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Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene

GSA

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase, chloroplastic (Os10g0502400), Glutamyl-tRNA reductase (OsJ_32069)
  2. Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (GSA)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathwayi: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processChlorophyll biosynthesis, Porphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:GSA
Ordered Locus Names:Os08g0532200, LOC_Os08g41990
ORF Names:OsJ_28060Imported, P0702E04.16
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40ChloroplastSequence analysisAdd BLAST40
ChainiPRO_000024747341 – 478Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ6YZE2.
PRIDEiQ6YZE2.

Expressioni

Gene expression databases

ExpressionAtlasiQ6YZE2. baseline and differential.
GenevisibleiQ6YZE2. OS.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os08g41990.1.

Structurei

3D structure databases

ProteinModelPortaliQ6YZE2.
SMRiQ6YZE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IPFV. Eukaryota.
COG0001. LUCA.
HOGENOMiHOG000020210.
InParanoidiQ6YZE2.
KOiK01845.
OMAiWGPLIFG.
OrthoDBiEOG093608WJ.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6YZE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAAAASAA AAAVASGISA RPVAPRPSPS RARAPRSVVR AAISVEKGEK
60 70 80 90 100
AYTVEKSEEI FNAAKELMPG GVNSPVRAFK SVGGQPIVFD SVKGSRMWDV
110 120 130 140 150
DGNEYIDYVG SWGPAIIGHA DDTVNAALIE TLKKGTSFGA PCVLENVLAE
160 170 180 190 200
MVISAVPSIE MVRFVNSGTE ACMGALRLVR AFTGREKILK FEGCYHGHAD
210 220 230 240 250
SFLVKAGSGV ATLGLPDSPG VPKGATSETL TAPYNDVEAV KKLFEENKGQ
260 270 280 290 300
IAAVFLEPVV GNAGFIPPQP GFLNALRDLT KQDGALLVFD EVMTGFRLAY
310 320 330 340 350
GGAQEYFGIT PDVSTLGKII GGGLPVGAYG GRKDIMEMVA PAGPMYQAGT
360 370 380 390 400
LSGNPLAMTA GIHTLKRLME PGTYDYLDKI TGDLVRGVLD AGAKTGHEMC
410 420 430 440 450
GGHIRGMFGF FFTAGPVHNF GDAKKSDTAK FGRFYRGMLE EGVYLAPSQF
460 470
EAGFTSLAHT SQDIEKTVEA AAKVLRRI
Length:478
Mass (Da):50,238
Last modified:July 5, 2004 - v1
Checksum:i672E23E08B8A0F11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005529 Genomic DNA. Translation: BAD11647.1.
AP008214 Genomic DNA. Translation: BAF24251.1.
AP014964 Genomic DNA. Translation: BAT06404.1.
CM000145 Genomic DNA. Translation: EAZ43454.1.
AK064826 mRNA. Translation: BAG89226.1.
AK104694 mRNA. Translation: BAG96887.1.
RefSeqiXP_015650872.1. XM_015795386.1.
UniGeneiOs.10144.

Genome annotation databases

EnsemblPlantsiOS08T0532200-01; OS08T0532200-01; OS08G0532200.
OS08T0532200-03; OS08T0532200-03; OS08G0532200.
GeneIDi4346136.
GrameneiOS08T0532200-01; OS08T0532200-01; OS08G0532200.
OS08T0532200-03; OS08T0532200-03; OS08G0532200.
KEGGiosa:4346136.

Similar proteinsi

Entry informationi

Entry nameiGSA_ORYSJ
AccessioniPrimary (citable) accession number: Q6YZE2
Secondary accession number(s): Q0J464
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families