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Protein
Submitted name:

Euchromatic histone-lysine N-methyltransferase 1a

Gene

ehmt1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-DRE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DRE-3214841 PKMTs methylate histone lysines
R-DRE-6804760 Regulation of TP53 Activity through Methylation
R-DRE-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Submitted name:
Euchromatic histone-lysine N-methyltransferase 1aImported
Gene namesi
Name:ehmt1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-040724-44 ehmt1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000068157
ExpressionAtlasiQ6ZM72 baseline

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6ZM72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini496 – 730ANK_REP_REGIONInterPro annotationAdd BLAST235
Repeati526 – 558ANKPROSITE-ProRule annotationAdd BLAST33
Repeati559 – 591ANKPROSITE-ProRule annotationAdd BLAST33
Repeati592 – 614ANKPROSITE-ProRule annotationAdd BLAST23
Repeati626 – 658ANKPROSITE-ProRule annotationAdd BLAST33
Repeati692 – 724ANKPROSITE-ProRule annotationAdd BLAST33
Domaini814 – 877Pre-SETInterPro annotationAdd BLAST64
Domaini880 – 996SETInterPro annotationAdd BLAST117

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG0666 LUCA
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOVERGENiHBG028394
KOiK11420

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038035 EHMT1
IPR007728 Pre-SET_dom
IPR001214 SET_dom
PANTHERiPTHR22884:SF364 PTHR22884:SF364, 3 hits
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZM72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTKKGMDS LADPQRKGKR PKSLGASPKA SKQLSASGSR KSTGSSFQLL
60 70 80 90 100
SGQTSLKPPA ENIISGNHSS VQQDKPETLE KQSFGSDNAD KRIPVVSVPE
110 120 130 140 150
AAHEEDEQRE PEGVKVVKPA PPRLAWKTMV RSAPAPPALK TLNRERSGYE
160 170 180 190 200
RDVESSPTQH LSLPQELKDS TQTAPKKKKR KMGLYNFVPK KKPKGSKKAN
210 220 230 240 250
VSLSSSNLQE ALRMTGSKGG QMSIEEAFRN KASSEKPEKQ TSTAVIEDAE
260 270 280 290 300
PHQNKETEDA PEGPAEEYTE LPLHALAHDS LFTTIPTGLR EDKENMETDD
310 320 330 340 350
TLEPPLCSCR METPKNQDVV TLAEGKCMAV ESVDGKLSLC RKVIMKQELM
360 370 380 390 400
RPSLRIPQLV LCEDHRAGMV KHQSCPGCGF FCRAGTFMEC QPDGNISHRF
410 420 430 440 450
HRSCASLIRG QVYCPHCGEE ASHAKEVTIP KPDCVASVPT AAVPAHKRDN
460 470 480 490 500
ALMDRVKLDS VMVDGAGDLA KESLESVLNA LEDGKYKKFK LPPKQLYFSA
510 520 530 540 550
KRGELQRILH MLVEGVDPNL RMDSEKRKTP LHCAAEEGHK DICHVLVQAG
560 570 580 590 600
ANLDMCDIEQ RTPLMYACNN NHLENVKYLL KAGASSAHKD MRGSTCLHLA
610 620 630 640 650
ARAGHTNVLQ YLLSLPSIDV NCKDDGGWAP LTWATENMRL EQVKMLISAG
660 670 680 690 700
ADVQIRDKEE NLCLHWAAFS GCDEIAQLLL DHRSDLHAVN VHGDTPLHIA
710 720 730 740 750
VRQNQLDCVM LFLSRGADVN LKNRDGETPL GCCNINSKMW TILNTNKKLT
760 770 780 790 800
DARRGRESLR ERLLCRDVSR GYEDIPVPCV NGVDHEPCPS NFKYIPENCF
810 820 830 840 850
TSQVNIDENI KHLQHCSCKD DCASSSCICG QLSMHCWYGK DGRLLKEFCR
860 870 880 890 900
DDPPFLFECN HACSCWRTCR NRVIQNGLRL RLQVFRTERM GWGVRTLQDI
910 920 930 940 950
PEGGFVCEFA GEIISDGEAN IRENDSYMFN LDNKAKAYCI DGQFYGNVSR
960 970 980 990 1000
FMNHLCEPNL FPVRVFTKHQ DMRFPRIAFF ASKHIQAGDE LGFDYGDHYW
1010 1020 1030 1040 1050
QIKKKYFRCQ CGSGKCRYSE VVPDRNHAES SAQTLSNQTV AQVEHIQSSN

TAIAITQP
Length:1,058
Mass (Da):118,047
Last modified:July 5, 2004 - v1
Checksum:i23A1FBC894960758
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831768 Genomic DNA No translation available.
AL929342 Genomic DNA No translation available.
RefSeqiNP_001025302.1, NM_001030131.2
UniGeneiDr.83090

Genome annotation databases

EnsembliENSDART00000126018; ENSDARP00000107170; ENSDARG00000068157
GeneIDi100005761
KEGGidre:100005761

Similar proteinsi

Entry informationi

Entry nameiQ6ZM72_DANRE
AccessioniPrimary (citable) accession number: Q6ZM72
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health