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Protein

Cysteine and histidine-rich protein 1

Gene

CYHR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 114RING-type; degenerateAdd BLAST47
Zinc fingeri110 – 183TRAF-typePROSITE-ProRule annotationAdd BLAST74

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and histidine-rich protein 1
Gene namesi
Name:CYHR1
Synonyms:KIAA0496
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:17806. CYHR1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187954.
PharmGKBiPA27081.

Polymorphism and mutation databases

BioMutaiCYHR1.
DMDMi182641989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288521 – 362Cysteine and histidine-rich protein 1Add BLAST362

Proteomic databases

MaxQBiQ6ZMK1.
PaxDbiQ6ZMK1.
PeptideAtlasiQ6ZMK1.
PRIDEiQ6ZMK1.

PTM databases

iPTMnetiQ6ZMK1.
PhosphoSitePlusiQ6ZMK1.

Expressioni

Gene expression databases

BgeeiENSG00000187954.
CleanExiHS_CYHR1.
ExpressionAtlasiQ6ZMK1. baseline and differential.
GenevisibleiQ6ZMK1. HS.

Organism-specific databases

HPAiHPA053653.
HPA059543.

Interactioni

Subunit structurei

Interacts with LGALS3.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119101. 30 interactors.
IntActiQ6ZMK1. 9 interactors.
STRINGi9606.ENSP00000387426.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CYHR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 114RING-type; degenerateAdd BLAST47
Zinc fingeri110 – 183TRAF-typePROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3002. Eukaryota.
ENOG410XVP0. LUCA.
GeneTreeiENSGT00390000018258.
HOGENOMiHOG000006931.
HOVERGENiHBG071683.
InParanoidiQ6ZMK1.
PhylomeDBiQ6ZMK1.
TreeFamiTF324281.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR008974. TRAF-like.
IPR013083. Znf_RING/FYVE/PHD.
IPR001293. Znf_TRAF.
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiView protein in PROSITE
PS50145. ZF_TRAF. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKPGAEWS TALSHLVLGV VSLHAAVSTA EASRGAAAGF LLQVLAATTT
60 70 80 90 100
LAPGLSTHED CLAGAWVATV IGLPLLAFDF HWCTNGHLMC AGCFIHLLAD
110 120 130 140 150
ARLKEEQATC PNCRCEISKS LCCRNLAVEK AVSELPSECG FCLRQFPRSL
160 170 180 190 200
LERHQKEECQ DRVTQCKYKR IGCPWHGPFH ELTVHEAACA HPTKTGSELM
210 220 230 240 250
EILDGMDQSH RKEMQLYNSI FSLLSFEKIG YTEVQFRPYR TDDFITRLYY
260 270 280 290 300
ETPRFTVLNQ TWVLKARVND SERNPNLSCK RTLSFQLLLK SKVTAPLECS
310 320 330 340 350
FLLLKGPYDD VRISPVIYHF VFTNESNETD YVPLPIIDSV ECNKLLAAKN
360
INLRLFLFQI QK
Length:362
Mass (Da):40,703
Last modified:April 8, 2008 - v2
Checksum:i2409CCF532C6C868
GO
Isoform 2 (identifier: Q6ZMK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,760
Checksum:i9FD5C02DBB6DE4D5
GO
Isoform 3 (identifier: Q6ZMK1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-362: CTNGHLMCAG...LRLFLFQIQK → VNGDRSSANL...ALHTQRLQWE

Show »
Length:192
Mass (Da):19,949
Checksum:i9FF840F39E5354F3
GO
Isoform 4 (identifier: Q6ZMK1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     233-362: EVQFRPYRTD...LRLFLFQIQK → GEAPRRLLHA...TPRSRRQAGD

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,766
Checksum:i57AB92448DFF67EB
GO

Sequence cautioni

The sequence BAD18724 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0328181 – 88Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_03281983 – 362CTNGH…FQIQK → VNGDRSSANLLLGGGMVLAV AGGHLGPEGRSVAGQAMLLV VAVTILIVAVFTANTYGMWG GAMLGVAGLLSRLEEDRLLL LPKEDVCRWALAVGSWAYCR ALHTQRLQWE in isoform 3. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_032820233 – 362EVQFR…FQIQK → GEAPRRLLHATQVWVGGLAA RSLGAAGSGHWALTAPDSRA LDKLPVDRWTPRSRRQAGD in isoform 4. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007965 mRNA. No translation available.
AK094514 mRNA. Translation: BAG52882.1.
AK160381 mRNA. Translation: BAD18724.1. Different initiation.
CH471162 Genomic DNA. Translation: EAW82088.1.
CH471162 Genomic DNA. Translation: EAW82089.1.
CH471162 Genomic DNA. Translation: EAW82091.1.
BC004544 mRNA. Translation: AAH04544.2.
BC005073 mRNA. Translation: AAH05073.1.
BC065484 mRNA. Translation: AAH65484.1.
CCDSiCCDS47943.1. [Q6ZMK1-1]
CCDS6426.1. [Q6ZMK1-3]
RefSeqiNP_001123360.1. NM_001129888.1. [Q6ZMK1-3]
NP_001317547.1. NM_001330618.1.
NP_116076.1. NM_032687.3. [Q6ZMK1-3]
NP_612505.1. NM_138496.1. [Q6ZMK1-1]
XP_006716623.1. XM_006716560.3. [Q6ZMK1-3]
XP_006716624.1. XM_006716561.3. [Q6ZMK1-3]
XP_011515353.1. XM_011517051.1. [Q6ZMK1-2]
UniGeneiHs.459379.

Genome annotation databases

EnsembliENST00000306145; ENSP00000304826; ENSG00000187954. [Q6ZMK1-3]
ENST00000403000; ENSP00000385962; ENSG00000187954. [Q6ZMK1-3]
ENST00000424149; ENSP00000414647; ENSG00000187954. [Q6ZMK1-3]
ENST00000438911; ENSP00000387426; ENSG00000187954. [Q6ZMK1-1]
GeneIDi50626.
KEGGihsa:50626.
UCSCiuc003zcv.3. human. [Q6ZMK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCYHR1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMK1
Secondary accession number(s): B3KSX0
, D3DWM3, Q9BSF6, Q9BSU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: August 30, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families