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Protein

L-lactate dehydrogenase A-like 6A

Gene

LDHAL6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.1 Publication

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A-like 6A (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase A-like 6B (LDHAL6B), L-lactate dehydrogenase (HEL-S-133P), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase A chain (LDHA), L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase C chain (LDHC)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99NADBy similarity1
Binding sitei106SubstrateBy similarity1
Binding sitei138NAD or substrateBy similarity1
Binding sitei169SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1
Binding sitei248SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 57NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-HSA-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase A-like 6A (EC:1.1.1.27)
Gene namesi
Name:LDHAL6A
Synonyms:LDHL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166800.9.
HGNCiHGNC:28335. LDHAL6A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166800.
PharmGKBiPA134950539.

Chemistry databases

DrugBankiDB00157. NADH.

Polymorphism and mutation databases

BioMutaiLDHAL6A.
DMDMi51316252.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001684572 – 332L-lactate dehydrogenase A-like 6AAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5N6-acetyllysine; alternateBy similarity1
Modified residuei5N6-succinyllysine; alternateBy similarity1
Modified residuei57N6-acetyllysine; alternateBy similarity1
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei118N6-acetyllysine; alternateBy similarity1
Modified residuei118N6-succinyllysine; alternateBy similarity1
Modified residuei232N6-acetyllysineBy similarity1
Modified residuei239PhosphotyrosineBy similarity1
Modified residuei243N6-acetyllysineBy similarity1
Modified residuei309PhosphothreonineBy similarity1
Modified residuei318N6-acetyllysine; alternateBy similarity1
Modified residuei318N6-succinyllysine; alternateBy similarity1
Modified residuei322PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6ZMR3.
MaxQBiQ6ZMR3.
PaxDbiQ6ZMR3.
PeptideAtlasiQ6ZMR3.
PRIDEiQ6ZMR3.

PTM databases

iPTMnetiQ6ZMR3.
PhosphoSitePlusiQ6ZMR3.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000166800.
CleanExiHS_LDHAL6A.
ExpressionAtlasiQ6ZMR3. baseline and differential.
GenevisibleiQ6ZMR3. HS.

Interactioni

Protein-protein interaction databases

BioGridi127750. 29 interactors.
IntActiQ6ZMR3. 3 interactors.
STRINGi9606.ENSP00000280706.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMR3.
SMRiQ6ZMR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ6ZMR3.
KOiK00016.
OMAiVDELVIC.
OrthoDBiEOG091G0HME.
PhylomeDBiQ6ZMR3.
TreeFamiTF314963.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZMR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIKSELIK NFAEEEAIHH NKISIVGTGS VGVACAISIL LKGLSDELVL
60 70 80 90 100
VDVDEGKLKG ETMDLQHGSP FMKMPNIVSS KDYLVTANSN LVIITAGARQ
110 120 130 140 150
KKGETRLDLV QRNVSIFKLM IPNITQYSPH CKLLIVTNPV DILTYVAWKL
160 170 180 190 200
SGFPKNRVIG SGCNLDSARF RYFIGQRLGI HSESCHGLIL GEHGDSSVPV
210 220 230 240 250
WSGVNIAGVP LKDLNPDIGT DKDPEQWENV HKKVISSGYE MVKMKGYTSW
260 270 280 290 300
GISLSVADLT ESILKNLRRV HPVSTLSKGL YGINEDIFLS VPCILGENGI
310 320 330
TDLIKVKLTL EEEACLQKSA ETLWEIQKEL KL
Length:332
Mass (Da):36,507
Last modified:July 5, 2004 - v1
Checksum:i7C1B9FCAE9050A9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY581313 mRNA. Translation: AAS93432.1.
AK131523 mRNA. Translation: BAD18662.1.
CH471064 Genomic DNA. Translation: EAW68387.1.
CH471064 Genomic DNA. Translation: EAW68388.1.
CCDSiCCDS7841.1.
RefSeqiNP_001137543.1. NM_001144071.1.
NP_659409.2. NM_144972.4.
UniGeneiHs.668877.

Genome annotation databases

EnsembliENST00000280706; ENSP00000280706; ENSG00000166800.
ENST00000396213; ENSP00000379516; ENSG00000166800.
GeneIDi160287.
KEGGihsa:160287.
UCSCiuc001mop.2. human.

Similar proteinsi

Entry informationi

Entry nameiLDH6A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMR3
Secondary accession number(s): D3DQY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families