Q6ZMV9 (KIF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF6

Gene names

Name:	KIF6
Synonyms:	C6orf102

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	814 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton Probable.
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APPBP2	Q92624	3	EBI-751100,EBI-743771

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZMV9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZMV9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Isoform 3 (identifier: Q6ZMV9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     728-744: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6ZMV9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
     708-720: PFLQTSDSQHEWS → SKIKALADSMSVM
     721-814: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 814	814	Kinesin-like protein KIF6		PRO_0000125441
Regions
	Domain	2 – 275	274	Kinesin-motor
	Nucleotide binding	97 – 104	8	ATP By similarity
	Coiled coil	356 – 385	30	Potential
	Coiled coil	456 – 494	39	Potential
	Coiled coil	588 – 683	96	Potential
Natural variations
	Alternative sequence	1 – 549	549	Missing in isoform 2 and isoform 4.		VSP_014468
	Alternative sequence	708 – 720	13	PFLQT…QHEWS → SKIKALADSMSVM in isoform 4.		VSP_014469
	Alternative sequence	721 – 814	94	Missing in isoform 4.		VSP_014470
	Alternative sequence	728 – 744	17	Missing in isoform 3.		VSP_014471
	Natural variant	386	1	A → E in a breast cancer sample; somatic mutation. Ref.5		VAR_036217
	Natural variant	512	1	R → H. Corresponds to variant rs2273063 [ dbSNP | Ensembl ].		VAR_049698
	Natural variant	719	1	W → R. Ref.1 Corresponds to variant rs20455 [ dbSNP | Ensembl ].		VAR_022810
Experimental info
	Sequence conflict	551	1	R → K in BAD18616. Ref.1
	Sequence conflict	558 – 584	27	CQEAF…QILKQ → NATILSSLTGPGLQHFGEKI QFAPQEN in CAD89950. Ref.4
	Sequence conflict	715	1	S → F in BAD18616. Ref.1
	Sequence conflict	772	1	E → G in BAD18616. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 3. Checksum: D0BB982845286F31	FASTA	814	92,569
	10 20 30 40 50 60 MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN NKRESYKFKF 70 80 90 100 110 120 QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG SGKTFTITGG AERYSDRGII 130 140 150 160 170 180 PRTLSYIFEQ LQKDSSKIYT THISYLEIYN ECGYDLLDPR HEASSLEDLP KVTILEDPDQ 190 200 210 220 230 240 NIHLKNLTLH QATTEEEALN LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT 250 260 270 280 290 300 VRHAKLHLVD LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS 310 320 330 340 350 360 MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV LNEEINPRLV 370 380 390 400 410 420 IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT SFLEDQDSDS RLEVGADMRK 430 440 450 460 470 480 VHHCFHHLKK LLNDKKILEN NTVSSESKDQ DCQEPLKEEE YRKLRDILKQ RDNEINILVN 490 500 510 520 530 540 MLKKEKKKAQ EALHLAGMDR REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR 550 560 570 580 590 600 SSLLHKKIGM REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR 610 620 630 640 650 660 SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY KTMFTRLKAL 670 680 690 700 710 720 KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV NSLDHTKPFL QTSDSQHEWS 730 740 750 760 770 780 QLLSNKSSGG WEVQDQGTGR FDVCDVNARK ILPSPCPSPH SQKQSSTSTP LEDSIPKRPV 790 800 810 SSIPLTGDSQ TDSDIIAFIK ARQSILQKQC LGSN
	Isoform 2 [UniParc]. Checksum: CDE6BB34F2EDEACA	FASTA	265	30,082
	10 20 30 40 50 60 MREEMSLGCQ EAFEIFKRDH ADSVTIDDNK QILKQRFSEA KALGESINEA RSKIGHLKEE 70 80 90 100 110 120 ITQRHIQQVA LGISENMAVP LMPDQQEEKL RSQLEEEKRR YKTMFTRLKA LKVEIEHLQL 130 140 150 160 170 180 LMDKAKVKLQ KEFEVWWAEE ATNLQVNSPA VNSLDHTKPF LQTSDSQHEW SQLLSNKSSG 190 200 210 220 230 240 GWEVQDQGTG RFDVCDVNAR KILPSPCPSP HSQKQSSTST PLEDSIPKRP VSSIPLTGDS 250 260 QTDSDIIAFI KARQSILQKQ CLGSN
	Isoform 3 [UniParc]. Checksum: B693765C871D24D9	FASTA	797	90,746
	10 20 30 40 50 60 MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN NKRESYKFKF 70 80 90 100 110 120 QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG SGKTFTITGG AERYSDRGII 130 140 150 160 170 180 PRTLSYIFEQ LQKDSSKIYT THISYLEIYN ECGYDLLDPR HEASSLEDLP KVTILEDPDQ 190 200 210 220 230 240 NIHLKNLTLH QATTEEEALN LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT 250 260 270 280 290 300 VRHAKLHLVD LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS 310 320 330 340 350 360 MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV LNEEINPRLV 370 380 390 400 410 420 IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT SFLEDQDSDS RLEVGADMRK 430 440 450 460 470 480 VHHCFHHLKK LLNDKKILEN NTVSSESKDQ DCQEPLKEEE YRKLRDILKQ RDNEINILVN 490 500 510 520 530 540 MLKKEKKKAQ EALHLAGMDR REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR 550 560 570 580 590 600 SSLLHKKIGM REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR 610 620 630 640 650 660 SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY KTMFTRLKAL 670 680 690 700 710 720 KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV NSLDHTKPFL QTSDSQHEWS 730 740 750 760 770 780 QLLSNKSDVN ARKILPSPCP SPHSQKQSST STPLEDSIPK RPVSSIPLTG DSQTDSDIIA 790 FIKARQSILQ KQCLGSN
	Isoform 4 [UniParc]. Checksum: 7053D9CB3640985B	FASTA	171	19,809
	10 20 30 40 50 60 MREEMSLGCQ EAFEIFKRDH ADSVTIDDNK QILKQRFSEA KALGESINEA RSKIGHLKEE 70 80 90 100 110 120 ITQRHIQQVA LGISENMAVP LMPDQQEEKL RSQLEEEKRR YKTMFTRLKA LKVEIEHLQL 130 140 150 160 170 LMDKAKVKLQ KEFEVWWAEE ATNLQVNSPA VNSLDHTKSK IKALADSMSV M

