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Q6ZMS4 (ZN852_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative zinc finger protein 852
Gene names
Name:ZNF852
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Sequence similarities

Contains 12 C2H2-type zinc fingers.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZMS4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZMS4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Putative zinc finger protein 852
PRO_0000332125

Regions

Zinc finger117 – 13923C2H2-type 1
Zinc finger145 – 16723C2H2-type 2
Zinc finger173 – 19523C2H2-type 3
Zinc finger201 – 22323C2H2-type 4
Zinc finger229 – 25123C2H2-type 5
Zinc finger257 – 27923C2H2-type 6
Zinc finger285 – 30723C2H2-type 7
Zinc finger313 – 33523C2H2-type 8
Zinc finger341 – 36323C2H2-type 9
Zinc finger369 – 39123C2H2-type 10
Zinc finger397 – 41923C2H2-type 11
Zinc finger425 – 44723C2H2-type 12

Natural variations

Alternative sequence1 – 1616Missing in isoform 2.
VSP_039373

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 15, 2010. Version 3.
Checksum: 69EB82FC9E8900D0

FASTA50957,994
        10         20         30         40         50         60 
MMLENDRSMA SLAGRNMMES SELTPKQEIF KGSESSNSTS GGLFGVVPGG TETGDVCEDT 

        70         80         90        100        110        120 
FKELEGQPSN EEGSRLESDF LEIIDEDKKK STKDRYEEYK EVEEHPPLSS SPVEHEGVLK 

       130        140        150        160        170        180 
GQKSYRCDEC GKAFYWSSHL IGHRRIHTGE KPYECNECGK TFRQTSQLIV HLRTHTGEKP 

       190        200        210        220        230        240 
YECSECGKAY RHSSHLIQHQ RLHNGEKPYK CNECAKAFNQ SSKLFDHQRT HTGEKPYECK 

       250        260        270        280        290        300 
ECGAAFSRSK NLVRHQFLHT GKKPYKCNEC GRAFCSNRNL IDHQRTHTGE KPYKCNECGK 

       310        320        330        340        350        360 
AFSRSKCLIR HQSLHTGEKP YKCSECGKAF NQISQLVEHE RIHTGEKPFK CSECGKAFGL 

       370        380        390        400        410        420 
SKCLIRHQRL HTSEKPYKCN ECGKSFNQNS YLIIHQRIHT GEKPYECNEC GKVFSYNSSL 

       430        440        450        460        470        480 
MVHQRTHTGE KPYKCNSCGK AFSDSSQLTV HQRVHTGEKN LMNVLSVGKP LVSVPLLITT 

       490        500 
SELMLERSPQ VWLGHLLKAW FSETDSKDL 

« Hide

Isoform 2 [UniParc].

Checksum: 89C5E2FF31D221AC
Show »

FASTA49356,216

References

[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-384 (ISOFORM 1).
Tissue: Melanoma.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-366 (ISOFORM 2).
Tissue: Uterus.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC099669 Genomic DNA. No translation available.
BC014381 mRNA. No translation available.
AK131507 mRNA. No translation available.
UniGeneHs.648974.

3D structure databases

ProteinModelPortalQ6ZMS4.
SMRQ6ZMS4. Positions 66-482.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6ZMS4.

Polymorphism databases

DMDM298286894.

Proteomic databases

PaxDbQ6ZMS4.
PRIDEQ6ZMS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000436261; ENSP00000389841; ENSG00000178917.
UCSCuc011azx.2. human. [Q6ZMS4-2]
uc011azy.2. human. [Q6ZMS4-1]

Organism-specific databases

GeneCardsGC03M044517.
HGNCHGNC:27713. ZNF852.
HPAHPA048312.
HPA049885.
neXtProtNX_Q6ZMS4.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
OrthoDBEOG7KSX7Q.
PhylomeDBQ6ZMS4.
TreeFamTF350837.

Gene expression databases

BgeeQ6ZMS4.
GenevestigatorQ6ZMS4.

Family and domain databases

Gene3D3.30.160.60. 12 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZN852_HUMAN
AccessionPrimary (citable) accession number: Q6ZMS4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM