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Q6ZMQ8

- LMTK1_HUMAN

UniProt

Q6ZMQ8 - LMTK1_HUMAN

Protein

Serine/threonine-protein kinase LMTK1

Gene

AATK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    May be involved in neuronal differentiation.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei156 – 1561ATPPROSITE-ProRule annotation
    Active sitei253 – 2531Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi131 – 1399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine kinase activity Source: UniProtKB-KW
    4. protein tyrosine kinase activity Source: Ensembl

    GO - Biological processi

    1. brain development Source: Ensembl
    2. negative regulation of axon extension Source: Ensembl
    3. neuron apoptotic process Source: Ensembl
    4. peptidyl-tyrosine autophosphorylation Source: Ensembl
    5. Rab protein signal transduction Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ6ZMQ8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase LMTK1 (EC:2.7.11.1)
    Alternative name(s):
    Apoptosis-associated tyrosine kinase
    Short name:
    AATYK
    Brain apoptosis-associated tyrosine kinase
    CDK5-binding protein
    Lemur tyrosine kinase 1
    p35-binding protein
    Short name:
    p35BP
    Gene namesi
    Name:AATK
    Synonyms:AATYK, KIAA0641, LMR1, LMTK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:21. AATK.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasm 1 Publication. Cytoplasmperinuclear region 1 Publication
    Note: Predominantly perinuclear.

    GO - Cellular componenti

    1. axonal growth cone Source: Ensembl
    2. endoplasmic reticulum Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    5. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24370.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13741374Serine/threonine-protein kinase LMTK1PRO_0000248300Add
    BLAST

    Post-translational modificationi

    Autophosphorylated. Phosphorylated by CDK5.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZMQ8.
    PaxDbiQ6ZMQ8.
    PRIDEiQ6ZMQ8.

    PTM databases

    PhosphoSiteiQ6ZMQ8.

    Expressioni

    Tissue specificityi

    Expressed in brain.1 Publication

    Inductioni

    Up-regulated during apoptosis.

    Gene expression databases

    ArrayExpressiQ6ZMQ8.
    BgeeiQ6ZMQ8.
    CleanExiHS_AATK.
    GenevestigatoriQ6ZMQ8.

    Organism-specific databases

    HPAiHPA009073.

    Interactioni

    Subunit structurei

    Interacts with CDK5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK5R1Q150786EBI-2008441,EBI-746189

    Protein-protein interaction databases

    BioGridi114984. 3 interactions.
    IntActiQ6ZMQ8. 5 interactions.
    STRINGi9606.ENSP00000324196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZMQ8.
    SMRiQ6ZMQ8. Positions 119-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 395271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi420 – 42910Poly-Gly
    Compositional biasi709 – 829121Pro-richAdd
    BLAST
    Compositional biasi847 – 8504Poly-Ser
    Compositional biasi1052 – 1151100Pro-richAdd
    BLAST
    Compositional biasi1159 – 11635Poly-Glu

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000049266.
    HOVERGENiHBG080533.
    InParanoidiQ6ZMQ8.
    KOiK17480.
    OMAiCPPFFED.
    OrthoDBiEOG7MH0XB.
    PhylomeDBiQ6ZMQ8.
    TreeFamiTF332280.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZMQ8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML     50
    ACLCCKKGGI GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV 100
    SLPMAKQPGR SVQLLKSTDV GRHSLLYLKE IGRGWFGKVF LGEVNSGISS 150
    AQVVVKELQA SASVQEQMQF LEEVQPYRAL KHSNLLQCLA QCAEVTPYLL 200
    VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG VLHLHRNNFV 250
    HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE 300
    LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT 350
    VREQQLKLPK PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA 400
    KGATEAEEEF ERRWRSLRPG GGGVGPGPGA AGPMLGGVVE LAAASSFPLL 450
    EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK WEAGRGAEAF PATLSPGRTA 500
    RLQELCAPDG APPGVVPVLS AHSPSLGSEY FIRLEEAAPA AGHDPDCAGC 550
    APSPPATADQ DDDSDGSTAA SLAMEPLLGH GPPVDVPWGR GDHYPRRSLA 600
    RDPLCPSRSP SPSAGPLSLA EGGAEDADWG VAAFCPAFFE DPLGTSPLGS 650
    SGAPPLPLTG EDELEEVGAR RAAQRGHWRS NVSANNNSGS RCPESWDPVS 700
    AGGHAEGCPS PKQTPRASPE PGYPGEPLLG LQAASAQEPG CCPGLPHLCS 750
    AQGLAPAPCL VTPSWTETAS SGGDHPQAEP KLATEAEGTT GPRLPLPSVP 800
    SPSQEGAPLP SEEASAPDAP DALPDSPTPA TGGEVSAIKL ASALNGSSSS 850
    PEVEAPSSED EDTAEATSGI FTDTSSDGLQ ARRPDVVPAF RSLQKQVGTP 900
    DSLDSLDIPS SASDGGYEVF SPSATGPSGG QPRALDSGYD TENYESPEFV 950
    LKEAQEGCEP QAFAELASEG EGPGPETRLS TSLSGLNEKN PYRDSAYFSD 1000
    LEAEAEATSG PEKKCGGDRA PGPELGLPST GQPSEQVCLR PGVSGEAQGS 1050
    GPGEVLPPLL QLEGSSPEPS TCPSGLVPEP PEPQGPAKVR PGPSPSCSQF 1100
    FLLTPVPLRS EGNSSEFQGP PGLLSGPAPQ KRMGGPGTPR APLRLALPGL 1150
    PAALEGRPEE EEEDSEDSDE SDEELRCYSV QEPSEDSEEE APAVPVVVAE 1200
    SQSARNLRSL LKMPSLLSET FCEDLERKKK AVSFFDDVTV YLFDQESPTR 1250
    ELGEPFPGAK ESPPTFLRGS PGSPSAPNRP QQADGSPNGS TAEEGGGFAW 1300
    DDDFPLMTAK AAFAMALDPA APAPAAPTPT PAPFSRFTVS PAPTSRFSIT 1350
    HVSDSDAESK RGPEAGAGGE SKEA 1374
    Length:1,374
    Mass (Da):144,569
    Last modified:September 5, 2006 - v2
    Checksum:iAD46BD688AF7103E
    GO
    Isoform 2 (identifier: Q6ZMQ8-2) [UniParc]FASTAAdd to Basket

    Also known as: hAATYKs-p35BP

    The sequence of this isoform differs from the canonical sequence as follows:
         1-433: Missing.
         468-503: Missing.
         897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
         916-1374: Missing.

    Show »
    Length:446
    Mass (Da):45,358
    Checksum:i38EA067D9AA55653
    GO
    Isoform 3 (identifier: Q6ZMQ8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         468-503: Missing.
         897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
         916-1374: Missing.

    Show »
    Length:879
    Mass (Da):93,226
    Checksum:iB31470ED8B3E5E78
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 6315MLACL…GIGFK → HQVKVQGCWGRWRWQ(PubMed:9734811)CuratedAdd
    BLAST
    Sequence conflicti511 – 5111A → T in BAD18667. (PubMed:14702039)Curated
    Sequence conflicti541 – 5411A → T in BAD18544. (PubMed:14702039)Curated
    Sequence conflicti557 – 5571T → I in BAD18544. (PubMed:14702039)Curated
    Sequence conflicti786 – 7861A → V in AAH47378. (PubMed:15489334)Curated
    Sequence conflicti790 – 7901T → A in BAD18667. (PubMed:14702039)Curated
    Sequence conflicti1028 – 10281P → R in AAH47378. (PubMed:15489334)Curated
    Sequence conflicti1271 – 12711P → H in AAH47378. (PubMed:15489334)Curated
    Sequence conflicti1324 – 13241P → R in AAH47378. (PubMed:15489334)Curated
    Sequence conflicti1360 – 13601K → E in AAH47378. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811S → F in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_032679
    Natural varianti97 – 971L → V in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_032680
    Natural varianti104 – 1041M → V in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_032681
    Natural varianti118 – 1181T → M.
    Corresponds to variant rs8082016 [ dbSNP | Ensembl ].
    VAR_027267
    Natural varianti703 – 7031G → C.3 Publications
    Corresponds to variant rs7503604 [ dbSNP | Ensembl ].
    VAR_032682
    Natural varianti815 – 8151S → R.1 Publication
    Corresponds to variant rs56032966 [ dbSNP | Ensembl ].
    VAR_032683
    Natural varianti923 – 9231S → L.1 Publication
    Corresponds to variant rs56313973 [ dbSNP | Ensembl ].
    VAR_032684
    Natural varianti1160 – 11601E → K.1 Publication
    Corresponds to variant rs55793641 [ dbSNP | Ensembl ].
    VAR_032685
    Natural varianti1192 – 11921P → S.1 Publication
    Corresponds to variant rs55856613 [ dbSNP | Ensembl ].
    VAR_032686
    Natural varianti1266 – 12661F → S.2 Publications
    Corresponds to variant rs36000545 [ dbSNP | Ensembl ].
    VAR_032687
    Natural varianti1332 – 13321A → T.1 Publication
    Corresponds to variant rs55713566 [ dbSNP | Ensembl ].
    VAR_032688

