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Protein

Cysteine and histidine-rich protein 1

Gene

CYHR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 114RING-type; degenerateAdd BLAST47
Zinc fingeri110 – 183TRAF-typePROSITE-ProRule annotationAdd BLAST74

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and histidine-rich protein 1
Gene namesi
Name:CYHR1
Synonyms:KIAA0496
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000187954.12
HGNCiHGNC:17806 CYHR1
MIMi616635 gene
neXtProtiNX_Q6ZMK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187954
PharmGKBiPA27081

Polymorphism and mutation databases

BioMutaiCYHR1
DMDMi182641989

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288521 – 362Cysteine and histidine-rich protein 1Add BLAST362

Proteomic databases

MaxQBiQ6ZMK1
PaxDbiQ6ZMK1
PeptideAtlasiQ6ZMK1
PRIDEiQ6ZMK1

PTM databases

CarbonylDBiQ6ZMK1
iPTMnetiQ6ZMK1
PhosphoSitePlusiQ6ZMK1

Expressioni

Gene expression databases

BgeeiENSG00000187954
CleanExiHS_CYHR1
ExpressionAtlasiQ6ZMK1 baseline and differential
GenevisibleiQ6ZMK1 HS

Organism-specific databases

HPAiHPA053653
HPA059543

Interactioni

Subunit structurei

Interacts with LGALS3.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11910130 interactors.
IntActiQ6ZMK1 9 interactors.
STRINGi9606.ENSP00000387426

Structurei

3D structure databases

ProteinModelPortaliQ6ZMK1
SMRiQ6ZMK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CYHR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 114RING-type; degenerateAdd BLAST47
Zinc fingeri110 – 183TRAF-typePROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3002 Eukaryota
ENOG410XVP0 LUCA
GeneTreeiENSGT00390000018258
HOGENOMiHOG000006931
HOVERGENiHBG071683
InParanoidiQ6ZMK1
PhylomeDBiQ6ZMK1
TreeFamiTF324281

Family and domain databases

Gene3Di3.30.40.101 hit
InterProiView protein in InterPro
IPR008974 TRAF-like
IPR013083 Znf_RING/FYVE/PHD
IPR001293 Znf_TRAF
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50145 ZF_TRAF, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKPGAEWS TALSHLVLGV VSLHAAVSTA EASRGAAAGF LLQVLAATTT
60 70 80 90 100
LAPGLSTHED CLAGAWVATV IGLPLLAFDF HWCTNGHLMC AGCFIHLLAD
110 120 130 140 150
ARLKEEQATC PNCRCEISKS LCCRNLAVEK AVSELPSECG FCLRQFPRSL
160 170 180 190 200
LERHQKEECQ DRVTQCKYKR IGCPWHGPFH ELTVHEAACA HPTKTGSELM
210 220 230 240 250
EILDGMDQSH RKEMQLYNSI FSLLSFEKIG YTEVQFRPYR TDDFITRLYY
260 270 280 290 300
ETPRFTVLNQ TWVLKARVND SERNPNLSCK RTLSFQLLLK SKVTAPLECS
310 320 330 340 350
FLLLKGPYDD VRISPVIYHF VFTNESNETD YVPLPIIDSV ECNKLLAAKN
360
INLRLFLFQI QK
Length:362
Mass (Da):40,703
Last modified:April 8, 2008 - v2
Checksum:i2409CCF532C6C868
GO
Isoform 2 (identifier: Q6ZMK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,760
Checksum:i9FD5C02DBB6DE4D5
GO
Isoform 3 (identifier: Q6ZMK1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-362: CTNGHLMCAG...LRLFLFQIQK → VNGDRSSANL...ALHTQRLQWE

Show »
Length:192
Mass (Da):19,949
Checksum:i9FF840F39E5354F3
GO
Isoform 4 (identifier: Q6ZMK1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     233-362: EVQFRPYRTD...LRLFLFQIQK → GEAPRRLLHA...TPRSRRQAGD

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,766
Checksum:i57AB92448DFF67EB
GO

Sequence cautioni

The sequence BAD18724 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0328181 – 88Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_03281983 – 362CTNGH…FQIQK → VNGDRSSANLLLGGGMVLAV AGGHLGPEGRSVAGQAMLLV VAVTILIVAVFTANTYGMWG GAMLGVAGLLSRLEEDRLLL LPKEDVCRWALAVGSWAYCR ALHTQRLQWE in isoform 3. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_032820233 – 362EVQFR…FQIQK → GEAPRRLLHATQVWVGGLAA RSLGAAGSGHWALTAPDSRA LDKLPVDRWTPRSRRQAGD in isoform 4. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007965 mRNA No translation available.
AK094514 mRNA Translation: BAG52882.1
AK160381 mRNA Translation: BAD18724.1 Different initiation.
CH471162 Genomic DNA Translation: EAW82088.1
CH471162 Genomic DNA Translation: EAW82089.1
CH471162 Genomic DNA Translation: EAW82091.1
BC004544 mRNA Translation: AAH04544.2
BC005073 mRNA Translation: AAH05073.1
BC065484 mRNA Translation: AAH65484.1
CCDSiCCDS47943.1 [Q6ZMK1-1]
CCDS6426.1 [Q6ZMK1-3]
RefSeqiNP_001123360.1, NM_001129888.1 [Q6ZMK1-3]
NP_001317547.1, NM_001330618.1
NP_116076.1, NM_032687.3 [Q6ZMK1-3]
NP_612505.1, NM_138496.1 [Q6ZMK1-1]
XP_006716623.1, XM_006716560.3 [Q6ZMK1-3]
XP_006716624.1, XM_006716561.3 [Q6ZMK1-3]
XP_011515353.1, XM_011517051.1 [Q6ZMK1-2]
UniGeneiHs.459379

Genome annotation databases

EnsembliENST00000306145; ENSP00000304826; ENSG00000187954 [Q6ZMK1-3]
ENST00000403000; ENSP00000385962; ENSG00000187954 [Q6ZMK1-3]
ENST00000424149; ENSP00000414647; ENSG00000187954 [Q6ZMK1-3]
ENST00000438911; ENSP00000387426; ENSG00000187954 [Q6ZMK1-1]
GeneIDi50626
KEGGihsa:50626
UCSCiuc003zcv.3 human [Q6ZMK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCYHR1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMK1
Secondary accession number(s): B3KSX0
, D3DWM3, Q9BSF6, Q9BSU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome