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Protein

ADAMTS-like protein 5

Gene

ADAMTSL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).

GO - Molecular functioni

  • heparin binding Source: UniProtKB
  • metalloendopeptidase activity Source: InterPro
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 5
Short name:
ADAMTSL-5
Alternative name(s):
Thrombospondin type-1 domain-containing protein 6
Gene namesi
Name:ADAMTSL5
Synonyms:THSD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:27912. ADAMTSL5.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • microfibril Source: UniProtKB
  • proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134867057.

Polymorphism and mutation databases

DMDMi557952602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242Sequence analysisAdd
BLAST
Chaini43 – 481439ADAMTS-like protein 5PRO_0000249582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 91By similarity
Disulfide bondi61 ↔ 96By similarity
Disulfide bondi72 ↔ 81By similarity
Glycosylationi218 – 2181N-linked (GlcNAc...)1 Publication
Disulfide bondi360 ↔ 425By similarity
Disulfide bondi363 ↔ 427By similarity
Disulfide bondi377 ↔ 479By similarity

Post-translational modificationi

Proteolytically cleaved to release a C-terminal fragment containing the NTR domain.
Contains at least one additional N-linked glycosylation site.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZMM2.
PeptideAtlasiQ6ZMM2.
PRIDEiQ6ZMM2.
TopDownProteomicsiQ6ZMM2-2. [Q6ZMM2-2]

PTM databases

PhosphoSiteiQ6ZMM2.

Expressioni

Gene expression databases

BgeeiQ6ZMM2.
CleanExiHS_ADAMTSL5.

Organism-specific databases

HPAiHPA044050.

Interactioni

Subunit structurei

Interacts with heparin, FBN1 and FBN2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-10254938,EBI-10173507
NOTCH2NLQ7Z3S93EBI-10254938,EBI-945833

Protein-protein interaction databases

BioGridi130874. 5 interactions.
IntActiQ6ZMM2. 4 interactions.
STRINGi9606.ENSP00000327608.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMM2.
SMRiQ6ZMM2. Positions 46-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 9753TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini360 – 479120NTRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 NTR domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
HOGENOMiHOG000034177.
HOVERGENiHBG080880.
InParanoidiQ6ZMM2.
OrthoDBiEOG7MWGWP.
PhylomeDBiQ6ZMM2.
TreeFamiTF351486.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR008993. TIMP-like_OB-fold.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01759. NTR. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00643. C345C. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKLRPGRVE WLASGHTERP HLFQNLLLFL WALLNCGLGV SAQGPGEWTP
60 70 80 90 100
WVSWTRCSSS CGRGVSVRSR RCLRLPGEEP CWGDSHEYRL CQLPDCPPGA
110 120 130 140 150
VPFRDLQCAL YNGRPVLGTQ KTYQWVPFHG APNQCDLNCL AEGHAFYHSF
160 170 180 190 200
GRVLDGTACS PGAQGVCVAG RCLSAGCDGL LGSGALEDRC GRCGGANDSC
210 220 230 240 250
LFVQRVFRDA GAFAGYWNVT LIPEGARHIR VEHRSRNHLA LMGGDGRYVL
260 270 280 290 300
NGHWVVSPPG TYEAAGTHVV YTRDTGPQET LQAAGPTSHD LLLQVLLQEP
310 320 330 340 350
NPGIEFEFWL PRERYSPFQA RVQALGWPLR QPQPRGVEPQ PPAAPAVTPA
360 370 380 390 400
QTPTLAPDPC PPCPDTRGRA HRLLHYCGSD FVFQARVLGH HHQAQETRYE
410 420 430 440 450
VRIQLVYKNR SPLRAREYVW APGHCPCPML APHRDYLMAV QRLVSPDGTQ
460 470 480
DQLLLPHAGY ARPWSPAEDS RIRLTARRCP G
Note: Major.
Length:481
Mass (Da):53,193
Last modified:November 13, 2013 - v3
Checksum:i8E0FDBBD63993F57
GO
Isoform 2 (identifier: Q6ZMM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-18: WLASGHTE → MDSAPLFP

Note: Minor.
Show »
Length:481
Mass (Da):53,171
Checksum:i767D3E470E274255
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971N → D in BAD18703 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 188WLASGHTE → MDSAPLFP in isoform 2. 2 PublicationsVSP_053358

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131571 mRNA. Translation: BAD18703.1.
AK302020 mRNA. Translation: BAG63419.1.
AC027307 Genomic DNA. No translation available.
BC040620 mRNA. Translation: AAH40620.1.
RefSeqiNP_998769.2. NM_213604.2.
XP_005259606.1. XM_005259549.3. [Q6ZMM2-1]
UniGeneiHs.371674.

Genome annotation databases

EnsembliENST00000413997; ENSP00000399364; ENSG00000185761.
GeneIDi339366.
KEGGihsa:339366.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131571 mRNA. Translation: BAD18703.1.
AK302020 mRNA. Translation: BAG63419.1.
AC027307 Genomic DNA. No translation available.
BC040620 mRNA. Translation: AAH40620.1.
RefSeqiNP_998769.2. NM_213604.2.
XP_005259606.1. XM_005259549.3. [Q6ZMM2-1]
UniGeneiHs.371674.

3D structure databases

ProteinModelPortaliQ6ZMM2.
SMRiQ6ZMM2. Positions 46-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130874. 5 interactions.
IntActiQ6ZMM2. 4 interactions.
STRINGi9606.ENSP00000327608.

PTM databases

PhosphoSiteiQ6ZMM2.

Polymorphism and mutation databases

DMDMi557952602.

Proteomic databases

PaxDbiQ6ZMM2.
PeptideAtlasiQ6ZMM2.
PRIDEiQ6ZMM2.
TopDownProteomicsiQ6ZMM2-2. [Q6ZMM2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000413997; ENSP00000399364; ENSG00000185761.
GeneIDi339366.
KEGGihsa:339366.

Organism-specific databases

CTDi339366.
GeneCardsiADAMTSL5.
HGNCiHGNC:27912. ADAMTSL5.
HPAiHPA044050.
neXtProtiNX_Q6ZMM2.
PharmGKBiPA134867057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
HOGENOMiHOG000034177.
HOVERGENiHBG080880.
InParanoidiQ6ZMM2.
OrthoDBiEOG7MWGWP.
PhylomeDBiQ6ZMM2.
TreeFamiTF351486.

Enzyme and pathway databases

ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii339366.
PROiQ6ZMM2.

Gene expression databases

BgeeiQ6ZMM2.
CleanExiHS_ADAMTSL5.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR008993. TIMP-like_OB-fold.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01759. NTR. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00643. C345C. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis and Uterus.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-366 (ISOFORM 2).
    Tissue: Brain.
  4. "A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module."
    Bader H.L., Wang L.W., Ho J.C., Tran T., Holden P., Fitzgerald J., Atit R.P., Reinhardt D.P., Apte S.S.
    Matrix Biol. 31:398-411(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, HEPARIN-BINDING, INTERACTION WITH FBN1 AND FBN2, GLYCOSYLATION AT ASN-218.

Entry informationi

Entry nameiATL5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMM2
Secondary accession number(s): B4DXK7, Q8IW95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 13, 2013
Last modified: June 8, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.