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 433433Missing in isoform 2. 1 PublicationVSP_020225Add
    BLAST
    Alternative sequencei468 – 50336Missing in isoform 2 and isoform 3. 1 PublicationVSP_020226Add
    BLAST
    Alternative sequencei897 – 91519VGTPD…SASDG → WPQREESLPRLCLLLRPRG in isoform 2 and isoform 3. 1 PublicationVSP_020227Add
    BLAST
    Alternative sequencei916 – 1374459Missing in isoform 2 and isoform 3. 1 PublicationVSP_020228Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131395 mRNA. Translation: BAD18544.1.
    AK131529 mRNA. Translation: BAD18667.1.
    AB014541 mRNA. Translation: BAA31616.2.
    BC047378 mRNA. Translation: AAH47378.1.
    CCDSiCCDS45807.1. [Q6ZMQ8-1]
    RefSeqiNP_001073864.2. NM_001080395.2. [Q6ZMQ8-1]
    NP_004911.2. NM_004920.2.
    UniGeneiHs.514575.

    Genome annotation databases

    EnsembliENST00000326724; ENSP00000324196; ENSG00000181409. [Q6ZMQ8-1]
    ENST00000374792; ENSP00000363924; ENSG00000181409. [Q6ZMQ8-3]
    GeneIDi9625.
    KEGGihsa:9625.
    UCSCiuc010dia.3. human. [Q6ZMQ8-1]

    Polymorphism databases

    DMDMi114149222.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    CGP resequencing studies

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131395 mRNA. Translation: BAD18544.1 .
    AK131529 mRNA. Translation: BAD18667.1 .
    AB014541 mRNA. Translation: BAA31616.2 .
    BC047378 mRNA. Translation: AAH47378.1 .
    CCDSi CCDS45807.1. [Q6ZMQ8-1 ]
    RefSeqi NP_001073864.2. NM_001080395.2. [Q6ZMQ8-1 ]
    NP_004911.2. NM_004920.2.
    UniGenei Hs.514575.

    3D structure databases

    ProteinModelPortali Q6ZMQ8.
    SMRi Q6ZMQ8. Positions 119-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114984. 3 interactions.
    IntActi Q6ZMQ8. 5 interactions.
    STRINGi 9606.ENSP00000324196.

    PTM databases

    PhosphoSitei Q6ZMQ8.

    Polymorphism databases

    DMDMi 114149222.

    Proteomic databases

    MaxQBi Q6ZMQ8.
    PaxDbi Q6ZMQ8.
    PRIDEi Q6ZMQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326724 ; ENSP00000324196 ; ENSG00000181409 . [Q6ZMQ8-1 ]
    ENST00000374792 ; ENSP00000363924 ; ENSG00000181409 . [Q6ZMQ8-3 ]
    GeneIDi 9625.
    KEGGi hsa:9625.
    UCSCi uc010dia.3. human. [Q6ZMQ8-1 ]

    Organism-specific databases

    CTDi 9625.
    GeneCardsi GC17M079091.
    HGNCi HGNC:21. AATK.
    HPAi HPA009073.
    MIMi 605276. gene.
    neXtProti NX_Q6ZMQ8.
    PharmGKBi PA24370.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000049266.
    HOVERGENi HBG080533.
    InParanoidi Q6ZMQ8.
    KOi K17480.
    OMAi CPPFFED.
    OrthoDBi EOG7MH0XB.
    PhylomeDBi Q6ZMQ8.
    TreeFami TF332280.

    Enzyme and pathway databases

    SignaLinki Q6ZMQ8.

    Miscellaneous databases

    GeneWikii AATK.
    GenomeRNAii 9625.
    NextBioi 36117.
    PROi Q6ZMQ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZMQ8.
    Bgeei Q6ZMQ8.
    CleanExi HS_AATK.
    Genevestigatori Q6ZMQ8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT CYS-703.
      Tissue: Cerebellum and Thalamus.
    2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-1374 (ISOFORM 1), VARIANT CYS-703.
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 786-1374 (ISOFORM 1), VARIANT SER-1266.
      Tissue: Brain.
    5. Cited for: ALTERNATIVE SPLICING (ISOFORM 2), INTERACTION WITH CDK5, PHOSPHORYLATION.
    6. "A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line."
      Raghunath M., Patti R., Bannerman P., Lee C.M., Baker S., Sutton L.N., Phillips P.C., Damodar Reddy C.
      Brain Res. Mol. Brain Res. 77:151-162(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PHE-81; VAL-97; VAL-104; CYS-703; ARG-815; LEU-923; LYS-1160; SER-1192; SER-1266 AND THR-1332.

    Entry informationi

    Entry nameiLMTK1_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZMQ8
    Secondary accession number(s): O75136, Q6ZN31, Q86X28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3