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Protein

Putative SMEK homolog 3

Gene

PPP4R3CP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative SMEK homolog 3
Alternative name(s):
Serine/threonine-protein phosphatase 4 regulatory subunit 3C pseudogeneImported
Gene namesi
Name:PPP4R3CPImported
Synonyms:SMEK3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33146. PPP4R3CP.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi206558317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Putative SMEK homolog 3PRO_0000344447Add
BLAST

Proteomic databases

EPDiQ6ZMV5.
PeptideAtlasiQ6ZMV5.
PRIDEiQ6ZMV5.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMV5.
SMRiQ6ZMV5. Positions 5-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMEK family.Curated

Phylogenomic databases

HOVERGENiHBG056624.
InParanoidiQ6ZMV5.
PhylomeDBiQ6ZMV5.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR006887. DUF625.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF04802. SMK-1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50729. SSF50729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV
60 70 80 90 100
ILRSQIPPDR PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA
110 120 130 140 150
QGKDPSIQTT VNISDEPEED FNEMSVISNM VVLPDCELNT LDQIADIVTS
160 170 180 190 200
VFSSPVTDRE RLAEILKNEA YIPKLLQLFH TCENLENTEG LHHLYEIIKG
210 220 230 240 250
ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD FLTNDAKFKE
260 270 280 290 300
VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA
310 320 330 340 350
EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ
360 370 380 390 400
SKDALFETLI QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE
410 420 430 440 450
FIISEAHVCK DSDLFINVII KQMICDTDPE LGGAVHLMVV LHTLLDPRNM
460 470 480 490 500
LTTPEKSERS EFLHFFYKHC MHKFTAPLLA ATSEHNCEED DIAGYDKSKN
510 520 530 540 550
CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR KALILMNSKH
560 570 580 590 600
THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN
610 620 630 640 650
SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER
660 670 680 690 700
DRQSQIQKNL HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EAVMPPLEDD
710 720 730 740 750
DEFMETKRTQ EGEAVMPPLE DDDKFTETKR THQEGEAVMP PLEDDDEFME
760 770 780 790 800
TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA CAAIGTGSPS GSSVVRLVDH
810 820 830
PDDEEEKEED EEEKEEDKED ETSPKKKPHL SS
Length:832
Mass (Da):95,776
Last modified:July 22, 2008 - v2
Checksum:iF93193A5AB719982
GO
Isoform 2 (identifier: Q6ZMV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     734-809: Missing.

Note: No experimental confirmation available.
Show »
Length:756
Mass (Da):87,501
Checksum:iECF527F7C7F7F413
GO

Sequence cautioni

The sequence BAB71482 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti412 – 4132SD → IY in BAD18620 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei734 – 80976Missing in isoform 2. 1 PublicationVSP_034762Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057429 mRNA. Translation: BAB71482.1. Different initiation.
AK131475 mRNA. Translation: BAD18620.1.
UniGeneiHs.350673.
Hs.641864.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057429 mRNA. Translation: BAB71482.1. Different initiation.
AK131475 mRNA. Translation: BAD18620.1.
UniGeneiHs.350673.
Hs.641864.

3D structure databases

ProteinModelPortaliQ6ZMV5.
SMRiQ6ZMV5. Positions 5-113.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi206558317.

Proteomic databases

EPDiQ6ZMV5.
PeptideAtlasiQ6ZMV5.
PRIDEiQ6ZMV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiSMEK3P.
HGNCiHGNC:33146. PPP4R3CP.
neXtProtiNX_Q6ZMV5.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG056624.
InParanoidiQ6ZMV5.
PhylomeDBiQ6ZMV5.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR006887. DUF625.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF04802. SMK-1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMEK3_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMV5
Secondary accession number(s): Q96M31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 6, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.