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Protein

Zinc finger protein 782

Gene

ZNF782

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 307C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri316 – 332C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST17
Zinc fingeri337 – 360C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 782
Gene namesi
Name:ZNF782
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196597.11
HGNCiHGNC:33110 ZNF782
neXtProtiNX_Q6ZMW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196597
PharmGKBiPA162410440

Polymorphism and mutation databases

BioMutaiZNF782
DMDMi74758686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630751 – 699Zinc finger protein 782Add BLAST699

Proteomic databases

MaxQBiQ6ZMW2
PaxDbiQ6ZMW2
PeptideAtlasiQ6ZMW2
PRIDEiQ6ZMW2

PTM databases

iPTMnetiQ6ZMW2
PhosphoSitePlusiQ6ZMW2

Expressioni

Gene expression databases

BgeeiENSG00000196597
CleanExiHS_ZNF782
ExpressionAtlasiQ6ZMW2 baseline and differential
GenevisibleiQ6ZMW2 HS

Organism-specific databases

HPAiHPA011013

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419397

Structurei

3D structure databases

ProteinModelPortaliQ6ZMW2
SMRiQ6ZMW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 307C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri316 – 332C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST17
Zinc fingeri337 – 360C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZMW2
KOiK09228
OMAiEHQKAHT
OrthoDBiEOG091G02KC
PhylomeDBiQ6ZMW2
TreeFamiTF350803

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequencei

Sequence statusi: Complete.

Q6ZMW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTFQASVSF QDVTVEFSQE EWQHMGPVER TLYRDVMLEN YSHLVSVGYC
60 70 80 90 100
FTKPELIFTL EQGEDPWLLE KEKGFLSRNS PEDSQPDEIS EKSPENQGKH
110 120 130 140 150
LLQVLFTNKL LTTEQEISGK PHNRDINIFR ARMMPCKCDI AGSACQGLSL
160 170 180 190 200
MAPHCQYSKE KAHERNVCDK WLISIKDGRT NTQEKSFAYS KIVKTLHHKE
210 220 230 240 250
EVIQHQTIQT LGQDFEYNES RKAFLEKAAL VTSNSTHPKG KSYNFNKFGE
260 270 280 290 300
NKYDKSTFII PQNMNPEKSH YEFNDTGNCF CRITHKTLTG GKSFSQKSHI
310 320 330 340 350
REHHRVHIGV KPFEYGKSFN RNSTLPVHQR THATDKYSDY HPCTETFSYQ
360 370 380 390 400
STFSVHQKVH IRAKPYEYNE CGKSCSMNSH LIWPQKSHTG EKPYECPECG
410 420 430 440 450
KAFSEKSRLR KHQRTHTGEK PYKCDGCDKA FSAKSGLRIH QRTHTGEKPF
460 470 480 490 500
ECHECGKSFN YKSILIVHQR THTGEKPFEC NECGKSFSHM SGLRNHRRTH
510 520 530 540 550
TGERPYKCDE CGKAFKLKSG LRKHHRTHTG EKPYKCNQCG KAFGQKSQLR
560 570 580 590 600
GHHRIHTGEK PYKCNHCGEA FSQKSNLRVH HRTHTGEKPY QCEECGKTFR
610 620 630 640 650
QKSNLRGHQR THTGEKPYEC NECGKAFSEK SVLRKHQRTH TGEKPYNCNQ
660 670 680 690
CGEAFSQKSN LRVHQRTHTG EKPYKCDKCG RTFSQKSSLR EHQKAHPGD
Length:699
Mass (Da):80,904
Last modified:July 5, 2004 - v1
Checksum:i8519D1CD3EEC15E2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029578130R → P. Corresponds to variant dbSNP:rs7870376Ensembl.1
Natural variantiVAR_029579165R → H. Corresponds to variant dbSNP:rs4645656Ensembl.1
Natural variantiVAR_052901246N → S. Corresponds to variant dbSNP:rs34763627Ensembl.1
Natural variantiVAR_052902289T → A. Corresponds to variant dbSNP:rs35403084Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131468 mRNA Translation: BAD18613.1
CH471174 Genomic DNA Translation: EAW92667.1
BC137073 mRNA Translation: AAI37074.1
CCDSiCCDS35075.1
RefSeqiNP_001001662.1, NM_001001662.2
NP_001333920.1, NM_001346991.1
XP_011516617.1, XM_011518315.2
XP_011516620.1, XM_011518318.2
UniGeneiHs.30567
Hs.674441
Hs.732126

Genome annotation databases

EnsembliENST00000481138; ENSP00000419397; ENSG00000196597
ENST00000535338; ENSP00000440624; ENSG00000196597
GeneIDi158431
KEGGihsa:158431
UCSCiuc004awp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN782_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMW2
Secondary accession number(s): B2RNR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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