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Protein

Interleukin-34

Gene

IL34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.4 Publications

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of macrophage differentiation Source: CACAO
  • positive regulation of monocyte differentiation Source: CACAO
  • positive regulation of protein phosphorylation Source: UniProtKB

Keywordsi

Molecular functionCytokine, Growth factor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-449836 Other interleukin signaling
SIGNORiQ6ZMJ4

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-34
Short name:
IL-34
Gene namesi
Name:IL34
Synonyms:C16orf77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000157368.10
HGNCiHGNC:28529 IL34
MIMi612081 gene
neXtProtiNX_Q6ZMJ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi146433
OpenTargetsiENSG00000157368
PharmGKBiPA162392024

Polymorphism and mutation databases

BioMutaiIL34
DMDMi74710540

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029434821 – 242Interleukin-34Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZMJ4
PeptideAtlasiQ6ZMJ4
PRIDEiQ6ZMJ4

Expressioni

Tissue specificityi

Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.1 Publication

Gene expression databases

BgeeiENSG00000157368
CleanExiHS_IL34
ExpressionAtlasiQ6ZMJ4 baseline and differential
GenevisibleiQ6ZMJ4 HS

Interactioni

Subunit structurei

Homodimer. Interacts with CSF1R.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CSF1RP073339EBI-15978980,EBI-2835440

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126985, 1 interactor
DIPiDIP-50037N
IntActiQ6ZMJ4, 3 interactors
STRINGi9606.ENSP00000288098

Structurei

Secondary structure

1242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 44Combined sources12
Helixi47 – 54Combined sources8
Turni55 – 57Combined sources3
Beta strandi64 – 66Combined sources3
Helixi68 – 70Combined sources3
Helixi74 – 81Combined sources8
Turni82 – 84Combined sources3
Helixi87 – 106Combined sources20
Helixi116 – 131Combined sources16
Turni132 – 135Combined sources4
Helixi140 – 150Combined sources11
Beta strandi157 – 159Combined sources3
Helixi161 – 180Combined sources20
Beta strandi181 – 184Combined sources4
Turni186 – 190Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DKCX-ray1.85A/B21-193[»]
4DKDX-ray3.00A/B21-193[»]
4DKEX-ray3.00A/B21-193[»]
4DKFX-ray2.61A/B21-193[»]
ProteinModelPortaliQ6ZMJ4
SMRiQ6ZMJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-34 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX9Y Eukaryota
ENOG410Z6RS LUCA
GeneTreeiENSGT00390000000932
HOGENOMiHOG000113048
HOVERGENiHBG108003
InParanoidiQ6ZMJ4
OMAiCEVPSPQ
OrthoDBiEOG091G0I1D
PhylomeDBiQ6ZMJ4
TreeFamiTF337386

Family and domain databases

Gene3Di1.20.1250.80, 1 hit
InterProiView protein in InterPro
IPR020415 IL-34
IPR038328 IL-34_sf
PANTHERiPTHR28606 PTHR28606, 1 hit
PfamiView protein in Pfam
PF15036 IL34, 1 hit
PRINTSiPR01938 INTRLEUKIN34

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRGFTWLRY LGIFLGVALG NEPLEMWPLT QNEECTVTGF LRDKLQYRSR
60 70 80 90 100
LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS
110 120 130 140 150
ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN
160 170 180 190 200
APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS
210 220 230 240
PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LP
Length:242
Mass (Da):27,482
Last modified:July 5, 2004 - v1
Checksum:iD1D8CC74C77AB23F
GO
Isoform 2 (identifier: Q6ZMJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Missing.

Show »
Length:241
Mass (Da):27,354
Checksum:iE50A531AF64D0DD2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033164123E → Q2 PublicationsCorresponds to variant dbSNP:rs8046424Ensembl.1
Natural variantiVAR_056920195S → T. Corresponds to variant dbSNP:rs7206509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03507981Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU599219 mRNA Translation: ACD13474.1
EU636994 mRNA Translation: ACD13452.1
AK172744 mRNA Translation: BAD18731.1
AK314913 mRNA Translation: BAG37425.1
AC020763 Genomic DNA No translation available.
CH471241 Genomic DNA Translation: EAW51801.1
BC029804 mRNA Translation: AAH29804.1
CCDSiCCDS10895.1 [Q6ZMJ4-1]
RefSeqiNP_001166242.1, NM_001172771.1 [Q6ZMJ4-2]
NP_001166243.1, NM_001172772.1 [Q6ZMJ4-1]
NP_689669.2, NM_152456.2 [Q6ZMJ4-1]
XP_011521204.1, XM_011522902.2 [Q6ZMJ4-1]
XP_011521205.1, XM_011522903.2 [Q6ZMJ4-1]
UniGeneiHs.461214

Genome annotation databases

EnsembliENST00000288098; ENSP00000288098; ENSG00000157368 [Q6ZMJ4-1]
ENST00000429149; ENSP00000397863; ENSG00000157368 [Q6ZMJ4-1]
GeneIDi146433
KEGGihsa:146433
UCSCiuc002ezh.2 human [Q6ZMJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL34_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMJ4
Secondary accession number(s): B2RC28
, B2Z4A8, B2ZC70, Q8N6L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health