GSA

Functionⁱ

Catalytic activityⁱ

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactorⁱ

Pathwayⁱ: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Glutamyl-tRNA reductase, chloroplastic (Os10g0502400), Glutamyl-tRNA reductase (OsJ_32069)
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (GSA)

This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathwayⁱ: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functionⁱ

glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
pyridoxal phosphate binding Source: InterPro
transaminase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

chlorophyll biosynthetic process Source: UniProtKB-UniPathway
protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Chlorophyll biosynthesis, Porphyrin biosynthesis
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayⁱ	UPA00251; UER00317. UPA00668.

UniPathwayⁱ

UPA00251; UER00317.
UPA00668.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8) Short name: GSA Alternative name(s): Glutamate-1-semialdehyde aminotransferase Short name: GSA-AT
Gene namesⁱ	Name:GSA Ordered Locus Names:Os08g0532200, LOC_Os08g41990 ORF Names:OsJ_28060Imported, P0702E04.16
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 8

Subcellular locationⁱ

Plastid › chloroplast Curated

GO - Cellular componentⁱ

chloroplast Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Chloroplast, Plastid

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 40	ChloroplastSequence analysisAdd BLAST		40
ChainⁱPRO_0000247473	41 – 478	Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticAdd BLAST		438

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	318	N6-(pyridoxal phosphate)lysineBy similarity		1

Proteomic databases

PaxDbⁱ	Q6YZE2.
PRIDEⁱ	Q6YZE2.

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q6YZE2. baseline and differential.
Genevisibleⁱ	Q6YZE2. OS.

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os08g41990.1.

STRINGⁱ

39947.LOC_Os08g41990.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6YZE2.
SMRⁱ	Q6YZE2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	ENOG410IPFV. Eukaryota. COG0001. LUCA.
HOGENOMⁱ	HOG000020210.
InParanoidⁱ	Q6YZE2.
KEGG Orthology (KO) More...KOⁱ	K01845.
OMAⁱ	WGPLIFG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608WJ.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610. OAT_like. 1 hit.
Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAPⁱ	MF_00375. HemL_aminotrans_3. 1 hit.
InterProⁱ	View protein in InterPro IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_sub2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202. Aminotran_3. 1 hit.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
TIGRFAMsⁱ	TIGR00713. hemL. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6YZE2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGAAAASAA AAAVASGISA RPVAPRPSPS RARAPRSVVR AAISVEKGEK 
        60         70         80         90        100
AYTVEKSEEI FNAAKELMPG GVNSPVRAFK SVGGQPIVFD SVKGSRMWDV 
       110        120        130        140        150
DGNEYIDYVG SWGPAIIGHA DDTVNAALIE TLKKGTSFGA PCVLENVLAE 
       160        170        180        190        200
MVISAVPSIE MVRFVNSGTE ACMGALRLVR AFTGREKILK FEGCYHGHAD 
       210        220        230        240        250
SFLVKAGSGV ATLGLPDSPG VPKGATSETL TAPYNDVEAV KKLFEENKGQ 
       260        270        280        290        300
IAAVFLEPVV GNAGFIPPQP GFLNALRDLT KQDGALLVFD EVMTGFRLAY 
       310        320        330        340        350
GGAQEYFGIT PDVSTLGKII GGGLPVGAYG GRKDIMEMVA PAGPMYQAGT 
       360        370        380        390        400
LSGNPLAMTA GIHTLKRLME PGTYDYLDKI TGDLVRGVLD AGAKTGHEMC 
       410        420        430        440        450
GGHIRGMFGF FFTAGPVHNF GDAKKSDTAK FGRFYRGMLE EGVYLAPSQF 
       460        470 
EAGFTSLAHT SQDIEKTVEA AAKVLRRI

Length:478

Mass (Da):50,238

Last modified:July 5, 2004 - v1

Checksum:ⁱ672E23E08B8A0F11

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP005529 Genomic DNA. Translation: BAD11647.1. AP008214 Genomic DNA. Translation: BAF24251.1. AP014964 Genomic DNA. Translation: BAT06404.1. CM000145 Genomic DNA. Translation: EAZ43454.1. AK064826 mRNA. Translation: BAG89226.1. AK104694 mRNA. Translation: BAG96887.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015650872.1. XM_015795386.1.
UniGeneⁱ	Os.10144.

Genome annotation databases

EnsemblPlantsⁱ	OS08T0532200-01; OS08T0532200-01; OS08G0532200. OS08T0532200-03; OS08T0532200-03; OS08G0532200.
GeneIDⁱ	4346136.
Grameneⁱ	OS08T0532200-01; OS08T0532200-01; OS08G0532200. OS08T0532200-03; OS08T0532200-03; OS08G0532200.
KEGGⁱ	osa:4346136.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP005529 Genomic DNA. Translation: BAD11647.1. AP008214 Genomic DNA. Translation: BAF24251.1. AP014964 Genomic DNA. Translation: BAT06404.1. CM000145 Genomic DNA. Translation: EAZ43454.1. AK064826 mRNA. Translation: BAG89226.1. AK104694 mRNA. Translation: BAG96887.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015650872.1. XM_015795386.1.
UniGeneⁱ	Os.10144.

3D structure databases

ProteinModelPortalⁱ	Q6YZE2.
SMRⁱ	Q6YZE2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os08g41990.1.

STRINGⁱ

39947.LOC_Os08g41990.1.

Proteomic databases

PaxDbⁱ	Q6YZE2.
PRIDEⁱ	Q6YZE2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	OS08T0532200-01; OS08T0532200-01; OS08G0532200. OS08T0532200-03; OS08T0532200-03; OS08G0532200.
GeneIDⁱ	4346136.
Grameneⁱ	OS08T0532200-01; OS08T0532200-01; OS08G0532200. OS08T0532200-03; OS08T0532200-03; OS08G0532200.
KEGGⁱ	osa:4346136.

Phylogenomic databases

eggNOGⁱ	ENOG410IPFV. Eukaryota. COG0001. LUCA.
HOGENOMⁱ	HOG000020210.
InParanoidⁱ	Q6YZE2.
KEGG Orthology (KO) More...KOⁱ	K01845.
OMAⁱ	WGPLIFG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608WJ.

Enzyme and pathway databases

UniPathwayⁱ	UPA00251; UER00317. UPA00668.

UniPathwayⁱ

UPA00251; UER00317.
UPA00668.

Gene expression databases

ExpressionAtlasⁱ	Q6YZE2. baseline and differential.
Genevisibleⁱ	Q6YZE2. OS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610. OAT_like. 1 hit.
Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAPⁱ	MF_00375. HemL_aminotrans_3. 1 hit.
InterProⁱ	View protein in InterPro IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_sub2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202. Aminotran_3. 1 hit.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
TIGRFAMsⁱ	TIGR00713. hemL. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00600. AA_TRANSFER_CLASS_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GSA_ORYSJ
Accessionⁱ	Q6YZE2Primary (citable) accession number: Q6YZE2 Secondary accession number(s): Q0J464
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	July 5, 2004
	Last modified:	June 7, 2017
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6YZE2 (GSA_ORYSJ)

Your basket is currently empty.

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protoporphyrin-IX biosynthesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: chlorophyll biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: protoporphyrin-IX biosynthesis

Pathwayⁱ: chlorophyll biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