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Protein

Serine/threonine-protein kinase LMTK1

Gene

AATK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei156ATPPROSITE-ProRule annotation1
Active sitei253Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi131 – 139ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS11615-MONOMER.
SignaLinkiQ6ZMQ8.
SIGNORiQ6ZMQ8.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK1 (EC:2.7.11.1)
Alternative name(s):
Apoptosis-associated tyrosine kinase
Short name:
AATYK
Brain apoptosis-associated tyrosine kinase
CDK5-binding protein
Lemur tyrosine kinase 1
p35-binding protein
Short name:
p35BP
Gene namesi
Name:AATK
Synonyms:AATYK, KIAA0641, LMR1, LMTK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:21. AATK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9625.
OpenTargetsiENSG00000181409.
PharmGKBiPA24370.

Polymorphism and mutation databases

BioMutaiAATK.
DMDMi114149222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483001 – 1374Serine/threonine-protein kinase LMTK1Add BLAST1374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei495PhosphoserineCombined sources1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1168PhosphoserineBy similarity1
Modified residuei1171PhosphoserineBy similarity1
Modified residuei1184PhosphoserineBy similarity1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1262PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated. Phosphorylated by CDK5.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZMQ8.
PaxDbiQ6ZMQ8.
PeptideAtlasiQ6ZMQ8.
PRIDEiQ6ZMQ8.

PTM databases

iPTMnetiQ6ZMQ8.
PhosphoSitePlusiQ6ZMQ8.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Inductioni

Up-regulated during apoptosis.

Gene expression databases

BgeeiENSG00000181409.
CleanExiHS_AATK.
ExpressionAtlasiQ6ZMQ8. baseline and differential.
GenevisibleiQ6ZMQ8. HS.

Organism-specific databases

HPAiHPA009073.

Interactioni

Subunit structurei

Interacts with CDK5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK5R1Q150786EBI-2008441,EBI-746189

Protein-protein interaction databases

BioGridi114984. 17 interactors.
IntActiQ6ZMQ8. 20 interactors.
STRINGi9606.ENSP00000324196.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 395Protein kinasePROSITE-ProRule annotationAdd BLAST271

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi420 – 429Poly-Gly10
Compositional biasi709 – 829Pro-richAdd BLAST121
Compositional biasi847 – 850Poly-Ser4
Compositional biasi1052 – 1151Pro-richAdd BLAST100
Compositional biasi1159 – 1163Poly-Glu5

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQE. Eukaryota.
ENOG410XQFM. LUCA.
GeneTreeiENSGT00640000091449.
HOGENOMiHOG000049266.
HOVERGENiHBG080533.
InParanoidiQ6ZMQ8.
KOiK17480.
OMAiRCPESWD.
OrthoDBiEOG091G00J6.
PhylomeDBiQ6ZMQ8.
TreeFamiTF332280.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML
60 70 80 90 100
ACLCCKKGGI GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV
110 120 130 140 150
SLPMAKQPGR SVQLLKSTDV GRHSLLYLKE IGRGWFGKVF LGEVNSGISS
160 170 180 190 200
AQVVVKELQA SASVQEQMQF LEEVQPYRAL KHSNLLQCLA QCAEVTPYLL
210 220 230 240 250
VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG VLHLHRNNFV
260 270 280 290 300
HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE
310 320 330 340 350
LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT
360 370 380 390 400
VREQQLKLPK PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA
410 420 430 440 450
KGATEAEEEF ERRWRSLRPG GGGVGPGPGA AGPMLGGVVE LAAASSFPLL
460 470 480 490 500
EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK WEAGRGAEAF PATLSPGRTA
510 520 530 540 550
RLQELCAPDG APPGVVPVLS AHSPSLGSEY FIRLEEAAPA AGHDPDCAGC
560 570 580 590 600
APSPPATADQ DDDSDGSTAA SLAMEPLLGH GPPVDVPWGR GDHYPRRSLA
610 620 630 640 650
RDPLCPSRSP SPSAGPLSLA EGGAEDADWG VAAFCPAFFE DPLGTSPLGS
660 670 680 690 700
SGAPPLPLTG EDELEEVGAR RAAQRGHWRS NVSANNNSGS RCPESWDPVS
710 720 730 740 750
AGGHAEGCPS PKQTPRASPE PGYPGEPLLG LQAASAQEPG CCPGLPHLCS
760 770 780 790 800
AQGLAPAPCL VTPSWTETAS SGGDHPQAEP KLATEAEGTT GPRLPLPSVP
810 820 830 840 850
SPSQEGAPLP SEEASAPDAP DALPDSPTPA TGGEVSAIKL ASALNGSSSS
860 870 880 890 900
PEVEAPSSED EDTAEATSGI FTDTSSDGLQ ARRPDVVPAF RSLQKQVGTP
910 920 930 940 950
DSLDSLDIPS SASDGGYEVF SPSATGPSGG QPRALDSGYD TENYESPEFV
960 970 980 990 1000
LKEAQEGCEP QAFAELASEG EGPGPETRLS TSLSGLNEKN PYRDSAYFSD
1010 1020 1030 1040 1050
LEAEAEATSG PEKKCGGDRA PGPELGLPST GQPSEQVCLR PGVSGEAQGS
1060 1070 1080 1090 1100
GPGEVLPPLL QLEGSSPEPS TCPSGLVPEP PEPQGPAKVR PGPSPSCSQF
1110 1120 1130 1140 1150
FLLTPVPLRS EGNSSEFQGP PGLLSGPAPQ KRMGGPGTPR APLRLALPGL
1160 1170 1180 1190 1200
PAALEGRPEE EEEDSEDSDE SDEELRCYSV QEPSEDSEEE APAVPVVVAE
1210 1220 1230 1240 1250
SQSARNLRSL LKMPSLLSET FCEDLERKKK AVSFFDDVTV YLFDQESPTR
1260 1270 1280 1290 1300
ELGEPFPGAK ESPPTFLRGS PGSPSAPNRP QQADGSPNGS TAEEGGGFAW
1310 1320 1330 1340 1350
DDDFPLMTAK AAFAMALDPA APAPAAPTPT PAPFSRFTVS PAPTSRFSIT
1360 1370
HVSDSDAESK RGPEAGAGGE SKEA
Length:1,374
Mass (Da):144,569
Last modified:September 5, 2006 - v2
Checksum:iAD46BD688AF7103E
GO
Isoform 2 (identifier: Q6ZMQ8-2) [UniParc]FASTAAdd to basket
Also known as: hAATYKs-p35BP

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: Missing.
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.

Show »
Length:446
Mass (Da):45,358
Checksum:i38EA067D9AA55653
GO
Isoform 3 (identifier: Q6ZMQ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.

Show »
Length:879
Mass (Da):93,226
Checksum:iB31470ED8B3E5E78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 63MLACL…GIGFK → HQVKVQGCWGRWRWQ (PubMed:9734811).CuratedAdd BLAST15
Sequence conflicti511A → T in BAD18667 (PubMed:14702039).Curated1
Sequence conflicti541A → T in BAD18544 (PubMed:14702039).Curated1
Sequence conflicti557T → I in BAD18544 (PubMed:14702039).Curated1
Sequence conflicti786A → V in AAH47378 (PubMed:15489334).Curated1
Sequence conflicti790T → A in BAD18667 (PubMed:14702039).Curated1
Sequence conflicti1028P → R in AAH47378 (PubMed:15489334).Curated1
Sequence conflicti1271P → H in AAH47378 (PubMed:15489334).Curated1
Sequence conflicti1324P → R in AAH47378 (PubMed:15489334).Curated1
Sequence conflicti1360K → E in AAH47378 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03267981S → F in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_03268097L → V in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_032681104M → V in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_027267118T → M.Corresponds to variant rs8082016dbSNPEnsembl.1
Natural variantiVAR_032682703G → C.3 PublicationsCorresponds to variant rs7503604dbSNPEnsembl.1
Natural variantiVAR_032683815S → R.1 PublicationCorresponds to variant rs56032966dbSNPEnsembl.1
Natural variantiVAR_032684923S → L.1 PublicationCorresponds to variant rs56313973dbSNPEnsembl.1
Natural variantiVAR_0326851160E → K.1 PublicationCorresponds to variant rs55793641dbSNPEnsembl.1
Natural variantiVAR_0326861192P → S.1 PublicationCorresponds to variant rs55856613dbSNPEnsembl.1
Natural variantiVAR_0326871266F → S.2 PublicationsCorresponds to variant rs36000545dbSNPEnsembl.1
Natural variantiVAR_0326881332A → T.1 PublicationCorresponds to variant rs55713566dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0202251 – 433Missing in isoform 2. 1 PublicationAdd BLAST433
Alternative sequenceiVSP_020226468 – 503Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_020227897 – 915VGTPD…SASDG → WPQREESLPRLCLLLRPRG in isoform 2 and isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_020228916 – 1374Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST459

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131395 mRNA. Translation: BAD18544.1.
AK131529 mRNA. Translation: BAD18667.1.
AB014541 mRNA. Translation: BAA31616.2.
BC047378 mRNA. Translation: AAH47378.1.
CCDSiCCDS45807.1. [Q6ZMQ8-1]
RefSeqiNP_001073864.2. NM_001080395.2. [Q6ZMQ8-1]
NP_004911.2. NM_004920.2.
UniGeneiHs.514575.

Genome annotation databases

EnsembliENST00000326724; ENSP00000324196; ENSG00000181409. [Q6ZMQ8-1]
ENST00000374792; ENSP00000363924; ENSG00000181409. [Q6ZMQ8-3]
GeneIDi9625.
KEGGihsa:9625.
UCSCiuc010dia.4. human. [Q6ZMQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131395 mRNA. Translation: BAD18544.1.
AK131529 mRNA. Translation: BAD18667.1.
AB014541 mRNA. Translation: BAA31616.2.
BC047378 mRNA. Translation: AAH47378.1.
CCDSiCCDS45807.1. [Q6ZMQ8-1]
RefSeqiNP_001073864.2. NM_001080395.2. [Q6ZMQ8-1]
NP_004911.2. NM_004920.2.
UniGeneiHs.514575.

3D structure databases

ProteinModelPortaliQ6ZMQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114984. 17 interactors.
IntActiQ6ZMQ8. 20 interactors.
STRINGi9606.ENSP00000324196.

PTM databases

iPTMnetiQ6ZMQ8.
PhosphoSitePlusiQ6ZMQ8.

Polymorphism and mutation databases

BioMutaiAATK.
DMDMi114149222.

Proteomic databases

MaxQBiQ6ZMQ8.
PaxDbiQ6ZMQ8.
PeptideAtlasiQ6ZMQ8.
PRIDEiQ6ZMQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326724; ENSP00000324196; ENSG00000181409. [Q6ZMQ8-1]
ENST00000374792; ENSP00000363924; ENSG00000181409. [Q6ZMQ8-3]
GeneIDi9625.
KEGGihsa:9625.
UCSCiuc010dia.4. human. [Q6ZMQ8-1]

Organism-specific databases

CTDi9625.
DisGeNETi9625.
GeneCardsiAATK.
HGNCiHGNC:21. AATK.
HPAiHPA009073.
MIMi605276. gene.
neXtProtiNX_Q6ZMQ8.
OpenTargetsiENSG00000181409.
PharmGKBiPA24370.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQE. Eukaryota.
ENOG410XQFM. LUCA.
GeneTreeiENSGT00640000091449.
HOGENOMiHOG000049266.
HOVERGENiHBG080533.
InParanoidiQ6ZMQ8.
KOiK17480.
OMAiRCPESWD.
OrthoDBiEOG091G00J6.
PhylomeDBiQ6ZMQ8.
TreeFamiTF332280.

Enzyme and pathway databases

BioCyciZFISH:HS11615-MONOMER.
SignaLinkiQ6ZMQ8.
SIGNORiQ6ZMQ8.

Miscellaneous databases

GeneWikiiAATK.
GenomeRNAii9625.
PROiQ6ZMQ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181409.
CleanExiHS_AATK.
ExpressionAtlasiQ6ZMQ8. baseline and differential.
GenevisibleiQ6ZMQ8. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMTK1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMQ8
Secondary accession number(s): O75136, Q6ZN31, Q86X28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.