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Protein

Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial

Gene

Os08g0536000

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-OSA-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-OSA-5362517. Signaling by Retinoic Acid.
R-OSA-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-B
Gene namesi
Ordered Locus Names:Os08g0536000, LOC_Os08g42410
ORF Names:OsJ_28086, OSJNBa0033D24.29, P0665C04.10
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionSequence analysisAdd BLAST34
ChainiPRO_000042137335 – 374Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrialAdd BLAST340

Proteomic databases

PaxDbiQ6Z1G7.
PRIDEiQ6Z1G7.

Expressioni

Gene expression databases

ExpressionAtlasiQ6Z1G7. baseline and differential.
GenevisibleiQ6Z1G7. OS.

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os08g42410.1.

Structurei

3D structure databases

ProteinModelPortaliQ6Z1G7.
SMRiQ6Z1G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
InParanoidiQ6Z1G7.
KOiK00162.
OMAiQEMTRDP.
OrthoDBiEOG09360DY5.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
InterProiView protein in InterPro
IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
PANTHERiPTHR11624:SF94. PTHR11624:SF94. 1 hit.
PfamiView protein in Pfam
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Z1G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIARRRLG SGCALGQLMQ ALRPAAAAAA ARTYSAAAKE MTVREALNSA
60 70 80 90 100
LDEEMSADPS VFLMGEEVGE YQGAYKISKG LLDKYGPDRV LDTPITEAGF
110 120 130 140 150
TGIGVGAAYQ GLRPVVEFMT FNFSMQAIDH IINSAAKSNY MSAGQINVPI
160 170 180 190 200
VFRGPNGAAA GVGAQHSQCY AAWYAHVPGL KVLTPYSAED ARGLLKAAIR
210 220 230 240 250
DPDPVVFLEN ELLYGESFPV SAEVLDSSFC LPIGKAKIEQ EGKDVTITAF
260 270 280 290 300
SKMVGYALQA AEILSKEGIS AEVINLRSIR PLDRATINAS VRKTNRLVTL
310 320 330 340 350
EEGFPQHGVG AEICMSVVED SFEYLDAPVE RIAGADVPMP YAANLERMAV
360 370
PQVEDIVRAA KRACYRAVPM AATA
Length:374
Mass (Da):39,945
Last modified:July 5, 2004 - v1
Checksum:i7347F762E5B7A1CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004464 Genomic DNA. Translation: BAD01226.1.
AP005439 Genomic DNA. Translation: BAD13111.1.
AP008214 Genomic DNA. Translation: BAF24274.1.
AP014964 Genomic DNA. Translation: BAT06442.1.
CM000145 Genomic DNA. Translation: EEE69070.1.
AK104686 mRNA. Translation: BAG96883.1.
RefSeqiXP_015650909.1. XM_015795423.1.
UniGeneiOs.18710.

Genome annotation databases

EnsemblPlantsiOS08T0536000-01; OS08T0536000-01; OS08G0536000.
GeneIDi4346159.
GrameneiOS08T0536000-01; OS08T0536000-01; OS08G0536000.
KEGGiosa:4346159.

Similar proteinsi

Entry informationi

Entry nameiODPB1_ORYSJ
AccessioniPrimary (citable) accession number: Q6Z1G7
Secondary accession number(s): A0A0N7KQ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: July 5, 2004
Last modified: December 20, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations