Q6YXZ7 (ANM5_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein arginine N-methyltransferase 5
EC=2.1.1.-
EC=2.1.1.125

Alternative name(s):
Shk1 kinase-binding protein 1 homolog

Gene names

Name:	PRMT5
Synonyms:	SKB1
Ordered Locus Names:	Os02g0139200, LOC_Os02g04660
ORF Names:	OJ1679_B08.2, OSJNBa0026E05.36, OsJ_005168

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	649 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Methylates arginine residues in proteins such as histone H4 By similarity.
Catalytic activity	S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-arginine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 649	649	Protein arginine N-methyltransferase 5		PRO_0000293995

Sequences

	Sequence		Length	Mass (Da)
	Q6YXZ7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8341E95D15624F0E	FASTA	649	72,673
	10 20 30 40 50 60 MPLGQRAGDK SESRYCGVEV LDFPAGEELP AVLSHSLSSS FDFLLAPLVD PDYRPTPGSV 70 80 90 100 110 120 LPVAASDLVL GPAQWSSHIV GKISEWIDLD AEDEQLRLDS EITLKQEIAW ASHLSLQACV 130 140 150 160 170 180 LPPPKRSSCA NYARVVNHIL QGLTNLQLWL RIPLEKSEPM DEDHDGAKDN SDMSDTVDSW 190 200 210 220 230 240 EWWNSFRLLC EHSSQLCVAL DVLSTLPSMN SLGRWFGEPV RAAILQTNAF LTNARGYPCL 250 260 270 280 290 300 SKRHQKLLTG FFNHSVQVII SGRSNHNVSQ GGVLSGDENH TEDTAVRHAL SPYLDYIAYI 310 320 330 340 350 360 YQRMDPLPEQ ERFEINYRDF LQSPLQPLMD NLEAQTYETF EKDTVKYTQY QRAIAKALVD 370 380 390 400 410 420 RVSDDDVSTT KTVLMVVGAG RGPLVRASLQ AAEETGRKLK VYAVEKNPNA VITLHSLIKL 430 440 450 460 470 480 EGWESLVTII SSDMRCWEAP EKADILVSEL LGSFGDNELS PECLDGAQRF LKPDGISIPS 490 500 510 520 530 540 SYTSFIEPIT ASKLHNDIKA HKDIAHFETA YVVKLHRIAR LAPTQSVFTF DHPNPSPNAS 550 560 570 580 590 600 NQRYTKLKFE IPQETGSCLV HGFAGYFDAV LYKDVHLGIE PNTATPNMFS WFPIFFPLRK 610 620 630 640 PIYVPSKTPI EVHFWRCCGA TKVWYEWAVT APSPSPIHNS NGRSYWVGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[3]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[4]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP005294 Genomic DNA. Translation: BAD10250.1. AP005647 Genomic DNA. Translation: BAD10543.1. AP008208 Genomic DNA. Translation: BAF07757.1. CM000139 Genomic DNA. No translation available. AK103804 mRNA. No translation available.
RefSeq	NP_001045843.1. NM_001052378.1.
UniGene	Os.17772.
3D structure databases
ProteinModelPortal	Q6YXZ7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6YXZ7.
Proteomic databases
PRIDE	Q6YXZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os02g04660.1; LOC_Os02g04660.1; LOC_Os02g04660.
GeneID	4328251.
KEGG	osa:4328251.
Organism-specific databases
Gramene	Q6YXZ7.
Phylogenomic databases
GeneTree	EPGT00050000018246.
HOGENOM	HBG628479.
OMA	LCDYNKR.
PhylomeDB	Q6YXZ7.
ProtClustDB	CLSN2680196.
Family and domain databases
InterPro	IPR007857. Skb1_MeTrfase. [Graphical view]
KO	K02516.
PANTHER	PTHR10738. Skb1_mtfrase. 1 hit.
Pfam	PF05185. PRMT5. 1 hit. [Graphical view]
PIRSF	PIRSF015894. Skb1_MeTrfase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ANM5_ORYSJ

Accession

Primary (citable) accession number: Q6YXZ7
Secondary accession number(s): A3A2Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program