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Protein

Transmembrane protein 184A

Gene

TMEM184A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 184A
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:28797. TMEM184A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6923HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406118.

Polymorphism and mutation databases

BioMutaiTMEM184A.
DMDMi74710509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Transmembrane protein 184APRO_0000300466Add
BLAST

Proteomic databases

MaxQBiQ6ZMB5.
PaxDbiQ6ZMB5.
PRIDEiQ6ZMB5.

PTM databases

iPTMnetiQ6ZMB5.

Expressioni

Tissue specificityi

Expressed in vascular cells (at protein level).1 Publication

Gene expression databases

BgeeiQ6ZMB5.
CleanExiHS_TMEM184A.
ExpressionAtlasiQ6ZMB5. baseline and differential.
GenevisibleiQ6ZMB5. HS.

Interactioni

Protein-protein interaction databases

BioGridi128441. 27 interactions.
IntActiQ6ZMB5. 1 interaction.
STRINGi9606.ENSP00000297477.

Structurei

3D structure databases

ProteinModelPortaliQ6ZMB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM184 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2641. Eukaryota.
ENOG410XQ3V. LUCA.
GeneTreeiENSGT00530000063204.
HOGENOMiHOG000116663.
HOVERGENiHBG051270.
InParanoidiQ6ZMB5.
OMAiPAGPQMD.
OrthoDBiEOG71ZP1P.
PhylomeDBiQ6ZMB5.
TreeFamiTF314160.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZMB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVSGILET AGVPLVSANW PQPSPPPAVP AGPQMDHMGN SSQGAPWLFL
60 70 80 90 100
TSALARGVSG IFVWTALVLT CHQIYLHLRS YTVPQEQRYI IRLLLIVPIY
110 120 130 140 150
AFDSWLSLLL LGDHQYYVYF DSVRDCYEAF VIYSFLSLCF QYLGGEGAIM
160 170 180 190 200
AEIRGKPIKS SCLYGTCCLR GMTYSIGFLR FCKQATLQFC LVKPVMAVTT
210 220 230 240 250
IILQAFGKYH DGDFNVRSGY LYVTLIYNAS VSLALYALFL FYFTTRELLR
260 270 280 290 300
PFQPVLKFLT IKAVIFLSFW QGLLLAILER CGVIPEVETS GGNKLGAGTL
310 320 330 340 350
AAGYQNFIIC VEMLFASVAL RYAFPCQVYA EKKENSPAPP APMQSISSGI
360 370 380 390 400
RETVSPQDIV QDAIHNFSPA YQHYTQQATH EAPRPGTHPS GGSGGSRKSR
410
SLEKRMLIPS EDL
Length:413
Mass (Da):45,777
Last modified:July 5, 2004 - v1
Checksum:i7107392E64DB2CB8
GO

Sequence cautioni

The sequence BAC86522.2 differs from that shown.Probable cloning artifact. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti391 – 3911G → GG in AAH26694 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181A → V.1 Publication
Corresponds to variant rs17852421 [ dbSNP | Ensembl ].
VAR_062157
Natural varianti390 – 3901S → G.1 Publication
Corresponds to variant rs3779607 [ dbSNP | Ensembl ].
VAR_060120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126312 mRNA. Translation: BAC86522.2. Sequence problems.
AK172850 mRNA. Translation: BAD18814.1.
CH471144 Genomic DNA. Translation: EAW87210.1.
BC026694 mRNA. Translation: AAH26694.1.
CCDSiCCDS43537.1.
RefSeqiNP_001091089.1. NM_001097620.1.
UniGeneiHs.592174.
Hs.707784.

Genome annotation databases

EnsembliENST00000297477; ENSP00000297477; ENSG00000164855.
GeneIDi202915.
KEGGihsa:202915.
UCSCiuc003skv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126312 mRNA. Translation: BAC86522.2. Sequence problems.
AK172850 mRNA. Translation: BAD18814.1.
CH471144 Genomic DNA. Translation: EAW87210.1.
BC026694 mRNA. Translation: AAH26694.1.
CCDSiCCDS43537.1.
RefSeqiNP_001091089.1. NM_001097620.1.
UniGeneiHs.592174.
Hs.707784.

3D structure databases

ProteinModelPortaliQ6ZMB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128441. 27 interactions.
IntActiQ6ZMB5. 1 interaction.
STRINGi9606.ENSP00000297477.

PTM databases

iPTMnetiQ6ZMB5.

Polymorphism and mutation databases

BioMutaiTMEM184A.
DMDMi74710509.

Proteomic databases

MaxQBiQ6ZMB5.
PaxDbiQ6ZMB5.
PRIDEiQ6ZMB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297477; ENSP00000297477; ENSG00000164855.
GeneIDi202915.
KEGGihsa:202915.
UCSCiuc003skv.4. human.

Organism-specific databases

CTDi202915.
GeneCardsiTMEM184A.
HGNCiHGNC:28797. TMEM184A.
neXtProtiNX_Q6ZMB5.
PharmGKBiPA162406118.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2641. Eukaryota.
ENOG410XQ3V. LUCA.
GeneTreeiENSGT00530000063204.
HOGENOMiHOG000116663.
HOVERGENiHBG051270.
InParanoidiQ6ZMB5.
OMAiPAGPQMD.
OrthoDBiEOG71ZP1P.
PhylomeDBiQ6ZMB5.
TreeFamiTF314160.

Miscellaneous databases

ChiTaRSiTMEM184A. human.
GenomeRNAii202915.
PROiQ6ZMB5.

Gene expression databases

BgeeiQ6ZMB5.
CleanExiHS_TMEM184A.
ExpressionAtlasiQ6ZMB5. baseline and differential.
GenevisibleiQ6ZMB5. HS.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Signet-ring cell carcinoma and Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-18 AND GLY-390.
    Tissue: Colon.
  4. "Transmembrane protein 184A is a receptor required for vascular smooth muscle cell responses to heparin."
    Pugh R.J., Slee J.B., Farwell S.L., Li Y., Barthol T., Patton W.A., Lowe-Krentz L.J.
    J. Biol. Chem. 291:5326-5341(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiT184A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZMB5
Secondary accession number(s): Q8TBQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.