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Reviewed, UniProtKB/Swiss-Prot Q6Z9U7 (MCES1_ORYSJ)

Last modified November 25, 2008. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    mRNA cap guanine-N7 methyltransferase 1
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase 1
    mRNA cap methyltransferase 1
Gene names
Ordered Locus Names: Os08g0180000, LOC_Os08g08200
ORF Names: P0455A11.11
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

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Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC By similarity.

Catalytic activity

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.

Subcellular location

NucleusBy similarity.

Sequence similarities

Belongs to the mRNA cap methyltransferase family.

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Ontologies

Keywords

   Biological processmRNA capping
mRNA processing
   Cellular componentNucleus
   LigandRNA-binding
S-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase

Gene Ontology (GO)

   Biological processmRNA capping

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369mRNA cap guanine-N7 methyltransferase 1
PRO_0000248332

Regions

Region70 – 712mRNA cap binding By similarity

Sites

Binding site741S-adenosyl-L-methionine By similarity
Binding site921S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site951mRNA cap By similarity
Binding site1011mRNA cap By similarity
Binding site1141S-adenosyl-L-methionine By similarity
Binding site1261mRNA cap By similarity
Binding site1491S-adenosyl-L-methionine By similarity
Binding site1711S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site1751mRNA cap By similarity
Binding site2631mRNA cap By similarity
Binding site3321mRNA cap By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6Z9U7-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C18AD9B1B380AE62

FASTA36942,040
        10         20         30         40         50         60 
MNKRPRDEPS SSFASAPKRQ YGAGGGGYGG HGYSEERSSA RRVADHYSAR SNQTLEEREN 

        70         80         90        100        110        120 
SPIIHLKKLN NWIKSVLIQL YAHPGDCVLD LACGKGGDLI KWDKAKVGYY VGVDIAEGSI 

       130        140        150        160        170        180 
KDCMTRYNGD TDQQRRKKFS FPARLICADC YEARLDEHLY EDAPFDICSC QFALHYSWST 

       190        200        210        220        230        240 
EARARQALAN VSALLRPGGV FIGTMPDANV IIKRLRETDG MEFGNGVYWI SFGEEYAEKK 

       250        260        270        280        290        300 
FPASRPFGIK YKFHLEDAVD CPEWVVPFHL FKLLAEEYDL ELVLTKNFHE FVHEYLQKPE 

       310        320        330        340        350        360 
FAELMRRLGA LGDGRQDQST LSQDEWEVAY LYLAFVLRKR GQPPSQRRAN NANRGKMFLT 


ENDIDFLGV

« Hide

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References

[1]"Oryza sativa nipponbare chromosome 8 genomic DNA sequence."
The international rice genome sequencing project (IRGSP) consortium
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed: 12869764] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

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Cross-references

Sequence databases

AP004692 Genomic DNA. Translation: BAD17036.1.
AP008214 Genomic DNA. Translation: BAF23050.1.
AK063927 mRNA. No translation available.
RefSeqNP_001061136.1.
UniGeneOs.21877

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4344818.
KEGGosa:4344818.

Organism-specific databases

GrameneQ6Z9U7.

Family and domain databases

InterProIPR016899. mRNA_G-N7_MeTrfase.
IPR004971. Pox_MCEL.
[Graphical view]
PfamPF03291. Pox_MCEL. 1 hit.
[Graphical view]
PIRSFPIRSF028762. ABD1. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameMCES1_ORYSJ
AccessionPrimary (citable) accession number: Q6Z9U7
Secondary accession number(s): Q0J7L5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents