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Protein

Protein phosphatase 1 regulatory subunit 21

Gene

PPP1R21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 21
Alternative name(s):
Coiled-coil domain-containing protein 128
KLRAQ motif-containing protein 1
Gene namesi
Name:PPP1R21
Synonyms:CCDC128, KLRAQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30595. PPP1R21.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722001.

Polymorphism and mutation databases

BioMutaiPPP1R21.
DMDMi74710533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780Protein phosphatase 1 regulatory subunit 21PRO_0000286098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei652 – 6521PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZMI0.
MaxQBiQ6ZMI0.
PaxDbiQ6ZMI0.
PRIDEiQ6ZMI0.

PTM databases

iPTMnetiQ6ZMI0.
PhosphoSiteiQ6ZMI0.

Expressioni

Gene expression databases

BgeeiQ6ZMI0.
CleanExiHS_KLRAQ1.
ExpressionAtlasiQ6ZMI0. baseline and differential.
GenevisibleiQ6ZMI0. HS.

Organism-specific databases

HPAiHPA036791.
HPA036792.

Interactioni

Subunit structurei

Interacts with PPP1CA.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126187. 34 interactions.
IntActiQ6ZMI0. 21 interactions.
MINTiMINT-4860779.
STRINGi9606.ENSP00000294952.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMI0.
SMRiQ6ZMI0. Positions 34-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 207207Sequence analysisAdd
BLAST
Coiled coili556 – 60752Sequence analysisAdd
BLAST
Coiled coili693 – 74250Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4421. Eukaryota.
ENOG410YXM0. LUCA.
GeneTreeiENSGT00390000006820.
HOGENOMiHOG000007280.
HOVERGENiHBG058887.
InParanoidiQ6ZMI0.
KOiK17562.
OMAiVPFNDTK.
OrthoDBiEOG7W6WM3.
PhylomeDBiQ6ZMI0.
TreeFamiTF320535.

Family and domain databases

InterProiIPR019348. KLRAQ/TTKRSYEDQ_C.
IPR019343. Unchr_KLRAQ/TTKRSYEDQ_N.
[Graphical view]
PfamiPF10205. KLRAQ. 1 hit.
PF10212. TTKRSYEDQ. 1 hit.
[Graphical view]
SMARTiSM01254. KLRAQ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ
60 70 80 90 100
SLRKLQQEMD SLTFRNLQLA KRVELLQDEL ALSEPRGKKN KKSGESSSQL
110 120 130 140 150
SQEQKSVFDE DLQKKIEENE RLHIQFFEAD EQHKHVEAEL RSRLATLETE
160 170 180 190 200
AAQHQAVVDG LTRKYMETIE KLQNDKAKLE VKSQTLEKEA KECRLRTEEC
210 220 230 240 250
QLQLKTLHED LSGRLEESLS IINEKVPFND TKYSQYNALN VPLHNRRHQL
260 270 280 290 300
KMRDIAGQAL AFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF
310 320 330 340 350
SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI
360 370 380 390 400
CFLRKILPYQ LKSLEEECES SLCTSALRAR NLELSQDMKK MTAVFEKLQT
410 420 430 440 450
YIALLALPST EPDGLLRTNY SSVLTNVGAA LHGFHDVMKD ISKHYSQKAA
460 470 480 490 500
IEHELPTATQ KLITTNDCIL SSVVALTNGA GKIASFFSNN LDYFIASLSY
510 520 530 540 550
GPKAASGFIS PLSAECMLQY KKKAAAYMKS LRKPLLESVP YEEALANRRI
560 570 580 590 600
LLSSTESREG LAQQVQQSLE KISKLEQEKE HWMLEAQLAK IKLEKENQRI
610 620 630 640 650
ADKLKNTGSA QLVGLAQENA AVSNTAGQDE ATAKAVLEPI QSTSLIGTLT
660 670 680 690 700
RTSDSEVPDV ESREDLIKNH YMARIVELTS QLQLADSKSV HFYAECRALS
710 720 730 740 750
KRLALAEKSK EALTEEMKLA SQNISRLQDE LTTTKRSYED QLSMMSDHLC
760 770 780
SMNETLSKQR EEIDTLKMSS KGNSKKNKSR
Length:780
Mass (Da):88,314
Last modified:July 5, 2004 - v1
Checksum:i8D265213DC80841A
GO
Isoform 2 (identifier: Q6ZMI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: Missing.

