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Protein

Protein PPP4R3C

Gene

PPP4R3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PPP4R3CCurated
Alternative name(s):
SMEK homolog 3
Serine/threonine-protein phosphatase 4 regulatory subunit 3CImported
Gene namesi
Name:PPP4R3CImported
Synonyms:PPP4R3CP, SMEK3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33146 PPP4R3C
neXtProtiNX_Q6ZMV5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000224960

Polymorphism and mutation databases

DMDMi206558317

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444471 – 832Protein PPP4R3CAdd BLAST832

Proteomic databases

EPDiQ6ZMV5
PeptideAtlasiQ6ZMV5
PRIDEiQ6ZMV5

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMEK family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000018199
HOVERGENiHBG056624
InParanoidiQ6ZMV5
OMAiRFMRRMI
PhylomeDBiQ6ZMV5

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR006887 DUF625
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF04802 SMK-1, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV
60 70 80 90 100
ILRSQIPPDR PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA
110 120 130 140 150
QGKDPSIQTT VNISDEPEED FNEMSVISNM VVLPDCELNT LDQIADIVTS
160 170 180 190 200
VFSSPVTDRE RLAEILKNEA YIPKLLQLFH TCENLENTEG LHHLYEIIKG
210 220 230 240 250
ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD FLTNDAKFKE
260 270 280 290 300
VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA
310 320 330 340 350
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ
360 370 380 390 400
SKDALFETLI QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE
410 420 430 440 450
FIISEAHVCK DSDLFINVII KQMICDTDPE LGGAVHLMVV LHTLLDPRNM
460 470 480 490 500
LTTPEKSERS EFLHFFYKHC MHKFTAPLLA ATSEHNCEED DIAGYDKSKN
510 520 530 540 550
CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR KALILMNSKH
560 570 580 590 600
THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN
610 620 630 640 650
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER
660 670 680 690 700
DRQSQIQKNL HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD
710 720 730 740 750
DEFMETKRTQ EGEAVMPPLE DDDKFTETKR THQEGEAVMP PLEDDDEFME
760 770 780 790 800
TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA CAAIGTGSPS GSSVVRLVDH
810 820 830
PDDEEEKEED EEEKEEDKED ETSPKKKPHL SS
Length:832
Mass (Da):95,804
Last modified:December 20, 2017 - v3
Checksum:iF9318B12F14DDB09
GO
Isoform 2 (identifier: Q6ZMV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     734-809: Missing.

Note: No experimental confirmation available.
Show »
Length:756
Mass (Da):87,529
Checksum:iF3FA37E8C8E7F413
GO

Sequence cautioni

The sequence BAB71482 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412 – 413SD → IY in BAD18620 (PubMed:14702039).Curated2
Sequence conflicti692V → A in BAD18620 (PubMed:14702039).Curated1
Sequence conflicti692V → A in BAB71482 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034762734 – 809Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057429 mRNA Translation: BAB71482.1 Different initiation.
AK131475 mRNA Translation: BAD18620.1
AC006210 Genomic DNA No translation available.
UniGeneiHs.350673
Hs.641864

Genome annotation databases

EnsembliENST00000412172; ENSP00000489770; ENSG00000224960 [Q6ZMV5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP4R3C_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV5
Secondary accession number(s): A0A1B0GTN1, Q96M31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 20, 2017
Last modified: May 23, 2018
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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