Q6ZMQ8 (LMTK1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase LMTK1
EC=2.7.11.1

Alternative name(s):
Apoptosis-associated tyrosine kinase
Short name=AATYK
Brain apoptosis-associated tyrosine kinase
CDK5-binding protein
Lemur tyrosine kinase 1
p35-binding protein
Short name=p35BP

Gene names

Name:	AATK
Synonyms:	AATYK, KIAA0641, LMR1, LMTK1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1374 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in neuronal differentiation. Ref.6
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with CDK5. Ref.5
Subcellular location	Membrane; Single-pass type I membrane protein By similarity. Cytoplasm. Cytoplasm › perinuclear region. Note: Predominantly perinuclear. Ref.6
Tissue specificity	Expressed in brain. Ref.6
Induction	Up-regulated during apoptosis.
Post-translational modification	Autophosphorylated. Phosphorylated by CDK5. Ref.5
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay. Source: HPA perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDK5R1	Q15078	6	EBI-2008441,EBI-746189

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZMQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZMQ8-2)

Also known as: hAATYKs-p35BP;

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: Missing.
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.

Isoform 3 (identifier: Q6ZMQ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1374	1374	Serine/threonine-protein kinase LMTK1		PRO_0000248300
Regions
	Transmembrane	32 – 52	21	Helical; Potential
	Domain	125 – 395	271	Protein kinase
	Nucleotide binding	131 – 139	9	ATP By similarity
	Compositional bias	420 – 429	10	Poly-Gly
	Compositional bias	709 – 829	121	Pro-rich
	Compositional bias	847 – 850	4	Poly-Ser
	Compositional bias	1052 – 1151	100	Pro-rich
	Compositional bias	1159 – 1163	5	Poly-Glu
Sites
	Active site	253	1	Proton acceptor By similarity
	Binding site	156	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 433	433	Missing in isoform 2.		VSP_020225
	Alternative sequence	468 – 503	36	Missing in isoform 2 and isoform 3.		VSP_020226
	Alternative sequence	897 – 915	19	VGTPD…SASDG → WPQREESLPRLCLLLRPRG in isoform 2 and isoform 3.		VSP_020227
	Alternative sequence	916 – 1374	459	Missing in isoform 2 and isoform 3.		VSP_020228
	Natural variant	81	1	S → F in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7		VAR_032679
	Natural variant	97	1	L → V in a lung adenocarcinoma sample; somatic mutation. Ref.7		VAR_032680
	Natural variant	104	1	M → V in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7		VAR_032681
	Natural variant	118	1	T → M. Corresponds to variant rs8082016 [ dbSNP | Ensembl ].		VAR_027267
	Natural variant	703	1	G → C. Ref.1 Ref.2 Ref.7 Corresponds to variant rs7503604 [ dbSNP | Ensembl ].		VAR_032682
	Natural variant	815	1	S → R. Ref.7 Corresponds to variant rs56032966 [ dbSNP | Ensembl ].		VAR_032683
	Natural variant	923	1	S → L. Ref.7 Corresponds to variant rs56313973 [ dbSNP | Ensembl ].		VAR_032684
	Natural variant	1160	1	E → K. Ref.7 Corresponds to variant rs55793641 [ dbSNP | Ensembl ].		VAR_032685
	Natural variant	1192	1	P → S. Ref.7 Corresponds to variant rs55856613 [ dbSNP | Ensembl ].		VAR_032686
	Natural variant	1266	1	F → S. Ref.4 Ref.7 Corresponds to variant rs36000545 [ dbSNP | Ensembl ].		VAR_032687
	Natural variant	1332	1	A → T. Ref.7 Corresponds to variant rs55713566 [ dbSNP | Ensembl ].		VAR_032688
Experimental info
	Sequence conflict	49 – 63	15	MLACL…GIGFK → HQVKVQGCWGRWRWQ Ref.2
	Sequence conflict	511	1	A → T in BAD18667. Ref.1
	Sequence conflict	541	1	A → T in BAD18544. Ref.1
	Sequence conflict	557	1	T → I in BAD18544. Ref.1
	Sequence conflict	786	1	A → V in AAH47378. Ref.4
	Sequence conflict	790	1	T → A in BAD18667. Ref.1
	Sequence conflict	1028	1	P → R in AAH47378. Ref.4
	Sequence conflict	1271	1	P → H in AAH47378. Ref.4
	Sequence conflict	1324	1	P → R in AAH47378. Ref.4
	Sequence conflict	1360	1	K → E in AAH47378. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: AD46BD688AF7103E	FASTA	1,374	144,569
	10 20 30 40 50 60 MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML ACLCCKKGGI 70 80 90 100 110 120 GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV SLPMAKQPGR SVQLLKSTDV 130 140 150 160 170 180 GRHSLLYLKE IGRGWFGKVF LGEVNSGISS AQVVVKELQA SASVQEQMQF LEEVQPYRAL 190 200 210 220 230 240 KHSNLLQCLA QCAEVTPYLL VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG 250 260 270 280 290 300 VLHLHRNNFV HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE 310 320 330 340 350 360 LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT VREQQLKLPK 370 380 390 400 410 420 PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA KGATEAEEEF ERRWRSLRPG 430 440 450 460 470 480 GGGVGPGPGA AGPMLGGVVE LAAASSFPLL EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK 490 500 510 520 530 540 WEAGRGAEAF PATLSPGRTA RLQELCAPDG APPGVVPVLS AHSPSLGSEY FIRLEEAAPA 550 560 570 580 590 600 AGHDPDCAGC APSPPATADQ DDDSDGSTAA SLAMEPLLGH GPPVDVPWGR GDHYPRRSLA 610 620 630 640 650 660 RDPLCPSRSP SPSAGPLSLA EGGAEDADWG VAAFCPAFFE DPLGTSPLGS SGAPPLPLTG 670 680 690 700 710 720 EDELEEVGAR RAAQRGHWRS NVSANNNSGS RCPESWDPVS AGGHAEGCPS PKQTPRASPE 730 740 750 760 770 780 PGYPGEPLLG LQAASAQEPG CCPGLPHLCS AQGLAPAPCL VTPSWTETAS SGGDHPQAEP 790 800 810 820 830 840 KLATEAEGTT GPRLPLPSVP SPSQEGAPLP SEEASAPDAP DALPDSPTPA TGGEVSAIKL 850 860 870 880 890 900 ASALNGSSSS PEVEAPSSED EDTAEATSGI FTDTSSDGLQ ARRPDVVPAF RSLQKQVGTP 910 920 930 940 950 960 DSLDSLDIPS SASDGGYEVF SPSATGPSGG QPRALDSGYD TENYESPEFV LKEAQEGCEP 970 980 990 1000 1010 1020 QAFAELASEG EGPGPETRLS TSLSGLNEKN PYRDSAYFSD LEAEAEATSG PEKKCGGDRA 1030 1040 1050 1060 1070 1080 PGPELGLPST GQPSEQVCLR PGVSGEAQGS GPGEVLPPLL QLEGSSPEPS TCPSGLVPEP 1090 1100 1110 1120 1130 1140 PEPQGPAKVR PGPSPSCSQF FLLTPVPLRS EGNSSEFQGP PGLLSGPAPQ KRMGGPGTPR 1150 1160 1170 1180 1190 1200 APLRLALPGL PAALEGRPEE EEEDSEDSDE SDEELRCYSV QEPSEDSEEE APAVPVVVAE 1210 1220 1230 1240 1250 1260 SQSARNLRSL LKMPSLLSET FCEDLERKKK AVSFFDDVTV YLFDQESPTR ELGEPFPGAK 1270 1280 1290 1300 1310 1320 ESPPTFLRGS PGSPSAPNRP QQADGSPNGS TAEEGGGFAW DDDFPLMTAK AAFAMALDPA 1330 1340 1350 1360 1370 APAPAAPTPT PAPFSRFTVS PAPTSRFSIT HVSDSDAESK RGPEAGAGGE SKEA
	Isoform 2 (hAATYKs-p35BP) [UniParc]. Checksum: 38EA067D9AA55653	FASTA	446	45,358
	10 20 30 40 50 60 MLGGVVELAA ASSFPLLEQF AGDGFHADGD DVLTELCAPD GAPPGVVPVL SAHSPSLGSE 70 80 90 100 110 120 YFIRLEEAAP AAGHDPDCAG CAPSPPATAD QDDDSDGSTA ASLAMEPLLG HGPPVDVPWG 130 140 150 160 170 180 RGDHYPRRSL ARDPLCPSRS PSPSAGPLSL AEGGAEDADW GVAAFCPAFF EDPLGTSPLG 190 200 210 220 230 240 SSGAPPLPLT GEDELEEVGA RRAAQRGHWR SNVSANNNSG SRCPESWDPV SAGGHAEGCP 250 260 270 280 290 300 SPKQTPRASP EPGYPGEPLL GLQAASAQEP GCCPGLPHLC SAQGLAPAPC LVTPSWTETA 310 320 330 340 350 360 SSGGDHPQAE PKLATEAEGT TGPRLPLPSV PSPSQEGAPL PSEEASAPDA PDALPDSPTP 370 380 390 400 410 420 ATGGEVSAIK LASALNGSSS SPEVEAPSSE DEDTAEATSG IFTDTSSDGL QARRPDVVPA 430 440 FRSLQKQWPQ REESLPRLCL LLRPRG
	Isoform 3 [UniParc]. Checksum: B31470ED8B3E5E78	FASTA	879	93,226
	10 20 30 40 50 60 MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML ACLCCKKGGI 70 80 90 100 110 120 GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV SLPMAKQPGR SVQLLKSTDV 130 140 150 160 170 180 GRHSLLYLKE IGRGWFGKVF LGEVNSGISS AQVVVKELQA SASVQEQMQF LEEVQPYRAL 190 200 210 220 230 240 KHSNLLQCLA QCAEVTPYLL VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG 250 260 270 280 290 300 VLHLHRNNFV HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE 310 320 330 340 350 360 LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT VREQQLKLPK 370 380 390 400 410 420 PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA KGATEAEEEF ERRWRSLRPG 430 440 450 460 470 480 GGGVGPGPGA AGPMLGGVVE LAAASSFPLL EQFAGDGFHA DGDDVLTELC APDGAPPGVV 490 500 510 520 530 540 PVLSAHSPSL GSEYFIRLEE AAPAAGHDPD CAGCAPSPPA TADQDDDSDG STAASLAMEP 550 560 570 580 590 600 LLGHGPPVDV PWGRGDHYPR RSLARDPLCP SRSPSPSAGP LSLAEGGAED ADWGVAAFCP 610 620 630 640 650 660 AFFEDPLGTS PLGSSGAPPL PLTGEDELEE VGARRAAQRG HWRSNVSANN NSGSRCPESW 670 680 690 700 710 720 DPVSAGGHAE GCPSPKQTPR ASPEPGYPGE PLLGLQAASA QEPGCCPGLP HLCSAQGLAP 730 740 750 760 770 780 APCLVTPSWT ETASSGGDHP QAEPKLATEA EGTTGPRLPL PSVPSPSQEG APLPSEEASA 790 800 810 820 830 840 PDAPDALPDS PTPATGGEVS AIKLASALNG SSSSPEVEAP SSEDEDTAEA TSGIFTDTSS 850 860 870 DGLQARRPDV VPAFRSLQKQ WPQREESLPR LCLLLRPRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT CYS-703. Tissue: Cerebellum and Thalamus.
[2]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-1374 (ISOFORM 1), VARIANT CYS-703. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 786-1374 (ISOFORM 1), VARIANT SER-1266. Tissue: Brain.
[5]	"Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein." Honma N., Asada A., Takeshita S., Enomoto M., Yamakawa E., Tsutsumi K., Saito T., Satoh T., Itoh H., Kaziro Y., Kishimoto T., Hisanaga S. Biochem. Biophys. Res. Commun. 310:398-404(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 2), INTERACTION WITH CDK5, PHOSPHORYLATION.
[6]	"A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line." Raghunath M., Patti R., Bannerman P., Lee C.M., Baker S., Sutton L.N., Phillips P.C., Damodar Reddy C. Brain Res. Mol. Brain Res. 77:151-162(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
[7]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PHE-81; VAL-97; VAL-104; CYS-703; ARG-815; LEU-923; LYS-1160; SER-1192; SER-1266 AND THR-1332.
+	Additional computationally mapped references.

