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Protein

Cyclin-dependent kinase F-4

Gene

CDKF-4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase F-4 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKF;4
Alternative name(s):
Serine/threonine-protein kinase MHK-like protein 2
Gene namesi
Name:CDKF-4
Ordered Locus Names:Os02g0700600, LOC_Os02g47220
ORF Names:OJ1111_E07.13-1, P0459B01.42-1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763 Componenti: Chromosome 2

Organism-specific databases

GrameneiQ6Z8C8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Cyclin-dependent kinase F-4PRO_0000296109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei156 – 1561PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6Z8C8.

Expressioni

Gene expression databases

ExpressionAtlasiQ6Z8C8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6Z8C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 283280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6Z8C8.
OMAiMDRQAPQ.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Z8C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRFKMIKEV GDGTFGSVWR AINKQNGEVV AVKKMKRKYY SFEECMSLRE
60 70 80 90 100
VKSLRRMNHP NIVKLKEVIR ENDILYFIME YMECNLYQLM KDRVKPFSEA
110 120 130 140 150
EVRNWCFQIF QALAYMHQRG YFHRDLKPEN LLVSKDVIKL ADFGLAREVT
160 170 180 190 200
SVPPYTEYVS TRWYRAPEVL LQSSIYDSAV DMWAMGAIMA ELLTLHPLFP
210 220 230 240 250
GTSEADEILK ICNVIGSPDE QSWPQGLSLA ETMKFQFPQV SGNQLAEVMT
260 270 280 290 300
SVSSEAVDLI SSLCSWDPCK RPKAAEVLQH TFFQGCTFVP PTVRSKAGVL
310 320 330 340 350
PKTPPCVGVK GVSEHGMPRR YSTGTLSTTK PHSNASLKSS GLSKTGVQRK
360 370 380 390 400
LQMDRQAPQK IKKPTESNNK LTTNRVPARN SPGHPVLRHS RSLPETGRAT
410 420 430 440 450
MHKVSTLTER LTHMSVTSRT RTTPKPAAPL LKAGLGKSDL LGKTDEIPPA

KRLTRKLVS
Length:459
Mass (Da):51,720
Last modified:July 5, 2004 - v1
Checksum:iB527ED78C8B15E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003994 Genomic DNA. Translation: BAD07520.1.
AP004778 Genomic DNA. Translation: BAD07891.1.
AP008208 Genomic DNA. Translation: BAF09755.1.
AK100056 mRNA. No translation available.
RefSeqiNP_001047841.1. NM_001054376.1.
UniGeneiOs.12650.

Genome annotation databases

EnsemblPlantsiOS02T0700600-01; OS02T0700600-01; OS02G0700600.
GeneIDi4330434.
KEGGiosa:4330434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003994 Genomic DNA. Translation: BAD07520.1.
AP004778 Genomic DNA. Translation: BAD07891.1.
AP008208 Genomic DNA. Translation: BAF09755.1.
AK100056 mRNA. No translation available.
RefSeqiNP_001047841.1. NM_001054376.1.
UniGeneiOs.12650.

3D structure databases

ProteinModelPortaliQ6Z8C8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6Z8C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0700600-01; OS02T0700600-01; OS02G0700600.
GeneIDi4330434.
KEGGiosa:4330434.

Organism-specific databases

GrameneiQ6Z8C8.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6Z8C8.
OMAiMDRQAPQ.

Gene expression databases

ExpressionAtlasiQ6Z8C8. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  4. "Genome-wide identification and expression analysis of rice cell cycle genes."
    Guo J., Song J., Wang F., Zhang X.S.
    Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiCDKF4_ORYSJ
AccessioniPrimary (citable) accession number: Q6Z8C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.