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Q6Z829

- WEE1_ORYSJ

UniProt

Q6Z829 - WEE1_ORYSJ

Protein

Wee1-like protein kinase

Gene

WEE1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei296 – 2961ATPPROSITE-ProRule annotation
    Active sitei387 – 3871Proton acceptorPROSITE-ProRule annotation
    Metal bindingi392 – 3921Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi404 – 4041Magnesium; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi273 – 2819ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    4. protein serine/threonine kinase activity Source: InterPro

    GO - Biological processi

    1. cell cycle arrest Source: EnsemblPlants/Gramene
    2. DNA replication checkpoint Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Wee1-like protein kinase (EC:2.7.10.2)
    Gene namesi
    Name:WEE1
    Ordered Locus Names:Os02g0135300, LOC_Os02g04240
    ORF Names:P0585B01.27
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiQ6Z829.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Wee1-like protein kinasePRO_0000295673Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Z829.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini267 – 510244Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000083236.
    OMAiRYRTDFH.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6Z829-1 [UniParc]FASTAAdd to Basket

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    MLRTKTPRPR GGKSRRATAA AGKERERERE REREGRSPSG ELSLQLEHVS    50
    LFSFLADAPR EGAAAARTPF TPFEELLEGS CDPDPTPPPP LPPLQPQATP 100
    MDADEVVEEK DSGILSQDFF CTPDYITPDA PQLGSGFDAN KENIPCPNSP 150
    EKSVCRSKRY KRDCSPKGLG SNDIFDSQWI APVQFEGLDD SEEEQLKESS 200
    SHKRGSYVSQ SAVALRCRVM PPPCIRNPYL NTDHQIDDNV FGGRQCKSSG 250
    FSPSVDGDGL SRYRTDFHEI EQIGRGNFSV VFKVLKRIDG CLYAVKRSIR 300
    QLHNDRERRQ AVKEVQALAA LGCHENIVGY FTSWFENKQL FIQMELCDRC 350
    LSMDRNQPLK CGEALELLYQ ICKGLDFIHE RGIAHLDVKP DNIYVRNGVY 400
    KLGDFGCATL IDRSLAIEDG DSRYMPPEML NDKYEHLDKV DIFSLGAAIY 450
    ELIRGTQLPD SGPQFTSLRE GKIALLPGCP MQFQSLIKSM MDPDPVRRPS 500
    AKEVLRHPIF DKLHKAPAKK 520
    Length:520
    Mass (Da):58,391
    Last modified:July 5, 2004 - v1
    Checksum:i934F492877B99F9F
    GO

    Sequence cautioni

    The sequence BAF07730.2 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004799 Genomic DNA. Translation: BAD10095.1.
    AP008208 Genomic DNA. Translation: BAF07730.2. Sequence problems.
    RefSeqiNP_001045816.2. NM_001052351.2.
    UniGeneiOs.98767.

    Genome annotation databases

    EnsemblPlantsiOS02T0135300-00; OS02T0135300-00; OS02G0135300.
    GeneIDi4328224.
    KEGGiosa:4328224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004799 Genomic DNA. Translation: BAD10095.1 .
    AP008208 Genomic DNA. Translation: BAF07730.2 . Sequence problems.
    RefSeqi NP_001045816.2. NM_001052351.2.
    UniGenei Os.98767.

    3D structure databases

    ProteinModelPortali Q6Z829.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS02T0135300-00 ; OS02T0135300-00 ; OS02G0135300 .
    GeneIDi 4328224.
    KEGGi osa:4328224.

    Organism-specific databases

    Gramenei Q6Z829.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000083236.
    OMAi RYRTDFH.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "Genome-wide identification and expression analysis of rice cell cycle genes."
      Guo J., Song J., Wang F., Zhang X.S.
      Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiWEE1_ORYSJ
    AccessioniPrimary (citable) accession number: Q6Z829
    Secondary accession number(s): Q0E458
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3