CDKF-4

Functionⁱ

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	33	ATPPROSITE-ProRule annotation		1
Active siteⁱ	125	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	10 – 18	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
protein serine/threonine kinase activity Source: GO_Central
RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

intracellular signal transduction Source: GO_Central
regulation of gene expression Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase F-4 (EC:2.7.11.22, EC:2.7.11.23) Short name: CDKF;4 Alternative name(s): Serine/threonine-protein kinase MHK-like protein 2
Gene namesⁱ	Name:CDKF-4 Ordered Locus Names:Os02g0700600, LOC_Os02g47220 ORF Names:OJ1111_E07.13-1, OsJ_08052Imported, P0459B01.42-1
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 2

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: GO_Central
nucleus Source: GO_Central

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000296109	1 – 459	Cyclin-dependent kinase F-4Add BLAST		459

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	151	PhosphoserineBy similarity		1
Modified residueⁱ	156	PhosphothreonineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6Z8C8.
PRIDEⁱ	Q6Z8C8.

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q6Z8C8. baseline and differential.
Genevisibleⁱ	Q6Z8C8. OS.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os02g47220.1.

STRINGⁱ

39947.LOC_Os02g47220.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6Z8C8.
SMRⁱ	Q6Z8C8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 283	Protein kinasePROSITE-ProRule annotationAdd BLAST		280

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0661. Eukaryota. ENOG410XPBB. LUCA.
HOGENOMⁱ	HOG000233024.
InParanoidⁱ	Q6Z8C8.
OMAⁱ	ENIMCNG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608EM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6Z8C8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDRFKMIKEV GDGTFGSVWR AINKQNGEVV AVKKMKRKYY SFEECMSLRE 
        60         70         80         90        100
VKSLRRMNHP NIVKLKEVIR ENDILYFIME YMECNLYQLM KDRVKPFSEA 
       110        120        130        140        150
EVRNWCFQIF QALAYMHQRG YFHRDLKPEN LLVSKDVIKL ADFGLAREVT 
       160        170        180        190        200
SVPPYTEYVS TRWYRAPEVL LQSSIYDSAV DMWAMGAIMA ELLTLHPLFP 
       210        220        230        240        250
GTSEADEILK ICNVIGSPDE QSWPQGLSLA ETMKFQFPQV SGNQLAEVMT 
       260        270        280        290        300
SVSSEAVDLI SSLCSWDPCK RPKAAEVLQH TFFQGCTFVP PTVRSKAGVL 
       310        320        330        340        350
PKTPPCVGVK GVSEHGMPRR YSTGTLSTTK PHSNASLKSS GLSKTGVQRK 
       360        370        380        390        400
LQMDRQAPQK IKKPTESNNK LTTNRVPARN SPGHPVLRHS RSLPETGRAT 
       410        420        430        440        450
MHKVSTLTER LTHMSVTSRT RTTPKPAAPL LKAGLGKSDL LGKTDEIPPA 

KRLTRKLVS

Length:459

Mass (Da):51,720

Last modified:July 5, 2004 - v1

Checksum:ⁱB527ED78C8B15E1F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP003994 Genomic DNA. Translation: BAD07520.1. AP004778 Genomic DNA. Translation: BAD07891.1. AP008208 Genomic DNA. Translation: BAF09755.1. AP014958 Genomic DNA. Translation: BAS80463.1. CM000139 Genomic DNA. Translation: EEE57632.1. AK100056 mRNA. Translation: BAG94420.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015626442.1. XM_015770956.1. XP_015626443.1. XM_015770957.1. XP_015626444.1. XM_015770958.1.
UniGeneⁱ	Os.12650.

Genome annotation databases

EnsemblPlantsⁱ	OS02T0700600-01; OS02T0700600-01; OS02G0700600.
GeneIDⁱ	4330434.
Grameneⁱ	OS02T0700600-01; OS02T0700600-01; OS02G0700600.
KEGGⁱ	osa:4330434.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP003994 Genomic DNA. Translation: BAD07520.1. AP004778 Genomic DNA. Translation: BAD07891.1. AP008208 Genomic DNA. Translation: BAF09755.1. AP014958 Genomic DNA. Translation: BAS80463.1. CM000139 Genomic DNA. Translation: EEE57632.1. AK100056 mRNA. Translation: BAG94420.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015626442.1. XM_015770956.1. XP_015626443.1. XM_015770957.1. XP_015626444.1. XM_015770958.1.
UniGeneⁱ	Os.12650.

3D structure databases

ProteinModelPortalⁱ	Q6Z8C8.
SMRⁱ	Q6Z8C8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os02g47220.1.

STRINGⁱ

39947.LOC_Os02g47220.1.

Proteomic databases

PaxDbⁱ	Q6Z8C8.
PRIDEⁱ	Q6Z8C8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	OS02T0700600-01; OS02T0700600-01; OS02G0700600.
GeneIDⁱ	4330434.
Grameneⁱ	OS02T0700600-01; OS02T0700600-01; OS02G0700600.
KEGGⁱ	osa:4330434.

Phylogenomic databases

eggNOGⁱ	KOG0661. Eukaryota. ENOG410XPBB. LUCA.
HOGENOMⁱ	HOG000233024.
InParanoidⁱ	Q6Z8C8.
OMAⁱ	ENIMCNG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608EM.

Gene expression databases

ExpressionAtlasⁱ	Q6Z8C8. baseline and differential.
Genevisibleⁱ	Q6Z8C8. OS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDKF4_ORYSJ
Accessionⁱ	Q6Z8C8Primary (citable) accession number: Q6Z8C8 Secondary accession number(s): B7EPX3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
	Last sequence update:	July 5, 2004
	Last modified:	June 7, 2017
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6Z8C8 (CDKF4_ORYSJ)

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Cyclin-dependent kinase F-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