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Q6ZDE3

- ABAH2_ORYSJ

UniProt

Q6ZDE3 - ABAH2_ORYSJ

Protein

Abscisic acid 8'-hydroxylase 2

Gene

CYP707A6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in the oxidative degradation of abscisic acid.

    Catalytic activityi

    +-abscisate + NADPH + O2 = 8'-hydroxyabscisate + NADP+ + H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. (+)-abscisic acid 8'-hydroxylase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. abscisic acid catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00093.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abscisic acid 8'-hydroxylase 2 (EC:1.14.13.93)
    Short name:
    ABA 8'-hydroxylase 2
    Alternative name(s):
    Cytochrome P450 707A6
    OsABA8ox2
    Gene namesi
    Name:CYP707A6
    Synonyms:ABA8OX2
    Ordered Locus Names:Os08g0472800, LOC_Os08g36860
    ORF Names:OsJ_026541, P0013B04.19
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 8

    Organism-specific databases

    GrameneiQ6ZDE3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Abscisic acid 8'-hydroxylase 2PRO_0000288646Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZDE3.
    PRIDEiQ6ZDE3.

    Expressioni

    Inductioni

    Not induced by ethylene treatment or flooding.

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os08g36860.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZDE3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi45 – 484Poly-Lys
    Compositional biasi260 – 28425Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000237614.
    KOiK09843.
    OMAiKHETIAK.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZDE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFLLFFVFV TAAVLCFVVP AFLLLCTSVQ RRRDVGQGGG RDWQKKKKLR    50
    LPPGSMGWPY VGETLQLYSQ DPNVFFASKQ KRYGEIFKTN LLGCPCVMLA 100
    SPEAARFVLV SQARLFKPTY PPSKERMIGP SALFFHQGEY HLRLRRLVQA 150
    ALAPDSLRAL VPDVDAAVAA TLAAWSGGHV ASTFHAMKKL SFDVGVVTIF 200
    GGRLGRRHRE ELRTNYSVVE RGYNCFPNRF PGTLYHKAIQ ARKRLRAILS 250
    EIVAERRARG GGGGGGGDDL LGGLMRSRDD GTAGAVALLT DDQIADNVVG 300
    VLFAAQDTTA SVLTWILKYL HDSPKLLEAV KAEQMAIYVA NEGGKRPLTW 350
    TQTRSMTLTH QVILESLRMA SIISFTFREA VADVEYKGFL IPKGWKVMPL 400
    FRNIHHNPDY FQDPQKFDPS RFKVAPRPST FLPFGSGVHA CPGNELAKLE 450
    MLVLVHRLVT AYRWEIVGAS DEVEYSPFPV PRGGLNAKLW KQEAEEDMYM 500
    AMGTITAAGA 510
    Length:510
    Mass (Da):56,556
    Last modified:July 5, 2004 - v1
    Checksum:iC1F583725741091E
    GO

    Sequence cautioni

    The sequence EAZ43058.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti430 – 4301T → S in AK120757. (PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004457 Genomic DNA. Translation: BAD09367.1.
    AP008214 Genomic DNA. Translation: BAF23935.1.
    CM000145 Genomic DNA. Translation: EAZ43058.1. Sequence problems.
    AK120757 mRNA. No translation available.
    RefSeqiNP_001062021.1. NM_001068556.1.
    UniGeneiOs.50329.

    Genome annotation databases

    EnsemblPlantsiOS08T0472800-01; OS08T0472800-01; OS08G0472800.
    GeneIDi4345810.
    KEGGiosa:4345810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004457 Genomic DNA. Translation: BAD09367.1 .
    AP008214 Genomic DNA. Translation: BAF23935.1 .
    CM000145 Genomic DNA. Translation: EAZ43058.1 . Sequence problems.
    AK120757 mRNA. No translation available.
    RefSeqi NP_001062021.1. NM_001068556.1.
    UniGenei Os.50329.

    3D structure databases

    ProteinModelPortali Q6ZDE3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os08g36860.1.

    Proteomic databases

    PaxDbi Q6ZDE3.
    PRIDEi Q6ZDE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS08T0472800-01 ; OS08T0472800-01 ; OS08G0472800 .
    GeneIDi 4345810.
    KEGGi osa:4345810.

    Organism-specific databases

    Gramenei Q6ZDE3.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000237614.
    KOi K09843.
    OMAi KHETIAK.

    Enzyme and pathway databases

    UniPathwayi UPA00093 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.
    5. Cited for: IDENTIFICATION, LACK OF INDUCTION.
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiABAH2_ORYSJ
    AccessioniPrimary (citable) accession number: Q6ZDE3
    Secondary accession number(s): A3BU19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3