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Reviewed, UniProtKB/Swiss-Prot Q6ZMM2 (ATL5_HUMAN)

Last modified November 24, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADAMTS-like protein 5
      Short name=ADAMTSL-5
Alternative name(s):
    Thrombospondin type-1 domain-containing protein 6
Gene names
Name: ADAMTSL5
Synonyms: THSD6
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 NTR domain.

Contains 1 TSP type-1 domain.

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.

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Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: InterPro

   Molecular functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 471439ADAMTS-like protein 5
PRO_0000249582

Regions

Domain35 – 8753TSP type-1
Domain350 – 469120NTR

Amino acid modifications

Glycosylation2081N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 81 By similarity
Disulfide bond51 ↔ 86 By similarity
Disulfide bond62 ↔ 71 By similarity
Disulfide bond350 ↔ 415 By similarity
Disulfide bond353 ↔ 417 By similarity
Disulfide bond367 ↔ 469 By similarity

Experimental info

Sequence conflict1871N → D in BAD18703. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q6ZMM2-1 [UniParc].

Last modified September 19, 2006. Version 2.
Checksum: 40D904CB48D43D2C

FASTA47152,046
        10         20         30         40         50         60 
MDSAPLFPRP HLFQNLLLFL WALLNCGLGV SAQGPGEWTP WVSWTRCSSS CGRGVSVRSR 

        70         80         90        100        110        120 
RCLRLPGEEP CWGDSHEYRL CQLPDCPPGA VPFRDLQCAL YNGRPVLGTQ KTYQWVPFHG 

       130        140        150        160        170        180 
APNQCDLNCL AEGHAFYHSF GRVLDGTACS PGAQGVCVAG RCLSAGCDGL LGSGALEDRC 

       190        200        210        220        230        240 
GRCGGANDSC LFVQRVFRDA GAFAGYWNVT LIPEGARHIR VEHRSRNHLA LMGGDGRYVL 

       250        260        270        280        290        300 
NGHWVVSPPG TYEAAGTHVV YTRDTGPQET LQAAGPTSHD LLLQVLLQEP NPGIEFEFWL 

       310        320        330        340        350        360 
PRERYSPFQA RVQALGWPLR QPQPRGVEPQ PPAAPAVTPA QTPTLAPDPC PPCPDTRGRA 

       370        380        390        400        410        420 
HRLLHYCGSD FVFQARVLGH HHQAQETRYE VRIQLVYKNR SPLRAREYVW APGHCPCPML 

       430        440        450        460        470 
APHRDYLMAV QRLVSPDGTQ DQLLLPHAGY ARPWSPAEDS RIRLTARRCP G

« Hide

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References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-356.
Tissue: Brain.

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Cross-references

Sequence databases

AK131571 mRNA. Translation: BAD18703.1.
BC040620 mRNA. Translation: AAH40620.1.
IPIIPI00940001.
RefSeqNP_998769.2.
UniGeneHs.371674

3D structure databases

HSSPHSSP built from PDB template 1LSL based on UniProtKB P07996.
ModBaseSearch...

Proteomic databases

PeptideAtlasQ6ZMM2.
PRIDEQ6ZMM2.

Genome annotation databases

EnsemblENST00000330475; ENSP00000327608; ENSG00000185761; Homo sapiens. [Genome view]
GeneID339366.
KEGGhsa:339366.

Organism-specific databases

CTD339366.
GeneCardsGC19M001460.
HGNCHGNC:27912. ADAMTSL5.
GenAtlasSearch...

Phylogenomic databases

OrthoDBEOG90CM2K

Gene expression databases

ArrayExpressQ6ZMM2.
BgeeQ6ZMM2.
CleanExHS_ADAMTSL5.
GenevestigatorQ6ZMM2.
GermOnlineENSG00000185761. Homo sapiens.

Family and domain databases

InterProIPR010294. ADAM_spacer1.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. Thrombospondin_1_rpt.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamPF05986. ADAM_spacer1. 1 hit.
PF01759. NTR. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSPR01857. ADAMTSFAMILY.
SMARTSM00209. TSP1. 1 hit.
[Graphical view]
PROSITEPS50189. NTR. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio97370.

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Entry information

Entry nameATL5_HUMAN
AccessionPrimary (citable) accession number: Q6ZMM2
Secondary accession number(s): Q8IW95
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: November 24, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents