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Protein

Probable apyrase 2

Gene

APY2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates.By similarity

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 8011ATP-bindingCuratedAdd
BLAST
Nucleotide bindingi216 – 22611ATP-bindingCuratedAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable apyrase 2 (EC:3.6.1.5)
Short name:
OsAPY2
Alternative name(s):
ATP-diphosphatase
ATP-diphosphohydrolase
Adenosine diphosphatase
Short name:
ADPase
Gene namesi
Name:APY2
Ordered Locus Names:Os07g0682800, LOC_Os07g48430
ORF Names:OsJ_25612, OSJNBa0060O17.4
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 7

Organism-specific databases

GrameneiQ6Z4P2.

Subcellular locationi

Membrane By similarity; Single-pass type II membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini47 – 467421ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Probable apyrase 2PRO_0000419908Add
BLAST

Proteomic databases

PRIDEiQ6Z4P2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi348 – 3536Poly-Gly

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
InParanoidiQ6Z4P2.
KOiK14641.
OMAiVQRGSFY.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Z4P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRYSALPGG GARPDTLADR LHRYRGVLLV ILAPLALVSL VLLLMPRSPA
60 70 80 90 100
SSSAAAGRRW GPLDANKYAV IFDAGSSGSR VHVFRFDANL DLLHIGDQIE
110 120 130 140 150
LFVQKKPGLS EYANNPQEAA KSLVSLLEDA KRVVPVELRG QTPVRVGATA
160 170 180 190 200
GLRALGAEKS EEILQAVRDL LREKSSFKTQ PDWVTVLDGP QEGAYEWVTI
210 220 230 240 250
NYLLGKLGKT YADTVGVVDL GGGSVQMAYA IAEKDAVKAP KPSEGEDSYV
260 270 280 290 300
KKLFLKGTTY YLYVHSYLHY GLLAARAEIL KAGNGKGYSY CTLEGHQGQY
310 320 330 340 350
KYGNGKFEAS ASPSGASYSK CRDDVVKALK VDQACTHMKC SFGGIWNGGG
360 370 380 390 400
GAGQKNLFVA SFFFDRAAEA GFVNPKAPVA KVKPSDFEKA AKRACKLNLK
410 420 430 440 450
DAEAAYPGVQ KDNIPYICMD LVYQYTLLVD GFGVGSHQEM TLVKKVPYSN
460
AFVEAAWPLG SAIEVAS
Length:467
Mass (Da):50,438
Last modified:July 5, 2004 - v1
Checksum:i22B61F6F36D43C3E
GO

Sequence cautioni

The sequence AK066262 differs from that shown. Reason: Erroneous termination at position 464. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005167 Genomic DNA. Translation: BAC83798.1.
AP008213 Genomic DNA. Translation: BAF22577.1.
CM000144 Genomic DNA. Translation: EAZ41118.1.
AK066262 mRNA. No translation available.
RefSeqiNP_001060663.1. NM_001067198.1.
UniGeneiOs.26730.

Genome annotation databases

GeneIDi4344315.
KEGGiosa:4344315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005167 Genomic DNA. Translation: BAC83798.1.
AP008213 Genomic DNA. Translation: BAF22577.1.
CM000144 Genomic DNA. Translation: EAZ41118.1.
AK066262 mRNA. No translation available.
RefSeqiNP_001060663.1. NM_001067198.1.
UniGeneiOs.26730.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6Z4P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4344315.
KEGGiosa:4344315.

Organism-specific databases

GrameneiQ6Z4P2.

Phylogenomic databases

eggNOGiCOG5371.
InParanoidiQ6Z4P2.
KOiK14641.
OMAiVQRGSFY.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiAPY2_ORYSJ
AccessioniPrimary (citable) accession number: Q6Z4P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.