Reviewed, UniProtKB/Swiss-Prot Q6YXP8 (NU1C_PHYPA)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Physcomitrella patens (Moss)

Taxonomic identifier

3218 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Bryophyta › Moss Superclass V › Bryopsida › Funariidae › Funariales › Funariaceae › Physcomitrella

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000240030
Regions
	Transmembrane	27 – 47	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	130 – 150	21	Potential
	Transmembrane	269 – 289	21	Potential
	Transmembrane	308 – 328	21	Potential
	Transmembrane	348 – 368	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6YXP8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 413D968F0F432EE1	FASTA	368	41,076
	10 20 30 40 50 60 MGFNTNLKEQ VITFFSALSL SKDFFNFIWI AFSILILLLT ITIGVLVLVW LERKISAGIQ 70 80 90 100 110 120 QRIGPEYAGP LGIIQALADG FKLLLKEDII PSKGDNWLFN IGPAIVVIPV FLSYLVIPFG 130 140 150 160 170 180 HNIILADLNI GVFFWIAISS IVPLGLLMAG YGSNNKYSFL GGLRAAAQSI SYEIPLALCV 190 200 210 220 230 240 LSISLQLSNS LSTVDIVEAQ AKYGFWGWNV WRQPIGFLAF FIASLAECER LPFDLPEAEE 250 260 270 280 290 300 ELVAGYQTEY SGIKFGLFYV ASYLNLLASS LFVTILYLGG WHFSIPFLLN SNYLEWVFSH 310 320 330 340 350 360 GSNQVINIII GIIIVLIKSY LFSFIAIMTR WTLPRVRMDQ LLDLGWKFLL PIALGNLLLT ASFQAFLL

References

[1]

"Complete chloroplast DNA sequence of the moss Physcomitrella patens: evidence for the loss and relocation of rpoA from the chloroplast to the nucleus." Sugiura C., Kobayashi Y., Setsuyuki A., Sugita C., Sugita M. Nucleic Acids Res. 31:5324-5331(2003) [PubMed: 12954768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Protonema.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP005672 Genomic DNA. Translation: BAC85093.1.
RefSeq	NP_904243.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2546729.
KEGG	ppp:PhpapaCp080.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_PHYPA

Accession

Primary (citable) accession number: Q6YXP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)