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Protein

Wee1-like protein kinase

Gene

WEE1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei296 – 2961ATPPROSITE-ProRule annotation
Active sitei387 – 3871Proton acceptorPROSITE-ProRule annotation
Metal bindingi392 – 3921Magnesium; via carbonyl oxygenBy similarity
Metal bindingi404 – 4041Magnesium; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi273 – 2819ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  4. protein serine/threonine kinase activity Source: EnsemblPlants/Gramene

GO - Biological processi

  1. cell proliferation Source: EnsemblPlants/Gramene
  2. cytokinesis by cell plate formation Source: EnsemblPlants/Gramene
  3. DNA endoreduplication Source: EnsemblPlants/Gramene
  4. DNA methylation Source: EnsemblPlants/Gramene
  5. DNA replication initiation Source: EnsemblPlants/Gramene
  6. double-strand break repair via homologous recombination Source: EnsemblPlants/Gramene
  7. gene silencing by RNA Source: EnsemblPlants/Gramene
  8. histone H3-K9 methylation Source: EnsemblPlants/Gramene
  9. mitotic nuclear division Source: EnsemblPlants/Gramene
  10. pollen development Source: EnsemblPlants/Gramene
  11. regulation of DNA replication Source: EnsemblPlants/Gramene
  12. regulation of G2/M transition of mitotic cell cycle Source: EnsemblPlants/Gramene
  13. somatic cell DNA recombination Source: EnsemblPlants/Gramene
  14. spindle assembly Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Wee1-like protein kinase (EC:2.7.10.2)
Gene namesi
Name:WEE1
Ordered Locus Names:Os02g0135300, LOC_Os02g04240
ORF Names:P0585B01.27
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 2

Organism-specific databases

GrameneiQ6Z829.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Wee1-like protein kinasePRO_0000295673Add
BLAST

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

ExpressionAtlasiQ6Z829. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ6Z829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini267 – 510244Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000083236.
InParanoidiQ6Z829.
OMAiCCILSQD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Z829-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRTKTPRPR GGKSRRATAA AGKERERERE REREGRSPSG ELSLQLEHVS
60 70 80 90 100
LFSFLADAPR EGAAAARTPF TPFEELLEGS CDPDPTPPPP LPPLQPQATP
110 120 130 140 150
MDADEVVEEK DSGILSQDFF CTPDYITPDA PQLGSGFDAN KENIPCPNSP
160 170 180 190 200
EKSVCRSKRY KRDCSPKGLG SNDIFDSQWI APVQFEGLDD SEEEQLKESS
210 220 230 240 250
SHKRGSYVSQ SAVALRCRVM PPPCIRNPYL NTDHQIDDNV FGGRQCKSSG
260 270 280 290 300
FSPSVDGDGL SRYRTDFHEI EQIGRGNFSV VFKVLKRIDG CLYAVKRSIR
310 320 330 340 350
QLHNDRERRQ AVKEVQALAA LGCHENIVGY FTSWFENKQL FIQMELCDRC
360 370 380 390 400
LSMDRNQPLK CGEALELLYQ ICKGLDFIHE RGIAHLDVKP DNIYVRNGVY
410 420 430 440 450
KLGDFGCATL IDRSLAIEDG DSRYMPPEML NDKYEHLDKV DIFSLGAAIY
460 470 480 490 500
ELIRGTQLPD SGPQFTSLRE GKIALLPGCP MQFQSLIKSM MDPDPVRRPS
510 520
AKEVLRHPIF DKLHKAPAKK
Length:520
Mass (Da):58,391
Last modified:July 5, 2004 - v1
Checksum:i934F492877B99F9F
GO

Sequence cautioni

The sequence BAF07730.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004799 Genomic DNA. Translation: BAD10095.1.
AP008208 Genomic DNA. Translation: BAF07730.2. Sequence problems.
RefSeqiNP_001045816.2. NM_001052351.2.
UniGeneiOs.98767.

Genome annotation databases

EnsemblPlantsiOS02T0135300-00; OS02T0135300-00; OS02G0135300.
GeneIDi4328224.
KEGGiosa:4328224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004799 Genomic DNA. Translation: BAD10095.1.
AP008208 Genomic DNA. Translation: BAF07730.2. Sequence problems.
RefSeqiNP_001045816.2. NM_001052351.2.
UniGeneiOs.98767.

3D structure databases

ProteinModelPortaliQ6Z829.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0135300-00; OS02T0135300-00; OS02G0135300.
GeneIDi4328224.
KEGGiosa:4328224.

Organism-specific databases

GrameneiQ6Z829.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000083236.
InParanoidiQ6Z829.
OMAiCCILSQD.

Gene expression databases

ExpressionAtlasiQ6Z829. baseline.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "Genome-wide identification and expression analysis of rice cell cycle genes."
    Guo J., Song J., Wang F., Zhang X.S.
    Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiWEE1_ORYSJ
AccessioniPrimary (citable) accession number: Q6Z829
Secondary accession number(s): Q0E458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.