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Protein

Wee1-like protein kinase

Gene

WEE1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei296ATPPROSITE-ProRule annotation1
Active sitei387Proton acceptorPROSITE-ProRule annotation1
Metal bindingi392Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi404Magnesium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi273 – 281ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-69202 Cyclin E associated events during G1/S transition
R-OSA-69656 Cyclin A:Cdk2-associated events at S phase entry

Names & Taxonomyi

Protein namesi
Recommended name:
Wee1-like protein kinase (EC:2.7.10.2)
Gene namesi
Name:WEE1
Ordered Locus Names:Os02g0135300, LOC_Os02g04240
ORF Names:P0585B01.27
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956731 – 520Wee1-like protein kinaseAdd BLAST520

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6Z829

Expressioni

Gene expression databases

ExpressionAtlasiQ6Z829 differential
GenevisibleiQ6Z829 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g04240.1

Structurei

3D structure databases

ProteinModelPortaliQ6Z829
SMRiQ6Z829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 510Protein kinasePROSITE-ProRule annotationAdd BLAST244

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0601 Eukaryota
ENOG410XS1M LUCA
HOGENOMiHOG000083236
InParanoidiQ6Z829
KOiK06632
OMAiNRIDGCL
OrthoDBiEOG09360DKT

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q6Z829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTKTPRPR GGKSRRATAA AGKERERERE REREGRSPSG ELSLQLEHVS
60 70 80 90 100
LFSFLADAPR EGAAAARTPF TPFEELLEGS CDPDPTPPPP LPPLQPQATP
110 120 130 140 150
MDADEVVEEK DSGILSQDFF CTPDYITPDA PQLGSGFDAN KENIPCPNSP
160 170 180 190 200
EKSVCRSKRY KRDCSPKGLG SNDIFDSQWI APVQFEGLDD SEEEQLKESS
210 220 230 240 250
SHKRGSYVSQ SAVALRCRVM PPPCIRNPYL NTDHQIDDNV FGGRQCKSSG
260 270 280 290 300
FSPSVDGDGL SRYRTDFHEI EQIGRGNFSV VFKVLKRIDG CLYAVKRSIR
310 320 330 340 350
QLHNDRERRQ AVKEVQALAA LGCHENIVGY FTSWFENKQL FIQMELCDRC
360 370 380 390 400
LSMDRNQPLK CGEALELLYQ ICKGLDFIHE RGIAHLDVKP DNIYVRNGVY
410 420 430 440 450
KLGDFGCATL IDRSLAIEDG DSRYMPPEML NDKYEHLDKV DIFSLGAAIY
460 470 480 490 500
ELIRGTQLPD SGPQFTSLRE GKIALLPGCP MQFQSLIKSM MDPDPVRRPS
510 520
AKEVLRHPIF DKLHKAPAKK
Length:520
Mass (Da):58,391
Last modified:July 5, 2004 - v1
Checksum:i934F492877B99F9F
GO

Sequence cautioni

The sequence BAF07730 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004799 Genomic DNA Translation: BAD10095.1
AP008208 Genomic DNA Translation: BAF07730.2 Sequence problems.
AP014958 Genomic DNA Translation: BAS76855.1
RefSeqiXP_015626457.1, XM_015770971.1

Genome annotation databases

EnsemblPlantsiOs02t0135300-00; Os02t0135300-00; Os02g0135300
GeneIDi4328224
GrameneiOs02t0135300-00; Os02t0135300-00; Os02g0135300
KEGGiosa:4328224

Similar proteinsi

Entry informationi

Entry nameiWEE1_ORYSJ
AccessioniPrimary (citable) accession number: Q6Z829
Secondary accession number(s): A0A0P0VED2, Q0E458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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