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Q6ZMU0

- Q6ZMU0_HUMAN

UniProt

Q6ZMU0 - Q6ZMU0_HUMAN

Protein

Delta-aminolevulinic acid dehydratase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi151 – 1511Zinc 1; catalyticUniRule annotation
    Metal bindingi153 – 1531Zinc 1; catalyticUniRule annotation
    Metal bindingi160 – 1601Zinc 2UniRule annotation
    Metal bindingi161 – 1611Zinc 1; catalyticUniRule annotation
    Active sitei228 – 2281Schiff-base intermediate with substrateUniRule annotation
    Binding sitei238 – 2381Substrate 1
    Binding sitei250 – 2501Substrate 1
    Metal bindingi252 – 2521Zinc 2UniRule annotation
    Active sitei281 – 2811Schiff-base intermediate with substrateUniRule annotation
    Binding sitei308 – 3081Substrate 2
    Binding sitei347 – 3471Substrate 2UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: InterPro
    2. porphobilinogen synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6ZMU0.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00442121.

    Interactioni

    Subunit structurei

    Homooctamer.UniRule annotation
    Homooctamer By similarity.

    Protein-protein interaction databases

    MINTiMINT-5005283.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZMU0.
    SMRiQ6ZMU0. Positions 44-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG001222.
    KOiK01698.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZMU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPTSSTPSL SRPGLGQAGK PDTGSHPPPT ISTSIFLSCF PTIPLSRPRT    50
    TGPSHSYQSI SHPRSCRDVP DDIQPITSLP GVARYGVKRL EEMLRPLVEE 100
    GLRCVLIFGV PSRVPKDERG SAADSEESPA IEAIHLLRKT FPNLLVACDV 150
    CLCPYTSHGH CGLLSENGAF RAEESRQRLA EVALAYAKAG CQVVAPSDMM 200
    DGRVEAIKEA LMAHGLGNRV SVMSYSAKFA SCFYGPFRDA AKSSPAFGDR 250
    RCYQLPPGAR GLALRAVDRD VREGADMLMV KPGMLYLDIV REVKDKHPDL 300
    PLAVYHVSGE FAMLWHGAQA GAFDLKAAVL EAMTAFRRAG ADIIITYYTP 350
    QLLQWLKEE 359
    Length:359
    Mass (Da):39,050
    Last modified:July 5, 2004 - v1
    Checksum:i4AD5E8C53B11BAED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131490 mRNA. Translation: BAD18635.1.
    RefSeqiNP_000022.3. NM_000031.5.
    UniGeneiHs.1227.

    Genome annotation databases

    GeneIDi210.
    KEGGihsa:210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131490 mRNA. Translation: BAD18635.1 .
    RefSeqi NP_000022.3. NM_000031.5.
    UniGenei Hs.1227.

    3D structure databases

    ProteinModelPortali Q6ZMU0.
    SMRi Q6ZMU0. Positions 44-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-5005283.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00442121.

    Proteomic databases

    PRIDEi Q6ZMU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 210.
    KEGGi hsa:210.

    Organism-specific databases

    CTDi 210.

    Phylogenomic databases

    HOVERGENi HBG001222.
    KOi K01698.

    Miscellaneous databases

    GenomeRNAii 210.
    NextBioi 840.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ6ZMU0_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZMU0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.