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Q6ZDY8 (SDHA_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Flavoprotein subunit of complex II
Short name=FP
Gene names
Name:SDH1
Ordered Locus Names:Os07g0134800, LOC_Os07g04240
ORF Names:P0507H12.27
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

FAD By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3131Mitochondrion Potential
Chain32 – 630599Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
PRO_0000247593

Regions

Nucleotide binding52 – 576FAD By similarity
Nucleotide binding75 – 9016FAD By similarity
Nucleotide binding442 – 4432FAD By similarity

Sites

Active site3251Proton acceptor By similarity
Binding site2601FAD By similarity
Binding site2811Substrate By similarity
Binding site2931Substrate By similarity
Binding site3921Substrate By similarity
Binding site4261FAD By similarity
Binding site4371Substrate By similarity

Amino acid modifications

Modified residue831Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6ZDY8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9BDEE1ABC77CF08C

FASTA63068,854
        10         20         30         40         50         60 
MWRGCVSRGL RSLSKGKGSS SSAPVSAAAR LFSTASSSYT VVDHSYDAVV VGAGGAGLRA 

        70         80         90        100        110        120 
AIGLSEHGFN TACITKLFPT RSHTVAAQGG INAALGNMTE DDWRWHMYDT VKGSDWLGDQ 

       130        140        150        160        170        180 
DSIQYMCREA PKAVIELENY GLPFSRTEDG KIYQRAFGGQ SLDFGKGGQA YRCACAADRT 

       190        200        210        220        230        240 
GHAMLHTLYG QAMKHNTQFF VEYFALDLIM DSEGTCQGVI ALNMEDGTLH RFRATNTILA 

       250        260        270        280        290        300 
TGGYGRAYFS ATSAHTCTGD GNAMVARAGL PLQDLEFVQF HPTGIYGAGC LITEGSRGEG 

       310        320        330        340        350        360 
GILRNSEGER FMERYAPTAK DLASRDVVSR SMTMEIREGR GVGPLKDHIY LHLNHLPPEV 

       370        380        390        400        410        420 
LKERLPGISE TAAIFAGVDV TKEPIPVLPT VHYNMGGIPT NYHGEVVTMK GDNPDSVVPG 

       430        440        450        460        470        480 
LMAAGEAACA SVHGANRLGA NSLLDIVVFG RACANRVAET AKPGEKQKPL QKSAGEKTIA 

       490        500        510        520        530        540 
WLDKLRNANG SLPTSKIRLN MQRVMQNNAA VFRTQETLEE GCKLITKAWE SYHDVKISDR 

       550        560        570        580        590        600 
SLIWNSDLIE TIELENLLIN ACITMHSAEA RKESRGAHAR EDFTKRDDEQ WMKHSLGYWE 

       610        620        630 
NEKVRLAYRP VHMNTLDSEV ESFPPKARVY 

« Hide

References

[1]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP004338 Genomic DNA. Translation: BAC83515.1.
AK065901 mRNA. No translation available.
RefSeqNP_001058845.1. NM_001065380.1.
UniGeneOs.22581.

3D structure databases

ProteinModelPortalQ6ZDY8.
SMRQ6ZDY8. Positions 36-630.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ6ZDY8.
PRIDEQ6ZDY8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS07T0134800-01; OS07T0134800-01; OS07G0134800.
GeneID4342350.
KEGGosa:4342350.

Organism-specific databases

GrameneQ6ZDY8.

Phylogenomic databases

eggNOGCOG1053.
HOGENOMHOG000160475.
KOK00234.
OMARDGPILQ.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHA_ORYSJ
AccessionPrimary (citable) accession number: Q6ZDY8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways