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Protein

Putative zinc finger protein 730

Gene

ZNF730

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 730
Gene namesi
Name:ZNF730
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32470. ZNF730.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74758685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Putative zinc finger protein 730PRO_0000328986Add
BLAST

Proteomic databases

PaxDbiQ6ZMV8.
PRIDEiQ6ZMV8.

PTM databases

PhosphoSiteiQ6ZMV8.

Expressioni

Gene expression databases

BgeeiQ6ZMV8.
CleanExiHS_ZNF730.
ExpressionAtlasiQ6ZMV8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329365.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV8.
SMRiQ6ZMV8. Positions 127-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMV8.
KOiK09228.
OMAiESSNCTT.
PhylomeDBiQ6ZMV8.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALTFRDVA IEFSLEEWQC LDTEQQNLYR NVMLDNYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQEK EPWNLKTHDM VAKPPVICSH IAQDLWPEQG IKDYFQEVIL
110 120 130 140 150
RQYKKCRHEN LLLRKGCKNV DEFKMHKKGY NRHNQCLTTS HSKIFQCDKY
160 170 180 190 200
VKVFHKFSNS NRHKIRHTSK KPFKCKECGK LFCILSHLAQ HKKIHTGEKS
210 220 230 240 250
YKCEEYGKAF NESSNCTTHK RITEKKPYKC KECGKAFNWF SHFTTHKRIH
260 270 280 290 300
TGEKPYQCEK CGKFFNQSTN LTTHKRIHTG EKPYKCEECG KAFNQSSNLT
310 320 330 340 350
EHKKIHTKEQ PYKCEKCGKA FKWSSTLTKH KRIHNGEKPY KCEECGKAFN
360 370 380 390 400
RSSTLNRHKI THTGGKPYKY KECGKAFNQS STLTIHKIIH TVEKFYKCEE
410 420 430 440 450
CGKAFSRISH LTTHKRIHTG EKPYKCEECG RAFNQSSTLT THKRIHTGEK
460 470 480 490 500
PYECEECGKA FNRSSTLTTH KIIHSGEKIY KCKECGKAFR RFSHLTRHKT

IHT
Length:503
Mass (Da):59,040
Last modified:July 5, 2004 - v1
Checksum:iEE2CE28DD60B55E3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti365 – 3651G → E.
Corresponds to variant rs7247102 [ dbSNP | Ensembl ].
VAR_057449

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131472 mRNA. Translation: BAD18617.1.
CCDSiCCDS59371.1.
RefSeqiNP_001264332.1. NM_001277403.1.
UniGeneiHs.427120.

Genome annotation databases

EnsembliENST00000597761; ENSP00000472959; ENSG00000183850.
GeneIDi100129543.
KEGGihsa:100129543.
UCSCiuc031rkc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131472 mRNA. Translation: BAD18617.1.
CCDSiCCDS59371.1.
RefSeqiNP_001264332.1. NM_001277403.1.
UniGeneiHs.427120.

3D structure databases

ProteinModelPortaliQ6ZMV8.
SMRiQ6ZMV8. Positions 127-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329365.

PTM databases

PhosphoSiteiQ6ZMV8.

Polymorphism and mutation databases

DMDMi74758685.

Proteomic databases

PaxDbiQ6ZMV8.
PRIDEiQ6ZMV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000597761; ENSP00000472959; ENSG00000183850.
GeneIDi100129543.
KEGGihsa:100129543.
UCSCiuc031rkc.2. human.

Organism-specific databases

CTDi100129543.
GeneCardsiZNF730.
HGNCiHGNC:32470. ZNF730.
neXtProtiNX_Q6ZMV8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMV8.
KOiK09228.
OMAiESSNCTT.
PhylomeDBiQ6ZMV8.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii100129543.
PROiQ6ZMV8.

Gene expression databases

BgeeiQ6ZMV8.
CleanExiHS_ZNF730.
ExpressionAtlasiQ6ZMV8. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN730_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.