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Q6ZMS4

- ZN852_HUMAN

UniProt

Q6ZMS4 - ZN852_HUMAN

Protein

Zinc finger protein 852

Gene

ZNF852

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 4 (01 Oct 2014)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri187 – 20923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri215 – 23723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri243 – 26523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri327 – 34923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri355 – 37723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri383 – 40523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 852
    Gene namesi
    Name:ZNF852
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:27713. ZNF852.

    Subcellular locationi

    Nucleus By similarity

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Zinc finger protein 852PRO_0000332125Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZMS4.
    PRIDEiQ6ZMS4.

    PTM databases

    PhosphoSiteiQ6ZMS4.

    Expressioni

    Gene expression databases

    BgeeiQ6ZMS4.
    GenevestigatoriQ6ZMS4.

    Organism-specific databases

    HPAiHPA048312.
    HPA049885.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZMS4.
    SMRiQ6ZMS4. Positions 96-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 8275KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri187 – 20923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri215 – 23723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri243 – 26523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri327 – 34923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri355 – 37723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri383 – 40523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ6ZMS4.
    TreeFamiTF350837.

    Family and domain databases

    Gene3Di3.30.160.60. 12 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZMS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRPQDTVAY EDLSEDYTQK KWKGLALSQR ALHWNMMLEN DRSMASLGRN    50
    MMESSELTPK QEIFKGSESS NSTSGGLFGV VPGGTETGDV CEDTFKELEG 100
    QPSNEEGSRL ESDFLEIIDE DKKKSTKDRY EEYKEVEEHP PLSSSPVEHE 150
    GVLKGQKSYR CDECGKAFYW SSHLIGHRRI HTGEKPYECN ECGKTFRQTS 200
    QLIVHLRTHT GEKPYECSEC GKAYRHSSHL IQHQRLHNGE KPYKCNECAK 250
    AFNQSSKLFD HQRTHTGEKP YECKECGAAF SRSKNLVRHQ FLHTGKKPYK 300
    CNECGRAFCS NRNLIDHQRT HTGEKPYKCN ECGKAFSRSK CLIRHQSLHT 350
    GEKPYKCSEC GKAFNQISQL VEHERIHTGE KPFKCSECGK AFGLSKCLIR 400
    HQRLHTSEKP YKCNECGKSF NQNSYLIIHQ RIHTGEKPYE CNECGKVFSY 450
    NSSLMVHQRT HTGEKPYKCN SCGKAFSDSS QLTVHQRVHT GEKNLMNVLS 500
    VGKPLVSVPL LITTSELMLE RSPQVWLGHL LKAWFSETDS KDL 543
    Length:543
    Mass (Da):62,084
    Last modified:October 1, 2014 - v4
    Checksum:i4DE82359226B9414
    GO

    Sequence cautioni

    The sequence BAG59499.1 differs from that shown. Reason: Frameshift at positions 494 and 534.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1581S → P in BAG59499. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK296954 mRNA. Translation: BAG59499.1. Frameshift.
    AC099669 Genomic DNA. No translation available.
    RefSeqiNP_001274278.1. NM_001287349.1.
    UniGeneiHs.648974.

    Genome annotation databases

    EnsembliENST00000436261; ENSP00000389841; ENSG00000178917.
    GeneIDi285346.
    KEGGihsa:285346.

    Polymorphism databases

    DMDMi298286894.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK296954 mRNA. Translation: BAG59499.1 . Frameshift.
    AC099669 Genomic DNA. No translation available.
    RefSeqi NP_001274278.1. NM_001287349.1.
    UniGenei Hs.648974.

    3D structure databases

    ProteinModelPortali Q6ZMS4.
    SMRi Q6ZMS4. Positions 96-489.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6ZMS4.

    Polymorphism databases

    DMDMi 298286894.

    Proteomic databases

    PaxDbi Q6ZMS4.
    PRIDEi Q6ZMS4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000436261 ; ENSP00000389841 ; ENSG00000178917 .
    GeneIDi 285346.
    KEGGi hsa:285346.

    Organism-specific databases

    GeneCardsi GC03M044517.
    HGNCi HGNC:27713. ZNF852.
    HPAi HPA048312.
    HPA049885.
    neXtProti NX_Q6ZMS4.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q6ZMS4.
    TreeFami TF350837.

    Miscellaneous databases

    NextBioi 35473026.

    Gene expression databases

    Bgeei Q6ZMS4.
    Genevestigatori Q6ZMS4.

    Family and domain databases

    Gene3Di 3.30.160.60. 12 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiZN852_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZMS4
    Secondary accession number(s): B4DLD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 1, 2014
    Last modified: October 1, 2014
    This is version 82 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3