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Protein

L-lactate dehydrogenase A-like 6A

Gene

LDHAL6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.1 Publication

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A-like 6A (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase A-like 6B (LDHAL6B), L-lactate dehydrogenase (HEL-S-133P), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase A chain (LDHA), L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase C chain (LDHC)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991NADBy similarity
Binding sitei106 – 1061SubstrateBy similarity
Binding sitei138 – 1381NAD or substrateBy similarity
Binding sitei169 – 1691SubstrateBy similarity
Active sitei193 – 1931Proton acceptorBy similarity
Binding sitei248 – 2481SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 5729NADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-HSA-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase A-like 6A (EC:1.1.1.27)
Gene namesi
Name:LDHAL6A
Synonyms:LDHL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28335. LDHAL6A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950539.

Polymorphism and mutation databases

BioMutaiLDHAL6A.
DMDMi51316252.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 332331L-lactate dehydrogenase A-like 6APRO_0000168457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6ZMR3.
MaxQBiQ6ZMR3.
PaxDbiQ6ZMR3.
PeptideAtlasiQ6ZMR3.
PRIDEiQ6ZMR3.

PTM databases

iPTMnetiQ6ZMR3.
PhosphoSiteiQ6ZMR3.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000166800.
CleanExiHS_LDHAL6A.
ExpressionAtlasiQ6ZMR3. baseline and differential.
GenevisibleiQ6ZMR3. HS.

Organism-specific databases

HPAiHPA043802.

Interactioni

Protein-protein interaction databases

BioGridi127750. 27 interactions.
IntActiQ6ZMR3. 3 interactions.
STRINGi9606.ENSP00000280706.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMR3.
SMRiQ6ZMR3. Positions 4-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ6ZMR3.
KOiK00016.
OMAiSARCRYE.
OrthoDBiEOG091G0HME.
PhylomeDBiQ6ZMR3.
TreeFamiTF314963.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZMR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIKSELIK NFAEEEAIHH NKISIVGTGS VGVACAISIL LKGLSDELVL
60 70 80 90 100
VDVDEGKLKG ETMDLQHGSP FMKMPNIVSS KDYLVTANSN LVIITAGARQ
110 120 130 140 150
KKGETRLDLV QRNVSIFKLM IPNITQYSPH CKLLIVTNPV DILTYVAWKL
160 170 180 190 200
SGFPKNRVIG SGCNLDSARF RYFIGQRLGI HSESCHGLIL GEHGDSSVPV
210 220 230 240 250
WSGVNIAGVP LKDLNPDIGT DKDPEQWENV HKKVISSGYE MVKMKGYTSW
260 270 280 290 300
GISLSVADLT ESILKNLRRV HPVSTLSKGL YGINEDIFLS VPCILGENGI
310 320 330
TDLIKVKLTL EEEACLQKSA ETLWEIQKEL KL
Length:332
Mass (Da):36,507
Last modified:July 5, 2004 - v1
Checksum:i7C1B9FCAE9050A9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY581313 mRNA. Translation: AAS93432.1.
AK131523 mRNA. Translation: BAD18662.1.
CH471064 Genomic DNA. Translation: EAW68387.1.
CH471064 Genomic DNA. Translation: EAW68388.1.
CCDSiCCDS7841.1.
RefSeqiNP_001137543.1. NM_001144071.1.
NP_659409.2. NM_144972.4.
UniGeneiHs.668877.

Genome annotation databases

EnsembliENST00000280706; ENSP00000280706; ENSG00000166800.
ENST00000396213; ENSP00000379516; ENSG00000166800.
GeneIDi160287.
KEGGihsa:160287.
UCSCiuc001mop.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY581313 mRNA. Translation: AAS93432.1.
AK131523 mRNA. Translation: BAD18662.1.
CH471064 Genomic DNA. Translation: EAW68387.1.
CH471064 Genomic DNA. Translation: EAW68388.1.
CCDSiCCDS7841.1.
RefSeqiNP_001137543.1. NM_001144071.1.
NP_659409.2. NM_144972.4.
UniGeneiHs.668877.

3D structure databases

ProteinModelPortaliQ6ZMR3.
SMRiQ6ZMR3. Positions 4-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127750. 27 interactions.
IntActiQ6ZMR3. 3 interactions.
STRINGi9606.ENSP00000280706.

PTM databases

iPTMnetiQ6ZMR3.
PhosphoSiteiQ6ZMR3.

Polymorphism and mutation databases

BioMutaiLDHAL6A.
DMDMi51316252.

Proteomic databases

EPDiQ6ZMR3.
MaxQBiQ6ZMR3.
PaxDbiQ6ZMR3.
PeptideAtlasiQ6ZMR3.
PRIDEiQ6ZMR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280706; ENSP00000280706; ENSG00000166800.
ENST00000396213; ENSP00000379516; ENSG00000166800.
GeneIDi160287.
KEGGihsa:160287.
UCSCiuc001mop.2. human.

Organism-specific databases

CTDi160287.
GeneCardsiLDHAL6A.
H-InvDBHIX0201669.
HGNCiHGNC:28335. LDHAL6A.
HPAiHPA043802.
neXtProtiNX_Q6ZMR3.
PharmGKBiPA134950539.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ6ZMR3.
KOiK00016.
OMAiSARCRYE.
OrthoDBiEOG091G0HME.
PhylomeDBiQ6ZMR3.
TreeFamiTF314963.

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.
ReactomeiR-HSA-70268. Pyruvate metabolism.

Miscellaneous databases

ChiTaRSiLDHAL6A. human.
GenomeRNAii160287.
PROiQ6ZMR3.

Gene expression databases

BgeeiENSG00000166800.
CleanExiHS_LDHAL6A.
ExpressionAtlasiQ6ZMR3. baseline and differential.
GenevisibleiQ6ZMR3. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDH6A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMR3
Secondary accession number(s): D3DQY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.