Q6Z8C8 (CDKF4_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase F-4
Short name=CDKF;4
EC=2.7.11.22
EC=2.7.11.23

Alternative name(s):
Serine/threonine-protein kinase MHK-like protein 2

Gene names

Name:	CDKF-4
Ordered Locus Names:	Os02g0700600, LOC_Os02g47220
ORF Names:	OJ1111_E07.13-1, P0459B01.42-1

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: UniProtKB-EC cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	Cyclin-dependent kinase F-4		PRO_0000296109
Regions
	Domain	4 – 283	280	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	125	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity
Amino acid modifications
	Modified residue	151	1	Phosphoserine By similarity
	Modified residue	156	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6Z8C8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B527ED78C8B15E1F	FASTA	459	51,720
	10 20 30 40 50 60 MDRFKMIKEV GDGTFGSVWR AINKQNGEVV AVKKMKRKYY SFEECMSLRE VKSLRRMNHP 70 80 90 100 110 120 NIVKLKEVIR ENDILYFIME YMECNLYQLM KDRVKPFSEA EVRNWCFQIF QALAYMHQRG 130 140 150 160 170 180 YFHRDLKPEN LLVSKDVIKL ADFGLAREVT SVPPYTEYVS TRWYRAPEVL LQSSIYDSAV 190 200 210 220 230 240 DMWAMGAIMA ELLTLHPLFP GTSEADEILK ICNVIGSPDE QSWPQGLSLA ETMKFQFPQV 250 260 270 280 290 300 SGNQLAEVMT SVSSEAVDLI SSLCSWDPCK RPKAAEVLQH TFFQGCTFVP PTVRSKAGVL 310 320 330 340 350 360 PKTPPCVGVK GVSEHGMPRR YSTGTLSTTK PHSNASLKSS GLSKTGVQRK LQMDRQAPQK 370 380 390 400 410 420 IKKPTESNNK LTTNRVPARN SPGHPVLRHS RSLPETGRAT MHKVSTLTER LTHMSVTSRT 430 440 450 RTTPKPAAPL LKAGLGKSDL LGKTDEIPPA KRLTRKLVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[3]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.
[4]	"Genome-wide identification and expression analysis of rice cell cycle genes." Guo J., Song J., Wang F., Zhang X.S. Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP003994 Genomic DNA. Translation: BAD07520.1. AP004778 Genomic DNA. Translation: BAD07891.1. AP008208 Genomic DNA. Translation: BAF09755.1. AK100056 mRNA. No translation available.
RefSeq	NP_001047841.1. NM_001054376.1.
UniGene	Os.12650.
3D structure databases
ProteinModelPortal	Q6Z8C8.
ModBase	Search...
MobiDB	Search...
Proteomic databases
PRIDE	Q6Z8C8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	OS02T0700600-01; OS02T0700600-01; OS02G0700600.
GeneID	4330434.
KEGG	osa:4330434.
Organism-specific databases
Gramene	Q6Z8C8.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233024.
OMA	FEECMSL.
ProtClustDB	CLSN2693106.
Gene expression databases
ArrayExpress	Q6Z8C8.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. SSF56112. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDKF4_ORYSJ

Accession

Primary (citable) accession number: Q6Z8C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 5, 2004
Last modified:	February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program