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Q6Z437 (MPK3_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 3

Short name=MAP kinase 3
EC=2.7.11.24
Alternative name(s):
MAP kinase 2
OsMAP3
OsMAPK2
Gene names
Name:MPK3
Synonyms:MAP3, MAPK2
Ordered Locus Names:Os02g0148100, LOC_Os02g05480
ORF Names:P0479D12.11
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-191 and Tyr-193, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Mitogen-activated protein kinase 3
PRO_0000239746

Regions

Domain32 – 319288Protein kinase
Nucleotide binding38 – 469ATP By similarity
Motif191 – 1933TXY

Sites

Active site1581Proton acceptor By similarity
Binding site611ATP By similarity

Amino acid modifications

Modified residue1911Phosphothreonine By similarity
Modified residue1931Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6Z437 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7F03ACCA17F0E033

FASTA37042,469
        10         20         30         40         50         60 
MAIMVDPPNG MGNQGKYYYS MWQTLFEIDT KYVPIKPIGR GAYGIVCSSI NRETNEKVAI 

        70         80         90        100        110        120 
KKIHNVFDNR VDALRTLREL KLLRHLRHEN VIALKDIMMP VHRRSFKDVY LVYELMDTDL 

       130        140        150        160        170        180 
HQIIKSPQGL SNDHCQYFLF QLLRGLKYLH SAEILHRDLK PGNLLVNANC DLKICDFGLA 

       190        200        210        220        230        240 
RTNSSKGQFM TEYVVTRWYR APELLLCCDN YGTSIDVWSV GCIFAELLGR KPIFPGTECL 

       250        260        270        280        290        300 
NQLKLIVNVL GTMSESDLEF IDNPKARRYI KSLPYTPGVP LASMYPHAHP LAIDLLQKML 

       310        320        330        340        350        360 
IFDPTKRISV TEALEHPYMS PLYDPSANPP AQVPIDLDID ENISADMIRE MMWHEMLHYH 

       370 
PEVVAAMSAR 

« Hide

References

« Hide 'large scale' references
[1]"Two novel mitogen-activated protein signaling components, OsMEK1 and OsMAP1, are involved in a moderate low-temperature signaling pathway in rice."
Wen J.-Q., Oono K., Imai R.
Plant Physiol. 129:1880-1891(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Developmental regulation of a rice MAP kinase gene expression."
Ho S.L., Jang J.M., Yu S.M.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[4]"Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
Reyna N.S., Yang Y.
Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF216317 mRNA. Translation: AAG40581.1.
AF241166 mRNA. Translation: AAF61238.1.
AP005191 Genomic DNA. Translation: BAD13057.1.
RefSeqNP_001045889.1. NM_001052424.1.
UniGeneOs.15659.

3D structure databases

ProteinModelPortalQ6Z437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6Z437. 5 interactions.

Proteomic databases

PRIDEQ6Z437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS02T0148100-01; OS02T0148100-01; OS02G0148100.
GeneID4328297.
KEGGosa:4328297.

Organism-specific databases

GrameneQ6Z437.

Phylogenomic databases

eggNOGCOG0515.
KOK04371.
OMAQGLSNDH.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPK3_ORYSJ
AccessionPrimary (citable) accession number: Q6Z437
Secondary accession number(s): Q9M545
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations