Q6YZE2 (GSA_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	GSA
Ordered Locus Names:	Os08g0532200, LOC_Os08g41990
ORF Names:	P0702E04.16

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Porphyrin-containing compound metabolism; chlorophyll biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Plastid › chloroplast Potential.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Porphyrin biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: UniProtKB-EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 40	40	Chloroplast Potential
	Chain	41 – 478	438	Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic		PRO_0000247473
Amino acid modifications
	Modified residue	318	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6YZE2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 672E23E08B8A0F11	FASTA	478	50,238
	10 20 30 40 50 60 MAGAAAASAA AAAVASGISA RPVAPRPSPS RARAPRSVVR AAISVEKGEK AYTVEKSEEI 70 80 90 100 110 120 FNAAKELMPG GVNSPVRAFK SVGGQPIVFD SVKGSRMWDV DGNEYIDYVG SWGPAIIGHA 130 140 150 160 170 180 DDTVNAALIE TLKKGTSFGA PCVLENVLAE MVISAVPSIE MVRFVNSGTE ACMGALRLVR 190 200 210 220 230 240 AFTGREKILK FEGCYHGHAD SFLVKAGSGV ATLGLPDSPG VPKGATSETL TAPYNDVEAV 250 260 270 280 290 300 KKLFEENKGQ IAAVFLEPVV GNAGFIPPQP GFLNALRDLT KQDGALLVFD EVMTGFRLAY 310 320 330 340 350 360 GGAQEYFGIT PDVSTLGKII GGGLPVGAYG GRKDIMEMVA PAGPMYQAGT LSGNPLAMTA 370 380 390 400 410 420 GIHTLKRLME PGTYDYLDKI TGDLVRGVLD AGAKTGHEMC GGHIRGMFGF FFTAGPVHNF 430 440 450 460 470 GDAKKSDTAK FGRFYRGMLE EGVYLAPSQF EAGFTSLAHT SQDIEKTVEA AAKVLRRI

References

[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP005529 Genomic DNA. Translation: BAD11647.1. AK064826 mRNA. No translation available. AK104694 mRNA. No translation available.
RefSeq	NP_001062337.1. NM_001068872.1.
UniGene	Os.10144.
3D structure databases
ProteinModelPortal	Q6YZE2.
SMR	Q6YZE2. Positions 56-475.
ModBase	Search...
MobiDB	Search...
Proteomic databases
PaxDb	Q6YZE2.
PRIDE	Q6YZE2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	OS08T0532200-01; OS08T0532200-01; OS08G0532200. OS08T0532200-03; OS08T0532200-03; OS08G0532200.
GeneID	4346136.
KEGG	osa:4346136.
Organism-specific databases
Gramene	Q6YZE2.
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	CSWGPLI.
ProtClustDB	PLN02482.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317. UPA00668.
Gene expression databases
ArrayExpress	Q6YZE2.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
PIRSF	PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAM	SSF53383. SSF53383. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_ORYSJ

Accession

Primary (citable) accession number: Q6YZE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 5, 2004
Last modified:	February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program