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT ARG-719. Tissue: Amygdala and Testis.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-814 (ISOFORM 3). Tissue: Spinal cord.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-386.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123217 mRNA. Translation: BAC85560.1. AK131471 mRNA. Translation: BAD18616.1. AL136087, AL160161 Genomic DNA. Translation: CAI19535.1. AL160161, AL136087 Genomic DNA. Translation: CAI19716.1. AL035464 , AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58469.1. AL035464 , AL136087, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58470.1. AL136087 , AL035464, AL160161, AL590387 Genomic DNA. Translation: CAJ58472.1. AL136087 , AL035464, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58473.1. AL160161 , AL035464, AL136087, AL590387 Genomic DNA. Translation: CAJ58475.1. AL160161 , AL035464, AL136087, AL161439, AL590387 Genomic DNA. Translation: CAJ58476.1. AL161439 , AL035464, AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58477.1. AL590387 , AL035464, AL136087, AL160161 Genomic DNA. Translation: CAJ58478.1. AL590387 , AL035464, AL136087, AL160161, AL161439 Genomic DNA. Translation: CAJ58479.1. BC022074 mRNA. Translation: AAH22074.1. BX649045 mRNA. No translation available. AL832634 mRNA. Translation: CAD89950.1.
IPI	IPI00414252. IPI00446729. IPI00607613. IPI00654807.
RefSeq	NP_659464.3. NM_145027.4.
UniGene	Hs.588202.
3D structure databases
ProteinModelPortal	Q6ZMV9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZMV9. 1 interaction.
MINT	MINT-1480043.
STRING	9606.ENSP00000287152.
PTM databases
PhosphoSite	Q6ZMV9.
Polymorphism databases
DMDM	146345445.
Proteomic databases
PaxDb	Q6ZMV9.
PRIDE	Q6ZMV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229913; ENSP00000229913; ENSG00000164627. ENST00000287152; ENSP00000287152; ENSG00000164627. ENST00000373216; ENSP00000362312; ENSG00000164627.
GeneID	221458.
KEGG	hsa:221458.
UCSC	uc003oos.2. human. uc003oot.2. human. uc010jxa.1. human.
Organism-specific databases
CTD	221458.
GeneCards	GC06M039297.
H-InvDB	HIX0005853.
HGNC	HGNC:21202. KIF6.
HPA	HPA038811.
MIM	613919. gene.
neXtProt	NX_Q6ZMV9.
PharmGKB	PA134920075.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5059.
HOVERGEN	HBG081854.
InParanoid	Q6ZMV9.
KO	K10397.
OMA	TGMREEM.
OrthoDB	EOG4TB49N.
PhylomeDB	Q6ZMV9.
Gene expression databases
ArrayExpress	Q6ZMV9.
Bgee	Q6ZMV9.
CleanEx	HS_KIF6.
Genevestigator	Q6ZMV9.
GermOnline	ENSG00000164627. Homo sapiens.
Family and domain databases
Gene3D	3.40.850.10. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	221458.
NextBio	91347.
SOURCE	Search...

Entry information

Entry name

KIF6_HUMAN

Accession

Primary (citable) accession number: Q6ZMV9
Secondary accession number(s): Q2MDE3 , Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	May 1, 2007
Last modified:	May 1, 2013
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.