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Protein

Transmembrane protease serine 11A

Gene

TMPRSS11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei230 – 2301Charge relay systemBy similarity
Active sitei275 – 2751Charge relay systemBy similarity
Active sitei371 – 3711Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Cell cycle

Protein family/group databases

MEROPSiS01.292.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11A (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 1
Epidermal type-II transmembrane serine protease
Esophageal cancer-susceptibility gene 1 protein
Gene namesi
Name:TMPRSS11A
Synonyms:ECRG1, HATL1, HESP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:27954. TMPRSS11A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei19 – 3921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini40 – 421382ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Transmembrane protease serine 11APRO_5000095974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi215 ↔ 231PROSITE-ProRule annotation
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi340 ↔ 356PROSITE-ProRule annotation
Disulfide bondi367 ↔ 396PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZMR5.
PRIDEiQ6ZMR5.

PTM databases

PhosphoSiteiQ6ZMR5.

Expressioni

Tissue specificityi

Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.1 Publication

Gene expression databases

BgeeiQ6ZMR5.
CleanExiHS_TMPRSS11A.
ExpressionAtlasiQ6ZMR5. baseline.
GenevestigatoriQ6ZMR5.

Interactioni

Subunit structurei

May interact with ZBTB17.

Protein-protein interaction databases

BioGridi130971. 7 interactions.
IntActiQ6ZMR5. 1 interaction.
STRINGi9606.ENSP00000334611.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMR5.
SMRiQ6ZMR5. Positions 46-156, 190-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 167121SEAPROSITE-ProRule annotationAdd
BLAST
Domaini190 – 420231Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ6ZMR5.
KOiK09750.
OrthoDBiEOG75B84T.
PhylomeDBiQ6ZMR5.
TreeFamiTF351684.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY
60 70 80 90 100
YHGSFKILDP QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN
110 120 130 140 150
YIKNQVVRLT PEEDGVKVDV IMVFQFPSTE QRAVREKKIQ SILNQKIRNL
160 170 180 190 200
RALPINASSV QVNAMSSSTG ELTVQASCGK RVVPLNVNRI ASGVIAPKAA
210 220 230 240 250
WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ WTVSFGTKIN
260 270 280 290 300
PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS
310 320 330 340 350
ASFQPNLTVH ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI
360 370 380 390 400
KPGMFCAGYM EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD
410 420
KPGVYTQVTY YRNWIASKTG I
Length:421
Mass (Da):47,569
Last modified:July 5, 2004 - v1
Checksum:iC695A10DF76EF87C
GO
Isoform 2 (identifier: Q6ZMR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-87: Missing.

Show »
Length:418
Mass (Da):47,254
Checksum:i96674ECABCA9B301
GO

Sequence cautioni

The sequence AAD41463.1 differs from that shown. Reason: Frameshift at position 371. Curated
The sequence CAD67985.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501Y → F in AAD41463 (PubMed:10920976).Curated
Sequence conflicti52 – 521H → P in AAD41463 (PubMed:10920976).Curated
Sequence conflicti173 – 1731T → I in AAD41463 (PubMed:10920976).Curated
Sequence conflicti267 – 2671Y → C in AAD41463 (PubMed:10920976).Curated
Sequence conflicti271 – 2711A → P in AAD41463 (PubMed:10920976).Curated
Sequence conflicti273 – 2731E → K in AAD41463 (PubMed:10920976).Curated
Sequence conflicti288 – 2881S → P in AAD41463 (PubMed:10920976).Curated
Sequence conflicti330 – 3301A → V in AAD41463 (PubMed:10920976).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931R → Q Common polymorphism; may be a susceptibility factor for developing esophageal cancer especially in smoking population. 2 Publications
Corresponds to variant rs353163 [ dbSNP | Ensembl ].
VAR_034797

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei85 – 873Missing in isoform 2. 3 PublicationsVSP_027610

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071882 mRNA. Translation: AAD41463.1. Frameshift.
AY498712 mRNA. Translation: AAS78642.1.
AK131518 mRNA. Translation: BAD18660.1.
AC096653 Genomic DNA. No translation available.
AC096727 Genomic DNA. No translation available.
BC111796 mRNA. Translation: AAI11797.1.
BN000133 mRNA. Translation: CAD67985.1. Sequence problems.
CCDSiCCDS3519.1. [Q6ZMR5-1]
RefSeqiNP_001107859.1. NM_001114387.1.
NP_872412.3. NM_182606.3.
XP_006714269.1. XM_006714206.1.
UniGeneiHs.450110.

Genome annotation databases

EnsembliENST00000508048; ENSP00000426911; ENSG00000187054.
GeneIDi339967.
KEGGihsa:339967.
UCSCiuc003hdr.1. human.

Polymorphism databases

DMDMi74758674.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071882 mRNA. Translation: AAD41463.1. Frameshift.
AY498712 mRNA. Translation: AAS78642.1.
AK131518 mRNA. Translation: BAD18660.1.
AC096653 Genomic DNA. No translation available.
AC096727 Genomic DNA. No translation available.
BC111796 mRNA. Translation: AAI11797.1.
BN000133 mRNA. Translation: CAD67985.1. Sequence problems.
CCDSiCCDS3519.1. [Q6ZMR5-1]
RefSeqiNP_001107859.1. NM_001114387.1.
NP_872412.3. NM_182606.3.
XP_006714269.1. XM_006714206.1.
UniGeneiHs.450110.

3D structure databases

ProteinModelPortaliQ6ZMR5.
SMRiQ6ZMR5. Positions 46-156, 190-421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130971. 7 interactions.
IntActiQ6ZMR5. 1 interaction.
STRINGi9606.ENSP00000334611.

Protein family/group databases

MEROPSiS01.292.

PTM databases

PhosphoSiteiQ6ZMR5.

Polymorphism databases

DMDMi74758674.

Proteomic databases

PaxDbiQ6ZMR5.
PRIDEiQ6ZMR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000508048; ENSP00000426911; ENSG00000187054.
GeneIDi339967.
KEGGihsa:339967.
UCSCiuc003hdr.1. human.

Organism-specific databases

CTDi339967.
GeneCardsiGC04M068776.
HGNCiHGNC:27954. TMPRSS11A.
MIMi611704. gene.
neXtProtiNX_Q6ZMR5.
PharmGKBiPA142670726.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ6ZMR5.
KOiK09750.
OrthoDBiEOG75B84T.
PhylomeDBiQ6ZMR5.
TreeFamiTF351684.

Miscellaneous databases

GenomeRNAii339967.
NextBioi35534976.
PROiQ6ZMR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZMR5.
CleanExiHS_TMPRSS11A.
ExpressionAtlasiQ6ZMR5. baseline.
GenevestigatoriQ6ZMR5.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of cDNA fragments related to human esophageal cancer."
    Su T., Liu H., Lu S.-H.
    Zhonghua Zhong Liu Za Zhi 20:254-257(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Esophagus.
  2. "Identification and characterization of a novel human type II transmembrane serine protease."
    Mariotti F., Mastrogiacomo A.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-293.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Human and mouse proteases: a comparative genomic approach."
    Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.
    Nat. Rev. Genet. 4:544-558(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1."
    Zhao N., Wang J., Cui Y., Guo L., Lu S.-H.
    J. Cell. Biochem. 92:65-76(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZBTB17.
  8. "Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1) and its related risk to esophageal squamous cell carcinoma."
    Li Y., Zhang X., Huang G., Miao X., Guo L., Lin D., Lu S.-H.
    Carcinogenesis 27:798-802(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-293.

Entry informationi

Entry nameiTM11A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMR5
Secondary accession number(s): J3KNQ8
, Q2NKI9, Q6JE90, Q7RTY4, Q86TK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.