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Q6ZMQ8 (LMTK1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase LMTK1

EC=2.7.11.1
Alternative name(s):
Apoptosis-associated tyrosine kinase
Short name=AATYK
Brain apoptosis-associated tyrosine kinase
CDK5-binding protein
Lemur tyrosine kinase 1
p35-binding protein
Short name=p35BP
Gene names
Name:AATK
Synonyms:AATYK, KIAA0641, LMR1, LMTK1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in neuronal differentiation. Ref.6

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with CDK5. Ref.5

Subcellular location

Membrane; Single-pass type I membrane protein By similarity. Cytoplasm. Cytoplasmperinuclear region. Note: Predominantly perinuclear. Ref.6

Tissue specificity

Expressed in brain. Ref.6

Induction

Up-regulated during apoptosis.

Post-translational modification

Autophosphorylated. Phosphorylated by CDK5. Ref.5

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRab protein signal transduction

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from electronic annotation. Source: Ensembl

negative regulation of axon extension

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

peptidyl-tyrosine autophosphorylation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxonal growth cone

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

recycling endosome

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine kinase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDK5R1Q150786EBI-2008441,EBI-746189

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZMQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZMQ8-2)

Also known as: hAATYKs-p35BP;

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: Missing.
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.
Isoform 3 (identifier: Q6ZMQ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13741374Serine/threonine-protein kinase LMTK1
PRO_0000248300

Regions

Transmembrane32 – 5221Helical; Potential
Domain125 – 395271Protein kinase
Nucleotide binding131 – 1399ATP By similarity
Compositional bias420 – 42910Poly-Gly
Compositional bias709 – 829121Pro-rich
Compositional bias847 – 8504Poly-Ser
Compositional bias1052 – 1151100Pro-rich
Compositional bias1159 – 11635Poly-Glu

Sites

Active site2531Proton acceptor By similarity
Binding site1561ATP By similarity

Natural variations

Alternative sequence1 – 433433Missing in isoform 2.
VSP_020225
Alternative sequence468 – 50336Missing in isoform 2 and isoform 3.
VSP_020226
Alternative sequence897 – 91519VGTPD…SASDG → WPQREESLPRLCLLLRPRG in isoform 2 and isoform 3.
VSP_020227
Alternative sequence916 – 1374459Missing in isoform 2 and isoform 3.
VSP_020228
Natural variant811S → F in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7
VAR_032679
Natural variant971L → V in a lung adenocarcinoma sample; somatic mutation. Ref.7
VAR_032680
Natural variant1041M → V in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7
VAR_032681
Natural variant1181T → M.
Corresponds to variant rs8082016 [ dbSNP | Ensembl ].
VAR_027267
Natural variant7031G → C. Ref.1 Ref.2 Ref.7
Corresponds to variant rs7503604 [ dbSNP | Ensembl ].
VAR_032682
Natural variant8151S → R. Ref.7
Corresponds to variant rs56032966 [ dbSNP | Ensembl ].
VAR_032683
Natural variant9231S → L. Ref.7
Corresponds to variant rs56313973 [ dbSNP | Ensembl ].
VAR_032684
Natural variant11601E → K. Ref.7
Corresponds to variant rs55793641 [ dbSNP | Ensembl ].
VAR_032685
Natural variant11921P → S. Ref.7
Corresponds to variant rs55856613 [ dbSNP | Ensembl ].
VAR_032686
Natural variant12661F → S. Ref.4 Ref.7
Corresponds to variant rs36000545 [ dbSNP | Ensembl ].
VAR_032687
Natural variant13321A → T. Ref.7
Corresponds to variant rs55713566 [ dbSNP | Ensembl ].
VAR_032688

Experimental info

Sequence conflict49 – 6315MLACL…GIGFK → HQVKVQGCWGRWRWQ Ref.2
Sequence conflict5111A → T in BAD18667. Ref.1
Sequence conflict5411A → T in BAD18544. Ref.1
Sequence conflict5571T → I in BAD18544. Ref.1
Sequence conflict7861A → V in AAH47378. Ref.4
Sequence conflict7901T → A in BAD18667. Ref.1
Sequence conflict10281P → R in AAH47378. Ref.4
Sequence conflict12711P → H in AAH47378. Ref.4
Sequence conflict13241P → R in AAH47378. Ref.4
Sequence conflict13601K → E in AAH47378. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: AD46BD688AF7103E

FASTA1,374144,569
        10         20         30         40         50         60 
MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML ACLCCKKGGI 

        70         80         90        100        110        120 
GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV SLPMAKQPGR SVQLLKSTDV 

       130        140        150        160        170        180 
GRHSLLYLKE IGRGWFGKVF LGEVNSGISS AQVVVKELQA SASVQEQMQF LEEVQPYRAL 

       190        200        210        220        230        240 
KHSNLLQCLA QCAEVTPYLL VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG 

       250        260        270        280        290        300 
VLHLHRNNFV HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE 

       310        320        330        340        350        360 
LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT VREQQLKLPK 

       370        380        390        400        410        420 
PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA KGATEAEEEF ERRWRSLRPG 

       430        440        450        460        470        480 
GGGVGPGPGA AGPMLGGVVE LAAASSFPLL EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK 

       490        500        510        520        530        540 
WEAGRGAEAF PATLSPGRTA RLQELCAPDG APPGVVPVLS AHSPSLGSEY FIRLEEAAPA 

       550        560        570        580        590        600 
AGHDPDCAGC APSPPATADQ DDDSDGSTAA SLAMEPLLGH GPPVDVPWGR GDHYPRRSLA 

       610        620        630        640        650        660 
RDPLCPSRSP SPSAGPLSLA EGGAEDADWG VAAFCPAFFE DPLGTSPLGS SGAPPLPLTG 

