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Protein

Sialic acid-binding Ig-like lectin 15

Gene

SIGLEC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds sialylated glycoproteins.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143Sialic acidBy similarity1

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 15
Short name:
Siglec-15
Alternative name(s):
CD33 antigen-like 3
Gene namesi
Name:SIGLEC15
Synonyms:CD33L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000197046.11
HGNCiHGNC:27596 SIGLEC15
neXtProtiNX_Q6ZMC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 263ExtracellularSequence analysisAdd BLAST244
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 328CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi143R → A: Abrogates glycan-binding. 1 Publication1
Mutagenesisi274K → A: Abrogates interaction with HCST and TYROBP. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000197046
PharmGKBiPA162403350

Polymorphism and mutation databases

BioMutaiSIGLEC15
DMDMi74762385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029436920 – 328Sialic acid-binding Ig-like lectin 15Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 142PROSITE-ProRule annotation
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi187 ↔ 237PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZMC9
PeptideAtlasiQ6ZMC9
PRIDEiQ6ZMC9

PTM databases

iPTMnetiQ6ZMC9
PhosphoSitePlusiQ6ZMC9

Expressioni

Tissue specificityi

Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Gene expression databases

BgeeiENSG00000197046
CleanExiHS_SIGLEC15
ExpressionAtlasiQ6ZMC9 baseline and differential

Organism-specific databases

HPAiHPA053509

Interactioni

Subunit structurei

Interacts with TYROBP and HCST.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000374125

Structurei

3D structure databases

ProteinModelPortaliQ6ZMC9
SMRiQ6ZMC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 158Ig-like V-typeAdd BLAST119
Domaini168 – 251Ig-like C2-typeAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 279Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJR Eukaryota
ENOG4111T39 LUCA
GeneTreeiENSGT00390000011536
HOGENOMiHOG000013049
HOVERGENiHBG099550
InParanoidiQ6ZMC9
KOiK16352
OMAiVYLFRFR
OrthoDBiEOG091G0PY1
PhylomeDBiQ6ZMC9
TreeFamiTF351096

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZMC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKSIWLLAC LAWVLPTGSF VRTKIDTTEN LLNTEVHSSP AQRWSMQVPP
60 70 80 90 100
EVSAEAGDAA VLPCTFTHPH RHYDGPLTAI WRAGEPYAGP QVFRCAAARG
110 120 130 140 150
SELCQTALSL HGRFRLLGNP RRNDLSLRVE RLALADDRRY FCRVEFAGDV
160 170 180 190 200
HDRYESRHGV RLHVTAAPRI VNISVLPSPA HAFRALCTAE GEPPPALAWS
210 220 230 240 250
GPALGNSLAA VRSPREGHGH LVTAELPALT HDGRYTCTAA NSLGRSEASV
260 270 280 290 300
YLFRFHGASG ASTVALLLGA LGFKALLLLG VLAARAARRR PEHLDTPDTP
310 320
PRSQAQESNY ENLSQMNPRS PPATMCSP
Length:328
Mass (Da):35,653
Last modified:July 5, 2004 - v1
Checksum:i534D6D2E76F04C8B
GO
Isoform 2 (identifier: Q6ZMC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEKSIWLLACLA → MTATRAATASGS
     13-166: Missing.

Note: No experimental confirmation available.
Show »
Length:174
Mass (Da):18,086
Checksum:i2B62AB00ADE77B9B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033174273F → L. Corresponds to variant dbSNP:rs2919643Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568171 – 12MEKSI…LACLA → MTATRAATASGS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_05681813 – 166Missing in isoform 2. 1 PublicationAdd BLAST154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172835 mRNA Translation: BAD18800.1
AK290400 mRNA Translation: BAF83089.1
AK290402 mRNA Translation: BAF83091.1
AK301189 mRNA Translation: BAG62771.1
AC087685 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01463.1
CCDSiCCDS32819.1 [Q6ZMC9-1]
RefSeqiNP_998767.1, NM_213602.2 [Q6ZMC9-1]
UniGeneiHs.287692

Genome annotation databases

EnsembliENST00000389474; ENSP00000374125; ENSG00000197046 [Q6ZMC9-1]
ENST00000546268; ENSP00000443509; ENSG00000197046 [Q6ZMC9-2]
GeneIDi284266
KEGGihsa:284266
UCSCiuc002lbl.2 human [Q6ZMC9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSIG15_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMC9
Secondary accession number(s): A8K2Y5, B4DVQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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