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Protein

Protein ZNF783

Gene

ZNF783

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF783
Gene namesi
Name:ZNF783
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000204946.9.
HGNCiHGNC:27222. ZNF783.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100289678.
OpenTargetsiENSG00000204946.
PharmGKBiPA162410441.

Polymorphism and mutation databases

DMDMi74722910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002709952 – 281Protein ZNF783Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6ZMS7.
PaxDbiQ6ZMS7.
PeptideAtlasiQ6ZMS7.
PRIDEiQ6ZMS7.

PTM databases

iPTMnetiQ6ZMS7.
PhosphoSitePlusiQ6ZMS7.

Expressioni

Gene expression databases

BgeeiENSG00000204946.
CleanExiHS_ZNF783.
ExpressionAtlasiQ6ZMS7. baseline and differential.
GenevisibleiQ6ZMS7. HS.

Organism-specific databases

HPAiHPA020375.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi941329. 3 interactors.
IntActiQ6ZMS7. 11 interactors.
STRINGi9606.ENSP00000410890.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMS7.
SMRiQ6ZMS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 214KRABPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 124Sequence analysisAdd BLAST77

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
InParanoidiQ6ZMS7.
KOiK09228.
OMAiRAFNRNH.
OrthoDBiEOG091G0P6J.
PhylomeDBiQ6ZMS7.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
PfamiView protein in Pfam
PF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAAPARDP ETDKHTEDQS PSTPLPQPAA EKNSYLYSTE ITLWTVVAAI
60 70 80 90 100
QALEKKVDSC LTRLLTLEGR TGTAEKKLAD CEKTAVEFGN QLEGKWAVLG
110 120 130 140 150
TLLQEYGLLQ RRLENVENLL RNRNFWILRL PPGSKGEAPK VPVTFDDVAV
160 170 180 190 200
YFSELEWGKL EDWQKELYKH VMRGNYETLV SLDYAISKPD ILTRIERGEE
210 220 230 240 250
PCLDRWGQEK GNEVEVGRPR MMGTGLPPYP EHLTSPLSPA QEELKEGQAP
260 270 280
KQQQDSEARV APAGPEAGLA LRTDLQGEAQ I
Length:281
Mass (Da):31,422
Last modified:July 5, 2004 - v1
Checksum:iC982CF8D00EC569A
GO
Isoform 2 (identifier: Q6ZMS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-281: LALRTDLQGEAQI → GGVAIKTEAQ...LPWPSRKEEG

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:546
Mass (Da):61,014
Checksum:iF5779538A80B8065
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06946663R → C1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055627269 – 281LALRT…GEAQI → GGVAIKTEAQSEDEMTPERL FLGVSRGQTECRIPRGPRNR PGGPSRHQAQGMPRVRAGEP RPPGASGETPRVLSRRRQRA FPCPDCGQSFRLKINLTIHQ RTHVEEGRQEAPGRSPTSCG DSQAMLEPGEVVVPGPVIRW LPEEPEGRRSVAGGRALVGR RPAASKMYHCSECLRFFQQR KSLLLHQRLHTGNGQGWPAC PYCGKAFRRPSDLFRHQRIH TGERPYQCPQCGRTFNRNHH LAVHMQTHARGQVGPHFPAA PARHGSLPLPWPSRKEEG in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131504 mRNA. Translation: BAD18648.1.
AC004890 Genomic DNA. No translation available.
CCDSiCCDS56519.1. [Q6ZMS7-2]
RefSeqiNP_001182149.1. NM_001195220.1. [Q6ZMS7-2]
UniGeneiHs.490512.

Genome annotation databases

EnsembliENST00000378052; ENSP00000367291; ENSG00000204946. [Q6ZMS7-1]
ENST00000434415; ENSP00000410890; ENSG00000204946. [Q6ZMS7-2]
ENST00000476295; ENSP00000418666; ENSG00000204946. [Q6ZMS7-1]
GeneIDi100289678.
KEGGihsa:100289678.
UCSCiuc011kuo.3. human. [Q6ZMS7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN783_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMS7
Secondary accession number(s): C9J9J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations