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Protein

Scavenger receptor class A member 5

Gene

SCARA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: UniProtKB
  • cellular response to heat Source: Ensembl
  • endocytosis Source: UniProtKB
  • iron ion transmembrane transport Source: UniProtKB
  • protein homotrimerization Source: UniProtKB
  • regulation of blood coagulation Source: UniProtKB
  • regulation of gene expression Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiR-HSA-3000480. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class A member 5UniRule annotation
Alternative name(s):
Scavenger receptor hlg
Gene namesi
Name:SCARA5UniRule annotation
ORF Names:UNQ2938/PRO28700
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28701. SCARA5.

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60CytoplasmicUniRule annotationAdd BLAST60
Transmembranei61 – 81Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd BLAST21
Topological domaini82 – 495ExtracellularUniRule annotationAdd BLAST414

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi286133.
OpenTargetsiENSG00000168079.
PharmGKBiPA142670948.

Polymorphism and mutation databases

BioMutaiSCARA5.
DMDMi74749535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002795181 – 495Scavenger receptor class A member 5Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)UniRule annotation1
Glycosylationi134N-linked (GlcNAc...)UniRule annotation1
Glycosylationi193N-linked (GlcNAc...)UniRule annotation1
Glycosylationi231N-linked (GlcNAc...)UniRule annotation1
Glycosylationi254N-linked (GlcNAc...)UniRule annotation1
Glycosylationi397N-linked (GlcNAc...)UniRule annotation1
Disulfide bondi418 ↔ 482UniRule annotation
Disulfide bondi431 ↔ 492UniRule annotation
Disulfide bondi462 ↔ 472UniRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZMJ2.
PeptideAtlasiQ6ZMJ2.
PRIDEiQ6ZMJ2.

PTM databases

iPTMnetiQ6ZMJ2.
PhosphoSitePlusiQ6ZMJ2.

Expressioni

Gene expression databases

BgeeiENSG00000168079.
CleanExiHS_SCARA5.
GenevisibleiQ6ZMJ2. HS.

Organism-specific databases

HPAiHPA024661.

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

BioGridi130309. 3 interactors.
STRINGi9606.ENSP00000346990.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMJ2.
SMRiQ6ZMJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini305 – 357Collagen-likeUniRule annotationAdd BLAST53
Domaini393 – 493SRCRUniRule annotationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili91 – 111UniRule annotationAdd BLAST21

Sequence similaritiesi

Belongs to the SCARA5 family.UniRule annotation
Contains 1 collagen-like domain.UniRule annotation
Contains 1 SRCR domain.UniRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVR. Eukaryota.
ENOG4111F18. LUCA.
GeneTreeiENSGT00850000132310.
HOGENOMiHOG000085659.
HOVERGENiHBG002473.
InParanoidiQ6ZMJ2.
OMAiMGMRGFK.
OrthoDBiEOG091G02XD.
PhylomeDBiQ6ZMJ2.
TreeFamiTF330855.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
HAMAPiMF_03070. SCARA5. 1 hit.
InterProiIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENKAMYLHT VSDCDTSSIC EDSFDGRSLS KLNLCEDGPC HKRRASICCT
60 70 80 90 100
QLGSLSALKH AVLGLYLLVF LILVGIFILA VSRPRSSPDD LKALTRNVNR
110 120 130 140 150
LNESFRDLQL RLLQAPLQAD LTEQVWKVQD ALQNQSDSLL ALAGAVQRLE
160 170 180 190 200
GALWGLQAQA VQTEQAVALL RDRTGQQSDT AQLELYQLQV ESNSSQLLLR
210 220 230 240 250
RHAGLLDGLA RRVGILGEEL ADVGGVLRGL NHSLSYDVAL HRTRLQDLRV
260 270 280 290 300
LVSNASEDTR RLRLAHVGME LQLKQELAML NAVTEDLRLK DWEHSIALRN
310 320 330 340 350
ISLAKGPPGP KGDQGDEGKE GRPGIPGLPG LRGLPGERGT PGLPGPKGDD
360 370 380 390 400
GKLGATGPMG MRGFKGDRGP KGEKGEKGDR AGDASGVEAP MMIRLVNGSG
410 420 430 440 450
PHEGRVEVYH DRRWGTVCDD GWDKKDGDVV CRMLGFRGVE EVYRTARFGQ
460 470 480 490
GTGRIWMDDV ACKGTEETIF RCSFSKWGVT NCGHAEDASV TCNRH
Length:495
Mass (Da):53,994
Last modified:July 5, 2004 - v1
Checksum:iC37E94B2D2E3F5CF
GO
Isoform 2 (identifier: Q6ZMJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-400: GVEAPMMIRLVNGSG → KDILLGPWDMVLAQG
     401-495: Missing.

