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Protein

Leucine-, glutamate- and lysine-rich protein 1

Gene

LEKR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-, glutamate- and lysine-rich protein 1
Gene namesi
Name:LEKR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:33765. LEKR1.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi296434564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Leucine-, glutamate- and lysine-rich protein 1PRO_0000325711Add
BLAST

Proteomic databases

PaxDbiQ6ZMV7.
PeptideAtlasiQ6ZMV7.
PRIDEiQ6ZMV7.

PTM databases

iPTMnetiQ6ZMV7.
PhosphoSiteiQ6ZMV7.

Expressioni

Gene expression databases

BgeeiENSG00000197980.
CleanExiHS_LEKR1.
ExpressionAtlasiQ6ZMV7. baseline and differential.

Organism-specific databases

HPAiHPA044039.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348936.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3 – 289287Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi382 – 3854Poly-Arg

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IPMR. Eukaryota.
ENOG411200S. LUCA.
GeneTreeiENSGT00400000024543.
HOGENOMiHOG000170886.
HOVERGENiHBG097773.
InParanoidiQ6ZMV7.
PhylomeDBiQ6ZMV7.
TreeFamiTF344195.

Sequencei

Sequence statusi: Complete.

Q6ZMV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKEKEDSL MTCQQIYKAL QEELTVKEKQ EEDIKRRINL AENELEITKT
60 70 80 90 100
LLNQTREEVL TLKNERELML ISHQKSIEQL QETLRQKLLS DDNWKEKIEA
110 120 130 140 150
ELAKERAQHL VEFEEQALLF KEETKLQLDI EKEKHQDVIQ KYKKEQEELQ
160 170 180 190 200
MKISDLITGA TRDLRQEVTT LKEKLHKSHI RYTEESNSKE KEIENLKNLV
210 220 230 240 250
AEFESRLKKE IDSNDSVSEN LRKEMEQKSD ELKRVMLAQT QLIEQFNQSQ
260 270 280 290 300
EENTFLQETV RRECEERFEL TEALSQAREQ LLELSKLRGS LPFSPCSLSK
310 320 330 340 350
GSLTSPAAAV SNHGERSLAR LNSEKGIQIP NLRGVSKPTT FPTSDKPKRV
360 370 380
RSGVPILPQP HPPRGGASSA NETRQRLAAI LRRRRSQQ
Length:388
Mass (Da):45,158
Last modified:May 18, 2010 - v2
Checksum:iA413D878DAE5F146
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801I → T in BAD18618 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti356 – 3561I → V.
Corresponds to variant rs61469347 [ dbSNP | Ensembl ].
VAR_061673

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131473 mRNA. Translation: BAD18618.1.
AC106708 Genomic DNA. No translation available.
AC092993 Genomic DNA. No translation available.
AC117392 Genomic DNA. No translation available.
UniGeneiHs.478048.

Genome annotation databases

EnsembliENST00000470811; ENSP00000418214; ENSG00000197980.
UCSCiuc003fba.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131473 mRNA. Translation: BAD18618.1.
AC106708 Genomic DNA. No translation available.
AC092993 Genomic DNA. No translation available.
AC117392 Genomic DNA. No translation available.
UniGeneiHs.478048.

3D structure databases

ProteinModelPortaliQ6ZMV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348936.

PTM databases

iPTMnetiQ6ZMV7.
PhosphoSiteiQ6ZMV7.

Polymorphism and mutation databases

DMDMi296434564.

Proteomic databases

PaxDbiQ6ZMV7.
PeptideAtlasiQ6ZMV7.
PRIDEiQ6ZMV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470811; ENSP00000418214; ENSG00000197980.
UCSCiuc003fba.2. human.

Organism-specific databases

GeneCardsiLEKR1.
HGNCiHGNC:33765. LEKR1.
HPAiHPA044039.
MIMi613536. gene.
neXtProtiNX_Q6ZMV7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPMR. Eukaryota.
ENOG411200S. LUCA.
GeneTreeiENSGT00400000024543.
HOGENOMiHOG000170886.
HOVERGENiHBG097773.
InParanoidiQ6ZMV7.
PhylomeDBiQ6ZMV7.
TreeFamiTF344195.

Miscellaneous databases

ChiTaRSiLEKR1. human.
PROiQ6ZMV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197980.
CleanExiHS_LEKR1.
ExpressionAtlasiQ6ZMV7. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLEKR1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.