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Q6ZIX2

- SMT1_ORYSJ

UniProt

Q6ZIX2 - SMT1_ORYSJ

Protein

Cycloartenol-C-24-methyltransferase 1

Gene

Smt1-1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. embryo development ending in seed dormancy Source: EnsemblPlants/Gramene
    2. sterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-7706.
    UniPathwayiUPA00766.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cycloartenol-C-24-methyltransferase 1 (EC:2.1.1.41)
    Alternative name(s):
    24-sterol C-methyltransferase 1
    Short name:
    Sterol C-methyltransferase 1
    Gene namesi
    Name:Smt1-1
    Ordered Locus Names:Os07g0206700, LOC_Os07g10600
    ORF Names:OJ1119_B04.19-1
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 7

    Organism-specific databases

    GrameneiQ6ZIX2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: EnsemblPlants/Gramene
    2. plasmodesma Source: EnsemblPlants/Gramene
    3. vacuole Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Cycloartenol-C-24-methyltransferase 1PRO_0000124803Add
    BLAST

    Proteomic databases

    PRIDEiQ6ZIX2.

    Interactioni

    Protein-protein interaction databases

    IntActiQ6ZIX2. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZIX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0500.
    KOiK00559.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZIX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSGAMDLA SGLGGKITKD EVKSAVDEYE KYHGYYGGKE EARKSNYTDM    50
    VNKYYDLATS FYEYGWGESF HFAHRWNGES LRESIKRHEH FLALQLGVKP 100
    GMKVLDVGCG IGGPLREIAK FSLASVTGLN NNEYQITRGK ELNRVAGVSG 150
    TCDFVKADFM KMPFSDNTFD AVYAIEATCH APDPVGCYKE IYRVLKPGQC 200
    FAVYEWCITD HYEPNNATHK RIKDEIELGN GLPDIRSTQQ CLQAAKDAGF 250
    EVIWDKDLAE DSPVPWYLPL DPSRFSLSSF RLTTVGRAIT RTMVKALEYV 300
    GLAPQGSERV SNFLEKAAEG LVEGGKKEIF TPMYFFLVRK PISE 344
    Length:344
    Mass (Da):38,612
    Last modified:July 5, 2004 - v1
    Checksum:i1510C2F576B47ADB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti299 – 2991Y → YKALEY in AAC34988. (PubMed:9746350)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042332 mRNA. Translation: AAC34988.1.
    AP003943 Genomic DNA. Translation: BAC83238.1.
    RefSeqiNP_001059154.1. NM_001065689.1.
    UniGeneiOs.2224.

    Genome annotation databases

    EnsemblPlantsiOS07T0206700-01; OS07T0206700-01; OS07G0206700.
    GeneIDi4342690.
    KEGGiosa:4342690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042332 mRNA. Translation: AAC34988.1 .
    AP003943 Genomic DNA. Translation: BAC83238.1 .
    RefSeqi NP_001059154.1. NM_001065689.1.
    UniGenei Os.2224.

    3D structure databases

    ProteinModelPortali Q6ZIX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6ZIX2. 2 interactions.

    Proteomic databases

    PRIDEi Q6ZIX2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS07T0206700-01 ; OS07T0206700-01 ; OS07G0206700 .
    GeneIDi 4342690.
    KEGGi osa:4342690.

    Organism-specific databases

    Gramenei Q6ZIX2.

    Phylogenomic databases

    eggNOGi COG0500.
    KOi K00559.

    Enzyme and pathway databases

    UniPathwayi UPA00766 .
    BioCyci MetaCyc:MONOMER-7706.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis."
      Bouvier-Nave P., Husselstein T., Benveniste P.
      Eur. J. Biochem. 256:88-96(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Nipponbare.
      Tissue: Root.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiSMT1_ORYSJ
    AccessioniPrimary (citable) accession number: Q6ZIX2
    Secondary accession number(s): O82426
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3