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Q6Z398 (HXK4_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase-4, chloroplastic

EC=2.7.1.1
Alternative name(s):
Hexokinase II
Gene names
Name:HXK4
Ordered Locus Names:Os07g0197100, LOC_Os07g09890
ORF Names:P0417F02.7, P0589E08.26
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Fructose and glucose phosphorylating enzyme. Ref.1

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Subcellular location

Plastidchloroplast stroma Probable Ref.1.

Tissue specificity

Expressed in roots, leaves, flowers, immature seeds, endosperm and seed coat. Ref.1

Developmental stage

Expressed during flower development until 8 days after flowering. Ref.1

Induction

Not induced by glucose or fructose treatment in leaves. Ref.1

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchloroplast stroma

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

hexokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3737Chloroplast Potential
Chain38 – 509472Hexokinase-4, chloroplastic
PRO_0000247567

Regions

Domain64 – 250187Hexokinase type-1
Domain256 – 498243Hexokinase type-2
Nucleotide binding111 – 1166ATP Potential
Region181 – 20727Glucose-binding Potential

Sequences

Sequence LengthMass (Da)Tools
Q6Z398 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C1DCA84034804BF8

FASTA50954,759
        10         20         30         40         50         60 
MSAAAAIASP IPAAIAVVQQ QRRGRSRGGG SGAAAVRCSA VAPTSAIAPI LADLRLRCAA 

        70         80         90        100        110        120 
PLPVLRRVAD AMASGMRAGL ADDGAGELKM IPSHVYSLPT GNETGLFYAL DLGGTNFRVL 

       130        140        150        160        170        180 
RVQLGGKDKR IIDTEFEQVS IPREIMHGIT EDLFDFIASG LSRFVATEGD KFHLPQGRKR 

       190        200        210        220        230        240 
ELGFTFSFPV NQTSIDSGIL IKWTKGFAVS GTAGKDVVAC LNAAMERQGL DMRVSALVND 

       250        260        270        280        290        300 
TVGTLAGARY WDDDVMVAVI LGTGTNACYI QRTEAIPKLQ HLKLETGNTI INTEWGAFSD 

       310        320        330        340        350        360 
GLPLTEFDRE MDDESINPGE QIFEKTISGM YLGEIVRRVL VKMAEVSDLF GHSFPKKLAE 

       370        380        390        400        410        420 
PFVLRTPHLC AMQQDTSDNL GEVESILSDV IGVSQASLLA RRVTVEVSDC IIRRGGRLAG 

       430        440        450        460        470        480 
AGIVGILEKM ENDSRGHIFG RRTVVAMDGG LYEKYPQYRR YMKEAVAELL GPERSNRIAI 

       490        500 
EHTKDGSGIG AALLAAANSK YAAAQISTR 

« Hide

References

« Hide 'large scale' references
[1]"Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
Strain: cv. Jinmi.
[2]"Rice hexokinase II mRNA."
Wu P., Jiang H.-W., Yi K.-K.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ116386 mRNA. Translation: AAZ93621.1.
AF372832 mRNA. Translation: AAK51560.1.
AP004379 Genomic DNA. Translation: BAD30694.1.
AP005257 Genomic DNA. Translation: BAC84178.1.
RefSeqNP_001059124.1. NM_001065659.1.
UniGeneOs.3294.

3D structure databases

ProteinModelPortalQ6Z398.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6Z398.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4342654.
KEGGosa:4342654.

Organism-specific databases

GrameneQ6Z398.

Phylogenomic databases

eggNOGCOG5026.
HOGENOMHOG000162670.
KOK00844.
OMAKYICECV.
ProtClustDBPLN02914.

Enzyme and pathway databases

BRENDA2.7.1.1. 4460.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXK4_ORYSJ
AccessionPrimary (citable) accession number: Q6Z398
Secondary accession number(s): Q94JW5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations