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Protein

Zinc finger protein 852

Gene

ZNF852

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 852
Gene namesi
Name:ZNF852
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:27713. ZNF852.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Zinc finger protein 852PRO_0000332125Add
BLAST

Proteomic databases

MaxQBiQ6ZMS4.
PaxDbiQ6ZMS4.
PRIDEiQ6ZMS4.

PTM databases

PhosphoSiteiQ6ZMS4.

Expressioni

Gene expression databases

BgeeiQ6ZMS4.
GenevestigatoriQ6ZMS4.

Organism-specific databases

HPAiHPA048312.
HPA049885.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8275KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMS4.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZMS4.
TreeFamiTF350837.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMS4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRPQDTVAY EDLSEDYTQK KWKGLALSQR ALHWNMMLEN DRSMASLGRN
60 70 80 90 100
MMESSELTPK QEIFKGSESS NSTSGGLFGV VPGGTETGDV CEDTFKELEG
110 120 130 140 150
QPSNEEGSRL ESDFLEIIDE DKKKSTKDRY EEYKEVEEHP PLSSSPVEHE
160 170 180 190 200
GVLKGQKSYR CDECGKAFYW SSHLIGHRRI HTGEKPYECN ECGKTFRQTS
210 220 230 240 250
QLIVHLRTHT GEKPYECSEC GKAYRHSSHL IQHQRLHNGE KPYKCNECAK
260 270 280 290 300
AFNQSSKLFD HQRTHTGEKP YECKECGAAF SRSKNLVRHQ FLHTGKKPYK
310 320 330 340 350
CNECGRAFCS NRNLIDHQRT HTGEKPYKCN ECGKAFSRSK CLIRHQSLHT
360 370 380 390 400
GEKPYKCSEC GKAFNQISQL VEHERIHTGE KPFKCSECGK AFGLSKCLIR
410 420 430 440 450
HQRLHTSEKP YKCNECGKSF NQNSYLIIHQ RIHTGEKPYE CNECGKVFSY
460 470 480 490 500
NSSLMVHQRT HTGEKPYKCN SCGKAFSDSS QLTVHQRVHT GEKNLMNVLS
510 520 530 540
VGKPLVSVPL LITTSELMLE RSPQVWLGHL LKAWFSETDS KDL
Length:543
Mass (Da):62,084
Last modified:October 1, 2014 - v4
Checksum:i4DE82359226B9414
GO

Sequence cautioni

The sequence BAG59499.1 differs from that shown. Reason: Frameshift at positions 494 and 534. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581S → P in BAG59499. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296954 mRNA. Translation: BAG59499.1. Frameshift.
AC099669 Genomic DNA. No translation available.
RefSeqiNP_001274278.1. NM_001287349.1.
UniGeneiHs.648974.

Genome annotation databases

EnsembliENST00000436261; ENSP00000389841; ENSG00000178917.
GeneIDi285346.
KEGGihsa:285346.
UCSCiuc011azy.2. human.

Polymorphism databases

DMDMi298286894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296954 mRNA. Translation: BAG59499.1. Frameshift.
AC099669 Genomic DNA. No translation available.
RefSeqiNP_001274278.1. NM_001287349.1.
UniGeneiHs.648974.

3D structure databases

ProteinModelPortaliQ6ZMS4.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6ZMS4.

Polymorphism databases

DMDMi298286894.

Proteomic databases

MaxQBiQ6ZMS4.
PaxDbiQ6ZMS4.
PRIDEiQ6ZMS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436261; ENSP00000389841; ENSG00000178917.
GeneIDi285346.
KEGGihsa:285346.
UCSCiuc011azy.2. human.

Organism-specific databases

CTDi285346.
GeneCardsiGC03M044517.
HGNCiHGNC:27713. ZNF852.
HPAiHPA048312.
HPA049885.
neXtProtiNX_Q6ZMS4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZMS4.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZMS4.
TreeFamiTF350837.

Miscellaneous databases

NextBioi35473026.

Gene expression databases

BgeeiQ6ZMS4.
GenevestigatoriQ6ZMS4.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZN852_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMS4
Secondary accession number(s): B4DLD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2014
Last modified: January 7, 2015
This is version 85 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.