARTiSM00320. WD40. 30 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
SSF50998. SSF50998. 5 hits.
SSF51004. SSF51004. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMAL6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMW3
Secondary accession number(s): A8MUB5, B6ZDG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.