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Q6ZMV9 (KIF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF6
Gene names
Name:KIF6
Synonyms:C6orf102
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length814 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmcytoskeleton Probable.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Contains 1 kinesin motor domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APPBP2Q926243EBI-751100,EBI-743771

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZMV9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZMV9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
Isoform 3 (identifier: Q6ZMV9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     728-744: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q6ZMV9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
     708-720: PFLQTSDSQHEWS → SKIKALADSMSVM
     721-814: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 814814Kinesin-like protein KIF6
PRO_0000125441

Regions

Domain5 – 345341Kinesin motor
Nucleotide binding97 – 1048ATP By similarity
Coiled coil356 – 38530 Potential
Coiled coil456 – 49439 Potential
Coiled coil588 – 68396 Potential

Natural variations

Alternative sequence1 – 549549Missing in isoform 2 and isoform 4.
VSP_014468
Alternative sequence708 – 72013PFLQT…QHEWS → SKIKALADSMSVM in isoform 4.
VSP_014469
Alternative sequence721 – 81494Missing in isoform 4.
VSP_014470
Alternative sequence728 – 74417Missing in isoform 3.
VSP_014471
Natural variant3861A → E in a breast cancer sample; somatic mutation. Ref.5
VAR_036217
Natural variant5121R → H.
Corresponds to variant rs2273063 [ dbSNP | Ensembl ].
VAR_049698
Natural variant7191W → R. Ref.1
Corresponds to variant rs20455 [ dbSNP | Ensembl ].
VAR_022810

Experimental info

Sequence conflict5511R → K in BAD18616. Ref.1
Sequence conflict558 – 58427CQEAF…QILKQ → NATILSSLTGPGLQHFGEKI QFAPQEN in CAD89950. Ref.4
Sequence conflict7151S → F in BAD18616. Ref.1
Sequence conflict7721E → G in BAD18616. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2007. Version 3.
Checksum: D0BB982845286F31

FASTA81492,569
        10         20         30         40         50         60 
MVKQTIQIFA RVKPPVRKHQ QGIYSIDEDE KLIPSLEIIL PRDLADGFVN NKRESYKFKF 

        70         80         90        100        110        120 
QRIFDQDANQ ETVFENIAKP VAGSVLAGYN GTIFAYGQTG SGKTFTITGG AERYSDRGII 

       130        140        150        160        170        180 
PRTLSYIFEQ LQKDSSKIYT THISYLEIYN ECGYDLLDPR HEASSLEDLP KVTILEDPDQ 

       190        200        210        220        230        240 
NIHLKNLTLH QATTEEEALN LLFLGDTNRM IAETPMNQAS TRSHCIFTIH LSSKEPGSAT 

       250        260        270        280        290        300 
VRHAKLHLVD LAGSERVAKT GVGGHLLTEA KYINLSLHYL EQVIIALSEK HRSHIPYRNS 

       310        320        330        340        350        360 
MMTSVLRDSL GGNCMTTMIA TLSLEKRNLD ESISTCRFAQ RVALIKNEAV LNEEINPRLV 

       370        380        390        400        410        420 
IKRLQKEIQE LKDELAMVTG EQRTEALTEA ELLQLEKLIT SFLEDQDSDS RLEVGADMRK 

       430        440        450        460        470        480 
VHHCFHHLKK LLNDKKILEN NTVSSESKDQ DCQEPLKEEE YRKLRDILKQ RDNEINILVN 

       490        500        510        520        530        540 
MLKKEKKKAQ EALHLAGMDR REFRQSQSPP FRLGNPEEGQ RMRLSSAPSQ AQDFSILGKR 

       550        560        570        580        590        600 
SSLLHKKIGM REEMSLGCQE AFEIFKRDHA DSVTIDDNKQ ILKQRFSEAK ALGESINEAR 

       610        620        630        640        650        660 
SKIGHLKEEI TQRHIQQVAL GISENMAVPL MPDQQEEKLR SQLEEEKRRY KTMFTRLKAL 

       670        680        690        700        710        720 
KVEIEHLQLL MDKAKVKLQK EFEVWWAEEA TNLQVNSPAV NSLDHTKPFL QTSDSQHEWS 

       730        740        750        760        770        780 
QLLSNKSSGG WEVQDQGTGR FDVCDVNARK ILPSPCPSPH SQKQSSTSTP LEDSIPKRPV 

       790        800        810 
SSIPLTGDSQ TDSDIIAFIK ARQSILQKQC LGSN 

« Hide

Isoform 2 [UniParc].

Checksum: CDE6BB34F2EDEACA
Show »

FASTA26530,082
Isoform 3 [UniParc].

Checksum: B693765C871D24D9
Show »

FASTA79790,746
Isoform 4 [UniParc].

Checksum: 7053D9CB3640985B
Show »

FASTA17119,809

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT ARG-719.
Tissue: Amygdala and Testis.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-814 (ISOFORM 3).
Tissue: Spinal cord.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-386.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK123217 mRNA. Translation: BAC85560.1.
AK131471 mRNA. Translation: BAD18616.1.
AL136087, AL160161 Genomic DNA. Translation: CAI19535.1.
AL160161, AL136087 Genomic DNA. Translation: CAI19716.1.
AL035464 expand/collapse EMBL AC list , AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58469.1.
AL035464 expand/collapse EMBL AC list , AL136087, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58470.1.
AL136087 expand/collapse EMBL AC list , AL035464, AL160161, AL590387 Genomic DNA. Translation: CAJ58472.1.
AL136087 expand/collapse EMBL AC list , AL035464, AL160161, AL161439, AL590387 Genomic DNA. Translation: CAJ58473.1.
AL160161 expand/collapse EMBL AC list , AL035464, AL136087, AL590387 Genomic DNA. Translation: CAJ58475.1.
AL160161 expand/collapse EMBL AC list , AL035464, AL136087, AL161439, AL590387 Genomic DNA. Translation: CAJ58476.1.
AL161439 expand/collapse EMBL AC list , AL035464, AL136087, AL160161, AL590387 Genomic DNA. Translation: CAJ58477.1.
AL590387 expand/collapse EMBL AC list , AL035464, AL136087, AL160161 Genomic DNA. Translation: CAJ58478.1.
AL590387 expand/collapse EMBL AC list , AL035464, AL136087, AL160161, AL161439 Genomic DNA. Translation: CAJ58479.1.
BC022074 mRNA. Translation: AAH22074.1.
BX649045 mRNA. No translation available.
AL832634 mRNA. Translation: CAD89950.1.
CCDSCCDS4844.1. [Q6ZMV9-1]
RefSeqNP_001275949.1. NM_001289020.1.
NP_001275950.1. NM_001289021.1.
NP_001275953.1. NM_001289024.1. [Q6ZMV9-2]
NP_659464.3. NM_145027.4. [Q6ZMV9-1]
UniGeneHs.588202.

3D structure databases

ProteinModelPortalQ6ZMV9.
SMRQ6ZMV9. Positions 4-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128728. 3 interactions.
IntActQ6ZMV9. 1 interaction.
MINTMINT-1480043.
STRING9606.ENSP00000287152.

PTM databases

PhosphoSiteQ6ZMV9.

Polymorphism databases

DMDM146345445.

Proteomic databases

MaxQBQ6ZMV9.
PaxDbQ6ZMV9.
PRIDEQ6ZMV9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000229913; ENSP00000229913; ENSG00000164627. [Q6ZMV9-2]
ENST00000287152; ENSP00000287152; ENSG00000164627. [Q6ZMV9-1]
ENST00000373216; ENSP00000362312; ENSG00000164627. [Q6ZMV9-3]
GeneID221458.
KEGGhsa:221458.
UCSCuc003oos.2. human. [Q6ZMV9-2]
uc003oot.2. human. [Q6ZMV9-1]

Organism-specific databases

CTD221458.
GeneCardsGC06M039297.
H-InvDBHIX0005853.
HGNCHGNC:21202. KIF6.
HPAHPA038811.
MIM613919. gene.
neXtProtNX_Q6ZMV9.
PharmGKBPA134920075.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOVERGENHBG081854.
InParanoidQ6ZMV9.
KOK10397.
OMAKTGMREE.
PhylomeDBQ6ZMV9.
TreeFamTF329752.

Gene expression databases

ArrayExpressQ6ZMV9.
BgeeQ6ZMV9.
CleanExHS_KIF6.
GenevestigatorQ6ZMV9.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi221458.
NextBio91347.
PROQ6ZMV9.
SOURCESearch...

Entry information

Entry nameKIF6_HUMAN
AccessionPrimary (citable) accession number: Q6ZMV9
Secondary accession number(s): Q2MDE3 expand/collapse secondary AC list , Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM