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Protein

Abscisic acid 8'-hydroxylase 2

Gene

CYP707A6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the oxidative degradation of abscisic acid.

Catalytic activityi

+-abscisate + NADPH + O2 = 8'-hydroxyabscisate + NADP+ + H2O.

Cofactori

hemeBy similarity

Pathwayi: abscisic acid degradation

This protein is involved in the pathway abscisic acid degradation, which is part of Plant hormone degradation.
View all proteins of this organism that are known to be involved in the pathway abscisic acid degradation and in Plant hormone degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi441Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.14.13.93 4460
ReactomeiR-OSA-211916 Vitamins
R-OSA-5365859 RA biosynthesis pathway
UniPathwayiUPA00093

Names & Taxonomyi

Protein namesi
Recommended name:
Abscisic acid 8'-hydroxylase 2 (EC:1.14.13.93)
Short name:
ABA 8'-hydroxylase 2
Alternative name(s):
Cytochrome P450 707A6
OsABA8ox2
Gene namesi
Name:CYP707A6
Synonyms:ABA8OX2
Ordered Locus Names:Os08g0472800, LOC_Os08g36860
ORF Names:OsJ_026541, P0013B04.19
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886461 – 510Abscisic acid 8'-hydroxylase 2Add BLAST510

Proteomic databases

PaxDbiQ6ZDE3
PRIDEiQ6ZDE3

Expressioni

Inductioni

Not induced by ethylene treatment or flooding.

Gene expression databases

ExpressionAtlasiQ6ZDE3 differential
GenevisibleiQ6ZDE3 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os08g36860.1

Structurei

3D structure databases

ProteinModelPortaliQ6ZDE3
SMRiQ6ZDE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 48Poly-Lys4
Compositional biasi260 – 284Gly-richAdd BLAST25

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
HOGENOMiHOG000237614
InParanoidiQ6ZDE3
KOiK09843
OMAiAHDTSAI
OrthoDBiEOG093607VK

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZDE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLLFFVFV TAAVLCFVVP AFLLLCTSVQ RRRDVGQGGG RDWQKKKKLR
60 70 80 90 100
LPPGSMGWPY VGETLQLYSQ DPNVFFASKQ KRYGEIFKTN LLGCPCVMLA
110 120 130 140 150
SPEAARFVLV SQARLFKPTY PPSKERMIGP SALFFHQGEY HLRLRRLVQA
160 170 180 190 200
ALAPDSLRAL VPDVDAAVAA TLAAWSGGHV ASTFHAMKKL SFDVGVVTIF
210 220 230 240 250
GGRLGRRHRE ELRTNYSVVE RGYNCFPNRF PGTLYHKAIQ ARKRLRAILS
260 270 280 290 300
EIVAERRARG GGGGGGGDDL LGGLMRSRDD GTAGAVALLT DDQIADNVVG
310 320 330 340 350
VLFAAQDTTA SVLTWILKYL HDSPKLLEAV KAEQMAIYVA NEGGKRPLTW
360 370 380 390 400
TQTRSMTLTH QVILESLRMA SIISFTFREA VADVEYKGFL IPKGWKVMPL
410 420 430 440 450
FRNIHHNPDY FQDPQKFDPS RFKVAPRPST FLPFGSGVHA CPGNELAKLE
460 470 480 490 500
MLVLVHRLVT AYRWEIVGAS DEVEYSPFPV PRGGLNAKLW KQEAEEDMYM
510
AMGTITAAGA
Length:510
Mass (Da):56,556
Last modified:July 5, 2004 - v1
Checksum:iC1F583725741091E
GO

Sequence cautioni

The sequence EAZ43058 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti430T → S in AK120757 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004457 Genomic DNA Translation: BAD09367.1
AP008214 Genomic DNA Translation: BAF23935.1
AP014964 Genomic DNA Translation: BAT05855.1
CM000145 Genomic DNA Translation: EAZ43058.1 Sequence problems.
AK120757 mRNA No translation available.
RefSeqiXP_015648451.1, XM_015792965.1
UniGeneiOs.50329

Genome annotation databases

EnsemblPlantsiOs08t0472800-01; Os08t0472800-01; Os08g0472800
GeneIDi4345810
GrameneiOs08t0472800-01; Os08t0472800-01; Os08g0472800
KEGGiosa:4345810

Similar proteinsi

Entry informationi

Entry nameiABAH2_ORYSJ
AccessioniPrimary (citable) accession number: Q6ZDE3
Secondary accession number(s): A0A0P0XGQ2, A3BU19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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