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Q6ZMU0

- Q6ZMU0_HUMAN

UniProt

Q6ZMU0 - Q6ZMU0_HUMAN

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Protein
Delta-aminolevulinic acid dehydratase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi151 – 1511Zinc 1; catalytic By similarityUniRule annotation
Metal bindingi153 – 1531Zinc 1; catalytic By similarityUniRule annotation
Metal bindingi160 – 1601Zinc 2 By similarityUniRule annotation
Metal bindingi161 – 1611Zinc 1; catalytic By similarityUniRule annotation
Active sitei228 – 2281Schiff-base intermediate with substrate By similarityUniRule annotation
Binding sitei238 – 2381Substrate 1 By similarity
Binding sitei250 – 2501Substrate 1 By similarity
Metal bindingi252 – 2521Zinc 2 By similarityUniRule annotation
Active sitei281 – 2811Schiff-base intermediate with substrate By similarityUniRule annotation
Binding sitei308 – 3081Substrate 2 By similarity
Binding sitei347 – 3471Substrate 2 By similarityUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. porphobilinogen synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiQ6ZMU0.

2D gel databases

REPRODUCTION-2DPAGEIPI00442121.

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

MINTiMINT-5005283.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMU0.
SMRiQ6ZMU0. Positions 44-357.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001222.
KOiK01698.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMU0-1 [UniParc]FASTAAdd to Basket

« Hide

MPPTSSTPSL SRPGLGQAGK PDTGSHPPPT ISTSIFLSCF PTIPLSRPRT    50
TGPSHSYQSI SHPRSCRDVP DDIQPITSLP GVARYGVKRL EEMLRPLVEE 100
GLRCVLIFGV PSRVPKDERG SAADSEESPA IEAIHLLRKT FPNLLVACDV 150
CLCPYTSHGH CGLLSENGAF RAEESRQRLA EVALAYAKAG CQVVAPSDMM 200
DGRVEAIKEA LMAHGLGNRV SVMSYSAKFA SCFYGPFRDA AKSSPAFGDR 250
RCYQLPPGAR GLALRAVDRD VREGADMLMV KPGMLYLDIV REVKDKHPDL 300
PLAVYHVSGE FAMLWHGAQA GAFDLKAAVL EAMTAFRRAG ADIIITYYTP 350
QLLQWLKEE 359
Length:359
Mass (Da):39,050
Last modified:July 5, 2004 - v1
Checksum:i4AD5E8C53B11BAED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131490 mRNA. Translation: BAD18635.1.
RefSeqiNP_000022.3. NM_000031.5.
UniGeneiHs.1227.

Genome annotation databases

GeneIDi210.
KEGGihsa:210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131490 mRNA. Translation: BAD18635.1 .
RefSeqi NP_000022.3. NM_000031.5.
UniGenei Hs.1227.

3D structure databases

ProteinModelPortali Q6ZMU0.
SMRi Q6ZMU0. Positions 44-357.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-5005283.

2D gel databases

REPRODUCTION-2DPAGE IPI00442121.

Proteomic databases

PRIDEi Q6ZMU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 210.
KEGGi hsa:210.

Organism-specific databases

CTDi 210.

Phylogenomic databases

HOVERGENi HBG001222.
KOi K01698.

Miscellaneous databases

GenomeRNAii 210.
NextBioi 840.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ6ZMU0_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMU0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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