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Protein

Cysteine and histidine-rich protein 1

Gene

CYHR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 11447RING-type; degenerateAdd
BLAST
Zinc fingeri110 – 18374TRAF-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and histidine-rich protein 1
Gene namesi
Name:CYHR1
Synonyms:KIAA0496
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:17806. CYHR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27081.

Polymorphism and mutation databases

BioMutaiCYHR1.
DMDMi182641989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Cysteine and histidine-rich protein 1PRO_0000328852Add
BLAST

Proteomic databases

MaxQBiQ6ZMK1.
PaxDbiQ6ZMK1.
PeptideAtlasiQ6ZMK1.
PRIDEiQ6ZMK1.

PTM databases

iPTMnetiQ6ZMK1.
PhosphoSiteiQ6ZMK1.

Expressioni

Gene expression databases

BgeeiQ6ZMK1.
CleanExiHS_CYHR1.
ExpressionAtlasiQ6ZMK1. baseline and differential.
GenevisibleiQ6ZMK1. HS.

Organism-specific databases

HPAiHPA053653.
HPA059543.

Interactioni

Subunit structurei

Interacts with LGALS3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KPNA4O006293EBI-3908824,EBI-396343

Protein-protein interaction databases

BioGridi119101. 26 interactions.
IntActiQ6ZMK1. 3 interactions.
STRINGi9606.ENSP00000387426.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CYHR1 family.Curated
Contains 1 RING-type zinc finger.Curated
Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 11447RING-type; degenerateAdd
BLAST
Zinc fingeri110 – 18374TRAF-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3002. Eukaryota.
ENOG410XVP0. LUCA.
GeneTreeiENSGT00390000018258.
HOGENOMiHOG000006931.
HOVERGENiHBG071683.
InParanoidiQ6ZMK1.
OrthoDBiEOG7JHM5S.
PhylomeDBiQ6ZMK1.
TreeFamiTF324281.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008974. TRAF-like.
IPR013083. Znf_RING/FYVE/PHD.
IPR001293. Znf_TRAF.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKPGAEWS TALSHLVLGV VSLHAAVSTA EASRGAAAGF LLQVLAATTT
60 70 80 90 100
LAPGLSTHED CLAGAWVATV IGLPLLAFDF HWCTNGHLMC AGCFIHLLAD
110 120 130 140 150
ARLKEEQATC PNCRCEISKS LCCRNLAVEK AVSELPSECG FCLRQFPRSL
160 170 180 190 200
LERHQKEECQ DRVTQCKYKR IGCPWHGPFH ELTVHEAACA HPTKTGSELM
210 220 230 240 250
EILDGMDQSH RKEMQLYNSI FSLLSFEKIG YTEVQFRPYR TDDFITRLYY
260 270 280 290 300
ETPRFTVLNQ TWVLKARVND SERNPNLSCK RTLSFQLLLK SKVTAPLECS
310 320 330 340 350
FLLLKGPYDD VRISPVIYHF VFTNESNETD YVPLPIIDSV ECNKLLAAKN
360
INLRLFLFQI QK
Length:362
Mass (Da):40,703
Last modified:April 8, 2008 - v2
Checksum:i2409CCF532C6C868
GO
Isoform 2 (identifier: Q6ZMK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,760
Checksum:i9FD5C02DBB6DE4D5
GO
Isoform 3 (identifier: Q6ZMK1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-362: CTNGHLMCAG...LRLFLFQIQK → VNGDRSSANL...ALHTQRLQWE

Show »
Length:192
Mass (Da):19,949
Checksum:i9FF840F39E5354F3
GO
Isoform 4 (identifier: Q6ZMK1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     233-362: EVQFRPYRTD...LRLFLFQIQK → GEAPRRLLHA...TPRSRRQAGD

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,766
Checksum:i57AB92448DFF67EB
GO

Sequence cautioni

The sequence BAD18724.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888Missing in isoform 2 and isoform 4. 2 PublicationsVSP_032818Add
BLAST
Alternative sequencei83 – 362280CTNGH…FQIQK → VNGDRSSANLLLGGGMVLAV AGGHLGPEGRSVAGQAMLLV VAVTILIVAVFTANTYGMWG GAMLGVAGLLSRLEEDRLLL LPKEDVCRWALAVGSWAYCR ALHTQRLQWE in isoform 3. 1 PublicationVSP_032819Add
BLAST
Alternative sequencei233 – 362130EVQFR…FQIQK → GEAPRRLLHATQVWVGGLAA RSLGAAGSGHWALTAPDSRA LDKLPVDRWTPRSRRQAGD in isoform 4. 1 PublicationVSP_032820Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007965 mRNA. No translation available.
AK094514 mRNA. Translation: BAG52882.1.
AK160381 mRNA. Translation: BAD18724.1. Different initiation.
CH471162 Genomic DNA. Translation: EAW82088.1.
CH471162 Genomic DNA. Translation: EAW82089.1.
CH471162 Genomic DNA. Translation: EAW82091.1.
BC004544 mRNA. Translation: AAH04544.2.
BC005073 mRNA. Translation: AAH05073.1.
BC065484 mRNA. Translation: AAH65484.1.
CCDSiCCDS47943.1. [Q6ZMK1-1]
CCDS6426.1. [Q6ZMK1-3]
RefSeqiNP_001123360.1. NM_001129888.1. [Q6ZMK1-3]
NP_116076.1. NM_032687.3. [Q6ZMK1-3]
NP_612505.1. NM_138496.1. [Q6ZMK1-1]
XP_006716623.1. XM_006716560.2. [Q6ZMK1-3]
XP_006716624.1. XM_006716561.2. [Q6ZMK1-3]
XP_011515353.1. XM_011517051.1. [Q6ZMK1-2]
UniGeneiHs.459379.

Genome annotation databases

EnsembliENST00000306145; ENSP00000304826; ENSG00000187954. [Q6ZMK1-3]
ENST00000403000; ENSP00000385962; ENSG00000187954. [Q6ZMK1-3]
ENST00000424149; ENSP00000414647; ENSG00000187954. [Q6ZMK1-3]
ENST00000438911; ENSP00000387426; ENSG00000187954. [Q6ZMK1-1]
GeneIDi50626.
KEGGihsa:50626.
UCSCiuc003zcv.3. human. [Q6ZMK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007965 mRNA. No translation available.
AK094514 mRNA. Translation: BAG52882.1.
AK160381 mRNA. Translation: BAD18724.1. Different initiation.
CH471162 Genomic DNA. Translation: EAW82088.1.
CH471162 Genomic DNA. Translation: EAW82089.1.
CH471162 Genomic DNA. Translation: EAW82091.1.
BC004544 mRNA. Translation: AAH04544.2.
BC005073 mRNA. Translation: AAH05073.1.
BC065484 mRNA. Translation: AAH65484.1.
CCDSiCCDS47943.1. [Q6ZMK1-1]
CCDS6426.1. [Q6ZMK1-3]
RefSeqiNP_001123360.1. NM_001129888.1. [Q6ZMK1-3]
NP_116076.1. NM_032687.3. [Q6ZMK1-3]
NP_612505.1. NM_138496.1. [Q6ZMK1-1]
XP_006716623.1. XM_006716560.2. [Q6ZMK1-3]
XP_006716624.1. XM_006716561.2. [Q6ZMK1-3]
XP_011515353.1. XM_011517051.1. [Q6ZMK1-2]
UniGeneiHs.459379.

3D structure databases

ProteinModelPortaliQ6ZMK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119101. 26 interactions.
IntActiQ6ZMK1. 3 interactions.
STRINGi9606.ENSP00000387426.

PTM databases

iPTMnetiQ6ZMK1.
PhosphoSiteiQ6ZMK1.

Polymorphism and mutation databases

BioMutaiCYHR1.
DMDMi182641989.

Proteomic databases

MaxQBiQ6ZMK1.
PaxDbiQ6ZMK1.
PeptideAtlasiQ6ZMK1.
PRIDEiQ6ZMK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306145; ENSP00000304826; ENSG00000187954. [Q6ZMK1-3]
ENST00000403000; ENSP00000385962; ENSG00000187954. [Q6ZMK1-3]
ENST00000424149; ENSP00000414647; ENSG00000187954. [Q6ZMK1-3]
ENST00000438911; ENSP00000387426; ENSG00000187954. [Q6ZMK1-1]
GeneIDi50626.
KEGGihsa:50626.
UCSCiuc003zcv.3. human. [Q6ZMK1-1]

Organism-specific databases

CTDi50626.
GeneCardsiCYHR1.
HGNCiHGNC:17806. CYHR1.
HPAiHPA053653.
HPA059543.
MIMi616635. gene.
neXtProtiNX_Q6ZMK1.
PharmGKBiPA27081.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3002. Eukaryota.
ENOG410XVP0. LUCA.
GeneTreeiENSGT00390000018258.
HOGENOMiHOG000006931.
HOVERGENiHBG071683.
InParanoidiQ6ZMK1.
OrthoDBiEOG7JHM5S.
PhylomeDBiQ6ZMK1.
TreeFamiTF324281.

Miscellaneous databases

ChiTaRSiCYHR1. human.
GenomeRNAii50626.
PROiQ6ZMK1.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZMK1.
CleanExiHS_CYHR1.
ExpressionAtlasiQ6ZMK1. baseline and differential.
GenevisibleiQ6ZMK1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008974. TRAF-like.
IPR013083. Znf_RING/FYVE/PHD.
IPR001293. Znf_TRAF.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex and Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-362 (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiCYHR1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMK1
Secondary accession number(s): B3KSX0
, D3DWM3, Q9BSF6, Q9BSU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.