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Q6ZIX2

- SMT1_ORYSJ

UniProt

Q6ZIX2 - SMT1_ORYSJ

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Protein
Cycloartenol-C-24-methyltransferase 1
Gene
Smt1-1, Os07g0206700, LOC_Os07g10600, OJ1119_B04.19-1
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol By similarity.

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. embryo development ending in seed dormancy Source: EnsemblPlants/Gramene
  2. sterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-7706.
UniPathwayiUPA00766.

Names & Taxonomyi

Protein namesi
Recommended name:
Cycloartenol-C-24-methyltransferase 1 (EC:2.1.1.41)
Alternative name(s):
24-sterol C-methyltransferase 1
Short name:
Sterol C-methyltransferase 1
Gene namesi
Name:Smt1-1
Ordered Locus Names:Os07g0206700, LOC_Os07g10600
ORF Names:OJ1119_B04.19-1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 7

Organism-specific databases

GrameneiQ6ZIX2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: EnsemblPlants/Gramene
  2. plasmodesma Source: EnsemblPlants/Gramene
  3. vacuole Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Cycloartenol-C-24-methyltransferase 1
PRO_0000124803Add
BLAST

Proteomic databases

PRIDEiQ6ZIX2.

Interactioni

Protein-protein interaction databases

IntActiQ6ZIX2. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZIX2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0500.
KOiK00559.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZIX2-1 [UniParc]FASTAAdd to Basket

« Hide

MSRSGAMDLA SGLGGKITKD EVKSAVDEYE KYHGYYGGKE EARKSNYTDM    50
VNKYYDLATS FYEYGWGESF HFAHRWNGES LRESIKRHEH FLALQLGVKP 100
GMKVLDVGCG IGGPLREIAK FSLASVTGLN NNEYQITRGK ELNRVAGVSG 150
TCDFVKADFM KMPFSDNTFD AVYAIEATCH APDPVGCYKE IYRVLKPGQC 200
FAVYEWCITD HYEPNNATHK RIKDEIELGN GLPDIRSTQQ CLQAAKDAGF 250
EVIWDKDLAE DSPVPWYLPL DPSRFSLSSF RLTTVGRAIT RTMVKALEYV 300
GLAPQGSERV SNFLEKAAEG LVEGGKKEIF TPMYFFLVRK PISE 344
Length:344
Mass (Da):38,612
Last modified:July 5, 2004 - v1
Checksum:i1510C2F576B47ADB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991Y → YKALEY in AAC34988. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042332 mRNA. Translation: AAC34988.1.
AP003943 Genomic DNA. Translation: BAC83238.1.
RefSeqiNP_001059154.1. NM_001065689.1.
UniGeneiOs.2224.

Genome annotation databases

EnsemblPlantsiOS07T0206700-01; OS07T0206700-01; OS07G0206700.
GeneIDi4342690.
KEGGiosa:4342690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042332 mRNA. Translation: AAC34988.1 .
AP003943 Genomic DNA. Translation: BAC83238.1 .
RefSeqi NP_001059154.1. NM_001065689.1.
UniGenei Os.2224.

3D structure databases

ProteinModelPortali Q6ZIX2.
ModBasei Search...

Protein-protein interaction databases

IntActi Q6ZIX2. 2 interactions.

Proteomic databases

PRIDEi Q6ZIX2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS07T0206700-01 ; OS07T0206700-01 ; OS07G0206700 .
GeneIDi 4342690.
KEGGi osa:4342690.

Organism-specific databases

Gramenei Q6ZIX2.

Phylogenomic databases

eggNOGi COG0500.
KOi K00559.

Enzyme and pathway databases

UniPathwayi UPA00766 .
BioCyci MetaCyc:MONOMER-7706.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis."
    Bouvier-Nave P., Husselstein T., Benveniste P.
    Eur. J. Biochem. 256:88-96(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Nipponbare.
    Tissue: Root.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiSMT1_ORYSJ
AccessioniPrimary (citable) accession number: Q6ZIX2
Secondary accession number(s): O82426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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