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Protein

Putative zinc finger protein 730

Gene

ZNF730

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.HMP:

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degenerateIEP:Add BLAST23
Zinc fingeri173 – 195C2H2-type 2IEP:Add BLAST23
Zinc fingeri228 – 250C2H2-type 3IEP:Add BLAST23
Zinc fingeri256 – 278C2H2-type 4IEP:Add BLAST23
Zinc fingeri284 – 306C2H2-type 5IEP:Add BLAST23
Zinc fingeri312 – 334C2H2-type 6IEP:Add BLAST23
Zinc fingeri340 – 362C2H2-type 7IEP:Add BLAST23
Zinc fingeri368 – 390C2H2-type 8; degenerateIEP:Add BLAST23
Zinc fingeri396 – 418C2H2-type 9IEP:Add BLAST23
Zinc fingeri424 – 446C2H2-type 10IEP:Add BLAST23
Zinc fingeri452 – 474C2H2-type 11IEP:Add BLAST23
Zinc fingeri480 – 502C2H2-type 12IEP:Add BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 730
Gene namesi
Name:ZNF730
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000183850.13.
HGNCiHGNC:32470. ZNF730.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183850.

Polymorphism and mutation databases

DMDMi74758685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289861 – 503Putative zinc finger protein 730Add BLAST503

Proteomic databases

MaxQBiQ6ZMV8.
PaxDbiQ6ZMV8.
PeptideAtlasiQ6ZMV8.
PRIDEiQ6ZMV8.

PTM databases

iPTMnetiQ6ZMV8.
PhosphoSitePlusiQ6ZMV8.

Expressioni

Gene expression databases

BgeeiENSG00000183850.
CleanExiHS_ZNF730.
ExpressionAtlasiQ6ZMV8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329365.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV8.
SMRiQ6ZMV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABIEP:Add BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degenerateIEP:Add BLAST23
Zinc fingeri173 – 195C2H2-type 2IEP:Add BLAST23
Zinc fingeri228 – 250C2H2-type 3IEP:Add BLAST23
Zinc fingeri256 – 278C2H2-type 4IEP:Add BLAST23
Zinc fingeri284 – 306C2H2-type 5IEP:Add BLAST23
Zinc fingeri312 – 334C2H2-type 6IEP:Add BLAST23
Zinc fingeri340 – 362C2H2-type 7IEP:Add BLAST23
Zinc fingeri368 – 390C2H2-type 8; degenerateIEP:Add BLAST23
Zinc fingeri396 – 418C2H2-type 9IEP:Add BLAST23
Zinc fingeri424 – 446C2H2-type 10IEP:Add BLAST23
Zinc fingeri452 – 474C2H2-type 11IEP:Add BLAST23
Zinc fingeri480 – 502C2H2-type 12IEP:Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMV8.
KOiK09228.
OMAiESSNCTT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZMV8.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.

Sequencei

Sequence statusi: Complete.

Q6ZMV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALTFRDVA IEFSLEEWQC LDTEQQNLYR NVMLDNYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQEK EPWNLKTHDM VAKPPVICSH IAQDLWPEQG IKDYFQEVIL
110 120 130 140 150
RQYKKCRHEN LLLRKGCKNV DEFKMHKKGY NRHNQCLTTS HSKIFQCDKY
160 170 180 190 200
VKVFHKFSNS NRHKIRHTSK KPFKCKECGK LFCILSHLAQ HKKIHTGEKS
210 220 230 240 250
YKCEEYGKAF NESSNCTTHK RITEKKPYKC KECGKAFNWF SHFTTHKRIH
260 270 280 290 300
TGEKPYQCEK CGKFFNQSTN LTTHKRIHTG EKPYKCEECG KAFNQSSNLT
310 320 330 340 350
EHKKIHTKEQ PYKCEKCGKA FKWSSTLTKH KRIHNGEKPY KCEECGKAFN
360 370 380 390 400
RSSTLNRHKI THTGGKPYKY KECGKAFNQS STLTIHKIIH TVEKFYKCEE
410 420 430 440 450
CGKAFSRISH LTTHKRIHTG EKPYKCEECG RAFNQSSTLT THKRIHTGEK
460 470 480 490 500
PYECEECGKA FNRSSTLTTH KIIHSGEKIY KCKECGKAFR RFSHLTRHKT

IHT
Length:503
Mass (Da):59,040
Last modified:July 5, 2004 - v1
Checksum:iEE2CE28DD60B55E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057449365G → E. Corresponds to variant dbSNP:rs7247102Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131472 mRNA. Translation: BAD18617.1.
CCDSiCCDS59371.1.
RefSeqiNP_001264332.1. NM_001277403.1.
UniGeneiHs.427120.

Genome annotation databases

EnsembliENST00000597761; ENSP00000472959; ENSG00000183850.
GeneIDi100129543.
KEGGihsa:100129543.
UCSCiuc031rkc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN730_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families