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Protein

Protein ZNF783

Gene

ZNF783

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF783
Gene namesi
Name:ZNF783
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:27222. ZNF783.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410441.

Polymorphism and mutation databases

DMDMi74722910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 281280Protein ZNF783PRO_0000270995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6ZMS7.
PaxDbiQ6ZMS7.
PRIDEiQ6ZMS7.

PTM databases

PhosphoSiteiQ6ZMS7.

Expressioni

Gene expression databases

BgeeiQ6ZMS7.
CleanExiHS_ZNF783.
ExpressionAtlasiQ6ZMS7. baseline and differential.
GenevisibleiQ6ZMS7. HS.

Organism-specific databases

HPAiHPA020375.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HRASLS5Q96KN8-33EBI-10254978,EBI-10290304
ZNF212Q9UDV65EBI-10254978,EBI-1640204
ZNF398Q8TD173EBI-10254978,EBI-8643207

Protein-protein interaction databases

BioGridi941329. 2 interactions.
IntActiQ6ZMS7. 3 interactions.
STRINGi9606.ENSP00000410890.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMS7.
SMRiQ6ZMS7. Positions 136-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 21472KRABPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili48 – 12477Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
InParanoidiQ6ZMS7.
KOiK09228.
OMAiQTECRIP.
OrthoDBiEOG73JKWC.
PhylomeDBiQ6ZMS7.

Family and domain databases

InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAAPARDP ETDKHTEDQS PSTPLPQPAA EKNSYLYSTE ITLWTVVAAI
60 70 80 90 100
QALEKKVDSC LTRLLTLEGR TGTAEKKLAD CEKTAVEFGN QLEGKWAVLG
110 120 130 140 150
TLLQEYGLLQ RRLENVENLL RNRNFWILRL PPGSKGEAPK VPVTFDDVAV
160 170 180 190 200
YFSELEWGKL EDWQKELYKH VMRGNYETLV SLDYAISKPD ILTRIERGEE
210 220 230 240 250
PCLDRWGQEK GNEVEVGRPR MMGTGLPPYP EHLTSPLSPA QEELKEGQAP
260 270 280
KQQQDSEARV APAGPEAGLA LRTDLQGEAQ I
Length:281
Mass (Da):31,422
Last modified:July 5, 2004 - v1
Checksum:iC982CF8D00EC569A
GO
Isoform 2 (identifier: Q6ZMS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-281: LALRTDLQGEAQI → GGVAIKTEAQ...LPWPSRKEEG

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:546
Mass (Da):61,014
Checksum:iF5779538A80B8065
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631R → C.1 Publication
VAR_069466

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei269 – 28113LALRT…GEAQI → GGVAIKTEAQSEDEMTPERL FLGVSRGQTECRIPRGPRNR PGGPSRHQAQGMPRVRAGEP RPPGASGETPRVLSRRRQRA FPCPDCGQSFRLKINLTIHQ RTHVEEGRQEAPGRSPTSCG DSQAMLEPGEVVVPGPVIRW LPEEPEGRRSVAGGRALVGR RPAASKMYHCSECLRFFQQR KSLLLHQRLHTGNGQGWPAC PYCGKAFRRPSDLFRHQRIH TGERPYQCPQCGRTFNRNHH LAVHMQTHARGQVGPHFPAA PARHGSLPLPWPSRKEEG in isoform 2. CuratedVSP_055627Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131504 mRNA. Translation: BAD18648.1.
AC004890 Genomic DNA. No translation available.
CCDSiCCDS56519.1. [Q6ZMS7-2]
RefSeqiNP_001182149.1. NM_001195220.1. [Q6ZMS7-2]
UniGeneiHs.490512.

Genome annotation databases

EnsembliENST00000378052; ENSP00000367291; ENSG00000204946. [Q6ZMS7-1]
ENST00000434415; ENSP00000410890; ENSG00000204946. [Q6ZMS7-2]
ENST00000476295; ENSP00000418666; ENSG00000204946. [Q6ZMS7-1]
GeneIDi100289678.
KEGGihsa:100289678.
UCSCiuc011kuo.3. human. [Q6ZMS7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131504 mRNA. Translation: BAD18648.1.
AC004890 Genomic DNA. No translation available.
CCDSiCCDS56519.1. [Q6ZMS7-2]
RefSeqiNP_001182149.1. NM_001195220.1. [Q6ZMS7-2]
UniGeneiHs.490512.

3D structure databases

ProteinModelPortaliQ6ZMS7.
SMRiQ6ZMS7. Positions 136-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi941329. 2 interactions.
IntActiQ6ZMS7. 3 interactions.
STRINGi9606.ENSP00000410890.

PTM databases

PhosphoSiteiQ6ZMS7.

Polymorphism and mutation databases

DMDMi74722910.

Proteomic databases

EPDiQ6ZMS7.
PaxDbiQ6ZMS7.
PRIDEiQ6ZMS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378052; ENSP00000367291; ENSG00000204946. [Q6ZMS7-1]
ENST00000434415; ENSP00000410890; ENSG00000204946. [Q6ZMS7-2]
ENST00000476295; ENSP00000418666; ENSG00000204946. [Q6ZMS7-1]
GeneIDi100289678.
KEGGihsa:100289678.
UCSCiuc011kuo.3. human. [Q6ZMS7-1]

Organism-specific databases

CTDi100289678.
GeneCardsiZNF783.
H-InvDBHIX0007188.
HGNCiHGNC:27222. ZNF783.
HPAiHPA020375.
neXtProtiNX_Q6ZMS7.
PharmGKBiPA162410441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
InParanoidiQ6ZMS7.
KOiK09228.
OMAiQTECRIP.
OrthoDBiEOG73JKWC.
PhylomeDBiQ6ZMS7.

Miscellaneous databases

GenomeRNAii100289678.
NextBioi20779419.
PROiQ6ZMS7.

Gene expression databases

BgeeiQ6ZMS7.
CleanExiHS_ZNF783.
ExpressionAtlasiQ6ZMS7. baseline and differential.
GenevisibleiQ6ZMS7. HS.

Family and domain databases

InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: VARIANT CYS-63.

Entry informationi

Entry nameiZN783_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMS7
Secondary accession number(s): C9J9J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.