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Protein

Delta-aminolevulinic acid dehydratase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi151Zinc 1; catalyticUniRule annotation1
Metal bindingi151Zinc; catalyticUniRule annotation1
Metal bindingi153Zinc 1; catalyticUniRule annotation1
Metal bindingi153Zinc; catalyticUniRule annotation1
Metal bindingi160Zinc 2UniRule annotation1
Metal bindingi161Zinc 1; catalyticUniRule annotation1
Metal bindingi161Zinc; catalyticUniRule annotation1
Active sitei228Schiff-base intermediate with substrateUniRule annotation1
Binding sitei238Substrate 1UniRule annotation1
Binding sitei250Substrate 1UniRule annotation1
Metal bindingi252Zinc 2UniRule annotation1
Active sitei281Schiff-base intermediate with substrateUniRule annotation1
Binding sitei308Substrate 2UniRule annotation1
Binding sitei347Substrate 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6ZMU0.
PRIDEiQ6ZMU0.

2D gel databases

REPRODUCTION-2DPAGEIPI00442121.

Expressioni

Gene expression databases

GenevisibleiQ6ZMU0. HS.

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Protein-protein interaction databases

MINTiMINT-5005283.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001222.
KOiK01698.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPTSSTPSL SRPGLGQAGK PDTGSHPPPT ISTSIFLSCF PTIPLSRPRT
60 70 80 90 100
TGPSHSYQSI SHPRSCRDVP DDIQPITSLP GVARYGVKRL EEMLRPLVEE
110 120 130 140 150
GLRCVLIFGV PSRVPKDERG SAADSEESPA IEAIHLLRKT FPNLLVACDV
160 170 180 190 200
CLCPYTSHGH CGLLSENGAF RAEESRQRLA EVALAYAKAG CQVVAPSDMM
210 220 230 240 250
DGRVEAIKEA LMAHGLGNRV SVMSYSAKFA SCFYGPFRDA AKSSPAFGDR
260 270 280 290 300
RCYQLPPGAR GLALRAVDRD VREGADMLMV KPGMLYLDIV REVKDKHPDL
310 320 330 340 350
PLAVYHVSGE FAMLWHGAQA GAFDLKAAVL EAMTAFRRAG ADIIITYYTP

QLLQWLKEE
Length:359
Mass (Da):39,050
Last modified:July 5, 2004 - v1
Checksum:i4AD5E8C53B11BAED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131490 mRNA. Translation: BAD18635.1.
RefSeqiNP_000022.3. NM_000031.5.
NP_001003945.1. NM_001003945.2.
NP_001304674.1. NM_001317745.1.
UniGeneiHs.1227.

Genome annotation databases

GeneIDi210.
KEGGihsa:210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131490 mRNA. Translation: BAD18635.1.
RefSeqiNP_000022.3. NM_000031.5.
NP_001003945.1. NM_001003945.2.
NP_001304674.1. NM_001317745.1.
UniGeneiHs.1227.

3D structure databases

ProteinModelPortaliQ6ZMU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-5005283.

2D gel databases

REPRODUCTION-2DPAGEIPI00442121.

Proteomic databases

PeptideAtlasiQ6ZMU0.
PRIDEiQ6ZMU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi210.
KEGGihsa:210.

Organism-specific databases

CTDi210.

Phylogenomic databases

HOVERGENiHBG001222.
KOiK01698.

Miscellaneous databases

GenomeRNAii210.

Gene expression databases

GenevisibleiQ6ZMU0. HS.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6ZMU0_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMU0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.