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Protein

ADAMTS-like protein 5

Gene

ADAMTSL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

GO - Molecular functioni

  • heparin binding Source: UniProtKB

Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 5
Short name:
ADAMTSL-5
Alternative name(s):
Thrombospondin type-1 domain-containing protein 6
Gene namesi
Name:ADAMTSL5
Synonyms:THSD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:27912 ADAMTSL5
neXtProtiNX_Q6ZMM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi339366
PharmGKBiPA134867057

Polymorphism and mutation databases

DMDMi557952602

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000024958243 – 481ADAMTS-like protein 5Add BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 91By similarity
Disulfide bondi61 ↔ 96By similarity
Disulfide bondi72 ↔ 81By similarity
Glycosylationi218N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi360 ↔ 425By similarity
Disulfide bondi363 ↔ 427By similarity
Disulfide bondi377 ↔ 479By similarity

Post-translational modificationi

Proteolytically cleaved to release a C-terminal fragment containing the NTR domain.
Contains at least one additional N-linked glycosylation site.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZMM2
PeptideAtlasiQ6ZMM2
PRIDEiQ6ZMM2
ProteomicsDBi67891
TopDownProteomicsiQ6ZMM2-2 [Q6ZMM2-2]

PTM databases

iPTMnetiQ6ZMM2

Expressioni

Gene expression databases

CleanExiHS_ADAMTSL5

Organism-specific databases

HPAiHPA044050

Interactioni

Subunit structurei

Interacts with heparin, FBN1 and FBN2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130874, 5 interactors
IntActiQ6ZMM2, 6 interactors
STRINGi9606.ENSP00000327608

Structurei

3D structure databases

ProteinModelPortaliQ6ZMM2
SMRiQ6ZMM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 97TSP type-1PROSITE-ProRule annotationAdd BLAST53
Domaini360 – 479NTRPROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
HOGENOMiHOG000034177
HOVERGENiHBG080880
InParanoidiQ6ZMM2
PhylomeDBiQ6ZMM2
TreeFamiTF351486

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008993 TIMP-like_OB-fold
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01759 NTR, 1 hit
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS50189 NTR, 1 hit
PS50092 TSP1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKLRPGRVE WLASGHTERP HLFQNLLLFL WALLNCGLGV SAQGPGEWTP
60 70 80 90 100
WVSWTRCSSS CGRGVSVRSR RCLRLPGEEP CWGDSHEYRL CQLPDCPPGA
110 120 130 140 150
VPFRDLQCAL YNGRPVLGTQ KTYQWVPFHG APNQCDLNCL AEGHAFYHSF
160 170 180 190 200
GRVLDGTACS PGAQGVCVAG RCLSAGCDGL LGSGALEDRC GRCGGANDSC
210 220 230 240 250
LFVQRVFRDA GAFAGYWNVT LIPEGARHIR VEHRSRNHLA LMGGDGRYVL
260 270 280 290 300
NGHWVVSPPG TYEAAGTHVV YTRDTGPQET LQAAGPTSHD LLLQVLLQEP
310 320 330 340 350
NPGIEFEFWL PRERYSPFQA RVQALGWPLR QPQPRGVEPQ PPAAPAVTPA
360 370 380 390 400
QTPTLAPDPC PPCPDTRGRA HRLLHYCGSD FVFQARVLGH HHQAQETRYE
410 420 430 440 450
VRIQLVYKNR SPLRAREYVW APGHCPCPML APHRDYLMAV QRLVSPDGTQ
460 470 480
DQLLLPHAGY ARPWSPAEDS RIRLTARRCP G
Note: Major.
Length:481
Mass (Da):53,193
Last modified:November 13, 2013 - v3
Checksum:i8E0FDBBD63993F57
GO
Isoform 2 (identifier: Q6ZMM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-18: WLASGHTE → MDSAPLFP

Note: Minor.
Show »
Length:481
Mass (Da):53,171
Checksum:i767D3E470E274255
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197N → D in BAD18703 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05335811 – 18WLASGHTE → MDSAPLFP in isoform 2. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131571 mRNA Translation: BAD18703.1
AK302020 mRNA Translation: BAG63419.1
AC027307 Genomic DNA No translation available.
BC040620 mRNA Translation: AAH40620.1
RefSeqiNP_998769.2, NM_213604.2
XP_005259606.1, XM_005259549.3 [Q6ZMM2-1]
UniGeneiHs.371674

Genome annotation databases

EnsembliENST00000413997; ENSP00000399364; ENSG00000185761
GeneIDi339366
KEGGihsa:339366

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATL5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMM2
Secondary accession number(s): B4DXK7, Q8IW95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 13, 2013
Last modified: June 20, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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