Q6ZMS4 (ZN852_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative zinc finger protein 852

Gene names

Name:

ZNF852

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Contains 12 C2H2-type zinc fingers.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZMS4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZMS4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Putative zinc finger protein 852		PRO_0000332125
Regions
	Zinc finger	117 – 139	23	C2H2-type 1
	Zinc finger	145 – 167	23	C2H2-type 2
	Zinc finger	173 – 195	23	C2H2-type 3
	Zinc finger	201 – 223	23	C2H2-type 4
	Zinc finger	229 – 251	23	C2H2-type 5
	Zinc finger	257 – 279	23	C2H2-type 6
	Zinc finger	285 – 307	23	C2H2-type 7
	Zinc finger	313 – 335	23	C2H2-type 8
	Zinc finger	341 – 363	23	C2H2-type 9
	Zinc finger	369 – 391	23	C2H2-type 10
	Zinc finger	397 – 419	23	C2H2-type 11
	Zinc finger	425 – 447	23	C2H2-type 12
Natural variations
	Alternative sequence	1 – 16	16	Missing in isoform 2.		VSP_039373

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 15, 2010. Version 3. Checksum: 69EB82FC9E8900D0	FASTA	509	57,994
	10 20 30 40 50 60 MMLENDRSMA SLAGRNMMES SELTPKQEIF KGSESSNSTS GGLFGVVPGG TETGDVCEDT 70 80 90 100 110 120 FKELEGQPSN EEGSRLESDF LEIIDEDKKK STKDRYEEYK EVEEHPPLSS SPVEHEGVLK 130 140 150 160 170 180 GQKSYRCDEC GKAFYWSSHL IGHRRIHTGE KPYECNECGK TFRQTSQLIV HLRTHTGEKP 190 200 210 220 230 240 YECSECGKAY RHSSHLIQHQ RLHNGEKPYK CNECAKAFNQ SSKLFDHQRT HTGEKPYECK 250 260 270 280 290 300 ECGAAFSRSK NLVRHQFLHT GKKPYKCNEC GRAFCSNRNL IDHQRTHTGE KPYKCNECGK 310 320 330 340 350 360 AFSRSKCLIR HQSLHTGEKP YKCSECGKAF NQISQLVEHE RIHTGEKPFK CSECGKAFGL 370 380 390 400 410 420 SKCLIRHQRL HTSEKPYKCN ECGKSFNQNS YLIIHQRIHT GEKPYECNEC GKVFSYNSSL 430 440 450 460 470 480 MVHQRTHTGE KPYKCNSCGK AFSDSSQLTV HQRVHTGEKN LMNVLSVGKP LVSVPLLITT 490 500 SELMLERSPQ VWLGHLLKAW FSETDSKDL
	Isoform 2 [UniParc]. Checksum: 89C5E2FF31D221AC	FASTA	493	56,216
	10 20 30 40 50 60 MMESSELTPK QEIFKGSESS NSTSGGLFGV VPGGTETGDV CEDTFKELEG QPSNEEGSRL 70 80 90 100 110 120 ESDFLEIIDE DKKKSTKDRY EEYKEVEEHP PLSSSPVEHE GVLKGQKSYR CDECGKAFYW 130 140 150 160 170 180 SSHLIGHRRI HTGEKPYECN ECGKTFRQTS QLIVHLRTHT GEKPYECSEC GKAYRHSSHL 190 200 210 220 230 240 IQHQRLHNGE KPYKCNECAK AFNQSSKLFD HQRTHTGEKP YECKECGAAF SRSKNLVRHQ 250 260 270 280 290 300 FLHTGKKPYK CNECGRAFCS NRNLIDHQRT HTGEKPYKCN ECGKAFSRSK CLIRHQSLHT 310 320 330 340 350 360 GEKPYKCSEC GKAFNQISQL VEHERIHTGE KPFKCSECGK AFGLSKCLIR HQRLHTSEKP 370 380 390 400 410 420 YKCNECGKSF NQNSYLIIHQ RIHTGEKPYE CNECGKVFSY NSSLMVHQRT HTGEKPYKCN 430 440 450 460 470 480 SCGKAFSDSS QLTVHQRVHT GEKNLMNVLS VGKPLVSVPL LITTSELMLE RSPQVWLGHL 490 LKAWFSETDS KDL

References

[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-384 (ISOFORM 1). Tissue: Melanoma.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-366 (ISOFORM 2). Tissue: Uterus.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC099669 Genomic DNA. No translation available. BC014381 mRNA. No translation available. AK131507 mRNA. No translation available.
IPI	IPI00888423. IPI01012700.
UniGene	Hs.648974.
3D structure databases
HSSP	HSSP built from PDB template 1X6E based on UniProtKB P17028.
ProteinModelPortal	Q6ZMS4.
SMR	Q6ZMS4. Positions 93-459.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZMS4.
Polymorphism databases
DMDM	298286894.
Proteomic databases
PaxDb	Q6ZMS4.
PRIDE	Q6ZMS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000436261; ENSP00000389841; ENSG00000178917.
UCSC	uc011azx.2. human. uc011azy.2. human.
Organism-specific databases
GeneCards	GC03M044517.
HGNC	HGNC:27713. ZNF852.
HPA	HPA048312. HPA049885.
neXtProt	NX_Q6ZMS4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
OrthoDB	EOG4QVCBM.
Gene expression databases
ArrayExpress	Q6ZMS4.
Bgee	Q6ZMS4.
Genevestigator	Q6ZMS4.
Family and domain databases
Gene3D	3.30.160.60. 12 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 12 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 12 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZN852_HUMAN

Accession

Primary (citable) accession number: Q6ZMS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.