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Protein

CBL-interacting protein kinase 23

Gene

CIPK23

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CBL-interacting protein kinase 23 (EC:2.7.11.1)
Alternative name(s):
OsCIPK23
Gene namesi
Name:CIPK23
Ordered Locus Names:Os07g0150700, LOC_Os07g05620
ORF Names:OJ1027_G06.32
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003383811 – 450CBL-interacting protein kinase 23Add BLAST450

Proteomic databases

PaxDbiQ6ZLP5

Expressioni

Inductioni

By drought stress.1 Publication

Gene expression databases

ExpressionAtlasiQ6ZLP5 differential
GenevisibleiQ6ZLP5 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os07g05620.1

Structurei

3D structure databases

ProteinModelPortaliQ6ZLP5
SMRiQ6ZLP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 268Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini306 – 331NAFPROSITE-ProRule annotationAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 183Activation loopBy similarityAdd BLAST30
Regioni339 – 368PPIBy similarityAdd BLAST30

Domaini

The activation loop within the kinase domain is the target of phosphorylation/activation by upstream protein kinases. The PPI motif mediates the interaction with the ABI (abscisic acid-insensitive) phosphatases (By similarity).By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233016
InParanoidiQ6ZLP5
OMAiAQPADIW
OrthoDBiEOG093608WZ

Family and domain databases

InterProiView protein in InterPro
IPR020636 Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009 Kinase-like_dom_sf
IPR018451 NAF/FISL_domain
IPR004041 NAF_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43895 PTHR43895, 1 hit
PfamiView protein in Pfam
PF03822 NAF, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50816 NAF, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZLP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSGGRTRV GRYELGRTLG EGTFAKVKFA RNADSGENVA IKILDKDKVL
60 70 80 90 100
KHKMIAQIKR EISTMKLIRH PNVIRMHEVM ASKTKIYIVM ELVTGGELFD
110 120 130 140 150
KIASRGRLKE DDARKYFQQL INAVDYCHSR GVYHRDLKPE NLLLDASGTL
160 170 180 190 200
KVSDFGLSAL SQQVREDGLL HTTCGTPNYV APEVINNKGY DGAKADLWSC
210 220 230 240 250
GVILFVLMAG YLPFEDSNLM SLYKKIFKAD FSCPSWFSTS AKKLIKKILD
260 270 280 290 300
PNPSTRITIA ELINNEWFKK GYQPPRFETA DVNLDDINSI FNESGDQTQL
310 320 330 340 350
VVERREERPS VMNAFELIST SQGLNLGTLF EKQSQGSVKR ETRFASRLPA
360 370 380 390 400
NEILSKIEAA AGPMGFNVQK RNYKLKLQGE NPGRKGQLAI ATEVFEVTPS
410 420 430 440 450
LYMVELRKSN GDTLEFHKFY HNISNGLKDV MWKPESSIIA GDEIQHRRSP
Length:450
Mass (Da):50,708
Last modified:July 5, 2004 - v1
Checksum:i0B97CDFD3A6FB395
GO
Isoform 2 (identifier: Q6ZLP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: Missing.

Note: Derived from EST data. May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:449
Mass (Da):50,580
Checksum:i9CDD409DCC45F223
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118Q → P in AK069726 (PubMed:12869764).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034045335Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003703 Genomic DNA Translation: BAC82911.1
AP008213 Genomic DNA Translation: BAF20815.1
AP014963 Genomic DNA Translation: BAT00079.1
AK069726 mRNA No translation available.
UniGeneiOs.27738
Os.9372

Genome annotation databases

EnsemblPlantsiOs07t0150700-01; Os07t0150700-01; Os07g0150700 [Q6ZLP5-1]
GrameneiOs07t0150700-01; Os07t0150700-01; Os07g0150700 [Q6ZLP5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiCIPKN_ORYSJ
AccessioniPrimary (citable) accession number: Q6ZLP5
Secondary accession number(s): A0A0P0X2P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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