GSA

Functionⁱ

Catalytic activityⁱ

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactorⁱ

Pathwayⁱ: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Glutamyl-tRNA reductase, chloroplastic (Os10g0502400), Glutamyl-tRNA reductase (OsJ_32069)
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (GSA)

This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathwayⁱ: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functionⁱ

glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
pyridoxal phosphate binding Source: InterPro
transaminase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chlorophyll biosynthetic process Source: UniProtKB-UniPathway
protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Chlorophyll biosynthesis, Porphyrin biosynthesis
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayⁱ	UPA00251; UER00317 UPA00668

UniPathwayⁱ

UPA00251; UER00317
UPA00668

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8) Short name: GSA Alternative name(s): Glutamate-1-semialdehyde aminotransferase Short name: GSA-AT
Gene namesⁱ	Name:GSA Ordered Locus Names:Os08g0532200, LOC_Os08g41990 ORF Names:OsJ_28060Imported, P0702E04.16
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 8

Keywords - Cellular componentⁱ

Chloroplast, Plastid

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 40	ChloroplastSequence analysisAdd BLAST		40
ChainⁱPRO_0000247473	41 – 478	Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticAdd BLAST		438

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	318	N6-(pyridoxal phosphate)lysineBy similarity		1

Proteomic databases

PaxDbⁱ	Q6YZE2
PRIDEⁱ	Q6YZE2

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q6YZE2 baseline and differential
Genevisibleⁱ	Q6YZE2 OS

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os08g41990.1

STRINGⁱ

39947.LOC_Os08g41990.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6YZE2
SMRⁱ	Q6YZE2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	ENOG410IPFV Eukaryota COG0001 LUCA
HOGENOMⁱ	HOG000020210
InParanoidⁱ	Q6YZE2
KEGG Orthology (KO) More...KOⁱ	K01845
OMAⁱ	WGPLIFG
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608WJ

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610 OAT_like, 1 hit
Gene3Dⁱ	3.40.640.101 hit 3.90.1150.102 hits
HAMAPⁱ	MF_00375 HemL_aminotrans_3, 1 hit
InterProⁱ	View protein in InterPro IPR004639 4pyrrol_synth_GluAld_NH2Trfase IPR005814 Aminotrans_3 IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202 Aminotran_3, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR00713 hemL, 1 hit
PROSITEⁱ	View protein in PROSITE PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6YZE2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGAAAASAA AAAVASGISA RPVAPRPSPS RARAPRSVVR AAISVEKGEK 
        60         70         80         90        100
AYTVEKSEEI FNAAKELMPG GVNSPVRAFK SVGGQPIVFD SVKGSRMWDV 
       110        120        130        140        150
DGNEYIDYVG SWGPAIIGHA DDTVNAALIE TLKKGTSFGA PCVLENVLAE 
       160        170        180        190        200
MVISAVPSIE MVRFVNSGTE ACMGALRLVR AFTGREKILK FEGCYHGHAD 
       210        220        230        240        250
SFLVKAGSGV ATLGLPDSPG VPKGATSETL TAPYNDVEAV KKLFEENKGQ 
       260        270        280        290        300
IAAVFLEPVV GNAGFIPPQP GFLNALRDLT KQDGALLVFD EVMTGFRLAY 
       310        320        330        340        350
GGAQEYFGIT PDVSTLGKII GGGLPVGAYG GRKDIMEMVA PAGPMYQAGT 
       360        370        380        390        400
LSGNPLAMTA GIHTLKRLME PGTYDYLDKI TGDLVRGVLD AGAKTGHEMC 
       410        420        430        440        450
GGHIRGMFGF FFTAGPVHNF GDAKKSDTAK FGRFYRGMLE EGVYLAPSQF 
       460        470 
EAGFTSLAHT SQDIEKTVEA AAKVLRRI

Length:478

Mass (Da):50,238

Last modified:July 5, 2004 - v1

Checksum:ⁱ672E23E08B8A0F11

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP005529 Genomic DNA Translation: BAD11647.1 AP008214 Genomic DNA Translation: BAF24251.1 AP014964 Genomic DNA Translation: BAT06404.1 CM000145 Genomic DNA Translation: EAZ43454.1 AK064826 mRNA Translation: BAG89226.1 AK104694 mRNA Translation: BAG96887.1
NCBI Reference Sequences More...RefSeqⁱ	XP_015650872.1, XM_015795386.1
UniGeneⁱ	Os.10144

Genome annotation databases

EnsemblPlantsⁱ	Os08t0532200-01; Os08t0532200-01; Os08g0532200 Os08t0532200-03; Os08t0532200-03; Os08g0532200
GeneIDⁱ	4346136
Grameneⁱ	Os08t0532200-01; Os08t0532200-01; Os08g0532200 Os08t0532200-03; Os08t0532200-03; Os08g0532200
KEGGⁱ	osa:4346136

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6YZE2	A0A0E0QLM7	Oryza rufipogon (Brownbeard rice) (Asian wild rice)	478	UniRef100_Q6YZE2	Cluster: Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6YZE2	A0A0E0QLM7 A0A287WK03 A0A1D6SCD0 A0A0E0E0X6 A0A1E5V7C2 A0A1D6CEU0 B7ZYW4 B4FF62 A0A059Q1T0 A0A059Q1Y3 +15	Oryza rufipogon (Brownbeard rice) (Asian wild rice) Hordeum vulgare subsp. vulgare (Domesticated barley) Triticum aestivum (Wheat) Oryza meridionalis Dichanthelium oligosanthes Zea mays (Maize) Saccharum hybrid cultivar R570 Oryza punctata (Red rice) Sorghum bicolor (Sorghum) (Sorghum vulgare) Brachypodium distachyon (Purple false brome) (Trachynia distachya) And more	478	UniRef90_Q6YZE2	Cluster: Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic	26

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6YZE2	A0A0E0QLM7 A0A287WK03 A0A1D6SCD0 A0A0E0E0X6 A0A1E5V7C2 A0A1D6CEU0 B7ZYW4 B4FF62 A0A059Q0N6 A0A059Q005 +2814	Oryza rufipogon (Brownbeard rice) (Asian wild rice) Hordeum vulgare subsp. vulgare (Domesticated barley) Triticum aestivum (Wheat) Oryza meridionalis Dichanthelium oligosanthes Zea mays (Maize) Saccharum hybrid cultivar R570 Sorghum bicolor (Sorghum) (Sorghum vulgare) Oryza punctata (Red rice) Brachypodium distachyon (Purple false brome) (Trachynia distachya) And more	478	UniRef50_Q6YZE2	Cluster: Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic	2,825

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP005529 Genomic DNA Translation: BAD11647.1 AP008214 Genomic DNA Translation: BAF24251.1 AP014964 Genomic DNA Translation: BAT06404.1 CM000145 Genomic DNA Translation: EAZ43454.1 AK064826 mRNA Translation: BAG89226.1 AK104694 mRNA Translation: BAG96887.1
NCBI Reference Sequences More...RefSeqⁱ	XP_015650872.1, XM_015795386.1
UniGeneⁱ	Os.10144

3D structure databases

ProteinModelPortalⁱ	Q6YZE2
SMRⁱ	Q6YZE2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os08g41990.1

STRINGⁱ

39947.LOC_Os08g41990.1

Proteomic databases

PaxDbⁱ	Q6YZE2
PRIDEⁱ	Q6YZE2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	Os08t0532200-01; Os08t0532200-01; Os08g0532200 Os08t0532200-03; Os08t0532200-03; Os08g0532200
GeneIDⁱ	4346136
Grameneⁱ	Os08t0532200-01; Os08t0532200-01; Os08g0532200 Os08t0532200-03; Os08t0532200-03; Os08g0532200
KEGGⁱ	osa:4346136

Phylogenomic databases

eggNOGⁱ	ENOG410IPFV Eukaryota COG0001 LUCA
HOGENOMⁱ	HOG000020210
InParanoidⁱ	Q6YZE2
KEGG Orthology (KO) More...KOⁱ	K01845
OMAⁱ	WGPLIFG
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608WJ

Enzyme and pathway databases

UniPathwayⁱ	UPA00251; UER00317 UPA00668

UniPathwayⁱ

UPA00251; UER00317
UPA00668

Gene expression databases

ExpressionAtlasⁱ	Q6YZE2 baseline and differential
Genevisibleⁱ	Q6YZE2 OS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610 OAT_like, 1 hit
Gene3Dⁱ	3.40.640.101 hit 3.90.1150.102 hits
HAMAPⁱ	MF_00375 HemL_aminotrans_3, 1 hit
InterProⁱ	View protein in InterPro IPR004639 4pyrrol_synth_GluAld_NH2Trfase IPR005814 Aminotrans_3 IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202 Aminotran_3, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR00713 hemL, 1 hit
PROSITEⁱ	View protein in PROSITE PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GSA_ORYSJ
Accessionⁱ	Q6YZE2Primary (citable) accession number: Q6YZE2 Secondary accession number(s): Q0J464
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	July 5, 2004
	Last modified:	February 28, 2018
	This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6YZE2 (GSA_ORYSJ)

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Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protoporphyrin-IX biosynthesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: chlorophyll biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Chloroplast

Chloroplast

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: protoporphyrin-IX biosynthesis

Pathwayⁱ: chlorophyll biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