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Protein

Cyclin-I2

Gene

CCNI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Cyclin

Enzyme and pathway databases

SignaLinkiQ6ZMN8.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-I2
Gene namesi
Name:CCNI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:33869. CCNI2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381968.

Polymorphism and mutation databases

DMDMi74749548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Cyclin-I2PRO_0000335821Add
BLAST

Proteomic databases

PaxDbiQ6ZMN8.
PRIDEiQ6ZMN8.

PTM databases

PhosphoSiteiQ6ZMN8.

Expressioni

Gene expression databases

BgeeiQ6ZMN8.
CleanExiHS_CCNI2.

Organism-specific databases

HPAiHPA056288.

Interactioni

Protein-protein interaction databases

BioGridi570168. 6 interactions.
STRINGi9606.ENSP00000368005.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMN8.
SMRiQ6ZMN8. Positions 156-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000111450.
HOVERGENiHBG050841.
InParanoidiQ6ZMN8.
OMAiLWRGGKP.
OrthoDBiEOG74N5GQ.
PhylomeDBiQ6ZMN8.
TreeFamiTF101007.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028861. CCNI2.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF57. PTHR10177:SF57. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGAQLPPQ PSSSEVSAVQ SPGGRPGAGL EETALGVPLP PSPGEAPLPR
60 70 80 90 100
SNRSRCPGTR QPGAASLHAA SAAVPVRPRR GTAPAGKTAD AVPAAAPEQA
110 120 130 140 150
PRPAPQSRKP RNLEGDLDER RLLCHLQLAQ DREARLWRGG KPQDEICDAF
160 170 180 190 200
EEVVLWLLRL QNTFYFSQST FNLALTIFGR LLISVKVKEK YLHCATITSL
210 220 230 240 250
RLAAKVNEEE EFIPQVKDFT KHYGSDYSPN ELLRMELAIL DRLHWDLYIG
260 270 280 290 300
TPLDFLTIFH ALVVLSWPHV LELLPQRNPS LHVASLTRQL QHCMAGHQLL
310 320 330 340 350
QFKGSTLALV IITLELERLM PGWCAPISDL LKKAQVGDMQ YSCCKELVMQ
360
QLRSLQSSSC TDNFVSPAN
Length:369
Mass (Da):40,622
Last modified:July 5, 2004 - v1
Checksum:i68B887A9C0044708
GO
Isoform 2 (identifier: Q6ZMN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: I → IEKYGVFCSNIKNHGLQ

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):42,441
Checksum:i3263E903B4AF7236
GO
Isoform 3 (identifier: Q6ZMN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-143: Q → QQ

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):40,750
Checksum:i4F73E6EB1B3805C7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911A → P.
Corresponds to variant rs803056 [ dbSNP | Ensembl ].
VAR_043471

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei143 – 1431Q → QQ in isoform 3. 1 PublicationVSP_057179
Alternative sequencei258 – 2581I → IEKYGVFCSNIKNHGLQ in isoform 2. 1 PublicationVSP_057180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131553 mRNA. Translation: BAD18687.1.
BC132837 mRNA. Translation: AAI32838.1.
BC136836 mRNA. Translation: AAI36837.1.
BC144416 mRNA. Translation: AAI44417.1.
BC144417 mRNA. Translation: AAI44418.1.
CCDSiCCDS34236.1. [Q6ZMN8-1]
CCDS75297.1. [Q6ZMN8-2]
RefSeqiNP_001034869.1. NM_001039780.3. [Q6ZMN8-1]
NP_001274181.1. NM_001287252.1. [Q6ZMN8-2]
NP_001274182.1. NM_001287253.1. [Q6ZMN8-3]
UniGeneiHs.522057.
Hs.714496.

Genome annotation databases

EnsembliENST00000378731; ENSP00000368005; ENSG00000205089. [Q6ZMN8-1]
ENST00000614847; ENSP00000478257; ENSG00000205089. [Q6ZMN8-2]
GeneIDi645121.
KEGGihsa:645121.
UCSCiuc003kxq.3. human. [Q6ZMN8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131553 mRNA. Translation: BAD18687.1.
BC132837 mRNA. Translation: AAI32838.1.
BC136836 mRNA. Translation: AAI36837.1.
BC144416 mRNA. Translation: AAI44417.1.
BC144417 mRNA. Translation: AAI44418.1.
CCDSiCCDS34236.1. [Q6ZMN8-1]
CCDS75297.1. [Q6ZMN8-2]
RefSeqiNP_001034869.1. NM_001039780.3. [Q6ZMN8-1]
NP_001274181.1. NM_001287252.1. [Q6ZMN8-2]
NP_001274182.1. NM_001287253.1. [Q6ZMN8-3]
UniGeneiHs.522057.
Hs.714496.

3D structure databases

ProteinModelPortaliQ6ZMN8.
SMRiQ6ZMN8. Positions 156-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi570168. 6 interactions.
STRINGi9606.ENSP00000368005.

PTM databases

PhosphoSiteiQ6ZMN8.

Polymorphism and mutation databases

DMDMi74749548.

Proteomic databases

PaxDbiQ6ZMN8.
PRIDEiQ6ZMN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378731; ENSP00000368005; ENSG00000205089. [Q6ZMN8-1]
ENST00000614847; ENSP00000478257; ENSG00000205089. [Q6ZMN8-2]
GeneIDi645121.
KEGGihsa:645121.
UCSCiuc003kxq.3. human. [Q6ZMN8-1]

Organism-specific databases

CTDi645121.
GeneCardsiCCNI2.
HGNCiHGNC:33869. CCNI2.
HPAiHPA056288.
neXtProtiNX_Q6ZMN8.
PharmGKBiPA162381968.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000111450.
HOVERGENiHBG050841.
InParanoidiQ6ZMN8.
OMAiLWRGGKP.
OrthoDBiEOG74N5GQ.
PhylomeDBiQ6ZMN8.
TreeFamiTF101007.

Enzyme and pathway databases

SignaLinkiQ6ZMN8.

Miscellaneous databases

GenomeRNAii645121.
NextBioi117099.
PROiQ6ZMN8.

Gene expression databases

BgeeiQ6ZMN8.
CleanExiHS_CCNI2.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028861. CCNI2.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF57. PTHR10177:SF57. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiCCNI2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMN8
Secondary accession number(s): B2RNE2, B7ZMB7, B7ZMB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.