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Protein

Delta-aminolevulinic acid dehydratase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi151 – 1511Zinc 1; catalyticUniRule annotation
Metal bindingi151 – 1511Zinc; catalyticUniRule annotation
Metal bindingi153 – 1531Zinc 1; catalyticUniRule annotation
Metal bindingi153 – 1531Zinc; catalyticUniRule annotation
Metal bindingi160 – 1601Zinc 2UniRule annotation
Metal bindingi161 – 1611Zinc 1; catalyticUniRule annotation
Metal bindingi161 – 1611Zinc; catalyticUniRule annotation
Active sitei228 – 2281Schiff-base intermediate with substrateUniRule annotation
Binding sitei238 – 2381Substrate 1UniRule annotation
Binding sitei250 – 2501Substrate 1UniRule annotation
Metal bindingi252 – 2521Zinc 2UniRule annotation
Active sitei281 – 2811Schiff-base intermediate with substrateUniRule annotation
Binding sitei308 – 3081Substrate 2UniRule annotation
Binding sitei347 – 3471Substrate 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiQ6ZMU0.

2D gel databases

REPRODUCTION-2DPAGEIPI00442121.

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Protein-protein interaction databases

MINTiMINT-5005283.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMU0.
SMRiQ6ZMU0. Positions 44-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001222.
KOiK01698.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPTSSTPSL SRPGLGQAGK PDTGSHPPPT ISTSIFLSCF PTIPLSRPRT
60 70 80 90 100
TGPSHSYQSI SHPRSCRDVP DDIQPITSLP GVARYGVKRL EEMLRPLVEE
110 120 130 140 150
GLRCVLIFGV PSRVPKDERG SAADSEESPA IEAIHLLRKT FPNLLVACDV
160 170 180 190 200
CLCPYTSHGH CGLLSENGAF RAEESRQRLA EVALAYAKAG CQVVAPSDMM
210 220 230 240 250
DGRVEAIKEA LMAHGLGNRV SVMSYSAKFA SCFYGPFRDA AKSSPAFGDR
260 270 280 290 300
RCYQLPPGAR GLALRAVDRD VREGADMLMV KPGMLYLDIV REVKDKHPDL
310 320 330 340 350
PLAVYHVSGE FAMLWHGAQA GAFDLKAAVL EAMTAFRRAG ADIIITYYTP

QLLQWLKEE
Length:359
Mass (Da):39,050
Last modified:July 5, 2004 - v1
Checksum:i4AD5E8C53B11BAED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131490 mRNA. Translation: BAD18635.1.
RefSeqiNP_000022.3. NM_000031.5.
UniGeneiHs.1227.

Genome annotation databases

GeneIDi210.
KEGGihsa:210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131490 mRNA. Translation: BAD18635.1.
RefSeqiNP_000022.3. NM_000031.5.
UniGeneiHs.1227.

3D structure databases

ProteinModelPortaliQ6ZMU0.
SMRiQ6ZMU0. Positions 44-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-5005283.

2D gel databases

REPRODUCTION-2DPAGEIPI00442121.

Proteomic databases

PRIDEiQ6ZMU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi210.
KEGGihsa:210.

Organism-specific databases

CTDi210.

Phylogenomic databases

HOVERGENiHBG001222.
KOiK01698.

Miscellaneous databases

GenomeRNAii210.
NextBioi840.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ6ZMU0_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMU0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.