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Q6Z437

- MPK3_ORYSJ

UniProt

Q6Z437 - MPK3_ORYSJ

Protein

Mitogen-activated protein kinase 3

Gene

MPK3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611ATPPROSITE-ProRule annotation
    Active sitei158 – 1581Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 469ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_205014. CREB phosphorylation through the activation of Ras.
    REACT_214549. Signalling to ERK5.
    REACT_215626. ERK2 activation.
    REACT_221522. ERKs are inactivated.
    REACT_221537. ERK1 activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 3 (EC:2.7.11.24)
    Short name:
    MAP kinase 3
    Alternative name(s):
    MAP kinase 2
    OsMAP3
    OsMAPK2
    Gene namesi
    Name:MPK3
    Synonyms:MAP3, MAPK2
    Ordered Locus Names:Os02g0148100, LOC_Os02g05480
    ORF Names:P0479D12.11
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiQ6Z437.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Mitogen-activated protein kinase 3PRO_0000239746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei191 – 1911PhosphothreonineBy similarity
    Modified residuei193 – 1931PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-191 and Tyr-193, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ6Z437.

    Interactioni

    Protein-protein interaction databases

    IntActiQ6Z437. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Z437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 319288Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi191 – 1933TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK04371.
    OMAiQGLSNDH.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6Z437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIMVDPPNG MGNQGKYYYS MWQTLFEIDT KYVPIKPIGR GAYGIVCSSI    50
    NRETNEKVAI KKIHNVFDNR VDALRTLREL KLLRHLRHEN VIALKDIMMP 100
    VHRRSFKDVY LVYELMDTDL HQIIKSPQGL SNDHCQYFLF QLLRGLKYLH 150
    SAEILHRDLK PGNLLVNANC DLKICDFGLA RTNSSKGQFM TEYVVTRWYR 200
    APELLLCCDN YGTSIDVWSV GCIFAELLGR KPIFPGTECL NQLKLIVNVL 250
    GTMSESDLEF IDNPKARRYI KSLPYTPGVP LASMYPHAHP LAIDLLQKML 300
    IFDPTKRISV TEALEHPYMS PLYDPSANPP AQVPIDLDID ENISADMIRE 350
    MMWHEMLHYH PEVVAAMSAR 370
    Length:370
    Mass (Da):42,469
    Last modified:July 5, 2004 - v1
    Checksum:i7F03ACCA17F0E033
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216317 mRNA. Translation: AAG40581.1.
    AF241166 mRNA. Translation: AAF61238.1.
    AP005191 Genomic DNA. Translation: BAD13057.1.
    RefSeqiNP_001045889.1. NM_001052424.1.
    UniGeneiOs.15659.

    Genome annotation databases

    EnsemblPlantsiOS02T0148100-01; OS02T0148100-01; OS02G0148100.
    GeneIDi4328297.
    KEGGiosa:4328297.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216317 mRNA. Translation: AAG40581.1 .
    AF241166 mRNA. Translation: AAF61238.1 .
    AP005191 Genomic DNA. Translation: BAD13057.1 .
    RefSeqi NP_001045889.1. NM_001052424.1.
    UniGenei Os.15659.

    3D structure databases

    ProteinModelPortali Q6Z437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6Z437. 5 interactions.

    Proteomic databases

    PRIDEi Q6Z437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS02T0148100-01 ; OS02T0148100-01 ; OS02G0148100 .
    GeneIDi 4328297.
    KEGGi osa:4328297.

    Organism-specific databases

    Gramenei Q6Z437.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K04371.
    OMAi QGLSNDH.

    Enzyme and pathway databases

    Reactomei REACT_205014. CREB phosphorylation through the activation of Ras.
    REACT_214549. Signalling to ERK5.
    REACT_215626. ERK2 activation.
    REACT_221522. ERKs are inactivated.
    REACT_221537. ERK1 activation.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two novel mitogen-activated protein signaling components, OsMEK1 and OsMAP1, are involved in a moderate low-temperature signaling pathway in rice."
      Wen J.-Q., Oono K., Imai R.
      Plant Physiol. 129:1880-1891(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Developmental regulation of a rice MAP kinase gene expression."
      Ho S.L., Jang J.M., Yu S.M.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMPK3_ORYSJ
    AccessioniPrimary (citable) accession number: Q6Z437
    Secondary accession number(s): Q9M545
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3