ID   KIF6_HUMAN              Reviewed;         814 AA.
AC   Q6ZMV9; Q2MDE3; Q2MDE4; Q5T8J6; Q6ZWE3; Q86T87; Q8WTV4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 3.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Kinesin-like protein KIF6;
GN   Name=KIF6; Synonyms=C6orf102;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT
RP   ARG-719.
RC   TISSUE=Amygdala, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-814 (ISOFORM 3).
RC   TISSUE=Spinal cord;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   VARIANT [LARGE SCALE ANALYSIS] GLU-386.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- INTERACTION:
CC       Q6ZMV9; Q92624: APPBP2; NbExp=3; IntAct=EBI-751100, EBI-743771;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q6ZMV9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZMV9-2; Sequence=VSP_014468;
CC       Name=3;
CC         IsoId=Q6ZMV9-3; Sequence=VSP_014471;
CC       Name=4;
CC         IsoId=Q6ZMV9-4; Sequence=VSP_014468, VSP_014469, VSP_014470;
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK123217; BAC85560.1; -; mRNA.
DR   EMBL; AK131471; BAD18616.1; -; mRNA.
DR   EMBL; AL035464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL160161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL161439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC022074; AAH22074.1; -; mRNA.
DR   EMBL; BX649045; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL832634; CAD89950.1; -; mRNA.
DR   CCDS; CCDS4844.1; -. [Q6ZMV9-1]
DR   CCDS; CCDS75449.1; -. [Q6ZMV9-2]
DR   RefSeq; NP_001275953.1; NM_001289024.1. [Q6ZMV9-2]
DR   RefSeq; NP_659464.3; NM_145027.4. [Q6ZMV9-1]
DR   RefSeq; XP_011512661.1; XM_011514359.2.
DR   AlphaFoldDB; Q6ZMV9; -.
DR   SMR; Q6ZMV9; -.
DR   BioGRID; 128728; 8.
DR   IntAct; Q6ZMV9; 8.
DR   MINT; Q6ZMV9; -.
DR   STRING; 9606.ENSP00000287152; -.
DR   ChEMBL; CHEMBL3308907; -.
DR   iPTMnet; Q6ZMV9; -.
DR   PhosphoSitePlus; Q6ZMV9; -.
DR   BioMuta; KIF6; -.
DR   DMDM; 146345445; -.
DR   jPOST; Q6ZMV9; -.
DR   MassIVE; Q6ZMV9; -.
DR   MaxQB; Q6ZMV9; -.
DR   PaxDb; 9606-ENSP00000287152; -.
DR   PeptideAtlas; Q6ZMV9; -.
DR   ProteomicsDB; 67924; -. [Q6ZMV9-1]
DR   ProteomicsDB; 67925; -. [Q6ZMV9-2]
DR   ProteomicsDB; 67926; -. [Q6ZMV9-3]
DR   ProteomicsDB; 67927; -. [Q6ZMV9-4]
DR   Antibodypedia; 29939; 246 antibodies from 26 providers.
DR   DNASU; 221458; -.
DR   Ensembl; ENST00000229913.9; ENSP00000229913.5; ENSG00000164627.18. [Q6ZMV9-2]
DR   Ensembl; ENST00000287152.12; ENSP00000287152.7; ENSG00000164627.18. [Q6ZMV9-1]
DR   GeneID; 221458; -.
DR   KEGG; hsa:221458; -.
DR   MANE-Select; ENST00000287152.12; ENSP00000287152.7; NM_145027.6; NP_659464.3.
DR   UCSC; uc003oos.3; human. [Q6ZMV9-1]
DR   AGR; HGNC:21202; -.
DR   CTD; 221458; -.
DR   DisGeNET; 221458; -.
DR   GeneCards; KIF6; -.
DR   HGNC; HGNC:21202; KIF6.
DR   HPA; ENSG00000164627; Tissue enhanced (brain, testis).
DR   MIM; 613919; gene.
DR   neXtProt; NX_Q6ZMV9; -.
DR   OpenTargets; ENSG00000164627; -.
DR   PharmGKB; PA134920075; -.
DR   VEuPathDB; HostDB:ENSG00000164627; -.
DR   eggNOG; KOG0242; Eukaryota.
DR   eggNOG; KOG4280; Eukaryota.
DR   GeneTree; ENSGT00940000157697; -.
DR   HOGENOM; CLU_001485_16_1_1; -.
DR   InParanoid; Q6ZMV9; -.
DR   OMA; KEIQHIQ; -.
DR   OrthoDB; 314559at2759; -.
DR   PhylomeDB; Q6ZMV9; -.
DR   TreeFam; TF329752; -.
DR   PathwayCommons; Q6ZMV9; -.
DR   Reactome; R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Reactome; R-HSA-983189; Kinesins.
DR   SignaLink; Q6ZMV9; -.
DR   BioGRID-ORCS; 221458; 15 hits in 1149 CRISPR screens.
DR   ChiTaRS; KIF6; human.
DR   GenomeRNAi; 221458; -.
DR   Pharos; Q6ZMV9; Tbio.
DR   PRO; PR:Q6ZMV9; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q6ZMV9; Protein.
DR   Bgee; ENSG00000164627; Expressed in right uterine tube and 138 other cell types or tissues.
DR   ExpressionAtlas; Q6ZMV9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24115:SF194; KINESIN-LIKE PROTEIN KIF6; 1.
DR   PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR   Genevisible; Q6ZMV9; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Motor protein; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..814
FT                   /note="Kinesin-like protein KIF6"
FT                   /id="PRO_0000125441"
FT   DOMAIN          5..345
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   REGION          752..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          356..385
FT                   /evidence="ECO:0000255"
FT   COILED          456..494
FT                   /evidence="ECO:0000255"
FT   COILED          588..683
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        757..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         97..104
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   VAR_SEQ         1..549
FT                   /note="Missing (in isoform 2 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_014468"
FT   VAR_SEQ         708..720
FT                   /note="PFLQTSDSQHEWS -> SKIKALADSMSVM (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_014469"
FT   VAR_SEQ         721..814
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_014470"
FT   VAR_SEQ         728..744
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_014471"
FT   VARIANT         386
FT                   /note="A -> E (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036217"
FT   VARIANT         512
FT                   /note="R -> H (in dbSNP:rs2273063)"
FT                   /id="VAR_049698"
FT   VARIANT         719
FT                   /note="W -> R (in dbSNP:rs20455)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_022810"
FT   CONFLICT        551
FT                   /note="R -> K (in Ref. 1; BAD18616)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        558..584
FT                   /note="CQEAFEIFKRDHADSVTIDDNKQILKQ -> NATILSSLTGPGLQHFGEKIQ
FT                   FAPQEN (in Ref. 4; CAD89950)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        715
FT                   /note="S -> F (in Ref. 1; BAD18616)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        772
FT                   /note="E -> G (in Ref. 1; BAD18616)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   814 AA;  92569 MW;  D0BB982845286F31 CRC64;
     MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN NKRESYKFKF
     QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG SGKTFTITGG AERYSDRGII
     PRTLSYIFEQ LQKDSSKIYT THISYLEIYN ECGYDLLDPR HEASSLEDLP KVTILEDPDQ
     NIHLKNLTLH QATTEEEALN LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT
     VRHAKLHLVD LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS
     MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV LNEEINPRLV
     IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT SFLEDQDSDS RLEVGADMRK
     VHHCFHHLKK LLNDKKILEN NTVSSESKDQ DCQEPLKEEE YRKLRDILKQ RDNEINILVN
     MLKKEKKKAQ EALHLAGMDR REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR
     SSLLHKKIGM REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR
     SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY KTMFTRLKAL
     KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV NSLDHTKPFL QTSDSQHEWS
     QLLSNKSSGG WEVQDQGTGR FDVCDVNARK ILPSPCPSPH SQKQSSTSTP LEDSIPKRPV
     SSIPLTGDSQ TDSDIIAFIK ARQSILQKQC LGSN
//