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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDH1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial (SDH2-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDH1), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (rps14), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (OsJ_29116), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (OsJ_25852), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial (SDH2-2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei260FADBy similarity1
Binding sitei281SubstrateBy similarity1
Binding sitei293SubstrateBy similarity1
Active sitei325Proton acceptorBy similarity1
Binding sitei392SubstrateBy similarity1
Binding sitei426FADBy similarity1
Binding sitei437SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 57FADBy similarity6
Nucleotide bindingi75 – 90FADBy similarityAdd BLAST16
Nucleotide bindingi442 – 443FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:SDH1
Ordered Locus Names:Os07g0134800, LOC_Os07g04240
ORF Names:P0507H12.27
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000024759332 – 630Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialAdd BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PaxDbiQ6ZDY8
PRIDEiQ6ZDY8

Expressioni

Gene expression databases

ExpressionAtlasiQ6ZDY8 differential
GenevisibleiQ6ZDY8 OS

Interactioni

Subunit structurei

Component of complex II composed of eight subunits in plants: four classical SDH subunits SDH1, SDH2, SDH3 and SDH4 (a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.), as well as four subunits unknown in mitochondria from bacteria and heterotrophic eukaryotes.1 Publication

Protein-protein interaction databases

STRINGi39947.LOC_Os07g04240.1

Structurei

3D structure databases

ProteinModelPortaliQ6ZDY8
SMRiQ6ZDY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
HOGENOMiHOG000160475
InParanoidiQ6ZDY8
KOiK00234
OMAiGDSPWEH
OrthoDBiEOG093604YT

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZDY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRGCVSRGL RSLSKGKGSS SSAPVSAAAR LFSTASSSYT VVDHSYDAVV
60 70 80 90 100
VGAGGAGLRA AIGLSEHGFN TACITKLFPT RSHTVAAQGG INAALGNMTE
110 120 130 140 150
DDWRWHMYDT VKGSDWLGDQ DSIQYMCREA PKAVIELENY GLPFSRTEDG
160 170 180 190 200
KIYQRAFGGQ SLDFGKGGQA YRCACAADRT GHAMLHTLYG QAMKHNTQFF
210 220 230 240 250
VEYFALDLIM DSEGTCQGVI ALNMEDGTLH RFRATNTILA TGGYGRAYFS
260 270 280 290 300
ATSAHTCTGD GNAMVARAGL PLQDLEFVQF HPTGIYGAGC LITEGSRGEG
310 320 330 340 350
GILRNSEGER FMERYAPTAK DLASRDVVSR SMTMEIREGR GVGPLKDHIY
360 370 380 390 400
LHLNHLPPEV LKERLPGISE TAAIFAGVDV TKEPIPVLPT VHYNMGGIPT
410 420 430 440 450
NYHGEVVTMK GDNPDSVVPG LMAAGEAACA SVHGANRLGA NSLLDIVVFG
460 470 480 490 500
RACANRVAET AKPGEKQKPL QKSAGEKTIA WLDKLRNANG SLPTSKIRLN
510 520 530 540 550
MQRVMQNNAA VFRTQETLEE GCKLITKAWE SYHDVKISDR SLIWNSDLIE
560 570 580 590 600
TIELENLLIN ACITMHSAEA RKESRGAHAR EDFTKRDDEQ WMKHSLGYWE
610 620 630
NEKVRLAYRP VHMNTLDSEV ESFPPKARVY
Length:630
Mass (Da):68,854
Last modified:July 5, 2004 - v1
Checksum:i9BDEE1ABC77CF08C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004338 Genomic DNA Translation: BAC83515.1
AP008213 Genomic DNA Translation: BAF20759.1
AP014963 Genomic DNA Translation: BAS99963.1
AK065901 mRNA Translation: BAG89728.1
RefSeqiXP_015646992.1, XM_015791506.1
UniGeneiOs.22581

Genome annotation databases

EnsemblPlantsiOs07t0134800-01; Os07t0134800-01; Os07g0134800
GeneIDi4342350
GrameneiOs07t0134800-01; Os07t0134800-01; Os07g0134800
KEGGiosa:4342350

Similar proteinsi

Entry informationi

Entry nameiSDHA_ORYSJ
AccessioniPrimary (citable) accession number: Q6ZDY8
Secondary accession number(s): A0A0P0X2R9, Q0D8R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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