Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6ZMR5

- TM11A_HUMAN

UniProt

Q6ZMR5 - TM11A_HUMAN

Protein

Transmembrane protease serine 11A

Gene

TMPRSS11A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei230 – 2301Charge relay systemBy similarity
    Active sitei275 – 2751Charge relay systemBy similarity
    Active sitei371 – 3711Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Cell cycle

    Protein family/group databases

    MEROPSiS01.292.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protease serine 11A (EC:3.4.21.-)
    Alternative name(s):
    Airway trypsin-like protease 1
    Epidermal type-II transmembrane serine protease
    Esophageal cancer-susceptibility gene 1 protein
    Gene namesi
    Name:TMPRSS11A
    Synonyms:ECRG1, HATL1, HESP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:27954. TMPRSS11A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670726.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Transmembrane protease serine 11APRO_5000095974Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi215 ↔ 231PROSITE-ProRule annotation
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi340 ↔ 356PROSITE-ProRule annotation
    Disulfide bondi367 ↔ 396PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6ZMR5.
    PRIDEiQ6ZMR5.

    PTM databases

    PhosphoSiteiQ6ZMR5.

    Expressioni

    Tissue specificityi

    Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.1 Publication

    Gene expression databases

    BgeeiQ6ZMR5.
    CleanExiHS_TMPRSS11A.
    GenevestigatoriQ6ZMR5.

    Interactioni

    Subunit structurei

    May interact with ZBTB17.

    Protein-protein interaction databases

    BioGridi130971. 1 interaction.
    IntActiQ6ZMR5. 1 interaction.
    STRINGi9606.ENSP00000334611.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZMR5.
    SMRiQ6ZMR5. Positions 46-156, 190-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini40 – 421382ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 167121SEAPROSITE-ProRule annotationAdd
    BLAST
    Domaini190 – 420231Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251823.
    HOVERGENiHBG013304.
    InParanoidiQ6ZMR5.
    KOiK09750.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ6ZMR5.
    TreeFamiTF351684.

    Family and domain databases

    Gene3Di3.30.70.960. 1 hit.
    InterProiIPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEiPS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZMR5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY    50
    YHGSFKILDP QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN 100
    YIKNQVVRLT PEEDGVKVDV IMVFQFPSTE QRAVREKKIQ SILNQKIRNL 150
    RALPINASSV QVNAMSSSTG ELTVQASCGK RVVPLNVNRI ASGVIAPKAA 200
    WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ WTVSFGTKIN 250
    PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS 300
    ASFQPNLTVH ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI 350
    KPGMFCAGYM EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD 400
    KPGVYTQVTY YRNWIASKTG I 421
    Length:421
    Mass (Da):47,569
    Last modified:July 5, 2004 - v1
    Checksum:iC695A10DF76EF87C
    GO
    Isoform 2 (identifier: Q6ZMR5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-87: Missing.

    Show »
    Length:418
    Mass (Da):47,254
    Checksum:i96674ECABCA9B301
    GO

    Sequence cautioni

    The sequence AAD41463.1 differs from that shown. Reason: Frameshift at position 371.
    The sequence CAD67985.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501Y → F in AAD41463. (PubMed:10920976)Curated
    Sequence conflicti52 – 521H → P in AAD41463. (PubMed:10920976)Curated
    Sequence conflicti173 – 1731T → I in AAD41463. (PubMed:10920976)Curated
    Sequence conflicti267 – 2671Y → C in AAD41463. (PubMed:10920976)Curated
    Sequence conflicti271 – 2711A → P in AAD41463. (PubMed:10920976)Curated
    Sequence conflicti273 – 2731E → K in AAD41463. (PubMed:10920976)Curated
    Sequence conflicti288 – 2881S → P in AAD41463. (PubMed:10920976)Curated
    Sequence conflicti330 – 3301A → V in AAD41463. (PubMed:10920976)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931R → Q Common polymorphism; may be a susceptibility factor for developing esophageal cancer especially in smoking population. 2 Publications
    Corresponds to variant rs353163 [ dbSNP | Ensembl ].
    VAR_034797

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei85 – 873Missing in isoform 2. 3 PublicationsVSP_027610

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071882 mRNA. Translation: AAD41463.1. Frameshift.
    AY498712 mRNA. Translation: AAS78642.1.
    AK131518 mRNA. Translation: BAD18660.1.
    AC096653 Genomic DNA. No translation available.
    AC096727 Genomic DNA. No translation available.
    BC111796 mRNA. Translation: AAI11797.1.
    BN000133 mRNA. Translation: CAD67985.1. Sequence problems.
    CCDSiCCDS3519.1. [Q6ZMR5-1]
    CCDS47065.1. [Q6ZMR5-2]
    RefSeqiNP_001107859.1. NM_001114387.1.
    NP_872412.3. NM_182606.3.
    XP_006714269.1. XM_006714206.1.
    UniGeneiHs.450110.

    Genome annotation databases

    EnsembliENST00000508048; ENSP00000426911; ENSG00000187054.
    GeneIDi339967.
    KEGGihsa:339967.

    Polymorphism databases

    DMDMi74758674.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071882 mRNA. Translation: AAD41463.1 . Frameshift.
    AY498712 mRNA. Translation: AAS78642.1 .
    AK131518 mRNA. Translation: BAD18660.1 .
    AC096653 Genomic DNA. No translation available.
    AC096727 Genomic DNA. No translation available.
    BC111796 mRNA. Translation: AAI11797.1 .
    BN000133 mRNA. Translation: CAD67985.1 . Sequence problems.
    CCDSi CCDS3519.1. [Q6ZMR5-1 ]
    CCDS47065.1. [Q6ZMR5-2 ]
    RefSeqi NP_001107859.1. NM_001114387.1.
    NP_872412.3. NM_182606.3.
    XP_006714269.1. XM_006714206.1.
    UniGenei Hs.450110.

    3D structure databases

    ProteinModelPortali Q6ZMR5.
    SMRi Q6ZMR5. Positions 46-156, 190-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130971. 1 interaction.
    IntActi Q6ZMR5. 1 interaction.
    STRINGi 9606.ENSP00000334611.

    Protein family/group databases

    MEROPSi S01.292.

    PTM databases

    PhosphoSitei Q6ZMR5.

    Polymorphism databases

    DMDMi 74758674.

    Proteomic databases

    PaxDbi Q6ZMR5.
    PRIDEi Q6ZMR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000508048 ; ENSP00000426911 ; ENSG00000187054 .
    GeneIDi 339967.
    KEGGi hsa:339967.

    Organism-specific databases

    CTDi 339967.
    GeneCardsi GC04M068776.
    HGNCi HGNC:27954. TMPRSS11A.
    MIMi 611704. gene.
    neXtProti NX_Q6ZMR5.
    PharmGKBi PA142670726.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251823.
    HOVERGENi HBG013304.
    InParanoidi Q6ZMR5.
    KOi K09750.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q6ZMR5.
    TreeFami TF351684.

    Miscellaneous databases

    GenomeRNAii 339967.
    NextBioi 35534976.
    PROi Q6ZMR5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZMR5.
    CleanExi HS_TMPRSS11A.
    Genevestigatori Q6ZMR5.

    Family and domain databases

    Gene3Di 3.30.70.960. 1 hit.
    InterProi IPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEi PS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and identification of cDNA fragments related to human esophageal cancer."
      Su T., Liu H., Lu S.-H.
      Zhonghua Zhong Liu Za Zhi 20:254-257(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Esophagus.
    2. "Identification and characterization of a novel human type II transmembrane serine protease."
      Mariotti F., Mastrogiacomo A.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-293.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Tongue.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Human and mouse proteases: a comparative genomic approach."
      Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.
      Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1."
      Zhao N., Wang J., Cui Y., Guo L., Lu S.-H.
      J. Cell. Biochem. 92:65-76(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZBTB17.
    8. "Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1) and its related risk to esophageal squamous cell carcinoma."
      Li Y., Zhang X., Huang G., Miao X., Guo L., Lin D., Lu S.-H.
      Carcinogenesis 27:798-802(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLN-293.

    Entry informationi

    Entry nameiTM11A_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZMR5
    Secondary accession number(s): J3KNQ8
    , Q2NKI9, Q6JE90, Q7RTY4, Q86TK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3