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Protein

Calcium-transporting ATPase

Gene

atp2a2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-418359. Reduction of cytosolic Ca++ levels.
R-DRE-5578775. Ion homeostasis.
R-DRE-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:atp2a2bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030131-867. atp2a2b.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7219HelicalUniRule annotationAdd
BLAST
Transmembranei78 – 10124HelicalUniRule annotationAdd
BLAST
Transmembranei254 – 27219HelicalUniRule annotationAdd
BLAST
Transmembranei292 – 31524HelicalUniRule annotationAdd
BLAST
Transmembranei752 – 77322HelicalUniRule annotationAdd
BLAST
Transmembranei825 – 84925HelicalUniRule annotationAdd
BLAST
Transmembranei923 – 94220HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ6ZM60.
PRIDEiQ6ZM60.

Expressioni

Gene expression databases

BgeeiQ6ZM60.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000047200.

Structurei

3D structure databases

ProteinModelPortaliQ6ZM60.
SMRiQ6ZM60. Positions 1-985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 7169Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]SAAS annotation
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129745.
HOGENOMiHOG000265621.
HOVERGENiHBG105648.
InParanoidiQ6ZM60.
KOiK05853.
OrthoDBiEOG73Z2SF.
PhylomeDBiQ6ZM60.
TreeFamiTF300651.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
IPR030327. SERCA2.
[Graphical view]
PANTHERiPTHR24093:SF234. PTHR24093:SF234. 2 hits.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZM60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENAHTKTVE EVYSFFAVNE STGLGLEQVK RQREKWGPNG KSLWELVVEQ
60 70 80 90 100
FEDLLVRILL LAACISFVLA WFEEGEETIT AFVEPFVILL ILIANAIVGV
110 120 130 140 150
WQERNAENAI EALKEYEPEM GKVYRQDRKT VQRIKARDIV PGDIVEVAVG
160 170 180 190 200
DKVPADIRLT SIKSTTLRVD QSILTGESVS VIKHTDPVPD PRAVNQDKKN
210 220 230 240 250
MLFSGTNIAA GKAVGVVVAT GVNTEIGKIR DEMASTEQER TPLQQKLDEF
260 270 280 290 300
GQQLSKVISL ICIAVWIINI GHFNDPVHGG SWVRGAVYYF KIAVALAVAA
310 320 330 340 350
IPEGLPAVIT TCLALGTRRM AKKNAIVRSL PSVETLGCTS VICSDKTGTL
360 370 380 390 400
TTNQMSVCRM FIVDQANGNT CSLKEFSISG STYAPDGQVC HEGKPVQCSK
410 420 430 440 450
FDALVEMASI CALCNDSSLD YNEAKGVYEK VGEATETALT CLVEKMNVFD
460 470 480 490 500
TELKGLSKVE RANACNSVIK QLMKKEFTLE FSRDRKSMSV YCTPNKARSS
510 520 530 540 550
MGKMFVKGAP EGVIDRCTHI RVGGNKVPMT PGIKEKIMSV IREYGTGRDT
560 570 580 590 600
LRCLALATRD NPLSKESLVL EDSTRFVEYE TDLTFVGCVG MLDPPRAEVA
610 620 630 640 650
ASIKLCRQAG IRVIMITGDN KGTAVAICRR IGIFGENDDV SRMAYTGREF
660 670 680 690 700
DDLSAAAQRE AVLTARCFAR VEPSHKSKIV EFLQSYDEIT AMTGDGVNDA
710 720 730 740 750
PALKKAEIGI AMGSGTAVAK TASEMVLADD NFSTIVAAVE EGRAIYNNMK
760 770 780 790 800
QFIRYLISSN VGEVVCIFLT AALGFPEALI PVQLLWVNLV TDGLPATALG
810 820 830 840 850
FNPPDLDIMS KPPRNAREPL ISGWLFFRYL AIGCYVGAAT VGAAAWWFIA
860 870 880 890 900
AEDGPRVTFY QLSHFLQCAP DNPEFEGLQC EIFGSPYPMT MALSVLVTIE
910 920 930 940 950
MCNALNSVSE NQSLLHMPPW ENVWLLGAIC LSMSLHFLIL YVEPLPMIFQ
960 970 980 990 1000
ITPLNVTQWL MVLKISLPVI LLDEVLKFAA RNYLDKPKDL DNPKGKACSL
1010 1020 1030
SACTEGISWP FVALSLPLVL WIYSTDTNVA ELFWS
Length:1,035
Mass (Da):113,581
Last modified:July 5, 2004 - v1
Checksum:i27170BDEC92984B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844518 Genomic DNA. No translation available.
RefSeqiNP_001025448.1. NM_001030277.1.
UniGeneiDr.76755.

Genome annotation databases

EnsembliENSDART00000047201; ENSDARP00000047200; ENSDARG00000005122.
GeneIDi568265.
KEGGidre:568265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844518 Genomic DNA. No translation available.
RefSeqiNP_001025448.1. NM_001030277.1.
UniGeneiDr.76755.

3D structure databases

ProteinModelPortaliQ6ZM60.
SMRiQ6ZM60. Positions 1-985.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000047200.

Proteomic databases

PaxDbiQ6ZM60.
PRIDEiQ6ZM60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000047201; ENSDARP00000047200; ENSDARG00000005122.
GeneIDi568265.
KEGGidre:568265.

Organism-specific databases

CTDi568265.
ZFINiZDB-GENE-030131-867. atp2a2b.

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129745.
HOGENOMiHOG000265621.
HOVERGENiHBG105648.
InParanoidiQ6ZM60.
KOiK05853.
OrthoDBiEOG73Z2SF.
PhylomeDBiQ6ZM60.
TreeFamiTF300651.

Enzyme and pathway databases

ReactomeiR-DRE-418359. Reduction of cytosolic Ca++ levels.
R-DRE-5578775. Ion homeostasis.
R-DRE-936837. Ion transport by P-type ATPases.

Gene expression databases

BgeeiQ6ZM60.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
IPR030327. SERCA2.
[Graphical view]
PANTHERiPTHR24093:SF234. PTHR24093:SF234. 2 hits.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  2. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ6ZM60_DANRE
AccessioniPrimary (citable) accession number: Q6ZM60
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.