ID   Q6ZM72_DANRE            Unreviewed;      1058 AA.
AC   Q6ZM72; A0A8M1N769;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 158.
DE   SubName: Full=Euchromatic histone-lysine N-methyltransferase 1a {ECO:0000313|Ensembl:ENSDARP00000107170};
DE   SubName: Full=Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 {ECO:0000313|RefSeq:NP_001025302.1};
DE            EC=2.1.1.43 {ECO:0000313|RefSeq:NP_001025302.1};
GN   Name=ehmt1a {ECO:0000313|Ensembl:ENSDARP00000107170,
GN   ECO:0000313|RefSeq:NP_001025302.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-040724-44};
GN   Synonyms=bZ1O1.6 {ECO:0000313|RefSeq:NP_001025302.1}, si:rp71-1o1.6
GN   {ECO:0000313|RefSeq:NP_001025302.1}, zgc:136244
GN   {ECO:0000313|RefSeq:NP_001025302.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000107170};
RN   [1] {ECO:0000313|RefSeq:NP_001025302.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001025302.1};
RX   PubMed=18231586; DOI=10.1371/journal.pone.0001499;
RA   Sun X.J., Xu P.F., Zhou T., Hu M., Fu C.T., Zhang Y., Jin Y., Chen Y.,
RA   Chen S.J., Huang Q.H., Liu T.X., Chen Z.;
RT   "Genome-wide survey and developmental expression mapping of zebrafish SET
RT   domain-containing genes.";
RL   PLoS ONE 3:E1499-E1499(2008).
RN   [2] {ECO:0000313|RefSeq:NP_001025302.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001025302.1};
RX   PubMed=24240475;
RA   Huang H.T., Kathrein K.L., Barton A., Gitlin Z., Huang Y.H., Ward T.P.,
RA   Hofmann O., Dibiase A., Song A., Tyekucheva S., Hide W., Zhou Y., Zon L.I.;
RT   "A network of epigenetic regulators guides developmental haematopoiesis in
RT   vivo.";
RL   Nat. Cell Biol. 15:1516-1525(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000107170, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107170};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000107170}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107170};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
RN   [5] {ECO:0000313|RefSeq:NP_001025302.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001025302.1};
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [6] {ECO:0000313|RefSeq:NP_001025302.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001025302.1};
RX   PubMed=28738802;
RA   Lee S.L.J., Horsfield J.A., Black M.A., Rutherford K., Fisher A.,
RA   Gemmell N.J.;
RT   "Histological and transcriptomic effects of 17alpha-methyltestosterone on
RT   zebrafish gonad development.";
RL   BMC Genomics 18:557-557(2017).
RN   [7] {ECO:0000313|RefSeq:NP_001025302.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001025302.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL831768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL929342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001025302.1; NM_001030131.2.
DR   Ensembl; ENSDART00000126018; ENSDARP00000107170; ENSDARG00000068157.
DR   Ensembl; ENSDART00000126018.3; ENSDARP00000107170.2; ENSDARG00000068157.8.
DR   GeneID; 100005761; -.
DR   KEGG; dre:100005761; -.
DR   AGR; ZFIN:ZDB-GENE-040724-44; -.
DR   CTD; 100005761; -.
DR   ZFIN; ZDB-GENE-040724-44; ehmt1a.
DR   OrthoDB; 5481936at2759; -.
DR   Proteomes; UP000000437; Chromosome 5.
DR   Bgee; ENSDARG00000068157; Expressed in early embryo and 20 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046974; F:histone H3K9 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006306; P:DNA methylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd20905; EHMT_ZBD; 1.
DR   CDD; cd10543; SET_EHMT; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR043550; EHMT1/EHMT2.
DR   InterPro; IPR047762; EHMT_CRR.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR   PANTHER; PTHR46307:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT1; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF21533; EHMT1-2_CRR; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 5.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   1: Evidence at protein level;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q6ZM72};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   REPEAT          526..558
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          559..591
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          592..614
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          626..658
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          692..724
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          814..877
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          880..996
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..197
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..262
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1058 AA;  118047 MW;  23A1FBC894960758 CRC64;
     MAKTKKGMDS LADPQRKGKR PKSLGASPKA SKQLSASGSR KSTGSSFQLL SGQTSLKPPA
     ENIISGNHSS VQQDKPETLE KQSFGSDNAD KRIPVVSVPE AAHEEDEQRE PEGVKVVKPA
     PPRLAWKTMV RSAPAPPALK TLNRERSGYE RDVESSPTQH LSLPQELKDS TQTAPKKKKR
     KMGLYNFVPK KKPKGSKKAN VSLSSSNLQE ALRMTGSKGG QMSIEEAFRN KASSEKPEKQ
     TSTAVIEDAE PHQNKETEDA PEGPAEEYTE LPLHALAHDS LFTTIPTGLR EDKENMETDD
     TLEPPLCSCR METPKNQDVV TLAEGKCMAV ESVDGKLSLC RKVIMKQELM RPSLRIPQLV
     LCEDHRAGMV KHQSCPGCGF FCRAGTFMEC QPDGNISHRF HRSCASLIRG QVYCPHCGEE
     ASHAKEVTIP KPDCVASVPT AAVPAHKRDN ALMDRVKLDS VMVDGAGDLA KESLESVLNA
     LEDGKYKKFK LPPKQLYFSA KRGELQRILH MLVEGVDPNL RMDSEKRKTP LHCAAEEGHK
     DICHVLVQAG ANLDMCDIEQ RTPLMYACNN NHLENVKYLL KAGASSAHKD MRGSTCLHLA
     ARAGHTNVLQ YLLSLPSIDV NCKDDGGWAP LTWATENMRL EQVKMLISAG ADVQIRDKEE
     NLCLHWAAFS GCDEIAQLLL DHRSDLHAVN VHGDTPLHIA VRQNQLDCVM LFLSRGADVN
     LKNRDGETPL GCCNINSKMW TILNTNKKLT DARRGRESLR ERLLCRDVSR GYEDIPVPCV
     NGVDHEPCPS NFKYIPENCF TSQVNIDENI KHLQHCSCKD DCASSSCICG QLSMHCWYGK
     DGRLLKEFCR DDPPFLFECN HACSCWRTCR NRVIQNGLRL RLQVFRTERM GWGVRTLQDI
     PEGGFVCEFA GEIISDGEAN IRENDSYMFN LDNKAKAYCI DGQFYGNVSR FMNHLCEPNL
     FPVRVFTKHQ DMRFPRIAFF ASKHIQAGDE LGFDYGDHYW QIKKKYFRCQ CGSGKCRYSE
     VVPDRNHAES SAQTLSNQTV AQVEHIQSSN TAIAITQP
//