Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative zinc finger protein 730

Gene

ZNF730

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 730
Gene namesi
Name:ZNF730
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000183850.13
HGNCiHGNC:32470 ZNF730
neXtProtiNX_Q6ZMV8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183850

Polymorphism and mutation databases

DMDMi74758685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289861 – 503Putative zinc finger protein 730Add BLAST503

Proteomic databases

EPDiQ6ZMV8
MaxQBiQ6ZMV8
PaxDbiQ6ZMV8
PeptideAtlasiQ6ZMV8
PRIDEiQ6ZMV8

PTM databases

iPTMnetiQ6ZMV8
PhosphoSitePlusiQ6ZMV8

Expressioni

Gene expression databases

BgeeiENSG00000183850
CleanExiHS_ZNF730
ExpressionAtlasiQ6ZMV8 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329365

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV8
SMRiQ6ZMV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZMV8
KOiK09228
OMAiESSNCTT
OrthoDBiEOG091G02KC
PhylomeDBiQ6ZMV8
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

Q6ZMV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALTFRDVA IEFSLEEWQC LDTEQQNLYR NVMLDNYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQEK EPWNLKTHDM VAKPPVICSH IAQDLWPEQG IKDYFQEVIL
110 120 130 140 150
RQYKKCRHEN LLLRKGCKNV DEFKMHKKGY NRHNQCLTTS HSKIFQCDKY
160 170 180 190 200
VKVFHKFSNS NRHKIRHTSK KPFKCKECGK LFCILSHLAQ HKKIHTGEKS
210 220 230 240 250
YKCEEYGKAF NESSNCTTHK RITEKKPYKC KECGKAFNWF SHFTTHKRIH
260 270 280 290 300
TGEKPYQCEK CGKFFNQSTN LTTHKRIHTG EKPYKCEECG KAFNQSSNLT
310 320 330 340 350
EHKKIHTKEQ PYKCEKCGKA FKWSSTLTKH KRIHNGEKPY KCEECGKAFN
360 370 380 390 400
RSSTLNRHKI THTGGKPYKY KECGKAFNQS STLTIHKIIH TVEKFYKCEE
410 420 430 440 450
CGKAFSRISH LTTHKRIHTG EKPYKCEECG RAFNQSSTLT THKRIHTGEK
460 470 480 490 500
PYECEECGKA FNRSSTLTTH KIIHSGEKIY KCKECGKAFR RFSHLTRHKT

IHT
Length:503
Mass (Da):59,040
Last modified:July 5, 2004 - v1
Checksum:iEE2CE28DD60B55E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057449365G → E. Corresponds to variant dbSNP:rs7247102Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131472 mRNA Translation: BAD18617.1
CCDSiCCDS59371.1
RefSeqiNP_001264332.1, NM_001277403.1
UniGeneiHs.427120

Genome annotation databases

EnsembliENST00000597761; ENSP00000472959; ENSG00000183850
GeneIDi100129543
KEGGihsa:100129543
UCSCiuc031rkc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN730_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health