Reviewed, UniProtKB/Swiss-Prot Q6YVM4 (CESA6_ORYSJ)

Names and origin

Protein names

Recommended name:
    Probable cellulose synthase A catalytic subunit 6 [UDP-forming]
    EC=2.4.1.12
Alternative name(s):
    OsCesA6

Gene names

Name:	CESA6
Ordered Locus Names:	Os07g0252400, LOC_Os07g14850
ORF Names:	P0669H03.13

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	1092 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation By similarity.
Catalytic activity	UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Glycan metabolism; plant cellulose biosynthesis.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation Cellulose biosynthesis
Cellular component	Cell membrane Membrane
Domain	Coiled coil Transmembrane Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cellulose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cellulose synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1092	1092	Probable cellulose synthase A catalytic subunit 6 [UDP-forming]		PRO_0000319366
Regions
	Topological domain	1 – 280	280	Cytoplasmic Potential
	Transmembrane	281 – 301	21	Potential
	Topological domain	302 – 303	2	Extracellular Potential
	Transmembrane	304 – 324	21	Potential
	Topological domain	325 – 868	544	Cytoplasmic Potential
	Transmembrane	869 – 889	21	Potential
	Topological domain	890 – 901	12	Extracellular Potential
	Transmembrane	902 – 922	21	Potential
	Topological domain	923 – 937	15	Cytoplasmic Potential
	Transmembrane	938 – 958	21	Potential
	Topological domain	959 – 987	29	Extracellular Potential
	Transmembrane	988 – 1008	21	Potential
	Topological domain	1009 – 1019	11	Cytoplasmic Potential
	Transmembrane	1020 – 1040	21	Potential
	Topological domain	1041 – 1049	9	Extracellular Potential
	Transmembrane	1050 – 1070	21	Potential
	Topological domain	1071 – 1092	22	Cytoplasmic Potential
	Zinc finger	42 – 88	47	RING-type; degenerate
	Coiled coil	453 – 480	28	Potential
Sites
	Active site	399	1	Potential
	Active site	792	1	Potential
	Metal binding	42	1	Zinc 1 By similarity
	Metal binding	45	1	Zinc 1 By similarity
	Metal binding	61	1	Zinc 2 By similarity
	Metal binding	64	1	Zinc 2 By similarity
	Metal binding	69	1	Zinc 1 By similarity
	Metal binding	72	1	Zinc 1 By similarity
	Metal binding	84	1	Zinc 2 By similarity
	Metal binding	87	1	Zinc 2 By similarity
	Binding site	565	1	Substrate Potential
	Binding site	567	1	Substrate Potential
Experimental info
	Sequence conflict	412	1	T → A in AK100914. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6YVM4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C6739B6FCB6A91D5	FASTA	1,092	122,410
	10 20 30 40 50 60 MEASAGLVAG SHNRNELVVI RRDGGGGGGV GGRRAAEAKA ACQICGDDVG EGPDGEPFVA 70 80 90 100 110 120 CNECAFPVCR NCYDYERREG SQACPQCKTR FKRLKGCPRV AGDEEEDGVD DLEGEFGLDG 130 140 150 160 170 180 REDDPQYIAE SMLRANMSYG RGGDLQPFQP IPNVPLLTNG QMVDDIPPEQ HALVPSYMGG 190 200 210 220 230 240 GGGGGKRIHP LPFADPSVPV QPRSMDPSKD LAAYGYGSVA WKERMEGWKQ KQERMQQLRS 250 260 270 280 290 300 EGGGDWDGDG DADLPLMDEA RQPLSRKVPI SSSRINPYRM IIIIRLVVLG FFFHYRVMHP 310 320 330 340 350 360 VNDAFALWLI SVICEIWFAM SWILDQFPKW LPIERETYLD RLSLRFDKEG QPSQLAPVDF 370 380 390 400 410 420 FVSTVDPSKE PPLVTANTVL SILSVDYPVE KVSCYVSDDG AAMLTFEALS ETSEFAKKWV 430 440 450 460 470 480 PFCKKFNIEP RAPEWYFQQK IDYLKDKVAA SFVRERRAMK RDYEEFKVRI NALVAKAQKV 490 500 510 520 530 540 PEEGWTMQDG SPWPGNNVRD HPGMIQVFLG QSGGRDVEGN ELPRLVYVSR EKRPGYNHHK 550 560 570 580 590 600 KAGAMNALVR VSAVLSNAPY LLNLDCDHYI NNSKAIREAM CFMMDPLVGK KVCYVQFPQR 610 620 630 640 650 660 FDGIDRHDRY ANRNVVFFDI NMKGLDGIQG PIYVGTGCVF RRQALYGYDA PKTKKPPSRT 670 680 690 700 710 720 CNCWPKWCCC CCCGNRHTKK KTTKPKPEKK KRLFFKKAEN QSPAYALGEI EEGAPGAETD 730 740 750 760 770 780 KAGIVNQQKL EKKFGQSSVF VASTLLENGG TLKSASPASL LKEAIHVISC GYEDKTDWGK 790 800 810 820 830 840 EIGWIYGSIT EDILTGFKMH CHGWRSIYCI PKRPAFKGSA PLNLSDRLHQ VLRWALGSVE 850 860 870 880 890 900 IFFSKHCPLW YGYGGGLKFL ERFSYINSIV YPWTSIPLLA YCTLPAICLL TGKFITPELT 910 920 930 940 950 960 NVASLWFMSL FICIFVTGIL EMRWSGVAID DWWRNEQFWV IGGVSSHLFA VFQGLLKVLA 970 980 990 1000 1010 1020 GVDTSFTVTS KAGDDEEFSE LYTFKWTTLL IPPTTLLLLN FIGVVAGVSN AINNGYESWG 1030 1040 1050 1060 1070 1080 PLFGKLFFAF WVIVHLYPFL KGLVGRQNRT PTIVIVWSIL LASIFSLLWV RIDPFLAKNN 1090 GPLLEECGLD CN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana." The rice annotation project (RAP) Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[3]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP005824 Genomic DNA. Translation: BAC84511.1. AP008213 Genomic DNA. Translation: BAF21217.1. AK100914 mRNA. No translation available.
RefSeq	NP_001059303.1.
UniGene	Os.10926
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Genome annotation databases
GeneID	4342850.
KEGG	osa:4342850.
Organism-specific databases
Gramene	Q6YVM4.
Family and domain databases
InterPro	IPR005150. Cellulose_synth. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF03552. Cellulose_synt. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CESA6_ORYSJ

Accession

Primary (citable) accession number: Q6YVM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)