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Protein

SH3 and cysteine-rich domain-containing protein 2

Gene

STAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri110 – 16152Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein 2
Alternative name(s):
24b2/STAC2
Src homology 3 and cysteine-rich domain-containing protein 2
Gene namesi
Name:STAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:23990. STAC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939947.

Polymorphism and mutation databases

BioMutaiSTAC2.
DMDMi74749556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411SH3 and cysteine-rich domain-containing protein 2PRO_0000274413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZMT1.
PRIDEiQ6ZMT1.

PTM databases

iPTMnetiQ6ZMT1.
PhosphoSiteiQ6ZMT1.

Expressioni

Gene expression databases

BgeeiQ6ZMT1.
CleanExiHS_STAC2.
ExpressionAtlasiQ6ZMT1. baseline and differential.
GenevisibleiQ6ZMT1. HS.

Organism-specific databases

HPAiHPA017288.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-948802,EBI-739832

Protein-protein interaction databases

BioGridi131192. 4 interactions.
IntActiQ6ZMT1. 2 interactions.
MINTiMINT-2879405.
STRINGi9606.ENSP00000327509.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMT1.
SMRiQ6ZMT1. Positions 99-166, 296-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini292 – 35160SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi70 – 10132Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri110 – 16152Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiQ6ZMT1.
OMAiAPSPCPI.
OrthoDBiEOG7XM2ZF.
PhylomeDBiQ6ZMT1.
TreeFamiTF332878.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEMSEKENE PDDAATHSPP GTVSALQETK LQRFKRSLSL KTILRSKSLE
60 70 80 90 100
NFFLRSGSEL KCPTEVLLTP PTPLPPPSPP PTASDRGLAT PSPSPCPVPR
110 120 130 140 150
PLAALKPVRL HSFQEHVFKR ASPCELCHQL IVGNSKQGLR CKMCKVSVHL
160 170 180 190 200
WCSEEISHQQ CPGKTSTSFR RNFSSPLLVH EPPPVCATSK ESPPTGDSGK
210 220 230 240 250
VDPVYETLRY GTSLALMNRS SFSSTSESPT RSLSERDELT EDGEGSIRSS
260 270 280 290 300
EEGPGDSASP VFTAPAESEG PGPEEKSPGQ QLPKATLRKD VGPMYSYVAL
310 320 330 340 350
YKFLPQENND LALQPGDRIM LVDDSNEDWW KGKIGDRVGF FPANFVQRVR
360 370 380 390 400
PGENVWRCCQ PFSGNKEQGY MSLKENQICV GVGRSKDADG FIRVSSGKKR
410
GLVPVDALTE I
Length:411
Mass (Da):45,009
Last modified:July 5, 2004 - v1
Checksum:i878DD19AFC305D0E
GO
Isoform 2 (identifier: Q6ZMT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Note: No experimental confirmation available.
Show »
Length:269
Mass (Da):29,484
Checksum:iA3EE27693F29E892
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 142142Missing in isoform 2. 1 PublicationVSP_022742Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ608762 mRNA. Translation: CAE75539.1.
AK131500 mRNA. Translation: BAD18644.1.
BC109231 mRNA. Translation: AAI09232.1.
CCDSiCCDS11335.1. [Q6ZMT1-1]
RefSeqiNP_945344.1. NM_198993.3. [Q6ZMT1-1]
UniGeneiHs.145068.

Genome annotation databases

EnsembliENST00000333461; ENSP00000327509; ENSG00000141750. [Q6ZMT1-1]
GeneIDi342667.
KEGGihsa:342667.
UCSCiuc002hrs.4. human. [Q6ZMT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ608762 mRNA. Translation: CAE75539.1.
AK131500 mRNA. Translation: BAD18644.1.
BC109231 mRNA. Translation: AAI09232.1.
CCDSiCCDS11335.1. [Q6ZMT1-1]
RefSeqiNP_945344.1. NM_198993.3. [Q6ZMT1-1]
UniGeneiHs.145068.

3D structure databases

ProteinModelPortaliQ6ZMT1.
SMRiQ6ZMT1. Positions 99-166, 296-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131192. 4 interactions.
IntActiQ6ZMT1. 2 interactions.
MINTiMINT-2879405.
STRINGi9606.ENSP00000327509.

PTM databases

iPTMnetiQ6ZMT1.
PhosphoSiteiQ6ZMT1.

Polymorphism and mutation databases

BioMutaiSTAC2.
DMDMi74749556.

Proteomic databases

PaxDbiQ6ZMT1.
PRIDEiQ6ZMT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333461; ENSP00000327509; ENSG00000141750. [Q6ZMT1-1]
GeneIDi342667.
KEGGihsa:342667.
UCSCiuc002hrs.4. human. [Q6ZMT1-1]

Organism-specific databases

CTDi342667.
GeneCardsiSTAC2.
HGNCiHGNC:23990. STAC2.
HPAiHPA017288.
neXtProtiNX_Q6ZMT1.
PharmGKBiPA134939947.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiQ6ZMT1.
OMAiAPSPCPI.
OrthoDBiEOG7XM2ZF.
PhylomeDBiQ6ZMT1.
TreeFamiTF332878.

Miscellaneous databases

ChiTaRSiSTAC2. human.
GenomeRNAii342667.
NextBioi98338.
PROiQ6ZMT1.

Gene expression databases

BgeeiQ6ZMT1.
CleanExiHS_STAC2.
ExpressionAtlasiQ6ZMT1. baseline and differential.
GenevisibleiQ6ZMT1. HS.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of 24b2/STAC2, a novel STAC-homologous gene up-regulated in cerebral ischemia in mice."
    Rossner M., Faucheron N., Wuerz R., von Ahsen O., Kammandel B., Schwaninger M., Schneider A.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSTAC2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMT1
Secondary accession number(s): Q32MA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.