Note: No experimental confirmation available.
Show »
Length:769
Mass (Da):87,153
Checksum:i0D3BE0812C0BD9BB
GO
Isoform 5 (identifier: Q6ZMI0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-564: Missing.
     646-656: Missing.

Show »
Length:738
Mass (Da):83,700
Checksum:i2CE41C4CC7F8E607
GO
Isoform 3 (identifier: Q6ZMI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     566-574: QQSLEKISK → WHWENYGNC
     575-780: Missing.

Note: No experimental confirmation available.
Show »
Length:574
Mass (Da):65,351
Checksum:iE870F809190BC08B
GO
Isoform 4 (identifier: Q6ZMI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-779: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):42,133
Checksum:i0FD933949E4EAC5F
GO

Sequence cautioni

The sequence AAH11978.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD18739.1 differs from that shown. Reason: Frameshift at position 115. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351Q → R in BAD18739 (PubMed:14702039).Curated
Sequence conflicti476 – 4761L → S in BAD18739 (PubMed:14702039).Curated
Sequence conflicti670 – 6701H → R in BAD18739 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei363 – 779417Missing in isoform 4. 1 PublicationVSP_024984Add
BLAST
Alternative sequencei534 – 56431Missing in isoform 5. 1 PublicationVSP_043216Add
BLAST
Alternative sequencei566 – 5749QQSLEKISK → WHWENYGNC in isoform 3. 1 PublicationVSP_024985
Alternative sequencei575 – 780206Missing in isoform 3. 1 PublicationVSP_024986Add
BLAST
Alternative sequencei646 – 65611Missing in isoform 2 and isoform 5. 2 PublicationsVSP_024987Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172753 mRNA. Translation: BAD18739.1. Frameshift.
AK172762 mRNA. Translation: BAD18745.1.
AY134855 mRNA. Translation: AAN08625.1.
AC093635 Genomic DNA. Translation: AAX93161.1.
CH471053 Genomic DNA. Translation: EAX00200.1.
BC011978 mRNA. Translation: AAH11978.2. Different initiation.
BC040721 mRNA. Translation: AAH40721.1.
BC111059 mRNA. Translation: AAI11060.1.
BC117279 mRNA. Translation: AAI17280.1.
BC143463 mRNA. Translation: AAI43464.1.
BC143466 mRNA. Translation: AAI43467.1.
CCDSiCCDS1839.1. [Q6ZMI0-2]
CCDS46278.1. [Q6ZMI0-1]
CCDS54358.1. [Q6ZMI0-5]
RefSeqiNP_001129101.1. NM_001135629.2. [Q6ZMI0-1]
NP_001180404.1. NM_001193475.1. [Q6ZMI0-5]
NP_694539.1. NM_152994.4. [Q6ZMI0-2]
UniGeneiHs.654619.

Genome annotation databases

EnsembliENST00000281394; ENSP00000281394; ENSG00000162869. [Q6ZMI0-2]
ENST00000294952; ENSP00000294952; ENSG00000162869. [Q6ZMI0-1]
ENST00000449090; ENSP00000415696; ENSG00000162869. [Q6ZMI0-5]
GeneIDi129285.
KEGGihsa:129285.
UCSCiuc002rwk.4. human. [Q6ZMI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172753 mRNA. Translation: BAD18739.1. Frameshift.
AK172762 mRNA. Translation: BAD18745.1.
AY134855 mRNA. Translation: AAN08625.1.
AC093635 Genomic DNA. Translation: AAX93161.1.
CH471053 Genomic DNA. Translation: EAX00200.1.
BC011978 mRNA. Translation: AAH11978.2. Different initiation.
BC040721 mRNA. Translation: AAH40721.1.
BC111059 mRNA. Translation: AAI11060.1.
BC117279 mRNA. Translation: AAI17280.1.
BC143463 mRNA. Translation: AAI43464.1.
BC143466 mRNA. Translation: AAI43467.1.
CCDSiCCDS1839.1. [Q6ZMI0-2]
CCDS46278.1. [Q6ZMI0-1]
CCDS54358.1. [Q6ZMI0-5]
RefSeqiNP_001129101.1. NM_001135629.2. [Q6ZMI0-1]
NP_001180404.1. NM_001193475.1. [Q6ZMI0-5]
NP_694539.1. NM_152994.4. [Q6ZMI0-2]
UniGeneiHs.654619.

3D structure databases

ProteinModelPortaliQ6ZMI0.
SMRiQ6ZMI0. Positions 34-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126187. 34 interactions.
IntActiQ6ZMI0. 21 interactions.
MINTiMINT-4860779.
STRINGi9606.ENSP00000294952.

PTM databases

iPTMnetiQ6ZMI0.
PhosphoSiteiQ6ZMI0.

Polymorphism and mutation databases

BioMutaiPPP1R21.
DMDMi74710533.

Proteomic databases

EPDiQ6ZMI0.
MaxQBiQ6ZMI0.
PaxDbiQ6ZMI0.
PRIDEiQ6ZMI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281394; ENSP00000281394; ENSG00000162869. [Q6ZMI0-2]
ENST00000294952; ENSP00000294952; ENSG00000162869. [Q6ZMI0-1]
ENST00000449090; ENSP00000415696; ENSG00000162869. [Q6ZMI0-5]
GeneIDi129285.
KEGGihsa:129285.
UCSCiuc002rwk.4. human. [Q6ZMI0-1]

Organism-specific databases

CTDi129285.
GeneCardsiPPP1R21.
H-InvDBHIX0200323.
HGNCiHGNC:30595. PPP1R21.
HPAiHPA036791.
HPA036792.
neXtProtiNX_Q6ZMI0.
PharmGKBiPA164722001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4421. Eukaryota.
ENOG410YXM0. LUCA.
GeneTreeiENSGT00390000006820.
HOGENOMiHOG000007280.
HOVERGENiHBG058887.
InParanoidiQ6ZMI0.
KOiK17562.
OMAiVPFNDTK.
OrthoDBiEOG7W6WM3.
PhylomeDBiQ6ZMI0.
TreeFamiTF320535.

Miscellaneous databases

ChiTaRSiPPP1R21. human.
GenomeRNAii129285.
PROiQ6ZMI0.

Gene expression databases

BgeeiQ6ZMI0.
CleanExiHS_KLRAQ1.
ExpressionAtlasiQ6ZMI0. baseline and differential.
GenevisibleiQ6ZMI0. HS.

Family and domain databases

InterProiIPR019348. KLRAQ/TTKRSYEDQ_C.
IPR019343. Unchr_KLRAQ/TTKRSYEDQ_N.
[Graphical view]
PfamiPF10205. KLRAQ. 1 hit.
PF10212. TTKRSYEDQ. 1 hit.
[Graphical view]
SMARTiSM01254. KLRAQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  2. Guo J.H., Yu L.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
    Tissue: Brain and Ovary.
  6. "Docking motif-guided mapping of the interactome of protein phosphatase-1."
    Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M.
    Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPP1CA.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPR21_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMI0
Secondary accession number(s): B7ZKY5
, B7ZKY7, E1B6W7, Q2TA78, Q6ZMI6, Q8IW83, Q8J029, Q96ES8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.