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Q6ZMR5 (TM11A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protease serine 11A

EC=3.4.21.-
Alternative name(s):
Airway trypsin-like protease 1
Epidermal type-II transmembrane serine protease
Esophageal cancer-susceptibility gene 1 protein
Gene names
Name:TMPRSS11A
Synonyms:ECRG1, HATL1, HESP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

Subunit structure

May interact with ZBTB17.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Tissue specificity

Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers. Ref.1

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Contains 1 SEA domain.

Sequence caution

The sequence AAD41463.1 differs from that shown. Reason: Frameshift at position 371.

The sequence CAD67985.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

integral component of plasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZMR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZMR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-87: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Transmembrane protease serine 11A
PRO_5000095974

Regions

Topological domain1 – 1818Cytoplasmic Potential
Transmembrane19 – 3921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain40 – 421382Extracellular Potential
Domain47 – 167121SEA
Domain190 – 420231Peptidase S1

Sites

Active site2301Charge relay system By similarity
Active site2751Charge relay system By similarity
Active site3711Charge relay system By similarity

Amino acid modifications

Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Disulfide bond215 ↔ 231 By similarity
Disulfide bond340 ↔ 356 By similarity
Disulfide bond367 ↔ 396 By similarity

Natural variations

Alternative sequence85 – 873Missing in isoform 2.
VSP_027610
Natural variant2931R → Q Common polymorphism; may be a susceptibility factor for developing esophageal cancer especially in smoking population. Ref.2 Ref.8
Corresponds to variant rs353163 [ dbSNP | Ensembl ].
VAR_034797

Experimental info

Sequence conflict501Y → F in AAD41463. Ref.1
Sequence conflict521H → P in AAD41463. Ref.1
Sequence conflict1731T → I in AAD41463. Ref.1
Sequence conflict2671Y → C in AAD41463. Ref.1
Sequence conflict2711A → P in AAD41463. Ref.1
Sequence conflict2731E → K in AAD41463. Ref.1
Sequence conflict2881S → P in AAD41463. Ref.1
Sequence conflict3301A → V in AAD41463. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C695A10DF76EF87C

FASTA42147,569
        10         20         30         40         50         60 
MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY YHGSFKILDP 

        70         80         90        100        110        120 
QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN YIKNQVVRLT PEEDGVKVDV 

       130        140        150        160        170        180 
IMVFQFPSTE QRAVREKKIQ SILNQKIRNL RALPINASSV QVNAMSSSTG ELTVQASCGK 

       190        200        210        220        230        240 
RVVPLNVNRI ASGVIAPKAA WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ 

       250        260        270        280        290        300 
WTVSFGTKIN PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS 

       310        320        330        340        350        360 
ASFQPNLTVH ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI KPGMFCAGYM 

       370        380        390        400        410        420 
EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD KPGVYTQVTY YRNWIASKTG 


I 

« Hide

Isoform 2 [UniParc].

Checksum: 96674ECABCA9B301
Show »

FASTA41847,254

References

« Hide 'large scale' references
[1]"Cloning and identification of cDNA fragments related to human esophageal cancer."
Su T., Liu H., Lu S.-H.
Zhonghua Zhong Liu Za Zhi 20:254-257(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Esophagus.
[2]"Identification and characterization of a novel human type II transmembrane serine protease."
Mariotti F., Mastrogiacomo A.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-293.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Tongue.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]"Human and mouse proteases: a comparative genomic approach."
Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.
Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1."
Zhao N., Wang J., Cui Y., Guo L., Lu S.-H.
J. Cell. Biochem. 92:65-76(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ZBTB17.
[8]"Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1) and its related risk to esophageal squamous cell carcinoma."
Li Y., Zhang X., Huang G., Miao X., Guo L., Lin D., Lu S.-H.
Carcinogenesis 27:798-802(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLN-293.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071882 mRNA. Translation: AAD41463.1. Frameshift.
AY498712 mRNA. Translation: AAS78642.1.
AK131518 mRNA. Translation: BAD18660.1.
AC096653 Genomic DNA. No translation available.
AC096727 Genomic DNA. No translation available.
BC111796 mRNA. Translation: AAI11797.1.
BN000133 mRNA. Translation: CAD67985.1. Sequence problems.
RefSeqNP_001107859.1. NM_001114387.1.
NP_872412.3. NM_182606.3.
UniGeneHs.450110.

3D structure databases

ProteinModelPortalQ6ZMR5.
SMRQ6ZMR5. Positions 46-156, 190-421.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130971. 1 interaction.
IntActQ6ZMR5. 1 interaction.
STRING9606.ENSP00000334611.

Protein family/group databases

MEROPSS01.292.

PTM databases

PhosphoSiteQ6ZMR5.

Polymorphism databases

DMDM74758674.

Proteomic databases

PaxDbQ6ZMR5.
PRIDEQ6ZMR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000508048; ENSP00000426911; ENSG00000187054.
GeneID339967.
KEGGhsa:339967.

Organism-specific databases

CTD339967.
GeneCardsGC04M068776.
HGNCHGNC:27954. TMPRSS11A.
MIM611704. gene.
neXtProtNX_Q6ZMR5.
PharmGKBPA142670726.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251823.
HOVERGENHBG013304.
InParanoidQ6ZMR5.
KOK09750.
OrthoDBEOG75B84T.
TreeFamTF351684.

Gene expression databases

ArrayExpressQ6ZMR5.
BgeeQ6ZMR5.
CleanExHS_TMPRSS11A.
GenevestigatorQ6ZMR5.

Family and domain databases

Gene3D3.30.70.960. 1 hit.
InterProIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339967.
NextBio35534976.
PROQ6ZMR5.
SOURCESearch...

Entry information

Entry nameTM11A_HUMAN
AccessionPrimary (citable) accession number: Q6ZMR5
Secondary accession number(s): J3KNQ8 expand/collapse secondary AC list , Q2NKI9, Q6JE90, Q7RTY4, Q86TK8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM