Q6ZMI0 (PPR21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase 1 regulatory subunit 21

Alternative name(s):
Coiled-coil domain-containing protein 128
KLRAQ motif-containing protein 1

Gene names

Name:	PPP1R21
Synonyms:	CCDC128, KLRAQ1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	780 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with PPP1CA. Ref.6
Sequence caution	The sequence AAH11978.2 differs from that shown. Reason: Erroneous initiation. The sequence BAD18739.1 differs from that shown. Reason: Frameshift at position 115.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	phosphatase binding Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZMI0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZMI0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6ZMI0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     534-564: Missing.
     646-656: Missing.

Isoform 3 (identifier: Q6ZMI0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     566-574: QQSLEKISK → WHWENYGNC
     575-780: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6ZMI0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     363-779: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 780	780	Protein phosphatase 1 regulatory subunit 21		PRO_0000286098
Regions
	Coiled coil	1 – 207	207	Potential
	Coiled coil	556 – 607	52	Potential
	Coiled coil	693 – 742	50	Potential
Natural variations
	Alternative sequence	363 – 779	417	Missing in isoform 4.		VSP_024984
	Alternative sequence	534 – 564	31	Missing in isoform 5.		VSP_043216
	Alternative sequence	566 – 574	9	QQSLEKISK → WHWENYGNC in isoform 3.		VSP_024985
	Alternative sequence	575 – 780	206	Missing in isoform 3.		VSP_024986
	Alternative sequence	646 – 656	11	Missing in isoform 2 and isoform 5.		VSP_024987
Experimental info
	Sequence conflict	235	1	Q → R in BAD18739. Ref.1
	Sequence conflict	476	1	L → S in BAD18739. Ref.1
	Sequence conflict	670	1	H → R in BAD18739. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8D265213DC80841A	FASTA	780	88,314
	10 20 30 40 50 60 MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ SLRKLQQEMD 70 80 90 100 110 120 SLTFRNLQLA KRVELLQDEL ALSEPRGKKN KKSGESSSQL SQEQKSVFDE DLQKKIEENE 130 140 150 160 170 180 RLHIQFFEAD EQHKHVEAEL RSRLATLETE AAQHQAVVDG LTRKYMETIE KLQNDKAKLE 190 200 210 220 230 240 VKSQTLEKEA KECRLRTEEC QLQLKTLHED LSGRLEESLS IINEKVPFND TKYSQYNALN 250 260 270 280 290 300 VPLHNRRHQL KMRDIAGQAL AFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF 310 320 330 340 350 360 SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI CFLRKILPYQ 370 380 390 400 410 420 LKSLEEECES SLCTSALRAR NLELSQDMKK MTAVFEKLQT YIALLALPST EPDGLLRTNY 430 440 450 460 470 480 SSVLTNVGAA LHGFHDVMKD ISKHYSQKAA IEHELPTATQ KLITTNDCIL SSVVALTNGA 490 500 510 520 530 540 GKIASFFSNN LDYFIASLSY GPKAASGFIS PLSAECMLQY KKKAAAYMKS LRKPLLESVP 550 560 570 580 590 600 YEEALANRRI LLSSTESREG LAQQVQQSLE KISKLEQEKE HWMLEAQLAK IKLEKENQRI 610 620 630 640 650 660 ADKLKNTGSA QLVGLAQENA AVSNTAGQDE ATAKAVLEPI QSTSLIGTLT RTSDSEVPDV 670 680 690 700 710 720 ESREDLIKNH YMARIVELTS QLQLADSKSV HFYAECRALS KRLALAEKSK EALTEEMKLA 730 740 750 760 770 780 SQNISRLQDE LTTTKRSYED QLSMMSDHLC SMNETLSKQR EEIDTLKMSS KGNSKKNKSR
	Isoform 2 [UniParc]. Checksum: 0D3BE0812C0BD9BB	FASTA	769	87,153
	10 20 30 40 50 60 MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ SLRKLQQEMD 70 80 90 100 110 120 SLTFRNLQLA KRVELLQDEL ALSEPRGKKN KKSGESSSQL SQEQKSVFDE DLQKKIEENE 130 140 150 160 170 180 RLHIQFFEAD EQHKHVEAEL RSRLATLETE AAQHQAVVDG LTRKYMETIE KLQNDKAKLE 190 200 210 220 230 240 VKSQTLEKEA KECRLRTEEC QLQLKTLHED LSGRLEESLS IINEKVPFND TKYSQYNALN 250 260 270 280 290 300 VPLHNRRHQL KMRDIAGQAL AFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF 310 320 330 340 350 360 SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI CFLRKILPYQ 370 380 390 400 410 420 LKSLEEECES SLCTSALRAR NLELSQDMKK MTAVFEKLQT YIALLALPST EPDGLLRTNY 430 440 450 460 470 480 SSVLTNVGAA LHGFHDVMKD ISKHYSQKAA IEHELPTATQ KLITTNDCIL SSVVALTNGA 490 500 510 520 530 540 GKIASFFSNN LDYFIASLSY GPKAASGFIS PLSAECMLQY KKKAAAYMKS LRKPLLESVP 550 560 570 580 590 600 YEEALANRRI LLSSTESREG LAQQVQQSLE KISKLEQEKE HWMLEAQLAK IKLEKENQRI 610 620 630 640 650 660 ADKLKNTGSA QLVGLAQENA AVSNTAGQDE ATAKAVLEPI QSTSLVPDVE SREDLIKNHY 670 680 690 700 710 720 MARIVELTSQ LQLADSKSVH FYAECRALSK RLALAEKSKE ALTEEMKLAS QNISRLQDEL 730 740 750 760 TTTKRSYEDQ LSMMSDHLCS MNETLSKQRE EIDTLKMSSK GNSKKNKSR
	Isoform 5 [UniParc]. Checksum: 2CE41C4CC7F8E607	FASTA	738	83,700
	10 20 30 40 50 60 MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ SLRKLQQEMD 70 80 90 100 110 120 SLTFRNLQLA KRVELLQDEL ALSEPRGKKN KKSGESSSQL SQEQKSVFDE DLQKKIEENE 130 140 150 160 170 180 RLHIQFFEAD EQHKHVEAEL RSRLATLETE AAQHQAVVDG LTRKYMETIE KLQNDKAKLE 190 200 210 220 230 240 VKSQTLEKEA KECRLRTEEC QLQLKTLHED LSGRLEESLS IINEKVPFND TKYSQYNALN 250 260 270 280 290 300 VPLHNRRHQL KMRDIAGQAL AFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF 310 320 330 340 350 360 SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI CFLRKILPYQ 370 380 390 400 410 420 LKSLEEECES SLCTSALRAR NLELSQDMKK MTAVFEKLQT YIALLALPST EPDGLLRTNY 430 440 450 460 470 480 SSVLTNVGAA LHGFHDVMKD ISKHYSQKAA IEHELPTATQ KLITTNDCIL SSVVALTNGA 490 500 510 520 530 540 GKIASFFSNN LDYFIASLSY GPKAASGFIS PLSAECMLQY KKKAAAYMKS LRKVQQSLEK 550 560 570 580 590 600 ISKLEQEKEH WMLEAQLAKI KLEKENQRIA DKLKNTGSAQ LVGLAQENAA VSNTAGQDEA 610 620 630 640 650 660 TAKAVLEPIQ STSLVPDVES REDLIKNHYM ARIVELTSQL QLADSKSVHF YAECRALSKR 670 680 690 700 710 720 LALAEKSKEA LTEEMKLASQ NISRLQDELT TTKRSYEDQL SMMSDHLCSM NETLSKQREE 730 IDTLKMSSKG NSKKNKSR
	Isoform 3 [UniParc]. Checksum: E870F809190BC08B	FASTA	574	65,351
	10 20 30 40 50 60 MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ SLRKLQQEMD 70 80 90 100 110 120 SLTFRNLQLA KRVELLQDEL ALSEPRGKKN KKSGESSSQL SQEQKSVFDE DLQKKIEENE 130 140 150 160 170 180 RLHIQFFEAD EQHKHVEAEL RSRLATLETE AAQHQAVVDG LTRKYMETIE KLQNDKAKLE 190 200 210 220 230 240 VKSQTLEKEA KECRLRTEEC QLQLKTLHED LSGRLEESLS IINEKVPFND TKYSQYNALN 250 260 270 280 290 300 VPLHNRRHQL KMRDIAGQAL AFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF 310 320 330 340 350 360 SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI CFLRKILPYQ 370 380 390 400 410 420 LKSLEEECES SLCTSALRAR NLELSQDMKK MTAVFEKLQT YIALLALPST EPDGLLRTNY 430 440 450 460 470 480 SSVLTNVGAA LHGFHDVMKD ISKHYSQKAA IEHELPTATQ KLITTNDCIL SSVVALTNGA 490 500 510 520 530 540 GKIASFFSNN LDYFIASLSY GPKAASGFIS PLSAECMLQY KKKAAAYMKS LRKPLLESVP 550 560 570 YEEALANRRI LLSSTESREG LAQQVWHWEN YGNC
