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Protein

Hexokinase-4, chloroplastic

Gene

HXK4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme.1 Publication

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi111 – 1166ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-4, chloroplastic (EC:2.7.1.1)
Alternative name(s):
Hexokinase II
Gene namesi
Name:HXK4
Ordered Locus Names:Os07g0197100, LOC_Os07g09890
ORF Names:P0417F02.7, P0589E08.26
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763 Componenti: Chromosome 7

Organism-specific databases

GrameneiQ6Z398.

Subcellular locationi

  1. Plastidchloroplast stroma 1 Publication

GO - Cellular componenti

  1. chloroplast stroma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737ChloroplastSequence AnalysisAdd
BLAST
Chaini38 – 509472Hexokinase-4, chloroplasticPRO_0000247567Add
BLAST

Proteomic databases

PRIDEiQ6Z398.

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds, endosperm and seed coat.1 Publication

Developmental stagei

Expressed during flower development until 8 days after flowering.1 Publication

Inductioni

Not induced by glucose or fructose treatment in leaves.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6Z398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 496452HexokinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni100 – 238139Hexokinase small subdomainPROSITE-ProRule annotationAdd
BLAST
Regioni181 – 20727Glucose-bindingSequence AnalysisAdd
BLAST
Regioni239 – 485247Hexokinase large subdomainPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ6Z398.
KOiK00844.
OMAiCLAKFVE.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Z398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAAIASP IPAAIAVVQQ QRRGRSRGGG SGAAAVRCSA VAPTSAIAPI
60 70 80 90 100
LADLRLRCAA PLPVLRRVAD AMASGMRAGL ADDGAGELKM IPSHVYSLPT
110 120 130 140 150
GNETGLFYAL DLGGTNFRVL RVQLGGKDKR IIDTEFEQVS IPREIMHGIT
160 170 180 190 200
EDLFDFIASG LSRFVATEGD KFHLPQGRKR ELGFTFSFPV NQTSIDSGIL
210 220 230 240 250
IKWTKGFAVS GTAGKDVVAC LNAAMERQGL DMRVSALVND TVGTLAGARY
260 270 280 290 300
WDDDVMVAVI LGTGTNACYI QRTEAIPKLQ HLKLETGNTI INTEWGAFSD
310 320 330 340 350
GLPLTEFDRE MDDESINPGE QIFEKTISGM YLGEIVRRVL VKMAEVSDLF
360 370 380 390 400
GHSFPKKLAE PFVLRTPHLC AMQQDTSDNL GEVESILSDV IGVSQASLLA
410 420 430 440 450
RRVTVEVSDC IIRRGGRLAG AGIVGILEKM ENDSRGHIFG RRTVVAMDGG
460 470 480 490 500
LYEKYPQYRR YMKEAVAELL GPERSNRIAI EHTKDGSGIG AALLAAANSK

YAAAQISTR
Length:509
Mass (Da):54,759
Last modified:July 5, 2004 - v1
Checksum:iC1DCA84034804BF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116386 mRNA. Translation: AAZ93621.1.
AF372832 mRNA. Translation: AAK51560.1.
AP004379 Genomic DNA. Translation: BAD30694.1.
AP005257 Genomic DNA. Translation: BAC84178.1.
RefSeqiNP_001059124.1. NM_001065659.1.
UniGeneiOs.3294.

Genome annotation databases

GeneIDi4342654.
KEGGiosa:4342654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116386 mRNA. Translation: AAZ93621.1.
AF372832 mRNA. Translation: AAK51560.1.
AP004379 Genomic DNA. Translation: BAD30694.1.
AP005257 Genomic DNA. Translation: BAC84178.1.
RefSeqiNP_001059124.1. NM_001065659.1.
UniGeneiOs.3294.

3D structure databases

ProteinModelPortaliQ6Z398.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6Z398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4342654.
KEGGiosa:4342654.

Organism-specific databases

GrameneiQ6Z398.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ6Z398.
KOiK00844.
OMAiCLAKFVE.

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
    Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
    Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
    Strain: cv. Jinmi.
  2. "Rice hexokinase II mRNA."
    Wu P., Jiang H.-W., Yi K.-K.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHXK4_ORYSJ
AccessioniPrimary (citable) accession number: Q6Z398
Secondary accession number(s): Q94JW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.