       670        680        690        700        710        720 
EDELEEVGAR RAAQRGHWRS NVSANNNSGS RCPESWDPVS AGGHAEGCPS PKQTPRASPE 

       730        740        750        760        770        780 
PGYPGEPLLG LQAASAQEPG CCPGLPHLCS AQGLAPAPCL VTPSWTETAS SGGDHPQAEP 

       790        800        810        820        830        840 
KLATEAEGTT GPRLPLPSVP SPSQEGAPLP SEEASAPDAP DALPDSPTPA TGGEVSAIKL 

       850        860        870        880        890        900 
ASALNGSSSS PEVEAPSSED EDTAEATSGI FTDTSSDGLQ ARRPDVVPAF RSLQKQVGTP 

       910        920        930        940        950        960 
DSLDSLDIPS SASDGGYEVF SPSATGPSGG QPRALDSGYD TENYESPEFV LKEAQEGCEP 

       970        980        990       1000       1010       1020 
QAFAELASEG EGPGPETRLS TSLSGLNEKN PYRDSAYFSD LEAEAEATSG PEKKCGGDRA 

      1030       1040       1050       1060       1070       1080 
PGPELGLPST GQPSEQVCLR PGVSGEAQGS GPGEVLPPLL QLEGSSPEPS TCPSGLVPEP 

      1090       1100       1110       1120       1130       1140 
PEPQGPAKVR PGPSPSCSQF FLLTPVPLRS EGNSSEFQGP PGLLSGPAPQ KRMGGPGTPR 

      1150       1160       1170       1180       1190       1200 
APLRLALPGL PAALEGRPEE EEEDSEDSDE SDEELRCYSV QEPSEDSEEE APAVPVVVAE 

      1210       1220       1230       1240       1250       1260 
SQSARNLRSL LKMPSLLSET FCEDLERKKK AVSFFDDVTV YLFDQESPTR ELGEPFPGAK 

      1270       1280       1290       1300       1310       1320 
ESPPTFLRGS PGSPSAPNRP QQADGSPNGS TAEEGGGFAW DDDFPLMTAK AAFAMALDPA 

      1330       1340       1350       1360       1370 
APAPAAPTPT PAPFSRFTVS PAPTSRFSIT HVSDSDAESK RGPEAGAGGE SKEA 

« Hide

Isoform 2 (hAATYKs-p35BP) [UniParc].

Checksum: 38EA067D9AA55653
Show »

FASTA44645,358
Isoform 3 [UniParc].

Checksum: B31470ED8B3E5E78
Show »

FASTA87993,226

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT CYS-703.
Tissue: Cerebellum and Thalamus.
[2]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-1374 (ISOFORM 1), VARIANT CYS-703.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 786-1374 (ISOFORM 1), VARIANT SER-1266.
Tissue: Brain.
[5]"Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein."
Honma N., Asada A., Takeshita S., Enomoto M., Yamakawa E., Tsutsumi K., Saito T., Satoh T., Itoh H., Kaziro Y., Kishimoto T., Hisanaga S.
Biochem. Biophys. Res. Commun. 310:398-404(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORM 2), INTERACTION WITH CDK5, PHOSPHORYLATION.
[6]"A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line."
Raghunath M., Patti R., Bannerman P., Lee C.M., Baker S., Sutton L.N., Phillips P.C., Damodar Reddy C.
Brain Res. Mol. Brain Res. 77:151-162(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
[7]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PHE-81; VAL-97; VAL-104; CYS-703; ARG-815; LEU-923; LYS-1160; SER-1192; SER-1266 AND THR-1332.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK131395 mRNA. Translation: BAD18544.1.
AK131529 mRNA. Translation: BAD18667.1.
AB014541 mRNA. Translation: BAA31616.2.
BC047378 mRNA. Translation: AAH47378.1.
RefSeqNP_001073864.2. NM_001080395.2.
NP_004911.2. NM_004920.2.
UniGeneHs.514575.

3D structure databases

ProteinModelPortalQ6ZMQ8.
SMRQ6ZMQ8. Positions 119-395.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114984. 3 interactions.
IntActQ6ZMQ8. 5 interactions.
STRING9606.ENSP00000324196.

PTM databases

PhosphoSiteQ6ZMQ8.

Polymorphism databases

DMDM114149222.

Proteomic databases

PaxDbQ6ZMQ8.
PRIDEQ6ZMQ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326724; ENSP00000324196; ENSG00000181409. [Q6ZMQ8-1]
ENST00000374792; ENSP00000363924; ENSG00000181409. [Q6ZMQ8-3]
GeneID9625.
KEGGhsa:9625.
UCSCuc010dia.3. human. [Q6ZMQ8-1]

Organism-specific databases

CTD9625.
GeneCardsGC17M079091.
HGNCHGNC:21. AATK.
HPAHPA009073.
MIM605276. gene.
neXtProtNX_Q6ZMQ8.
PharmGKBPA24370.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000049266.
HOVERGENHBG080533.
InParanoidQ6ZMQ8.
KOK17480.
OMACPPFFED.
OrthoDBEOG7MH0XB.
PhylomeDBQ6ZMQ8.
TreeFamTF332280.

Enzyme and pathway databases

SignaLinkQ6ZMQ8.

Gene expression databases

ArrayExpressQ6ZMQ8.
BgeeQ6ZMQ8.
CleanExHS_AATK.
GenevestigatorQ6ZMQ8.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAATK.
GenomeRNAi9625.
NextBio36117.
PROQ6ZMQ8.
SOURCESearch...

Entry information

Entry nameLMTK1_HUMAN
AccessionPrimary (citable) accession number: Q6ZMQ8
Secondary accession number(s): O75136, Q6ZN31, Q86X28
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM