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Q6ZIX2 (SMT1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cycloartenol-C-24-methyltransferase 1

EC=2.1.1.41
Alternative name(s):
24-sterol C-methyltransferase 1
Short name=Sterol C-methyltransferase 1
Gene names
Name:Smt1-1
Ordered Locus Names:Os07g0206700, LOC_Os07g10600
ORF Names:OJ1119_B04.19-1
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid biosynthesis; sterol biosynthesis.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Cycloartenol-C-24-methyltransferase 1
PRO_0000124803

Experimental info

Sequence conflict2991Y → YKALEY in AAC34988. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6ZIX2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1510C2F576B47ADB

FASTA34438,612
        10         20         30         40         50         60 
MSRSGAMDLA SGLGGKITKD EVKSAVDEYE KYHGYYGGKE EARKSNYTDM VNKYYDLATS 

        70         80         90        100        110        120 
FYEYGWGESF HFAHRWNGES LRESIKRHEH FLALQLGVKP GMKVLDVGCG IGGPLREIAK 

       130        140        150        160        170        180 
FSLASVTGLN NNEYQITRGK ELNRVAGVSG TCDFVKADFM KMPFSDNTFD AVYAIEATCH 

       190        200        210        220        230        240 
APDPVGCYKE IYRVLKPGQC FAVYEWCITD HYEPNNATHK RIKDEIELGN GLPDIRSTQQ 

       250        260        270        280        290        300 
CLQAAKDAGF EVIWDKDLAE DSPVPWYLPL DPSRFSLSSF RLTTVGRAIT RTMVKALEYV 

       310        320        330        340 
GLAPQGSERV SNFLEKAAEG LVEGGKKEIF TPMYFFLVRK PISE 

« Hide

References

« Hide 'large scale' references
[1]"Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis."
Bouvier-Nave P., Husselstein T., Benveniste P.
Eur. J. Biochem. 256:88-96(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Nipponbare.
Tissue: Root.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF042332 mRNA. Translation: AAC34988.1.
AP003943 Genomic DNA. Translation: BAC83238.1.
RefSeqNP_001059154.1. NM_001065689.1.
UniGeneOs.2224.

3D structure databases

ProteinModelPortalQ6ZIX2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6ZIX2. 2 interactions.

Proteomic databases

PRIDEQ6ZIX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS07T0206700-01; OS07T0206700-01; OS07G0206700.
GeneID4342690.
KEGGosa:4342690.

Organism-specific databases

GrameneQ6ZIX2.

Phylogenomic databases

eggNOGCOG0500.
KOK00559.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-7706.
UniPathwayUPA00766.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSMT1_ORYSJ
AccessionPrimary (citable) accession number: Q6ZIX2
Secondary accession number(s): O82426
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways