Reviewed, UniProtKB/Swiss-Prot Q6ZFT5 (KPRS4_ORYSJ)

Names and origin

Protein names

Recommended name:
    Ribose-phosphate pyrophosphokinase 4
    EC=2.7.6.1
Alternative name(s):
    Phosphoribosyl pyrophosphate synthetase 4

Gene names

Ordered Locus Names:	Os02g0714600, LOC_Os02g48390
ORF Names:	OJ1191_G08.2, OJ1479_B12.26

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Ribose-phosphate pyrophosphokinase 4		PRO_0000141100
Regions
	Region	228 – 243	16	Binding of phosphoribosylpyrophosphate Potential
Sites
	Metal binding	145	1	Magnesium By similarity
	Metal binding	147	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ZFT5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A4B9D49F688B0F59	FASTA	325	36,149
	10 20 30 40 50 60 MEVVVARQPK AKKQINLFYC SECEELALKV AASSDTIHLQ SINWRSFDDG FPNLFINNAH 70 80 90 100 110 120 DIRGQHVAFL ASFSSPSVIF EQISVIFALP KLFIASFTLV LPFFPTGSFE RVEEEGDVAT 130 140 150 160 170 180 AFTLARILSM IPKSRGGPTS VVIYDIHALQ ERFYFGDDVL PCFETGIPLL LQRLRQLPDA 190 200 210 220 230 240 DNITIAFPDD GAWKRFHKLL LNFPMVVCAK VREGDKRIVR IKEGNPEGRH VVIVDDLVQS 250 260 270 280 290 300 GGTLRECQKV LAAHGAAKVS AYVTHAVFPK QSYERFTHTN SAGSADKFAY FWITDSCPQT 310 320 VKAINQQPPF EVLSLAGSIA DALQI

References

[1]	"Oryza sativa nipponbare chromosome 2 genomic DNA sequence." The international rice genome sequencing project (IRGSP) consortium Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP004047 Genomic DNA. Translation: BAD09159.1. AP004165 Genomic DNA. Translation: BAD07797.1. AK103643 mRNA. No translation available. AK104867 mRNA. No translation available.
RefSeq	NP_001047921.1.
UniGene	Os.8840
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4330515.
KEGG	osa:4330515.
Organism-specific databases
Gramene	Q6ZFT5.
Family and domain databases
InterPro	IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. ribP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHETASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPRS4_ORYSJ

Accession

Primary (citable) accession number: Q6ZFT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)