	Isoform 4 [UniParc]. Checksum: 0FD933949E4EAC5F	FASTA	363	42,133
	10 20 30 40 50 60 MASAELQGKY QKLAQEYSKL RAQNQVLKKG VVDEQANSAA LKEQLKMKDQ SLRKLQQEMD 70 80 90 100 110 120 SLTFRNLQLA KRVELLQDEL ALSEPRGKKN KKSGESSSQL SQEQKSVFDE DLQKKIEENE 130 140 150 160 170 180 RLHIQFFEAD EQHKHVEAEL RSRLATLETE AAQHQAVVDG LTRKYMETIE KLQNDKAKLE 190 200 210 220 230 240 VKSQTLEKEA KECRLRTEEC QLQLKTLHED LSGRLEESLS IINEKVPFND TKYSQYNALN 250 260 270 280 290 300 VPLHNRRHQL KMRDIAGQAL AFVQDLVTAL LNFHTYTEQR IQIFPVDSAI DTISPLNQKF 310 320 330 340 350 360 SQYLHENASY VRPLEEGMLH LFESITEDTV TVLETTVKLK TFSEHLTSYI CFLRKILPYQ LKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[2]	Guo J.H., Yu L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Ovary.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5). Tissue: Brain and Ovary.
[6]	"Docking motif-guided mapping of the interactome of protein phosphatase-1." Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M. Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PPP1CA.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK172753 mRNA. Translation: BAD18739.1. Frameshift. AK172762 mRNA. Translation: BAD18745.1. AY134855 mRNA. Translation: AAN08625.1. AC093635 Genomic DNA. Translation: AAX93161.1. CH471053 Genomic DNA. Translation: EAX00200.1. BC011978 mRNA. Translation: AAH11978.2. Different initiation. BC040721 mRNA. Translation: AAH40721.1. BC111059 mRNA. Translation: AAI11060.1. BC117279 mRNA. Translation: AAI17280.1. BC143463 mRNA. Translation: AAI43464.1. BC143466 mRNA. Translation: AAI43467.1.
IPI	IPI00396527. IPI00747521. IPI00845272. IPI00845285.
RefSeq	NP_001129101.1. NM_001135629.2. NP_001180404.1. NM_001193475.1. NP_694539.1. NM_152994.4.
UniGene	Hs.654619.
3D structure databases
ProteinModelPortal	Q6ZMI0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZMI0. 1 interaction.
PTM databases
PhosphoSite	Q6ZMI0.
Polymorphism databases
DMDM	74710533.
Proteomic databases
PaxDb	Q6ZMI0.
PRIDE	Q6ZMI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281394; ENSP00000281394; ENSG00000162869. ENST00000294952; ENSP00000294952; ENSG00000162869. ENST00000449090; ENSP00000415696; ENSG00000162869.
GeneID	129285.
KEGG	hsa:129285.
UCSC	uc002rwi.1. human. uc002rwj.3. human. uc002rwk.3. human. uc002rwl.3. human.
Organism-specific databases
CTD	129285.
GeneCards	GC02P048670.
H-InvDB	HIX0200323.
HGNC	HGNC:30595. PPP1R21.
HPA	HPA036791.
neXtProt	NX_Q6ZMI0.
PharmGKB	PA164722001.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG312769.
HOGENOM	HOG000007280.
HOVERGEN	HBG058887.
InParanoid	Q6ZMI0.
OMA	VPFNDTK.
Gene expression databases
ArrayExpress	Q6ZMI0.
Bgee	Q6ZMI0.
CleanEx	HS_KLRAQ1.
Genevestigator	Q6ZMI0.
Family and domain databases
InterPro	IPR019348. KLRAQ/TTKRSYEDQ_C. IPR019343. Unchr_KLRAQ/TTKRSYEDQ_N. [Graphical view]
Pfam	PF10205. KLRAQ. 1 hit. PF10212. TTKRSYEDQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PPP1R21. human.
GenomeRNAi	129285.
NextBio	82557.

Entry information

Entry name

PPR21_HUMAN

Accession

Primary (citable) accession number: Q6ZMI0
Secondary accession number(s): B7ZKY5 , B7ZKY7, E1B6W7, Q2TA78, Q6ZMI6, Q8IW83, Q8J029, Q96ES8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.