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Protein

Kinesin-like protein KIF6

Gene

KIF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: GO_Central

GO - Biological processi

  1. metabolic process Source: GOC
  2. microtubule-based movement Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF6
Gene namesi
Name:KIF6
Synonyms:C6orf102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21202. KIF6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: GO_Central
  3. male germ cell nucleus Source: Ensembl
  4. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Kinesin-like protein KIF6PRO_0000125441Add
BLAST

Proteomic databases

MaxQBiQ6ZMV9.
PaxDbiQ6ZMV9.
PRIDEiQ6ZMV9.

PTM databases

PhosphoSiteiQ6ZMV9.

Expressioni

Gene expression databases

BgeeiQ6ZMV9.
CleanExiHS_KIF6.
ExpressionAtlasiQ6ZMV9. baseline and differential.
GenevestigatoriQ6ZMV9.

Organism-specific databases

HPAiHPA038811.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-751100,EBI-743771

Protein-protein interaction databases

BioGridi128728. 5 interactions.
IntActiQ6ZMV9. 1 interaction.
MINTiMINT-1480043.
STRINGi9606.ENSP00000287152.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV9.
SMRiQ6ZMV9. Positions 3-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 345341Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili356 – 38530Sequence AnalysisAdd
BLAST
Coiled coili456 – 49439Sequence AnalysisAdd
BLAST
Coiled coili588 – 68396Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00730000110885.
HOVERGENiHBG081854.
InParanoidiQ6ZMV9.
KOiK10397.
OMAiKQQQGIY.
PhylomeDBiQ6ZMV9.
TreeFamiTF329752.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN
60 70 80 90 100
NKRESYKFKF QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG
110 120 130 140 150
SGKTFTITGG AERYSDRGII PRTLSYIFEQ LQKDSSKIYT THISYLEIYN
160 170 180 190 200
ECGYDLLDPR HEASSLEDLP KVTILEDPDQ NIHLKNLTLH QATTEEEALN
210 220 230 240 250
LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT VRHAKLHLVD
260 270 280 290 300
LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS
310 320 330 340 350
MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV
360 370 380 390 400
LNEEINPRLV IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT
410 420 430 440 450
SFLEDQDSDS RLEVGADMRK VHHCFHHLKK LLNDKKILEN NTVSSESKDQ
460 470 480 490 500
DCQEPLKEEE YRKLRDILKQ RDNEINILVN MLKKEKKKAQ EALHLAGMDR
510 520 530 540 550
REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR SSLLHKKIGM
560 570 580 590 600
REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR
610 620 630 640 650
SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY
660 670 680 690 700
KTMFTRLKAL KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV
710 720 730 740 750
NSLDHTKPFL QTSDSQHEWS QLLSNKSSGG WEVQDQGTGR FDVCDVNARK
760 770 780 790 800
ILPSPCPSPH SQKQSSTSTP LEDSIPKRPV SSIPLTGDSQ TDSDIIAFIK
810
ARQSILQKQC LGSN
Length:814
Mass (Da):92,569
Last modified:May 1, 2007 - v3
Checksum:iD0BB982845286F31
GO
Isoform 2 (identifier: Q6ZMV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Show »
Length:265
Mass (Da):30,082
Checksum:iCDE6BB34F2EDEACA
GO
Isoform 3 (identifier: Q6ZMV9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     728-744: Missing.

Note: No experimental confirmation available.

Show »
Length:797
Mass (Da):90,746
Checksum:iB693765C871D24D9
GO
Isoform 4 (identifier: Q6ZMV9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
     708-720: PFLQTSDSQHEWS → SKIKALADSMSVM
     721-814: Missing.

Note: No experimental confirmation available.

Show »
Length:171
Mass (Da):19,809
Checksum:i7053D9CB3640985B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti551 – 5511R → K in BAD18616 (PubMed:14702039).Curated
Sequence conflicti558 – 58427CQEAF…QILKQ → NATILSSLTGPGLQHFGEKI QFAPQEN in CAD89950 (PubMed:17974005).CuratedAdd
BLAST
Sequence conflicti715 – 7151S → F in BAD18616 (PubMed:14702039).Curated
Sequence conflicti772 – 7721E → G in BAD18616 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti386 – 3861A → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_036217
Natural varianti512 – 5121R → H.
Corresponds to variant rs2273063 [ dbSNP | Ensembl ].
VAR_049698
Natural varianti719 – 7191W → R.1 Publication
Corresponds to variant rs20455 [ dbSNP | Ensembl ].
VAR_022810

