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Protein

Leucine-, glutamate- and lysine-rich protein 1

Gene

LEKR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-, glutamate- and lysine-rich protein 1
Gene namesi
Name:LEKR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000197980.11
HGNCiHGNC:33765 LEKR1
MIMi613536 gene
neXtProtiNX_Q6ZMV7

Pathology & Biotechi

Organism-specific databases

DisGeNETi389170
OpenTargetsiENSG00000197980

Polymorphism and mutation databases

DMDMi296434564

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257111 – 388Leucine-, glutamate- and lysine-rich protein 1Add BLAST388

Proteomic databases

PaxDbiQ6ZMV7
PeptideAtlasiQ6ZMV7
PRIDEiQ6ZMV7

PTM databases

iPTMnetiQ6ZMV7
PhosphoSitePlusiQ6ZMV7

Expressioni

Gene expression databases

BgeeiENSG00000197980
CleanExiHS_LEKR1
ExpressionAtlasiQ6ZMV7 baseline and differential

Organism-specific databases

HPAiHPA044039

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348936

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV7
SMRiQ6ZMV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3 – 289Sequence analysisAdd BLAST287

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi382 – 385Poly-Arg4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IPMR Eukaryota
ENOG411200S LUCA
GeneTreeiENSGT00910000144257
HOGENOMiHOG000170886
HOVERGENiHBG097773
InParanoidiQ6ZMV7
PhylomeDBiQ6ZMV7
TreeFamiTF344195

Family and domain databases

InterProiView protein in InterPro
IPR038799 LEKR1
PANTHERiPTHR34251 PTHR34251, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZMV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKEKEDSL MTCQQIYKAL QEELTVKEKQ EEDIKRRINL AENELEITKT
60 70 80 90 100
LLNQTREEVL TLKNERELML ISHQKSIEQL QETLRQKLLS DDNWKEKIEA
110 120 130 140 150
ELAKERAQHL VEFEEQALLF KEETKLQLDI EKEKHQDVIQ KYKKEQEELQ
160 170 180 190 200
MKISDLITGA TRDLRQEVTT LKEKLHKSHI RYTEESNSKE KEIENLKNLV
210 220 230 240 250
AEFESRLKKE IDSNDSVSEN LRKEMEQKSD ELKRVMLAQT QLIEQFNQSQ
260 270 280 290 300
EENTFLQETV RRECEERFEL TEALSQAREQ LLELSKLRGS LPFSPCSLSK
310 320 330 340 350
GSLTSPAAAV SNHGERSLAR LNSEKGIQIP NLRGVSKPTT FPTSDKPKRV
360 370 380
RSGVPILPQP HPPRGGASSA NETRQRLAAI LRRRRSQQ
Length:388
Mass (Da):45,158
Last modified:May 18, 2010 - v2
Checksum:iA413D878DAE5F146
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180I → T in BAD18618 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061673356I → V. Corresponds to variant dbSNP:rs61469347Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131473 mRNA Translation: BAD18618.1
AC106708 Genomic DNA No translation available.
AC092993 Genomic DNA No translation available.
AC117392 Genomic DNA No translation available.
UniGeneiHs.478048

Genome annotation databases

EnsembliENST00000470811; ENSP00000418214; ENSG00000197980
UCSCiuc003fba.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLEKR1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health