Reviewed, UniProtKB/Swiss-Prot Q6ZDY8 (DHSA_ORYSJ)

Names and origin

Protein names

Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    EC=1.3.5.1
Alternative name(s):
    Flavoprotein subunit of complex II
      Short name=FP

Gene names

Name:	SDH1
Ordered Locus Names:	Os07g0134800, LOC_Os07g04240
ORF Names:	P0507H12.27

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.
Catalytic activity	Succinate + ubiquinone = fumarate + ubiquinol.
Cofactor	FAD By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Subunit structure	Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro succinate dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 31	31	Mitochondrion Potential
	Chain	32 – 630	599	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial		PRO_0000247593
Regions
	Nucleotide binding	75 – 90	16	FAD By similarity
Sites
	Active site	325	1	Proton acceptor By similarity
	Binding site	281	1	Substrate By similarity
	Binding site	293	1	Substrate By similarity
	Binding site	392	1	Substrate By similarity
	Binding site	437	1	Substrate By similarity
Amino acid modifications
	Modified residue	83	1	Tele-8alpha-FAD histidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ZDY8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9BDEE1ABC77CF08C	FASTA	630	68,854
	10 20 30 40 50 60 MWRGCVSRGL RSLSKGKGSS SSAPVSAAAR LFSTASSSYT VVDHSYDAVV VGAGGAGLRA 70 80 90 100 110 120 AIGLSEHGFN TACITKLFPT RSHTVAAQGG INAALGNMTE DDWRWHMYDT VKGSDWLGDQ 130 140 150 160 170 180 DSIQYMCREA PKAVIELENY GLPFSRTEDG KIYQRAFGGQ SLDFGKGGQA YRCACAADRT 190 200 210 220 230 240 GHAMLHTLYG QAMKHNTQFF VEYFALDLIM DSEGTCQGVI ALNMEDGTLH RFRATNTILA 250 260 270 280 290 300 TGGYGRAYFS ATSAHTCTGD GNAMVARAGL PLQDLEFVQF HPTGIYGAGC LITEGSRGEG 310 320 330 340 350 360 GILRNSEGER FMERYAPTAK DLASRDVVSR SMTMEIREGR GVGPLKDHIY LHLNHLPPEV 370 380 390 400 410 420 LKERLPGISE TAAIFAGVDV TKEPIPVLPT VHYNMGGIPT NYHGEVVTMK GDNPDSVVPG 430 440 450 460 470 480 LMAAGEAACA SVHGANRLGA NSLLDIVVFG RACANRVAET AKPGEKQKPL QKSAGEKTIA 490 500 510 520 530 540 WLDKLRNANG SLPTSKIRLN MQRVMQNNAA VFRTQETLEE GCKLITKAWE SYHDVKISDR 550 560 570 580 590 600 SLIWNSDLIE TIELENLLIN ACITMHSAEA RKESRGAHAR EDFTKRDDEQ WMKHSLGYWE 610 620 630 NEKVRLAYRP VHMNTLDSEV ESFPPKARVY

References

[1]	"Oryza sativa nipponbare chromosome 7 genomic DNA sequence." The international rice genome sequencing project (IRGSP) consortium Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP004338 Genomic DNA. Translation: BAC83515.1. AK065901 mRNA. No translation available.
RefSeq	NP_001058845.1.
UniGene	Os.22581
3D structure databases
SMR	Q6ZDY8. Positions 36-630.
ModBase	Search...
Genome annotation databases
GeneID	4342350.
KEGG	osa:4342350.
Organism-specific databases
Gramene	Q6ZDY8.
Phylogenomic databases
PhylomeDB	Q6ZDY8.
Family and domain databases
InterPro	IPR003953. FAD_bind2_N. IPR003952. FRD_SDH_FAD_BS. IPR015939. Fum_Rdtase/Succ_DH_flav-like_C. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR011281. Succ_DH_flav_su_fwd. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR01816. sdhA_forward. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSA_ORYSJ

Accession

Primary (citable) accession number: Q6ZDY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)