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):43,293
Checksum:i4AE238BD2A24ECA5
GO
Isoform 3 (identifier: Q6ZMJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-80: Missing.
     386-400: GVEAPMMIRLVNGSG → KDILLGPWDMVLAQG
     401-495: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):38,702
Checksum:i57B0BFBF6F2CE183
GO
Isoform 4 (identifier: Q6ZMJ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-305: Missing.

Show »
Length:270
Mass (Da):28,871
Checksum:iCC626D37B06F19E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93A → S in AAQ17470 (Ref. 3) Curated1
Sequence conflicti95T → A in AAQ17470 (Ref. 3) Curated1
Sequence conflicti108L → S in AAQ17470 (Ref. 3) Curated1
Sequence conflicti246Q → R in AAQ17470 (Ref. 3) Curated1
Sequence conflicti377K → E in AAQ17470 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05206245A → T.Corresponds to variant rs17058374dbSNPEnsembl.1
Natural variantiVAR_030915316D → H.1 PublicationCorresponds to variant rs17058207dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02347238 – 80Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_02347381 – 305Missing in isoform 4. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_023474386 – 400GVEAP…VNGSG → KDILLGPWDMVLAQG in isoform 2 and isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_023475401 – 495Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358150 mRNA. Translation: AAQ88517.1.
AK172746 mRNA. Translation: BAD18733.1.
AY337579 mRNA. Translation: AAQ17470.1.
BC033153 mRNA. Translation: AAH33153.1.
CCDSiCCDS6064.1. [Q6ZMJ2-1]
RefSeqiNP_776194.2. NM_173833.5. [Q6ZMJ2-1]
UniGeneiHs.591833.

Genome annotation databases

EnsembliENST00000354914; ENSP00000346990; ENSG00000168079. [Q6ZMJ2-1]
ENST00000380385; ENSP00000369746; ENSG00000168079. [Q6ZMJ2-4]
ENST00000518030; ENSP00000430713; ENSG00000168079. [Q6ZMJ2-3]
ENST00000524352; ENSP00000428663; ENSG00000168079. [Q6ZMJ2-2]
GeneIDi286133.
KEGGihsa:286133.
UCSCiuc003xgj.4. human. [Q6ZMJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358150 mRNA. Translation: AAQ88517.1.
AK172746 mRNA. Translation: BAD18733.1.
AY337579 mRNA. Translation: AAQ17470.1.
BC033153 mRNA. Translation: AAH33153.1.
CCDSiCCDS6064.1. [Q6ZMJ2-1]
RefSeqiNP_776194.2. NM_173833.5. [Q6ZMJ2-1]
UniGeneiHs.591833.

3D structure databases

ProteinModelPortaliQ6ZMJ2.
SMRiQ6ZMJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130309. 3 interactors.
STRINGi9606.ENSP00000346990.

PTM databases

iPTMnetiQ6ZMJ2.
PhosphoSitePlusiQ6ZMJ2.

Polymorphism and mutation databases

BioMutaiSCARA5.
DMDMi74749535.

Proteomic databases

PaxDbiQ6ZMJ2.
PeptideAtlasiQ6ZMJ2.
PRIDEiQ6ZMJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354914; ENSP00000346990; ENSG00000168079. [Q6ZMJ2-1]
ENST00000380385; ENSP00000369746; ENSG00000168079. [Q6ZMJ2-4]
ENST00000518030; ENSP00000430713; ENSG00000168079. [Q6ZMJ2-3]
ENST00000524352; ENSP00000428663; ENSG00000168079. [Q6ZMJ2-2]
GeneIDi286133.
KEGGihsa:286133.
UCSCiuc003xgj.4. human. [Q6ZMJ2-1]

Organism-specific databases

CTDi286133.
DisGeNETi286133.
GeneCardsiSCARA5.
HGNCiHGNC:28701. SCARA5.
HPAiHPA024661.
MIMi611306. gene.
neXtProtiNX_Q6ZMJ2.
OpenTargetsiENSG00000168079.
PharmGKBiPA142670948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJVR. Eukaryota.
ENOG4111F18. LUCA.
GeneTreeiENSGT00850000132310.
HOGENOMiHOG000085659.
HOVERGENiHBG002473.
InParanoidiQ6ZMJ2.
OMAiMGMRGFK.
OrthoDBiEOG091G02XD.
PhylomeDBiQ6ZMJ2.
TreeFamiTF330855.

Enzyme and pathway databases

ReactomeiR-HSA-3000480. Scavenging by Class A Receptors.

Miscellaneous databases

GenomeRNAii286133.
PROiQ6ZMJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168079.
CleanExiHS_SCARA5.
GenevisibleiQ6ZMJ2. HS.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
HAMAPiMF_03070. SCARA5. 1 hit.
InterProiIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCAR5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMJ2
Secondary accession number(s): Q6UXZ1, Q7Z4A1, Q8N4Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.