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Protein

Zinc finger protein 782

Gene

ZNF782

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri279 – 30729C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33217C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 36024C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri674 – 69623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 782
Gene namesi
Name:ZNF782
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:33110. ZNF782.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410440.

Polymorphism and mutation databases

BioMutaiZNF782.
DMDMi74758686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Zinc finger protein 782PRO_0000263075Add
BLAST

Proteomic databases

PaxDbiQ6ZMW2.
PeptideAtlasiQ6ZMW2.
PRIDEiQ6ZMW2.

PTM databases

iPTMnetiQ6ZMW2.
PhosphoSiteiQ6ZMW2.

Expressioni

Gene expression databases

BgeeiQ6ZMW2.
CleanExiHS_ZNF782.
ExpressionAtlasiQ6ZMW2. baseline and differential.
GenevisibleiQ6ZMW2. HS.

Organism-specific databases

HPAiHPA011013.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419397.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMW2.
SMRiQ6ZMW2. Positions 291-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri279 – 30729C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33217C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 36024C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri674 – 69623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMW2.
KOiK09228.
OMAiEHQKAHT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZMW2.
TreeFamiTF350803.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTFQASVSF QDVTVEFSQE EWQHMGPVER TLYRDVMLEN YSHLVSVGYC
60 70 80 90 100
FTKPELIFTL EQGEDPWLLE KEKGFLSRNS PEDSQPDEIS EKSPENQGKH
110 120 130 140 150
LLQVLFTNKL LTTEQEISGK PHNRDINIFR ARMMPCKCDI AGSACQGLSL
160 170 180 190 200
MAPHCQYSKE KAHERNVCDK WLISIKDGRT NTQEKSFAYS KIVKTLHHKE
210 220 230 240 250
EVIQHQTIQT LGQDFEYNES RKAFLEKAAL VTSNSTHPKG KSYNFNKFGE
260 270 280 290 300
NKYDKSTFII PQNMNPEKSH YEFNDTGNCF CRITHKTLTG GKSFSQKSHI
310 320 330 340 350
REHHRVHIGV KPFEYGKSFN RNSTLPVHQR THATDKYSDY HPCTETFSYQ
360 370 380 390 400
STFSVHQKVH IRAKPYEYNE CGKSCSMNSH LIWPQKSHTG EKPYECPECG
410 420 430 440 450
KAFSEKSRLR KHQRTHTGEK PYKCDGCDKA FSAKSGLRIH QRTHTGEKPF
460 470 480 490 500
ECHECGKSFN YKSILIVHQR THTGEKPFEC NECGKSFSHM SGLRNHRRTH
510 520 530 540 550
TGERPYKCDE CGKAFKLKSG LRKHHRTHTG EKPYKCNQCG KAFGQKSQLR
560 570 580 590 600
GHHRIHTGEK PYKCNHCGEA FSQKSNLRVH HRTHTGEKPY QCEECGKTFR
610 620 630 640 650
QKSNLRGHQR THTGEKPYEC NECGKAFSEK SVLRKHQRTH TGEKPYNCNQ
660 670 680 690
CGEAFSQKSN LRVHQRTHTG EKPYKCDKCG RTFSQKSSLR EHQKAHPGD
Length:699
Mass (Da):80,904
Last modified:July 5, 2004 - v1
Checksum:i8519D1CD3EEC15E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301R → P.
Corresponds to variant rs7870376 [ dbSNP | Ensembl ].
VAR_029578
Natural varianti165 – 1651R → H.
Corresponds to variant rs4645656 [ dbSNP | Ensembl ].
VAR_029579
Natural varianti246 – 2461N → S.
Corresponds to variant rs34763627 [ dbSNP | Ensembl ].
VAR_052901
Natural varianti289 – 2891T → A.
Corresponds to variant rs35403084 [ dbSNP | Ensembl ].
VAR_052902

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131468 mRNA. Translation: BAD18613.1.
CH471174 Genomic DNA. Translation: EAW92667.1.
BC137073 mRNA. Translation: AAI37074.1.
CCDSiCCDS35075.1.
RefSeqiNP_001001662.1. NM_001001662.1.
XP_005251799.1. XM_005251742.3.
XP_011516616.1. XM_011518314.1.
XP_011516617.1. XM_011518315.1.
XP_011516618.1. XM_011518316.1.
XP_011516619.1. XM_011518317.1.
XP_011516620.1. XM_011518318.1.
UniGeneiHs.30567.
Hs.674441.
Hs.732126.

Genome annotation databases

EnsembliENST00000481138; ENSP00000419397; ENSG00000196597.
ENST00000535338; ENSP00000440624; ENSG00000196597.
GeneIDi158431.
KEGGihsa:158431.
UCSCiuc004awp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131468 mRNA. Translation: BAD18613.1.
CH471174 Genomic DNA. Translation: EAW92667.1.
BC137073 mRNA. Translation: AAI37074.1.
CCDSiCCDS35075.1.
RefSeqiNP_001001662.1. NM_001001662.1.
XP_005251799.1. XM_005251742.3.
XP_011516616.1. XM_011518314.1.
XP_011516617.1. XM_011518315.1.
XP_011516618.1. XM_011518316.1.
XP_011516619.1. XM_011518317.1.
XP_011516620.1. XM_011518318.1.
UniGeneiHs.30567.
Hs.674441.
Hs.732126.

3D structure databases

ProteinModelPortaliQ6ZMW2.
SMRiQ6ZMW2. Positions 291-699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419397.

PTM databases

iPTMnetiQ6ZMW2.
PhosphoSiteiQ6ZMW2.

Polymorphism and mutation databases

BioMutaiZNF782.
DMDMi74758686.

Proteomic databases

PaxDbiQ6ZMW2.
PeptideAtlasiQ6ZMW2.
PRIDEiQ6ZMW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000481138; ENSP00000419397; ENSG00000196597.
ENST00000535338; ENSP00000440624; ENSG00000196597.
GeneIDi158431.
KEGGihsa:158431.
UCSCiuc004awp.2. human.

Organism-specific databases

CTDi158431.
GeneCardsiZNF782.
HGNCiHGNC:33110. ZNF782.
HPAiHPA011013.
neXtProtiNX_Q6ZMW2.
PharmGKBiPA162410440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMW2.
KOiK09228.
OMAiEHQKAHT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZMW2.
TreeFamiTF350803.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii158431.
PROiQ6ZMW2.

Gene expression databases

BgeeiQ6ZMW2.
CleanExiHS_ZNF782.
ExpressionAtlasiQ6ZMW2. baseline and differential.
GenevisibleiQ6ZMW2. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiZN782_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMW2
Secondary accession number(s): B2RNR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.