Web resources

CGP resequencing studies

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK131395 mRNA. Translation: BAD18544.1. AK131529 mRNA. Translation: BAD18667.1. AB014541 mRNA. Translation: BAA31616.2. BC047378 mRNA. Translation: AAH47378.1.
IPI	IPI00784827. IPI00797912. IPI00883789.
RefSeq	NP_001073864.2. NM_001080395.2. NP_004911.2. NM_004920.2.
UniGene	Hs.514575.
3D structure databases
HSSP	HSSP built from PDB template 1JQH based on UniProtKB P08069.
ProteinModelPortal	Q6ZMQ8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZMQ8. 5 interactions.
STRING	9606.ENSP00000324196.
PTM databases
PhosphoSite	Q6ZMQ8.
Polymorphism databases
DMDM	114149222.
Proteomic databases
PaxDb	Q6ZMQ8.
PRIDE	Q6ZMQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326724; ENSP00000324196; ENSG00000181409. ENST00000374792; ENSP00000363924; ENSG00000181409.
GeneID	9625.
KEGG	hsa:9625.
UCSC	uc010dia.3. human.
Organism-specific databases
CTD	9625.
GeneCards	GC17M079091.
HGNC	HGNC:21. AATK.
HPA	HPA009073.
MIM	605276. gene.
neXtProt	NX_Q6ZMQ8.
PharmGKB	PA24370.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000049266.
HOVERGEN	HBG080533.
InParanoid	Q6ZMQ8.
OMA	ESQSARN.
OrthoDB	EOG4N5VW8.
Gene expression databases
ArrayExpress	Q6ZMQ8.
Bgee	Q6ZMQ8.
CleanEx	HS_AATK.
Genevestigator	Q6ZMQ8.
GermOnline	ENSG00000181409. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9625.
NextBio	36117.
SOURCE	Search...

Entry information

Entry name

LMTK1_HUMAN

Accession

Primary (citable) accession number: Q6ZMQ8
Secondary accession number(s): O75136, Q6ZN31, Q86X28

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.