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Q6ZMJ4

- IL34_HUMAN

UniProt

Q6ZMJ4 - IL34_HUMAN

Protein

Interleukin-34

Gene

IL34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.4 Publications

    GO - Molecular functioni

    1. macrophage colony-stimulating factor receptor binding Source: UniProtKB

    GO - Biological processi

    1. inflammatory response Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW
    3. positive regulation of cell proliferation Source: UniProtKB
    4. positive regulation of protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-34
    Short name:
    IL-34
    Gene namesi
    Name:IL34
    Synonyms:C16orf77
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:28529. IL34.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162392024.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 242222Interleukin-34PRO_0000294348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6ZMJ4.
    PRIDEiQ6ZMJ4.

    Expressioni

    Tissue specificityi

    Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.1 Publication

    Gene expression databases

    BgeeiQ6ZMJ4.
    CleanExiHS_IL34.
    GenevestigatoriQ6ZMJ4.

    Organism-specific databases

    HPAiHPA055971.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CSF1R.3 Publications

    Protein-protein interaction databases

    BioGridi126985. 1 interaction.
    DIPiDIP-50037N.
    IntActiQ6ZMJ4. 1 interaction.
    MINTiMINT-2878814.
    STRINGi9606.ENSP00000288098.

    Structurei

    Secondary structure

    1
    242
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 4412
    Helixi47 – 548
    Turni55 – 573
    Beta strandi64 – 663
    Helixi68 – 703
    Helixi74 – 818
    Turni82 – 843
    Helixi87 – 10620
    Helixi116 – 13116
    Turni132 – 1354
    Helixi140 – 15011
    Beta strandi157 – 1593
    Helixi161 – 18020
    Beta strandi181 – 1844
    Turni186 – 1905

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DKCX-ray1.85A/B21-193[»]
    4DKDX-ray3.00A/B21-193[»]
    4DKEX-ray3.00A/B21-193[»]
    4DKFX-ray2.61A/B21-193[»]
    ProteinModelPortaliQ6ZMJ4.
    SMRiQ6ZMJ4. Positions 32-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-34 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46280.
    HOGENOMiHOG000113048.
    HOVERGENiHBG108003.
    InParanoidiQ6ZMJ4.
    OMAiAWLHYLG.
    PhylomeDBiQ6ZMJ4.
    TreeFamiTF337386.

    Family and domain databases

    InterProiIPR020415. IL-34.
    [Graphical view]
    PfamiPF15036. IL34. 1 hit.
    [Graphical view]
    PRINTSiPR01938. INTRLEUKIN34.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZMJ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRGFTWLRY LGIFLGVALG NEPLEMWPLT QNEECTVTGF LRDKLQYRSR    50
    LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS 100
    ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN 150
    APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS 200
    PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LP 242
    Length:242
    Mass (Da):27,482
    Last modified:July 5, 2004 - v1
    Checksum:iD1D8CC74C77AB23F
    GO
    Isoform 2 (identifier: Q6ZMJ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-81: Missing.

    Show »
    Length:241
    Mass (Da):27,354
    Checksum:iE50A531AF64D0DD2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231E → Q.2 Publications
    Corresponds to variant rs8046424 [ dbSNP | Ensembl ].
    VAR_033164
    Natural varianti195 – 1951S → T.
    Corresponds to variant rs7206509 [ dbSNP | Ensembl ].
    VAR_056920

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 811Missing in isoform 2. 1 PublicationVSP_035079

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU599219 mRNA. Translation: ACD13474.1.
    EU636994 mRNA. Translation: ACD13452.1.
    AK172744 mRNA. Translation: BAD18731.1.
    AK314913 mRNA. Translation: BAG37425.1.
    AC020763 Genomic DNA. No translation available.
    CH471241 Genomic DNA. Translation: EAW51801.1.
    BC029804 mRNA. Translation: AAH29804.1.
    CCDSiCCDS10895.1. [Q6ZMJ4-1]
    RefSeqiNP_001166242.1. NM_001172771.1. [Q6ZMJ4-2]
    NP_001166243.1. NM_001172772.1. [Q6ZMJ4-1]
    NP_689669.2. NM_152456.2. [Q6ZMJ4-1]
    UniGeneiHs.461214.

    Genome annotation databases

    EnsembliENST00000288098; ENSP00000288098; ENSG00000157368. [Q6ZMJ4-1]
    ENST00000429149; ENSP00000397863; ENSG00000157368. [Q6ZMJ4-1]
    GeneIDi146433.
    KEGGihsa:146433.
    UCSCiuc002ezh.2. human. [Q6ZMJ4-1]
    uc002ezi.2. human. [Q6ZMJ4-2]

    Polymorphism databases

    DMDMi74710540.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU599219 mRNA. Translation: ACD13474.1 .
    EU636994 mRNA. Translation: ACD13452.1 .
    AK172744 mRNA. Translation: BAD18731.1 .
    AK314913 mRNA. Translation: BAG37425.1 .
    AC020763 Genomic DNA. No translation available.
    CH471241 Genomic DNA. Translation: EAW51801.1 .
    BC029804 mRNA. Translation: AAH29804.1 .
    CCDSi CCDS10895.1. [Q6ZMJ4-1 ]
    RefSeqi NP_001166242.1. NM_001172771.1. [Q6ZMJ4-2 ]
    NP_001166243.1. NM_001172772.1. [Q6ZMJ4-1 ]
    NP_689669.2. NM_152456.2. [Q6ZMJ4-1 ]
    UniGenei Hs.461214.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DKC X-ray 1.85 A/B 21-193 [» ]
    4DKD X-ray 3.00 A/B 21-193 [» ]
    4DKE X-ray 3.00 A/B 21-193 [» ]
    4DKF X-ray 2.61 A/B 21-193 [» ]
    ProteinModelPortali Q6ZMJ4.
    SMRi Q6ZMJ4. Positions 32-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126985. 1 interaction.
    DIPi DIP-50037N.
    IntActi Q6ZMJ4. 1 interaction.
    MINTi MINT-2878814.
    STRINGi 9606.ENSP00000288098.

    Polymorphism databases

    DMDMi 74710540.

    Proteomic databases

    PaxDbi Q6ZMJ4.
    PRIDEi Q6ZMJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288098 ; ENSP00000288098 ; ENSG00000157368 . [Q6ZMJ4-1 ]
    ENST00000429149 ; ENSP00000397863 ; ENSG00000157368 . [Q6ZMJ4-1 ]
    GeneIDi 146433.
    KEGGi hsa:146433.
    UCSCi uc002ezh.2. human. [Q6ZMJ4-1 ]
    uc002ezi.2. human. [Q6ZMJ4-2 ]

    Organism-specific databases

    CTDi 146433.
    GeneCardsi GC16P070680.
    H-InvDB HIX0013203.
    HGNCi HGNC:28529. IL34.
    HPAi HPA055971.
    MIMi 612081. gene.
    neXtProti NX_Q6ZMJ4.
    PharmGKBi PA162392024.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46280.
    HOGENOMi HOG000113048.
    HOVERGENi HBG108003.
    InParanoidi Q6ZMJ4.
    OMAi AWLHYLG.
    PhylomeDBi Q6ZMJ4.
    TreeFami TF337386.

    Miscellaneous databases

    GeneWikii Interleukin_34.
    GenomeRNAii 146433.
    NextBioi 85355.
    PROi Q6ZMJ4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZMJ4.
    CleanExi HS_IL34.
    Genevestigatori Q6ZMJ4.

    Family and domain databases

    InterProi IPR020415. IL-34.
    [Graphical view ]
    Pfami PF15036. IL34. 1 hit.
    [Graphical view ]
    PRINTSi PR01938. INTRLEUKIN34.
    ProtoNeti Search...

    Publicationsi

    1. "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome."
      Lin H., Lee E., Hestir K., Leo C., Huang M., Bosch E., Halenbeck R., Wu G., Zhou A., Behrens D., Hollenbaugh D., Linnemann T., Qin M., Wong J., Chu K., Doberstein S.K., Williams L.T.
      Science 320:807-811(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-123.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-123.
      Tissue: Adipose tissue and Amygdala.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation."
      Chihara T., Suzu S., Hassan R., Chutiwitoonchai N., Hiyoshi M., Motoyoshi K., Kimura F., Okada S.
      Cell Death Differ. 17:1917-1927(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CSF1R.
    7. "Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."
      Eda H., Zhang J., Keith R.H., Michener M., Beidler D.R., Monahan J.B.
      Cytokine 52:215-220(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN RELEASE OF PROINFLAMMATORY CHEMOKINES.
    8. "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells."
      Wei S., Nandi S., Chitu V., Yeung Y.G., Yu W., Huang M., Williams L.T., Lin H., Stanley E.R.
      J. Leukoc. Biol. 88:495-505(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CSF1R.

    Entry informationi

    Entry nameiIL34_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZMJ4
    Secondary accession number(s): B2RC28
    , B2Z4A8, B2ZC70, Q8N6L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3