Q6ZMR5 (TM11A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protease serine 11A
EC=3.4.21.-

Alternative name(s):
Airway trypsin-like protease 1
Epidermal type-II transmembrane serine protease
Esophageal cancer-susceptibility gene 1 protein

Gene names

Name:	TMPRSS11A
Synonyms:	ECRG1, HATL1, HESP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Subunit structure	May interact with ZBTB17.
Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Tissue specificity	Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers. Ref.1
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 1 SEA domain.
Sequence caution	The sequence AAD41463.1 differs from that shown. Reason: Frameshift at position 371. The sequence CAD67985.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZMR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZMR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-87: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Transmembrane protease serine 11A		PRO_5000095974
Regions
	Topological domain	1 – 18	18	Cytoplasmic Potential
	Transmembrane	19 – 39	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	40 – 421	382	Extracellular Potential
	Domain	45 – 167	123	SEA
	Domain	190 – 420	231	Peptidase S1
Sites
	Active site	230	1	Charge relay system By similarity
	Active site	275	1	Charge relay system By similarity
	Active site	371	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	156	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
	Disulfide bond	215 ↔ 231		By similarity
	Disulfide bond	340 ↔ 356		By similarity
	Disulfide bond	367 ↔ 396		By similarity
Natural variations
	Alternative sequence	85 – 87	3	Missing in isoform 2.		VSP_027610
	Natural variant	293	1	R → Q Common polymorphism; may be a susceptibility factor for developing esophageal cancer especially in smoking population. Ref.2 Ref.8 Corresponds to variant rs353163 [ dbSNP | Ensembl ].		VAR_034797
Experimental info
	Sequence conflict	50	1	Y → F in AAD41463. Ref.1
	Sequence conflict	52	1	H → P in AAD41463. Ref.1
	Sequence conflict	173	1	T → I in AAD41463. Ref.1
	Sequence conflict	267	1	Y → C in AAD41463. Ref.1
	Sequence conflict	271	1	A → P in AAD41463. Ref.1
	Sequence conflict	273	1	E → K in AAD41463. Ref.1
	Sequence conflict	288	1	S → P in AAD41463. Ref.1
	Sequence conflict	330	1	A → V in AAD41463. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C695A10DF76EF87C	FASTA	421	47,569
	10 20 30 40 50 60 MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY YHGSFKILDP 70 80 90 100 110 120 QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN YIKNQVVRLT PEEDGVKVDV 130 140 150 160 170 180 IMVFQFPSTE QRAVREKKIQ SILNQKIRNL RALPINASSV QVNAMSSSTG ELTVQASCGK 190 200 210 220 230 240 RVVPLNVNRI ASGVIAPKAA WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ 250 260 270 280 290 300 WTVSFGTKIN PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS 310 320 330 340 350 360 ASFQPNLTVH ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI KPGMFCAGYM 370 380 390 400 410 420 EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD KPGVYTQVTY YRNWIASKTG I
	Isoform 2 [UniParc]. Checksum: 96674ECABCA9B301	FASTA	418	47,254
	10 20 30 40 50 60 MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY YHGSFKILDP 70 80 90 100 110 120 QINNNFGQSN TYQLKDLRET TENLVDEIFI DSAWKKNYIK NQVVRLTPEE DGVKVDVIMV 130 140 150 160 170 180 FQFPSTEQRA VREKKIQSIL NQKIRNLRAL PINASSVQVN AMSSSTGELT VQASCGKRVV 190 200 210 220 230 240 PLNVNRIASG VIAPKAAWPW QASLQYDNIH QCGATLISNT WLVTAAHCFQ KYKNPHQWTV 250 260 270 280 290 300 SFGTKINPPL MKRNVRRFII HEKYRSAARE YDIAVVQVSS RVTFSDDIRR ICLPEASASF 310 320 330 340 350 360 QPNLTVHITG FGALYYGGES QNDLREARVK IISDDVCKQP QVYGNDIKPG MFCAGYMEGI 370 380 390 400 410 YDACRGDSGG PLVTRDLKDT WYLIGIVSWG DNCGQKDKPG VYTQVTYYRN WIASKTGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and identification of cDNA fragments related to human esophageal cancer." Su T., Liu H., Lu S.-H. Zhonghua Zhong Liu Za Zhi 20:254-257(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Esophagus.
[2]	"Identification and characterization of a novel human type II transmembrane serine protease." Mariotti F., Mastrogiacomo A. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-293.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Tongue.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]	"Human and mouse proteases: a comparative genomic approach." Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C. Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1." Zhao N., Wang J., Cui Y., Guo L., Lu S.-H. J. Cell. Biochem. 92:65-76(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ZBTB17.
[8]	"Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1) and its related risk to esophageal squamous cell carcinoma." Li Y., Zhang X., Huang G., Miao X., Guo L., Lin D., Lu S.-H. Carcinogenesis 27:798-802(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLN-293.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071882 mRNA. Translation: AAD41463.1. Frameshift. AY498712 mRNA. Translation: AAS78642.1. AK131518 mRNA. Translation: BAD18660.1. AC096653 Genomic DNA. No translation available. AC096727 Genomic DNA. No translation available. BC111796 mRNA. Translation: AAI11797.1. BN000133 mRNA. Translation: CAD67985.1. Sequence problems.
IPI	IPI00418563. IPI00855891.
RefSeq	NP_001107859.1. NM_001114387.1. NP_872412.3. NM_182606.3.
UniGene	Hs.450110.
3D structure databases
HSSP	HSSP built from PDB template 1EZX based on UniProtKB P00760.
ProteinModelPortal	Q6ZMR5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZMR5. 1 interaction.
STRING	9606.ENSP00000334611.
Protein family/group databases
MEROPS	S01.292.
PTM databases
PhosphoSite	Q6ZMR5.
Polymorphism databases
DMDM	74758674.
Proteomic databases
PaxDb	Q6ZMR5.
PRIDE	Q6ZMR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000508048; ENSP00000426911; ENSG00000187054.
GeneID	339967.
KEGG	hsa:339967.
UCSC	uc003hdr.1. human.
Organism-specific databases
CTD	339967.
GeneCards	GC04M068776.
HGNC	HGNC:27954. TMPRSS11A.
MIM	611704. gene.
neXtProt	NX_Q6ZMR5.
PharmGKB	PA142670726.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000251823.
HOVERGEN	HBG013304.
InParanoid	Q6ZMR5.
KO	K09750.
Gene expression databases
ArrayExpress	Q6ZMR5.
Bgee	Q6ZMR5.
CleanEx	HS_TMPRSS11A.
Genevestigator	Q6ZMR5.
Family and domain databases
InterPro	IPR017329. Pept_S1A_HAT/DESC1. IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR000082. SEA. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF01390. SEA. 1 hit. PF00089. Trypsin. 1 hit. [Graphical view]
PIRSF	PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50024. SEA. False negative. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	339967.
NextBio	97640.
SOURCE	Search...

Entry information

Entry name

TM11A_HUMAN

Accession

Primary (citable) accession number: Q6ZMR5
Secondary accession number(s): Q2NKI9 , Q6JE90, Q7RTY4, Q86TK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.