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Q6ZMU0 (Q6ZMU0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515

EC=4.2.1.24 RuleBase RU000515
OrganismHomo sapiens (Human) EMBL BAD18635.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Subunit structure

Homooctamer By similarity.

Sequence similarities

Belongs to the ALADH family. RuleBase RU004161

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2281Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Active site2811Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Metal binding1511Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
Metal binding1531Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
Metal binding1601Zinc 2 By similarity PIRSR PIRSR001415-4
Metal binding1611Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
Metal binding2521Zinc 2 By similarity PIRSR PIRSR001415-4
Binding site2381Substrate 1 By similarity
Binding site2501Substrate 1 By similarity
Binding site3081Substrate 2 By similarity
Binding site3471Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

Sequence LengthMass (Da)Tools
Q6ZMU0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4AD5E8C53B11BAED

FASTA35939,050
        10         20         30         40         50         60 
MPPTSSTPSL SRPGLGQAGK PDTGSHPPPT ISTSIFLSCF PTIPLSRPRT TGPSHSYQSI 

        70         80         90        100        110        120 
SHPRSCRDVP DDIQPITSLP GVARYGVKRL EEMLRPLVEE GLRCVLIFGV PSRVPKDERG 

       130        140        150        160        170        180 
SAADSEESPA IEAIHLLRKT FPNLLVACDV CLCPYTSHGH CGLLSENGAF RAEESRQRLA 

       190        200        210        220        230        240 
EVALAYAKAG CQVVAPSDMM DGRVEAIKEA LMAHGLGNRV SVMSYSAKFA SCFYGPFRDA 

       250        260        270        280        290        300 
AKSSPAFGDR RCYQLPPGAR GLALRAVDRD VREGADMLMV KPGMLYLDIV REVKDKHPDL 

       310        320        330        340        350 
PLAVYHVSGE FAMLWHGAQA GAFDLKAAVL EAMTAFRRAG ADIIITYYTP QLLQWLKEE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK131490 mRNA. Translation: BAD18635.1.
RefSeqNP_000022.3. NM_000031.5.
UniGeneHs.1227.

3D structure databases

ProteinModelPortalQ6ZMU0.
SMRQ6ZMU0. Positions 44-357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-5005283.

2D gel databases

REPRODUCTION-2DPAGEIPI00442121.

Proteomic databases

PRIDEQ6ZMU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID210.
KEGGhsa:210.

Organism-specific databases

CTD210.

Phylogenomic databases

HOVERGENHBG001222.
KOK01698.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERPTHR11458. PTHR11458. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
SMARTSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi210.
NextBio840.

Entry information

Entry nameQ6ZMU0_HUMAN
AccessionPrimary (citable) accession number: Q6ZMU0
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.