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 549549Missing in isoform 2 and isoform 4. 2 PublicationsVSP_014468Add
BLAST
Alternative sequencei708 – 72013PFLQT…QHEWS → SKIKALADSMSVM in isoform 4. 1 PublicationVSP_014469Add
BLAST
Alternative sequencei721 – 81494Missing in isoform 4. 1 PublicationVSP_014470Add
BLAST
Alternative sequencei728 – 74417Missing in isoform 3. 1 PublicationVSP_014471Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123217 mRNA. Translation: BAC85560.1.
AK131471 mRNA. Translation: BAD18616.1.
AL136087, AL160161 Genomic DNA. Translation: CAI19535.1.
AL160161, AL136087 Genomic DNA. Translation: CAI19716.1.
AL035464
, AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58469.1.
AL035464
, AL136087, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58470.1.
AL136087
, AL035464, AL160161, AL590387 Genomic DNA. Translation: CAJ58472.1.
AL136087
, AL035464, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58473.1.
AL160161
, AL035464, AL136087, AL590387 Genomic DNA. Translation: CAJ58475.1.
AL160161
, AL035464, AL136087, AL161439, AL590387 Genomic DNA. Translation: CAJ58476.1.
AL161439
, AL035464, AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58477.1.
AL590387
, AL035464, AL136087, AL160161 Genomic DNA. Translation: CAJ58478.1.
AL590387
, AL035464, AL136087, AL160161, AL161439 Genomic DNA. Translation: CAJ58479.1.
BC022074 mRNA. Translation: AAH22074.1.
BX649045 mRNA. No translation available.
AL832634 mRNA. Translation: CAD89950.1.
CCDSiCCDS4844.1. [Q6ZMV9-1]
CCDS75449.1. [Q6ZMV9-2]
RefSeqiNP_001275949.1. NM_001289020.1.
NP_001275950.1. NM_001289021.1.
NP_001275953.1. NM_001289024.1. [Q6ZMV9-2]
NP_659464.3. NM_145027.4. [Q6ZMV9-1]
UniGeneiHs.588202.

Genome annotation databases

EnsembliENST00000229913; ENSP00000229913; ENSG00000164627. [Q6ZMV9-2]
ENST00000287152; ENSP00000287152; ENSG00000164627. [Q6ZMV9-1]
GeneIDi221458.
KEGGihsa:221458.
UCSCiuc003oos.2. human. [Q6ZMV9-2]
uc003oot.2. human. [Q6ZMV9-1]

Polymorphism databases

DMDMi146345445.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123217 mRNA. Translation: BAC85560.1.
AK131471 mRNA. Translation: BAD18616.1.
AL136087, AL160161 Genomic DNA. Translation: CAI19535.1.
AL160161, AL136087 Genomic DNA. Translation: CAI19716.1.
AL035464
, AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58469.1.
AL035464
, AL136087, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58470.1.
AL136087
, AL035464, AL160161, AL590387 Genomic DNA. Translation: CAJ58472.1.
AL136087
, AL035464, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58473.1.
AL160161
, AL035464, AL136087, AL590387 Genomic DNA. Translation: CAJ58475.1.
AL160161
, AL035464, AL136087, AL161439, AL590387 Genomic DNA. Translation: CAJ58476.1.
AL161439
, AL035464, AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58477.1.
AL590387
, AL035464, AL136087, AL160161 Genomic DNA. Translation: CAJ58478.1.
AL590387
, AL035464, AL136087, AL160161, AL161439 Genomic DNA. Translation: CAJ58479.1.
BC022074 mRNA. Translation: AAH22074.1.
BX649045 mRNA. No translation available.
AL832634 mRNA. Translation: CAD89950.1.
CCDSiCCDS4844.1. [Q6ZMV9-1]
CCDS75449.1. [Q6ZMV9-2]
RefSeqiNP_001275949.1. NM_001289020.1.
NP_001275950.1. NM_001289021.1.
NP_001275953.1. NM_001289024.1. [Q6ZMV9-2]
NP_659464.3. NM_145027.4. [Q6ZMV9-1]
UniGeneiHs.588202.

3D structure databases

ProteinModelPortaliQ6ZMV9.
SMRiQ6ZMV9. Positions 3-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128728. 5 interactions.
IntActiQ6ZMV9. 1 interaction.
MINTiMINT-1480043.
STRINGi9606.ENSP00000287152.

PTM databases

PhosphoSiteiQ6ZMV9.

Polymorphism databases

DMDMi146345445.

Proteomic databases

MaxQBiQ6ZMV9.
PaxDbiQ6ZMV9.
PRIDEiQ6ZMV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229913; ENSP00000229913; ENSG00000164627. [Q6ZMV9-2]
ENST00000287152; ENSP00000287152; ENSG00000164627. [Q6ZMV9-1]
GeneIDi221458.
KEGGihsa:221458.
UCSCiuc003oos.2. human. [Q6ZMV9-2]
uc003oot.2. human. [Q6ZMV9-1]

Organism-specific databases

CTDi221458.
GeneCardsiGC06M039297.
H-InvDBHIX0005853.
HGNCiHGNC:21202. KIF6.
HPAiHPA038811.
MIMi613919. gene.
neXtProtiNX_Q6ZMV9.
PharmGKBiPA134920075.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00730000110885.
HOVERGENiHBG081854.
InParanoidiQ6ZMV9.
KOiK10397.
OMAiKQQQGIY.
PhylomeDBiQ6ZMV9.
TreeFamiTF329752.

Miscellaneous databases

GenomeRNAii221458.
NextBioi91347.
PROiQ6ZMV9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZMV9.
CleanExiHS_KIF6.
ExpressionAtlasiQ6ZMV9. baseline and differential.
GenevestigatoriQ6ZMV9.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT ARG-719.
    Tissue: Amygdala and Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-814 (ISOFORM 3).
    Tissue: Spinal cord.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-386.

Entry informationi

Entry nameiKIF6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV9
Secondary accession number(s): Q2MDE3
, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 2007
Last modified: March 4, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.